Tinonzwisisa kutya, kuvhunduka, uye mibvunzo yakawanda inomuka kana ukaona kuti une kenza yemazamu. Asi chinhu chakakosha panguva ino ndechekuva neruzivo rwakakodzera. Nekuti, haasi ese kenza yemazamu akafanana. Kune marapirwo akagadzirirwa mamwe marudzi ekenza. Zvakanaka, imwe nzira yekurapa yakashandiswa zvinobudirira kune vanhu vazhinji ndeyekurapa nehomoni . Ngatitaurei nezvazvo nhasi.
Chii chinonzi hormone therapy? Yakakodzera munhu wese here?
Zvichitaurwa zviri nyore, mamwe mahormone ari mumiviri yedu anobatsira kukura kwemasero ekenza yemazamu. Zvikuru, mahormone maviri anonzi estrogen neprogesterone.
Funga nezvemasero ekenza sedzimba diki. Mamwe masero ekenza ane 'masuo' akakosha (mareceptor) anobvumira mahormone aya kupinda. Tinodaidza makenza ane masuo aya kuti hormone receptor-positive . Vanachiremba, mungave makacherechedza izvi mumushumo wenyu seER-positive (masuo eestrogen) kana PR-positive (masuo eprogesterone).
Kurapa nemahormone kunoshanda kune kenza dzine magedhi aya emahormone. Kurapa uku kunovhara magedhi iwayo kana kuderedza kugadzirwa kwemahormone iwayo mumuviri. Izvi zvinobvisa "kudya" kwavanoda mumaseru ekenza, zvichiita kuti arege kukura kana kufa.
Chinhu chakakosha ndechekuti, kana masero ako egomarara asina mahormone receptors aya, kureva kuti, kana asina mahormone receptor , mahormone aya haashande. Vanachiremba vanokurudzira mamwe marapirwo kuvanhu vakadaro.
Ndedzipi mhando huru dzekurapa kwemahormone?
Kune mhando dzakawanda dzemishonga yemahormone dzinoshandiswa pakurapa kenza yemazamu. Chiremba wako achasarudza mushonga wakakodzera iwe zvichienderana nezvinhu zvakawanda, kusanganisira zera rako, rudzi rwekenza, uye kana wakambosvika panguva yekuguma kuenda kumwedzi. Ngatitarisei mhando mbiri huru.
| Rudzi rwekurapwa | Chinonyanya kupiwa kuna ani? | Migumisiro yekuziva |
|---|---|---|
| Tamoxifen | Kuvakadzi vezera ripi zvaro (vasati vasvika uye vasvika pakuguma kuenda kumwedzi). Mushonga wave uchishandiswa zvinobudirira kwemakumi emakore. | Kuwanda zvishoma kwenjodzi yekenza yemudumbu, kuungana kweropa mumakumbo nemumapapu, sitiroko, cataract, uye kupisa kwakanyanya. |
| Aromatase Inhibitors (AIs) Semuenzaniso: Anastrozole, Letrozole | Zvikurukuru kuvakadzi mushure mekuguma kuenda kumwedzi. | Kushaya simba kwemapfupa (Osteoporosis) uye njodzi yekutyoka, kurwadziwa kwemajoini netsandanyama, matambudziko ekurangarira, uye njodzi yechirwere chemwoyo yakawedzera zvishoma. |
Zvimwe zvishoma nezveTamoxifen
Iri ipiritsi raunotora zuva nezuva. Tsvagiridzo yakaratidza kuti kuritora kwemakore akati wandei, kazhinji makore angangoita mashanu, kunoderedza zvakanyanya njodzi yekudzoka kwekenza uye njodzi yekukura nekenza itsva.
Zvisinei, unofanirawo kuziva nezvemigumisiro yatakakurukura patafura iyoyo. Kunyanya njodzi yekenza yemuchibereko. Ndosaka zvichidikanwa kuti uongorore chiuno chako nguva nenguva uchitora mushonga uyu. Zvakare, kana ukasangana nekubuda ropa kusingawanzoitiki, unofanira kuudza chiremba wako nekukasika.
Zvimwe zvishoma nezve Aromatase Inhibitors (AIs)
Rudzi urwu rwemushonga runoshanda nekumisa kugadzirwa kwehomoni inonzi estrogen mumadzimai mushure mekupedza kuenda kumwedzi. Izvi zvinobvisa masero ekenza homoni yaanoda kuti akure.
Dambudziko guru remushonga uyu iosteoporosis , inova njodzi yekuti mapfupa ashaye simba uye aputsike nyore nyore. Nekuda kweizvi, chiremba wako angangoita bvunzo yehuremu hwemapfupa usati watanga kutora mushonga uyu uye paunenge uchitora. Anogonawo kukurudzira kuti utore calcium nevhitamini D supplements.
Mamwe marapirwo epamusoro uye epamusoro
Pamusoro pemhando huru dzemishonga dzataurwa pamusoro apa, kune dzimwe mhando dzemishonga dzinoshandiswa, kunyanya kana kenza yapararira kune dzimwe nhengo dzemuviri (dzakapararira kana kuti dzakapararira).
Semuenzaniso, kune mishonga yakaita se`Fulvestrant (Faslodex)` uye` Toremifene (Fareston)`. Pamusoro pezvo, kune mishonga yakawanda yepamusoro inonzi` Targeted Therapy` nhasi. `Palbociclib (Ibrance)`, `Abemaciclib (Verzenio)`, `Alpelisib (Piqray)` mienzaniso yemishonga yakadaro. Iyi inoshanda nekutarisa mapuroteni chaiwo anobatsira masero ekenza kukura. Iyi inowanzopihwa varwere pamwe chete nekurapwa kwemahormone kwataurwa pamusoro apa.
Sarudzo dzese dzekurapa idzi dzinoitwa zvichienderana nemamiriro ako ezvinhu, rudzi rwekenza, zera rako, uye hutano hwako hwese. Saka usatya kukurukura chero mibvunzo yauinayo nachiremba wako.
Kurapwa kwakakosha kune avo vasati vasvika panguva yekuenda kumwedzi (Ovarian Ablation)
Kana usati wasvika panguva yekuenda kumwedzi, zvichireva kuti uri kuenda kumwedzi nguva dzose , hormone huru yeestrogen yemuviri wako inogadzirwa nemaovari ako. Saka, kune munhu ane kenza yeER-positive, chiremba wako anogona kusarudza kumisa maovari aya kugadzira estrogen. Izvi zvinonzi ovarian ablation/suppression .
Kune nzira dzinoverengeka dzekuita izvi:
- Kubviswa kwemazai ekubereka nepamuviri : Iyi inzira inogara iripo.
- Kurapa maovari nemwaranzi: Izvi zvinogonawo kumisa kushanda kwemaovari zvachose.
- Mishonga yekumisa maovari kushanda kwenguva pfupi: Mishonga inonzi `(LHRH) agonists` (inowanzo shandiswa majekiseni) inoshandiswa pakuita izvi. Chero bedzi uchitora mishonga iyi, maovari ako haazoburitse mahormone.
Tsvagiridzo yakaratidza kuti pamwe chete nekudzvinyirira mazai aya, kurapwa nemahormone senge tamoxifen kunogona kuwana mhedzisiro yakanaka kwazvo.
Mharidzo Yekuenda Nayo Kumba
- Kurapa nehomoni hakusi mushonga wekenza dzese dzemazamu. Kunongopihwa kune kenza dzine hormone receptor-positive (ER/PR-positive) .
- Kurapa kwakakodzera iwe (semuenzaniso Tamoxifen kana Aromatase Inhibitor) kuchasarudzwa nachiremba wako, zvichienderana nezera rako uye mamiriro ehutano hwako.
- Mishonga yese iyi inogona kuva nemigumisiro yakaipa. Usaitye, ingoziva kuti chii. Kana ukaona zviratidzo zvisingawanzoitiki, taurira chiremba wako nekukasika.
- Zvakakosha kuti chiremba anyore bvunzo nenguva panguva yekurapwa.
- Iva nechokwadi chekukurukura pachena zvaunotya, kusava nechokwadi, uye mibvunzo yako nechikwata chako chekurapa. Izvi zvichava simba guru murwendo rwako rwekurapwa.
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