Mushonga mutsva wekuderedza kushushikana: Zvaunofanira kuziva nezveAuvelity

Kuora mwoyo chirwere chinoita kuti hupenyu huve nerima uye hureme. Kana uri kunetseka neizvi, ungasawana zororo rakawanda sezvaunofunga nemishonga yauri kushandisa parizvino. Saka, pari zvino, mhando itsva dzemishonga dzabudawo kurapa kuora mwoyo. Nhasi tiri kutaura nezvemushonga unonzi `Auvelity' waunza tariro itsva kudaro. Uyu mushonga wakatenderwa muUnited States muna 2022 uye unoshandiswa pakurapa Major Depression Disorder.

Chii chinonzi Auvelity? Inoshanda sei?

Zvichitaurwa zviri nyore, 'Auvelity' musanganiswa wemishonga miviri. Izvi zvinoreva kuti kune mhando mbiri dzemishonga mupiritsi rimwe chete. Idzi ndi 'dextromethorphan' ne 'bupropion'. Funga nezvazvo sekushanda pamwe chete. Vanhu vaviri vanoshanda pamwe chete vanoita mishonga inopfuura mumwe chete.

• Bupropion : Uyu mushonga watove unoshandiswa kurapa kushungurudzika . Unoshanda nekuwedzera huwandu hwemakemikari muuropi hwedu anonzi `dopamine` uye `norepinephrine`, ayo anokanganisa mafungiro edu.
• Dextromethorphan : Ungave uchiziva nezveuyu. Mamwe manyuchi ekukosora ane mushonga uyu. Zvisinei, mushonga uyu wakawanikwawo uchikanganisa makemikari ari muuropi ane chekuita nemanzwiro.

Saka, kana mishonga iyi miviri ikasanganiswa , inobatsira zvikuru mukuderedza zviratidzo zvekuora mwoyo kupfuura bupropion chete.

Kubudirira kwemushonga uyu kwakaedzwa sei?

Vasati vapa vanhu mushonga, vanoedza kuti wakachengeteka uye unoshanda sei. Zvidzidzo zviviri zvakafanana zvekiriniki zvakaitwa pa`Auvelity`. Muizvi, nzira yakakosha yakashandiswa kuyera kuoma kwekuora mwoyo. Inonzi ``Montgomery-Asberg Depression Rating Scale (MADRS).`` Zvakafanana nemubvunzo. Unobvunzwa mibvunzo gumi nezvezvinhu zvakaita sekusuruvara, matambudziko ekurara, uye kunzwa uine mhosva uye unopihwa mamaki. Unogona kupa mamaki kubva pa0 kusvika pa60. Kana mamaki akakwira, kuora mwoyo kwako kunowedzera. Kudzikira kwemaki mushure mekutora mushonga kunoreva kuti chirwere chiri kuva nani. Zvidzidzo izvi zvaisanganisira vanhu vane makore 18-65 vane kuora mwoyo kwakanyanya. Zvisinei, vanhu vane zvimwe zvirwere zvepfungwa (senge `bipolar disorder`, `psychotic disorder`), vanhu vane njodzi huru yekuzviuraya, uye vanhu vane pfari havana kubatanidzwa.

Ndezvipi zvakabuda muzvidzidzo izvi?

Mhedzisiro yacho inokurudzira zvikuru. Mushonga wekuti `Auvelity` waishanda zvakanyanya mukuderedza zviratidzo zvekuora mwoyo kupfuura placebo ne`bupropion` chete. Izvi zvinoreva kuti mamakisi e`MADRS` aive akaderera kune avo vakatora `Auvelity` pane kune avo vakatora mimwe mishonga.

Ko Auvelity inogona kupindirana nemimwe mishonga here? (Kudyidzana kweMishonga)

Ichi chikamu chakakosha zvikuru . Ehe, Auvelity inogona kupindirana nemimwe mishonga yauri kutora. Saka, unofanira kuudza chiremba wako nezvemishonga yese yauri kutora, kusanganisira mishonga inotengeswa muchitoro chemishonga, mavhitamini, uye kunyange mishonga yeAyurvedic.

Dambudziko rine njodzi rinonzi Serotonin Syndrome

Kana Auvelity ikatorwa pamwe chete nemimwe mishonga inorwisa kuora mwoyo inowedzera huwandu hweserotonin, inogona kukonzera kuwedzera kusingadiwe kwe serotonin muuropi. Izvi zvinonzi Serotonin Syndrome. Iyi idambudziko rinotyisidzira hupenyu. Kana ukaona zviratidzo izvi, enda kuchipatara chiri pedyo neEmergency Department (ETU) nekukasika. Panofanira kuva nemusiyano wemazuva gumi nemana pakati pekutora mishonga yeMAOI yekudzora marwadzo nekutora Auvelity.

Mimwe migumisiro

• Nemishonga inowedzera dopamine: `Auvelity` inowedzera dopamine muuropi. Saka kana ikatorwa pamwe chete nemimwe mishonga inowedzera dopamine (yakadai semishonga yeParkinson's disease), huwandu hwedopamine hunogona kuwedzera zvakanyanya, zvichikonzera kusagadzikana, kudedera,Kufamba netsoka kungave kwakaoma.
• Nedoro: Kunwa doro kunofanira kudziviswa kana kuderedzwa zvakanyanya kana uchinwa `Auvelity`. Kunwa doro pamwe chete kunowedzera njodzi yekubatwa nepfari .
• Mishonga yemwoyo: Kushanda kwemishonga yemwoyo yakaita sedigoxin kunogona kuchinjwa neAuvelity. Zvakakosha kuzivisa chiremba wako nezveizvi.
• Mimwe mishonga inoputswa nechiropa: Chiropa chedu chakafanana nefekitori inoputswa mishonga. Kugona kwemuviri kunokanganisa sisitimu yeenzyme inonzi ``cytochrome P450 (CYP450)`` musystem iyi. Izvi zvinogona kuchinja mashandiro anoita mimwe mishonga yaunotora.

Mushonga uyu unoshandiswa sei uye ndeapi mhedzisiro yawo?

`Auvelity` mushonga unopihwa nachiremba chete. Muyero wenguva dzose ipiritsi rimwe pazuva kwemazuva matatu ekutanga, wozobva wanwa piritsi rimwe kaviri pazuva (kubva pamaawa masere zvichienda mberi).

Migumisiro inogona kuitika uye zvinhu zvekuchenjerera

• Kukwira kweropa: Chiremba wako anogona kukuudza kuti ugare uchiongorora BP yako.
• Dzungu: Mushonga uyu unogona kukonzera dzungu. Saka, chenjerera paunenge uchityaira, uchishandisa michina, uye uchiita zvinhu zvinogona kusanganisira kudonha.
• Mhedzisiro pamaziso: Udza chiremba wako kana ukanzwa kurwadziwa kwemaziso, kutsvuka, kana kuchinja kwekuona.
• Kuchinja kwemaitiro: Vamwe vanhu vanogona kusangana nekuvhiringidzika kwepfungwa, kuona kana kunzwa zvinhu zvisipo (kufungidzira), uye kunetseka kuziva chokwadi.
• Kubatwa nepfari: Njodzi iyi inowedzera kana ikanwiwa nedoro. Kana ukasangana nepfari paunenge uchinwa mushonga, rega kutora mushonga wacho nekukasika woudza chiremba wako.
• Madzimai ane pamuviri neanoyamwisa: Mushonga uyu hauna kuchengetedzeka panguva yekuzvitakura kana kuyamwisa. Kana uchironga kuva nepamuviri, une pamuviri, kana kuti uchiyamwisa, zivisa chiremba wako nekukasika.

Kuziva kwakakosha nezvepfungwa dzekuzviuraya

Kufanana nemimwe mishonga yekuderedza kushungurudzika, Auvelity inogona kuwedzera zvishoma njodzi yekufunga kana kuita zvekuzviuraya mune vamwe vanhu, kunyanya pakutanga kwekurapwa.Izvi zvinowanzoitika pakati pevechidiki. Kana iwe kana mumwe munhu mumhuri mako ari kufunga izvi, usave wega.

• Fonera 1926 (National Mental Health Helpline) nekukasika.
• Kana zvisina kudaro, enda kuEmergency Treatment Unit (ETU) yechipatara chiri pedyo.
• Udza chiremba wako nezveizvi nekukasika.

Izvi hazvisi zvekuvanza. Zvakakosha zvikuru kuwana rubatsiro nekukurumidza. Kuora mwoyo, kushushikana, hutano hwepfungwa, kuora mwoyo, dextromethorphan, bupropion, serotonin syndrome, mishonga yekuora mwoyo, migumisiro yakaipa