Ese twavuga ku muti wa Amvuttra uvura indwara z'umutima witwa ATTR-CM? (ATTR-CM na Amvuttra)

Ushobora kuba utarigeze wumva indwara zibaho iyo ubwoko bwa poroteyine mu mubiri wacu bwikubye nabi bukajya mu ngingo z'ingenzi nk'umutima n'imitsi. Izi akenshi ni indwara zidakunze kugaragara. Mu buvuzi, ubu bwoko bwa poroteyine bwitwa amyloidosis . Uyu munsi, tugiye kuvuga ku ndwara idakunze kugaragara yitwa ATTR-CM, yibasira cyane umutima, ni ukuvuga aho izi poroteyine zishyirwa mu mitsi y'umutima, n'umuti ugezweho witwa Amvuttra ukoreshwa muri yo.

ATTR-CM ni iki mu by'ukuri?

Muri make, ATTR-CM ni indwara ituma, bitewe n'inenge y'uturemangingo cyangwa ibaho mu buryo busanzwe iyo umuntu asaze, poroteyine TTR, ikorerwa mu mubiri wacu, ihindura imiterere yayo, ikanaterana, maze ikagira ingaruka mu mitsi y'umutima. Izina ryuzuye ry'iyi ndwara ni Transthyretin Amyloid Cardiomyopathy.

Tekereza kuri ibi, inkuta z'umutima wacu zigomba kuba zoroshye kugira ngo zikore neza. Ariko iyo izi poroteyine ziyongera, inkuta z'umutima ziba nini kandi zikomeye . Ibi twita cardiomyopathy. Ibi bituma umutima udashobora gukompa amaraso neza. Uko igihe kigenda gihita, ibi bishobora no gutuma umutima unanirwa.

Bamwe mu bantu barwaye ATTR-CM ntibagira ibimenyetso na bimwe, ariko abandi bagira ibimenyetso bisa n'iby'indwara y'umutima isanzwe.

• Guhumeka gake (dyspnea)
• Kubyimba, cyane cyane mu maguru no mu tuguru
• Urujijo cyangwa kwiheba
• Umutima utera cyane cyangwa umutima utera nabi
• Kubabara mu gatuza

Ibi bishobora gutuma wumva unaniwe vuba iyo ukora ibintu nko kuzamuka ingazi, gukora imirimo yo mu rugo, cyangwa kugenda n'amaguru hafi.

Byongeye kandi, hari n'ibindi bimenyetso bitajyanye n'umutima bishobora kubaho. Urugero, intege nke, kugira ibinya cyangwa ububabare mu maboko no mu maguru, kubira ibyuya byinshi, kuzerera cyangwa gucika intege, ndetse n'ibibazo by'igogora.

Ubuvuzi bwa Amvuttra bukora bute?

Kugira ngo tubisobanukirwe, tugomba kubanza kumenya bike kuri poroteyine yitwa TTR. TTR (Transthyretin) ni poroteyine ikorerwa mu mwijima wacu. Inshingano yayo nyamukuru ni ugutwara imisemburo ya tiroyide na vitamine A mu mubiri wose.

Ku bantu barwaye ATTR-CM, ubusembwa bw'uturemangingo butuma poroteyine ya TTR ikorwa mu buryo butari bwo. Iyi shusho idakwiye ya poroteyine irarundana ikajya mu mutima.

Umuti witwa Amvuttra ukora nk'umuti utuma imiterere y'uturemangingo idakora neza. Ni ukuvuga ko uyu muti ujya mu mwijima ugahagarika poroteyine ya TTR ifite ikibazo.Bigabanya imikorere ya gene iri gukorwa. Ni nko kugabanya ijwi rya radiyo.

Amvuttra ni urushinge rwo munsi y'umubiri. Uru rukingo ubusanzwe rutangwa n'umuganga buri mezi atatu .

Ni gute intsinzi y'uyu muti yageragejwe?

Kimwe n'umuti mushya uwo ari wo wose, ubushobozi bwa AMVUTTRA bwemejwe binyuze mu bushakashatsi bunini. Muri ubu bushakashatsi, abarwayi 655 ba ATTR-CM bahawe urukingo rwa Amvuttra, abandi bagize itsinda bahabwa urukingo rwa placebo rutagira umuti buri mezi 12 mu gihe cy'imyaka itatu.

Abashakashatsi barebye ibintu byinshi kugira ngo bapime niba uyu muti ufite akamaro.

• Ikizamini cy'iminota itandatu yo kugenda n'amaguru: Iki gipima uburebure ushobora kugenda ku muvuduko usanzwe mu minota 6. Intera iragabanuka uko indwara y'umutima wawe irushaho kwiyongera.
• Icyiciro cy’ishyirahamwe ry’umutima rya New York (NYHA): Iki cyiciro gipima ubukana bw’ibimenyetso by’umutima. Hari ibyiciro bine (I, II, III, IV). Uko umubare w’ibyiciro uba munini, niko indwara iba ikomeye kurushaho.

• Urutonde rw'ibibazo ku buzima bwiza (KCCQ-OS): Ibi bipima ingaruka z'indwara ku buzima bw'umurwayi.

Ubushakashatsi bwagaragaje iki?

Mu mpera z'igihe cy'imyaka itatu yo kuvurwa, abashakashatsi basesenguye ibyavuye mu bushakashatsi.

Icyagaragaye cyane ni uko abarwayi bahawe Amvuttra bari bafite ibyago bingana na 28% byo gupfa cyangwa kujya mu bitaro bitunguranye cyangwa gusura ibyihutirwa (ETU) bitewe n’indwara z’umutima , ugereranije n’abahawe urukingo rw’impimbano (placebo).

Ikindi kintu cy'ingenzi ni uko mu mpera z'amezi 42, ibyago byo gupfa bivuye ku mpamvu iyo ari yo yose byagabanutseho 35% mu itsinda ryahawe Amvuttra.

Byongeye kandi, abarwayi bahawe Amvuttra bagabanutse cyane mu bushobozi bwo kugenda no mu mibereho yabo.

Ariko ibuka ko ibi byavuye mu bushakashatsi bishobora kuba bitameze kimwe kuri buri wese. Wowe na muganga wawe muzakenera gufata umwanzuro hamwe niba Amvuttra ikubereye kandi niba inyungu zayo ziruta ingaruka mbi.

Reka twige ku bisubizo n'ingaruka mbi byagize.

Bifata igihe kingana iki kugira ngo ubone ibisubizo?

Amvuttra ni umuti ukora uko igihe kigenda. Kubwibyo, ibisubizo ntibihita bigaragara. Bishobora gufata amezi menshi cyangwa arenga kugira ngo ibimenyetso birusheho kugaragara neza.

Ni gute wakwirinda ingaruka mbi?

Imwe mu ngaruka mbi z’ingenzi za Amvuttra ni ukugabanuka kwa vitamine A mu maraso. Ibi biterwa nuko poroteyine ya TTR ariyo itwara vitamine A mu mubiri wose. Iyo umuti ugabanyije umusaruro wa TTR, ubwikorezi bwa vitamine A nabwo buragabanuka.

• Muganga wawe azagutegeka gupima amaraso buri gihe kugira ngo arebe urugero rwa vitamine A yawe. Ni ingenzi cyane gukora ibi bizamini ku gihe.
• Shyiramo ibiryo bikungahaye kuri vitamine A (urugero: karoti, ibijumba, epinari, amagi, amata, urusenda rutukura ) mu ndyo yawe.
• Niba ubonye impinduka mu kureba kwawe (cyane cyane kureba nabi nijoro), menyesha muganga wawe ako kanya.
• Bitewe n'urugero rwa vitamine A ufite, muganga wawe ashobora kukugira inama yo gufata inyongeramusaruro ya vitamine A.

Izi si zo ngaruka mbi zonyine za Amvuttra. Niba ufite ibindi bimenyetso bikubangamiye, menya neza ko wavuganye na muganga wawe .