Ndinoziva kuti zvakaoma kutaura zvaunonzwa kana chiremba wako akakuudza kuti une kenza yemazamu. Zvakajairika kuva nemibvunzo yakawanda nekutya zvinouya mupfungwa dzako. Asi chimwe chezvinhu zvakakosha zvinogona kukubatsira kuburikidza nerwendo urwu rwakaoma ndechekunzwisisa rudzi chairwo rwekenza yako. Kuziva danho rekenza, rudzi rwayo, saizi yayo, uye mamwe mapuroteni ari mumasero ako ekenza kwakakosha zvikuru pakusarudza kurapwa.
Zvichitaurwa zviri nyore, chii chinonzi HER2-Negative?
Ngatinzwisise izvi nenzira iyi. Masero ari mumuviri wedu akafanana nedzimba diki. Dzimba idzi dzine 'antenna' dzakakosha dzinogamuchira mameseji kubva kunze. Mukurapa, tinodana idzi receptors. Kubva kumaantenna aya ndipo panogamirwa sero mashoko akadai sekuti 'kukura' uye 'kupatsanura'.
HER2 (Human Epidermal Growth Factor Receptor 2) ndeimwe yeantenna dzakakosha kudaro. HER2 inobatsira kudzora kukura kwemasero ane hutano. Zvisinei, masero ekenza dzimwe nguva anoita antenna iyi yeHER2 yakawandisa, kupfuura zvakajairika. Zvadaro kenza inogamuchira meseji inogara ichiiudza kuti 'ikure', uye kenza inotanga kupararira nekukurumidza. Tinoidaidza kuti HER2-Positive .
Saka, kana chiremba wako akati kenza yako yemazamu haina HER2 , zvinoreva kuti masero ako ekenza haana HER2 yakawedzerwa. Zvichitaurwa zviri nyore, kenza yako haina chinhu chikuru chinoita kuti ikure nekukurumidza.
Aya mashoko akanaka chaizvo, nekuti kenza yeHER2-negative inowanzova isina simba kupfuura kenza yeHER2-positive. Ruzhinji rwekenza dzemazamu pasi rose dzinonzi HER2-negative.
Unoziva sei chaizvo mamiriro eHER2 ekenza yako?
Zviratidzo zvegomarara reHER2-negative neHER2-positive zvakafanana. Chiremba wako haagoni kukuudza rudzi rwegomarara raunaro nekungokuongorora. Iye achafanirwa kutora sampuli diki yegomarara rako (biopsy) oriongorora. Kuongororwa uku kuchaona kuti puroteni yeHER2 yakawanda sei iri mumasero egomarara iri.
Tinofanira kutarisa zvinopfuura HER2 chete!
HER2 haisiriyo yega chinhu chinokanganisa kukura kwegomarara. Kune mamwe marudzi maviri emareceptor (mareceptor emahormone - HR) mumuviri wedu anonzwa mahormone.
- MaReceptor eEstrogen (ER)
- MaProgesterone Receptors (PR)
Kana mareceptor aya aripo pamasero ekenza, mahormone eestrogen neprogesterone anogona kubatsira kukura kwekenza. Vanachiremba vanotaura nezvemareceptor ese aya pamwe chete. Izvi zvinoreva kuti kenza yako yeHER2-negative inogona kukamurwa kuita mhando mbiri:
1. HR-Positive / HER2-Negative: Izvi zvinoreva kuti kenza haina HER2, asi inonzwa mahormone. Iyi ndiyo mhando yekenza yemazamu inonyanya kuwanikwa .
2. HR-Negative / HER2-Negative: Izvi zvinoreva kuti kenza haina kubatwa neHER2 kana mahormone. Nekuti mareceptor ese matatu aya (HER2, ER, PR) haapo, rudzi urwu runonziwo Triple Negative .
Kuziva zvese izvi kuchakubatsira iwe nachiremba wako kuti munzwisise zvakajeka maitiro egomarara renyu, izvo zvichakubatsirai kusarudza nzira yakakodzera uye inoshanda yekurapa .
Ndeipi mishonga yekurapa kenza yeHER2-negative?
Nekuti kenza yako haina HER2-negative, hauzopiwi mushonga wakanangana nayo, uyo unotarisa puroteni yeHER2. Izvi zvinodaro nekuti mishonga yacho inofanira kunge iine antenna yeHER2 pamasero ekenza kuti ishande. Pane kudaro, mamwe marapirwo achasarudzwa zvichienderana nedanho rekenza yako uye kana iine hutachiona hwemahormone.
- Kuvhiyiwa nemwaranzi: Kana kenza ikaonekwa nekukurumidza, kuvhiyiwa kunogona kuibvisa zvachose. Kurapa nemwaranzi kunogonawo kukurudzirwa usati wavhiyiwa kana kuti mushure mekuvhiyiwa.
- Kurapa neEndocrine/ Hormone : Kurapa uku kwakakosha zvikuru kana kenza yako iri HR-Positive/HER2-Negative. Kunoshanda nekuderedza huwandu hwemahormone akaita seestrogen mumuviri. Kana mahormone apera, masero ekenza anorasikirwa neshoko rekukura, uye kenza inogona kudzikira kana kumira kukura.
- Kurapa neKemotherapy: Dzimwe nguva chemotherapy inogona kupihwa pamwe chete nekurapa nehomoni kune kenza ine HR-positive / HER2-negative. Izvi zvinoenderana nezvinhu zvakaita sedanho uye giredhi rekenza, zera rako, uye hutano hwako hwese. Dzimwe nguva mhedzisiro yechemotherapy inogona kupfuura mabhenefiti, saka zvakakosha kutaura nachiremba wako nezvezvakakunakira.
- Kurapa Nezvirwere Zvinodzivirira Muviri: Kana kenza yako iri negative katatu uye yakura, uye iine imwe protein inonzi PD-L1, kurapwa uku kungave sarudzo. Kunoshanda nekukurudzira masoja emuviri wako kuti arwise kenza.
Maonero uye Kufungidzira
Chinhu chinonyanya kukosha nezvegomarara remazamu ndechekuriwana risati rapararira kune dzimwe nhengo dzemuviri. Kana gomarara rako reHER2-negative riri pazamu, mwero wekurarama kwemakore mashanu wakakwira zvikuru. Izvi zvinonyanya kuitika kana gomarara rako riine HR-positive.
Gomarara rine kenza nhatu rakanyanya kuoma kurapa nekuti haripindure kana richirapwa nehomoni kana mishonga inotarirwa neHER2. Rinogonawo kuva nehasha.
Pazasi pane mwero wekurarama kwemakore mashanu zvichienderana nedanho regomarara. Aya ndiwo avhareji chete, yeuka kuti mamiriro ako ega anogona kunge akasiyana.
| Rudzi rwegomarara | Kupararira kwazvakaita | makore mashanu ekurarama kwemhuri |
|---|---|---|
| HR-Positive / HER2-Negative (Rudzi rwakajairika) | Zvakaganhurirwa pazamu (Zvinowanikwa munzvimbo dzakasiyana) | 100% |
| Pararira kune ma lymph nodes ari pedyo (mudunhu) | 90% | |
| Kure | 31% | |
| Katatu-Negative (HR-Negative / HER2-Negative) | Zvakaganhurirwa pazamu (Zvinowanikwa munzvimbo dzakasiyana) | 91% |
| Pararira kune ma lymph nodes ari pedyo (mudunhu) | 65% | |
| Kure | 12% |
Usavhunduke nenhamba idzi. Idzi ingori avhareji kubva kuzviuru zvevanhu. Maonero ako ega ega achaenderana nezvinhu zvakawanda, kusanganisira kuti muviri wako unopindura sei kana warapwa uye hutano hwako hwese. Saka, taura nachiremba wako nezvechirwere chako uye chero mimwe miedzo yaungade.
Mharidzo Yekuenda Nayo Kumba
- HER2-Negative zvinoreva kuti masero ako egomarara haana puroteni inokosha inoita kuti akure nekukurumidza. Izvi zvinowanzoita kuti kenza idzi dzisanyanya kurwadza.
- Kunyangwe kana kenza yako iri HER2-negative, kuziva kana inonzwa mahormone (HR-positive) kana kwete (HR-negative) kwakakosha pakusarudza kurapwa.
- Nzira dzekurapa dzinoenderana nerudzi uye danho regomarara, pamwe nehutano hwako. Kuvhiyiwa, kurapwa nemwaranzi, kurapwa nehomoni, uye chemotherapy ndiwo marapirwo makuru.
- Kurwa negomarara uku hakusi chinhu chaunofanira kuita uri wega. Taura nachiremba wako nezvemibvunzo yako yese nezvaunotya. Kuva neruzivo rwakakodzera ndiko kusimba kwako kukuru parwendo urwu.
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