Reka twige serivisi yo gusukura umubiri wawe cyane! (Autophagy)?

Uyu munsi tugiye kuvuga ku buryo butangaje kandi bw'ingenzi cyane bubaho mu mibiri yacu. Ni nk'isuku ikomeye ihora ikora mu mibiri yacu. Ushobora kuba utarabyumva mbere, ariko ni ikintu bigira ingaruka zikomeye ku buzima bwacu, cyane cyane uko tugenda dusaza. Tubyita "Auto PH agy". Iryo jambo risa n'aho ritangaje gato, si byo se? Ariko reka tubisobanure mu buryo bworoshye.

"Autophagy" ni iki? Mu magambo make...

Tekereza ko uko ukoresha urugo rwawe, buri gikoresho cyo mu nzu kirashaje, ibindi bikameneka, ibindi bikaba ubusa. None se twakora iki? Dukuraho ibintu bidafite akamaro, rimwe na rimwe dufata ibice byiza by'ibintu bishaje tukabikora bishya, cyangwa tugasukura inzu tukayitunganya, sibyo? Ibyo ni ko biba mu turemangingo, ari two duto cyane mu mibiri yacu.

Mu magambo make, `(Autophagy)` ni inzira aho uturemangingo tw’umubiri wacu dukura ibice bishaje, byangiritse, cyangwa bidafite akamaro mu mibiri yabyo hanyuma tukabisubiramo, bivuze ko bishobora kongera gukoreshwa. Ni nk’uturemangingo twacu twisukura. Ibi bishobora kandi kuvugwa ko ari sisitemu yo "kugenzura ubuziranenge" mu turemangingo twacu. Kuko iyo imyanda idakenewe yirundanyije mu turemangingo, iyo selile ntishobora gukora neza. `(Autophagy)` ikuraho iyo myanda, kandi nibiba ngombwa, ikayikuramo ibintu by’ingirakamaro, bigafasha uturemangingo gukora neza.

Kuki iyi "Autophagy" ari ingenzi cyane?

Noneho ushobora kuba urimo gutekereza uti "Sawa, ni byiza ko uturemangingo twisukura, ariko ikibazo ni ikihe?" Autophagy ni ingenzi cyane kugira ngo uturemangingo twacu tubeho kandi dukore neza. Reka turebe zimwe mu ngingo z'ingenzi:

• Ibice by'uturemangingo byangiritse birasanwa kandi bigakorwa neza: Nk'uko ameza mashya akorwa hakoreshejwe ibiti byiza mu ntebe yangiritse, ni ko n'uturemangingo dukora ibice bishya kandi by'ingirakamaro mu bice byabyo bishaje.
• Ikuraho ibice bidafite akamaro kandi bitwara umwanya: Iyo ingirabuzimafatizo yuzuyemo ibintu bitari ngombwa, irushaho gukora neza. Autophagy ikuraho uyu mutwaro utari ngombwa, igatuma ingirabuzimafatizo zikora neza mu buryo bwihuse.
• Isenya ibintu nka mikorobe, bagiteri, na virusi byangiza uturemangingo: Iyi gahunda ishobora no kumenya no gusenya ibintu bimwe na bimwe byangiza byinjira mu turemangingo twacu. Ni ukuvuga ko ibi binafasha ubudahangarwa bwacu bw'umubiri .

Uretse ibi, "Autophagy" ifite isano rikomeye n'uko dusaza ndetse n'igihe tumara tumeze neza.Ubusanzwe, uko tugenda dusaza, iyi gahunda ya "Autophagy" igenda igabanuka gato. Icyaba ari uko imyanda itangira kwirundanya mu turemangingo, kandi imikorere y'uturemangingo ikagabanuka. Bityo rero, kubungabunga iyi gahunda neza bishobora kuba ingenzi kugira ngo umuntu agire ubuzima bwiza kandi burambye.

Iyi gahunda `(Autophagy)` ibaho ite koko?

Noneho reka turebe uburyo ubu buryo butangaje bwo gusukura bukora imbere mu kagari. Ibi bishobora kumvikana nk'ibya siyansi, ariko reka mbisobanure mu buryo bworoshye.

Iyi gahunda ya `(Autophagy)` yoroherezwa n'ubwoko bwihariye bwa poroteyine . Izi zitwa `(Autophagy-related proteins)` cyangwa `(ATGs)`. Izi poroteyine `(ATGs)` zikusanya imyanda iri mu ngirabuzimafatizo, ni ukuvuga ibice bishaje kandi byangiritse, maze zigakora imiterere isa n'urukiramende ruyikikije. Ibi byitwa `(Autophagosome)`. Tekereza nk'aho upfunyika imyanda.

Hanyuma, iyi "Autophagosome", iyo sakoshi y'imyanda, ijya mu kindi gice cyihariye cy'ingirabuzimafatizo. Yitwa "Lysosome." Iyi "Lysosome" imeze nk'"uburyo bwo guta imyanda" mu ingirabuzimafatizo. Icyo ikora ni ukumena ibintu biri muri iyo sakoshi y'imyanda, ni ukuvuga kubyicamo ibice bito.

Ijambo "Autophagy" mu by'ukuri rikomoka ku magambo abiri y'Ikigiriki. "Autos" bisobanura "kwiyima" na "Phagomai" bivuga "kurya." Bisobanura "kwiyima." Ni nk'aho ingirabuzimafatizo "irya" ibice byayo idashaka, si byo se?

Rero iyo `(Lysosome)` imaze gusya imyanda, irekura ibice byiza (nk'ibikoresho fatizo) bishobora kongera gukoreshwa. Hanyuma ingirabuzimafatizo ikoresha ibyo bikoresho fatizo kugira ngo ikore ibice bishya ikeneye. Ntabwo ari ibintu bitangaje?

Ni ryari iyi gahunda ya "Autophagy" iterwa imbaraga mu mubiri wacu?

Ubusanzwe iyi gahunda ya "Autophagy" yihuta iyo uturemangingo twacu tudafite intungamubiri cyangwa ogisijeni dukeneye, cyangwa iyo uturemangingo twangiritse.

Tekereza kuri ubu buryo: `(Autophagy)` ni uburyo bwo kongera gukoresha ibintu bufasha ingirabuzimafatizo gukoresha neza umutungo wayo. Rero, iyo umutungo uboneka ku ngirabuzimafatizo uturutse hanze (nk'ibiribwa, ogisijeni) ari muke, ingirabuzimafatizo igomba gukoresha neza umutungo ifite. Icyo gihe ni bwo uburyo bwo gukora `(Autophagy)` burushaho gukora.

Mu magambo make, ni nk'aho ingirabuzimafatizo "zirya" ubwazo zigerageza kubaho. Ariko icyiza kuri ibi ni uko ingirabuzimafatizo zitangira gukora neza kurushaho kubera uku kugerageza kubaho.

Ese dushobora kubikora nkana kugira ngo dutere imbere iyi gahunda ya "Autophagy"?

Noneho ushobora kuba urimo gutekereza uti "Ah, none se twatangira ibi uko tubyifuza? Byaba byiza cyane!" Hari uburyo bumwe na bumwe bwo guha uturemangingo twacu " stress " no kudufasha gutangira iyi gahunda ya "Autophagy". Ni:

• Kwiyiriza ubusa: Ibi bivuze kutarya igihe runaka. Ibi bivuze ko umubiri uhagarika kwakira intungamubiri ziturutse hanze y'umubiri, maze uturemangingo tugahatirwa kongera gukoresha ibice byatwo kugira ngo bikore ingufu.
• Kugabanya kalori: Ibi bikubiyemo kugabanya umubare wa kalori urya ku munsi utaretse kurya burundu, nko kwiyiriza ubusa. Ibi bishobora kandi gutera "Autophagy" kuko uturemangingo twumva tubuze intungamubiri.
• Guhindura indyo irimo ibinure byinshi kandi irimo karubohidrati nke: Ibi nibyo abantu benshi bita "indyo ya Keto." Ikibaho muri ibi ni uko uburyo umubiri ukoresha ingufu buhinduka. Aho gukoresha karubohidrati (isukari, isukari), utangira gutwika ibinure kugira ngo ubone ingufu. Iyi mpinduka ishobora no gutangiza inzira ya "Autophagy."
• Imyitozo ngororamubiri: Mu gihe cy'imyitozo ngororamubiri, cyane cyane iyo imitsi yacu iri mu muvuduko runaka, imikorere ya poroteyine za "ATGs" zavuzwe haruguru ishobora kwiyongera kandi "Autophagy" ishobora gukangurirwa. Ibi bishobora gutandukana bitewe n'ubwoko bw'imyitozo ngororamubiri ikorwa n'ubukana bwayo.

Ariko, hari ikintu cy'ingenzi cyane ugomba kwibuka hano. Nubwo hari uburyo bwo gushishikariza `(Autophagy)`, ntabwo bukwiriye buri wese. Urugero, niba utwite, wonsa, cyangwa ufite ikibazo nka `(Diabetes Mellitus)`, kwiyiriza ubusa, kugabanya karori, cyangwa guhindura `(Keto diet)` mu buryo butunguranye bishobora guteza akaga. Mu buryo nk'ubwo, si byiza gutangira siporo igoye utarinze kuvugana na muganga.

Ugomba kwiyiriza ubusa igihe kingana iki kugira ngo utangire `(Autophagy)`?

Ubushakashatsi ku nyamaswa bugaragaza ko autophagy ishobora guterwa no kwiyiriza ubusa amasaha 24 kugeza kuri 48. Ariko, nta bushakashatsi buhagije buratangwa ku gihe nyacyo bifata kugira ngo autophagy ikore ku bantu.

Rero, niba urimo gutekereza guhindura cyane imirire yawe nko kwiyiriza ubusa, menya neza ko wavuganye na muganga. Nubwo kwiyiriza ubusa bishobora kuba byiza kuri bamwe, bishobora kwangiza ubuzima bw'abandi. Bityo rero ntugafate ibyago bitari ngombwa.

Ni iyihe sano iri hagati ya `(Autophagy)` n'indwara?

Mu bihe byashize, abahanga mu bya siyansi bibwiraga ko "Autophagy" ari igikorwa gisanzwe cyo gusukura uturemangingo, ubwoko bw' "isuku yo mu rugo." Ariko, ubushakashatsi bwakozwe mu myaka 20 ishize bwagaragaje ko "Autophagy" ishobora kugira uruhare runini mu gukumira no gusubiza indwara .

Urugero, ubushakashatsi bwagaragaje ko ibibazo bijyanye n'inzira ya "Autophagy" bishobora kuba bifitanye isano n'indwara zikurikira:

• `(Indwara ya Crohn)` (Indwara ya Crohn)
• `(Diyabete)` (Diyabete)
• Indwara z'umutima
• `(Indwara ya Huntington)` (Indwara ya Huntington)
• Indwara y'impyiko
• Indwara y'umwijima
• `(Indwara ya Parkinson)` (Indwara ya Parkinson)

Nanone, ibibazo bijyanye n'inzira ya `(Autophagy)` byagaragaye ko bifitanye isano na kanseri . Iyo ``imyanda`` yikusanyije mu turemangingo, bishobora kongera ibyago byo gukora amakosa mu bigize imiterere y'uturemangingo, ni ukuvuga ``(DNA)`. Izi mpinduka muri ``(DNA)` zishobora gutera ``(mutations genetic)`, bishobora gutuma habaho ikorwa ry'uturemangingo twa kanseri.

Ariko, biragoye kumenya niba `(Autophagy)` ari nziza cyangwa mbi mu kwirinda indwara. Urugero, hari ubushakashatsi bwagaragaje ko `(Autophagy)` ifasha mu gukumira ibibyimba mu ntangiriro za kanseri. Ariko, ubundi bushakashatsi bwagaragaje ko `(Autophagy)` ishobora gutuma uturemangingo twa kanseri dukora neza ndetse igafasha no gukura kwa kanseri.

Nanone, ubushakashatsi bwinshi bwakozwe ku isano iri hagati ya autophagy n'indwara ntibwakozwe ku bantu. Akenshi bwakorewe ku nyamaswa nk'imbeba. Rero, uko abahanga mu bya siyansi bamenya byinshi kuri iyi gahunda, dushobora gusobanukirwa neza uburyo igira ingaruka ku ndwara zimwe na zimwe no ku buzima bwacu bw'igihe kirekire.

Amaherezo, ibintu byo kwibuka (Ubutumwa bwo kujyana mu rugo)

Mu minsi ishize, ubwo havugwaga cyane kuri `(Autophagy)`, hari abantu bagiye babyita "icyerekezo cy'ubuzima" gusa - uburyo bwo kuguma ukiri muto no kugira uturemangingo tuzima. Ariko, `(Autophagy)` mu by'ukuri ntabwo byoroshye cyane.

Nibyo koko autophagy ni ingenzi ku turemangingo tuzima. Ni ukuri kandi ko ibibazo bijyanye n'imikorere ya autophagy bifitanye isano n'indwara zimwe na zimwe. Ariko, nta bushakashatsi buhagije buhari bwo kuvuga ko gukangura autophagy ari byiza ku buzima bwiza.

Bitewe n'ubuzima bwawe, kwiyiriza ubusa, kugabanya karori, guhindura cyane imirire yawe, cyangwa gutangira gukora siporo igoye mu buryo butunguranye bishobora guteza akaga. Kubwibyo, ni ngombwa kuvugana na muganga wawe mbere yo guhindura imibereho yawe bishobora kugira ingaruka ku mikorere karemano y'umubiri wawe. Si byiza gufata ibi nk' 'icyerekezo' hanyuma ugahita uhagarika kurya, ukagabanya karori, cyangwa ugatangira gukora siporo igoye. Muganga wawe ni we wenyine uzi icyo bifitiye umubiri wawe akamaro.

` Autophagy, gusukura uturemangingo, kwiyiriza ubusa, ubuzima bwiza bw'uturemangingo, gusaza, imikorere y'umubiri, ubuzima bwiza