Mashoko haagone kuratidza kusuruvara uye kushaya simba kwatinonzwa kana mudiwa wedu, pamwe amai, baba, kana shamwari, akabatwa nechirwere cheAlzheimer , chinokonzera kurasikirwa nendangariro. Vanachiremba nemasayendisiti pasi rese vari kushanda nesimba kuti vawane mushonga wechirwere ichi. Nekuda kwekuedza kwakadaro, nyika yakatanga kutaura nezvemushonga weAducanumab , unouya pasi pezita rekuti Aduhelm. Asi kunyangwe paine tariro huru yemushonga uyu, pakavawo negakava guru. Iye zvino kugadzirwa kwemushonga uyu kwamiswa. Saka nhasi, ngatitaurei nezvemushonga uyu weAduhelm, kuti waishanda sei, uye nei usingachawanikwe.
Zvichitaurwa zviri nyore, chii chinonzi Aduhelm (Aducanumab) iyi?
Aduhelm mushonga unopiwa varwere vari muchikamu chekutanga chechirwere cheAlzheimer, kureva avo vane dambudziko repfungwa diki . Uri weboka remishonga inonzi monoclonal antibodies .
Fungidzira, kana chirwere cheAlzheimer chikatanga, rudzi rweprotein inonzi amyloid runoungana pakati pemasero etsinga muuropi hwedu, ruchizvivanza semarara. Tinoti izvi amyloid plaques . Ma plaques aya anokuvadza masero europi uye anoita kuti afe. Basa guru remushonga weAduhelm nderekuona ma amyloid plaques anoungana muuropi uye kubatsira muviri kubvisa.
Mushonga uyu wakatenderwa neUS FDA nenzira isingawanzoitiki, uchiregeredza zvakakurudzirwa nebhodhi remazano resangano racho. Nekuda kweizvozvo, vamwe nyanzvi dzezvekurapa vakabvunza nezvekudiwa kwekutsvaga kwakawanda nezvekuchengetedzeka uye kushanda kwemushonga uyu.
Zvisinei, kambani yaigadzira mushonga uyu yakarega kuugadzira zvachose muna 2024. Tichaona kuti sei gare gare.
Mushonga uyu unoshanda sei mumuviri?
Uyu mushonga unopihwa kamwe chete pamwedzi kuburikidza nekuisa mutsinga. Sezvatakambotaura, chimwe chezviratidzo zvikuru zvechirwere cheAlzheimer kuunganidzwa kweprotein inonzi amyloid-beta muuropi, zvichiita kuti pave nemaplaque. Izvi zvinoita kuti masero europi afe, chinova ndicho chikonzero chikuru chekurasikirwa nendangariro nekuchinja kwemaitiro.
Mushonga weAduhelm unoshanda semuongorori wezvirwere. Unopinda muuropi uye unoona kuti ma plaque e amyloid ari kupi. Unoaziva uye unoanamatira. Wobva watumira chiratidzo kumasoja emuviri wedu, uchiti, "Hechino chimwe chinhu chinofanira kubviswa." Ipapo masero emasoja emuviri anopinda oparadza ma plaque iwayo.
Masayendisiti akafunga kuti nekubvisa plaque nenzira iyi, masero europi aizomira kufa uye kuora kwekuyeuka nepfungwa dzekufunga kwaizodzorwa.
Mushonga uyu unoshanda zvechokwadi here? Sei paine gakava rakadai nezvazvo?
Uyu ndiwo mubvunzo unobvunzwa nevanhu vazhinji. Zvidzidzo zviviri zvikuru zvakaitwa kuti vaongorore kushanda kwemushonga weAduhelm.
1. Ongororo yekutanga: Izvi zvakaratidza kuti mushonga weAduhelm wakadzikisa huwandu hwemaplaque e-amyloid muuropi. Wakaderedzawo zvishoma mwero wekuderera kwendangariro nekukwanisa kuita mabasa ezuva nezuva kune avo vakatora mushonga wakawanda . Asi mushonga uyu hauna kukwanisa kumisa kana kudzora chirwere ichi.
2. Chidzidzo chechipiri: Chidzidzo ichi hachina kuratidza kubatsira kwevarwere. Saka, chidzidzo ichi chakamiswa pakati.
Mhedzisiro yechidzidzo chimwe chete ichocho haina kukwana kugutsa bhodhi remazano reFDA. Asi FDA yakasarudza kubvumidza mushonga uyu. Asi panguva imwe chete, yakapa Biogen, kambani inogadzira mushonga uyu, makore mapfumbamwe kuti iite imwe ongororo yekusimbisa kushanda kwemushonga uyu. Kubvumidzwa uku kwakangoerekana kwakonzera gakava guru, uye mamwe makambani makuru ezvipatara akasarudza kusapa varwere vavo kusvika rumwe ruzivo rwakawanda nezvemushonga uyu rwawanikwa.
Musiyano uripo pakati peAducanumab neLecanemab
Kune mumwe mushonga unonzi Lecanemab (Leqembi) wakafanana neAducanumab (Aduhelm). Iantibody yemonoclonal zvakare. Zvese izvi zvinoshanda nekutarisa mapuroteni eamyloid muuropi. Zvisinei, pane musiyano mudiki pamashandiro azvinoita. Kureva kuti, mishonga iyi miviri inoshanda pamatanho maviri akasiyana mukugadzirwa kweamyloid plaque. Lecanemab yakagamuchira mvumo yeFDA muna 2023. Tsvagiridzo yakaratidza kuti inogona kunonoka kufambira mberi kwechirwere neinenge 20%-30%.
Ndezvipi migumisiro yeAducanumab?
Kufanana nemushonga upi zvawo, Aducanumab inogona kukonzera migumisiro yakaipa . Mimwe yeiyi inogona kunge yakakomba, saka zvakakosha kuti uizive.
| Mhedzisiro Yepadivi | Tsananguro iri nyore |
|---|---|
| Kuzvimba kwehuropi kwechinguvana | Iyi ndiyo mhedzisiro inonyanya kutaurwa nezvayo. Kazhinji haina zviratidzo uye inowanikwa kuburikidza nekuskena. |
| Kubuda ropa kudiki muuropi | Izvi zvinowanzova zviitiko zvekubuda ropa zvisina kujeka zvinogona kuonekwa chete kuburikidza nekuskena. |
| Musoro | Mhedzisiro yakajairika. |
| Kudonha | Kudonha kwemuviri kwave kutaurwa nekuti kuenzana kwemuviri kunogona kukanganiswa. |
| Manyoka | Migumisiro ine chekuita nekugaya chikafu inogona kuitika. |
| Kuvhiringidzika | Kujeka kwekufunga kunogona kukanganiswa kwenguva pfupi. |
Chinhu chinonyanya kukosha ndechekuti kana munhu anotora mushonga werudzi urwu akaona zviratidzo zvisingawanzoitiki, anofanira kuzivisa chiremba wake nekukasika.
Saka sei mushonga uyu wakamiswa?
Muna Ndira 2024, Biogen yakazivisa kuti yaizorega kugadzira nekutengesa Aducanumab zvachose. Vanhu vazhinji vaifunga kuti izvi zvaikonzerwa nekunetseka nezvekuchengetedzwa kwemushonga kana kusashanda zvakanaka kwawo. Asi handicho chikonzero chaicho.
Kambani iyi yakatsanangura kuti danho iri rakaitwa nekuti yakasarudza kuisa zviwanikwa zvayo (mari, mapoka ekutsvagisa, nezvimwewo) pakugadzira nekusimudzira mimwe mishonga yeAlzheimer's, kunyanya mishonga yakaita seLecanemab. Kureva kuti, ichi chaive chisarudzo chebhizinesi nekutarisira zviwanikwa, kwete chisarudzo chakaitwa nekuda kwekunetseka nezvekuchengetedzeka kana kushanda kwemushonga wacho.
Nechisarudzo ichi, mushure meMbudzi 1, 2024, kunyangwe varwere vakagamuchira mushonga uyu netsamba havazokwanisi kuuwana.
Mharidzo Yekuenda Nayo Kumba
- Aduhelm (Aducanumab) mushonga wakatangwa kurapa chirwere cheAlzheimer's chiri kutanga, asi ikozvino wamiswa .
- Maitiro ayo makuru aive ekubatsira muviri kubvisa ma plaque e amyloid anoungana muuropi.
- Kwave nenharo huru munharaunda yezvekurapa nezvekushanda kwemushonga uyu. Kunyange hazvo zvimwe zvidzidzo zvakaratidza kubatsira kudiki, zvimwe hazvina.
- Izvi hazvina kubviswa pakugadzirwa nekuda kwedambudziko rekuchengetedza, asi nekuti kambani inogadzira yakasarudza kushandisa mimwe mishonga.
- Kana iwe kana mumwe munhu waunoda muine zvinokunetsai kana mibvunzo nezvechirwere cheAlzheimer, chinhu chakanakisisa chekuita ndechekubvunza chiremba wemhuri yenyu kana nyanzvi. Dzivisai kuita sarudzo zvichibva paruzivo rwunowanikwa paInternet chete.
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