Ngatidzidzei nezveGABA (gamma-aminobutyric acid), chakavanzika cheuropi chinodzikamisa pfungwa dzako.

Dzimwe nguva unonzwa kuremerwa, kunetseka, kana kungotya chete here? Kana kuti unotambura nekushaya hope husiku? Kuseri kwezvinhu izvi kungave kune chinhu chidiki chinotakura makemikari muuropi hwedu. Ndizvo zvatichataura nezvazvo nhasi. IGABA. Inoshanda sebhatani 'rinotonhorera' muuropi hwedu.

Chii chinonzi GABA (gamma-aminobutyric acid)?

Zvichitaurwa zviri nyore, GABA ikemikari inotumira mameseji pakati pemasero etsinga (neurons) muuropi hwedu. Zvakafanana nepostman akangwara mumuviri wedu. Asi chinonyanya kukosha ndechekuti inonyanya "kudzikamisa" mashandiro europi asingakoshi. Kureva kuti, inomisa masero etsinga europi kuti asanyanye kukurudzirwa uye kuvhiringidzika. Masayendisiti anodana mhando idzi dzemakemikari kuti neurotransmitters. Funga nezveGABA se "brake" inodzora kumhanya kwesystem yedu yetsinga, inosanganisira uropi hwedu nemuzongoza. Ndiyo inotibatsira kuti tisanyanya kufara kana kutya.

GABA inoshanda sei? Chii chinoitika muuropi hwedu?

Zvino tarisai mashandiro anoita GABA iyi muuropi hwedu. Inzira inoshamisa zvikuru. Tine mamiriyoni nemabhiriyoni emasero etsinga muuropi hwedu. Tinofanira kutumira meseji kubva kune imwe tsinga kuenda kune imwe. Pane mukaha mudiki pakati pemasero maviri aya etsinga. Izvozvo zvinonzi `(Synapse)` kana kuti mubatanidzwa wetsinga.

`(Neurotransmitter)` yakafanana neGABA inoita izvi nekutora meseji iyi ichiyambuka muganhu uyu yoibatanidza kune `(Receptors)` chaiyo iri pasero rinotevera retsinga. Zvakafanana nekiyi inoiswa mukiyi. Sezvo isiri kiyi yese inogona kuvhura kiyi yega yega, haisi `(Neurotransmitter)` yese inogona kubatana kune `(Receptor)` yega yega. GABA inewo `(Receptors)` mbiri chaiyo dzinoiona - `(GABA-A)` uye `(GABA-B)`.

Saka, kana GABA ikaenda yobatana nemareceptor aya, inoderedza kugona kwemasero etsinga anotevera kupindura. Kureva kuti, inoderedza mukana wekuti sero iroro riite meseji isina basa kana kuitumira kune mumwe munhu. Ndosaka GABA ichinzi "inhibitory" kana kuti soft neurotransmitter.

Ndezvipi zvakanakira hutano zvinopihwa neGABA?

Saka, ndezvipi zvakanakira zvehutano zvatinowana kubva kuGABA, iyo inodzikamisa uropi nenzira iyi? Zvechokwadi kune zvakawanda. Fungidzira, uri "kushushikana" zvakanyanya, kureva kuti, kana uri pasi pekushushikana kwakanyanya, pfungwa dzako hadzisi panzvimbo imwe chete, unonetseka zvikuru, uye chipfuva chako chinonzwa sekunge chiri kurova. Panguva yakadaro, kana huwandu hweGABA mumuviri wako hwakakodzera, huchadzikamisa pfungwa dzako uye huchakubatsira kuderedza kushushikana uku .

GABA ine kugona kukuru kwekudzora kuzvidya mwoyo . Inobatsira kuderedza kutya kusingakoshi uye kuzvidya mwoyo pamusoro pezvinhu zvese.

Chimwe chinhu ndechekuti, vamwe vanhu havagone kurara husiku. Vanongotenderera-tenderera pavanoenda kunorara, asi havaratidzike sevanorara zvachose. Ongororo yazvino inoratidza kuti GABA inobatsirawo pakurara zvakanaka uye kunozorodza .

GABA neGlutamate: Kuchinja kwe'On-Off' kweUropi

Pamwe chete neGABA, kune imwe `(Neurotransmitter)` inokosha zvikuru muuropi hwedu. Ndiyo `(Glutamate)`. Idzi mbiri dzinoshanda semativi maviri emari, kana semaswichi maviri e'on' ne'off'. Kureva kuti, munzira dzakasiyana.

• GABA: 'Inodzima' mashandiro europi uye inohudzikamisa (inodzivisa).
• Glutamate: 'Inobatidza' uye inosimudzira mashandiro europi (stimulant).

Saka, kuti uropi hwedu hushande zvakanaka uye zvine hutano, panofanira kuva nekuenzana kwakanaka pakati pesimba rekudzikamisa reGABA nesimba rekukurudzira re`(Glutamate) . Kungofanana ne accelerator nebhureki remota. Kana zvese zvikafamba zvakanaka uye nenguva ndipo patinogona kufamba zvakanaka uye zvakachengeteka. Kana kuenzana uku kukarasikirwa, matambudziko akasiyana-siyana anomuka. Zvinoshamisa kuti, chinhu ichi chinodzikamisa chinonzi GABA chinogadzirwawo kubva muchinhu chinosimudzira `(Glutamate). Chinhu chakakosha `(enzyme)` chinobatanidzwa machiri, kureva enzyme (`glutamic acid decarboxylase`).

GABA inoshandawo pamwe chete neimwe neurotransmitter, serotonin. Kutaura zvazviri, ma neurotransmitter mazhinji anoshanda pamwe chete, dzimwe nguva achipesana, kuti miviri yedu nepfungwa dzedu zvirambe zvichishanda zvakanaka.

Zvirwere zvinogona kukonzerwa nemazinga akaderera eGABA

Fungidzira kuti chii chaizoitika dai kutaurirana uku kweGABA kwaisashanda zvakanaka, zvichireva kuti huwandu hweGABA muuropi hwaive hwakaderera? Izvi zvinogona kukonzera matambudziko akasiyana-siyana etsinga nepfungwa. Tsvagiridzo yakawana kuti kudzikira kwekushanda kweGABA kunogona kukonzera zvirwere zvakaita se:

• Kuzvidya mwoyo uye matambudziko emanzwiro: Kunzwa kutya nguva dzose, kunetseka, kurasikirwa nemufaro, uye kutadza kuisa pfungwa pachinhu chimwe chete.
Schizophrenia : Chirwere chepfungwa chakaoma chinoratidzwa nekurasikirwa nehukama nezviripo, kuona, kunzwa, uye kufunga zvinhu zvisiri zvechokwadi.
• Dambudziko reAutism spectrum: Dambudziko rekukura rinoratidzwa nekusashanda zvakanaka kwevanhu pamwe nekutaurirana.
• Kuora mwoyo: Kunzwa kusuruvara kwenguva refu, kurasikirwa nehanya nechimwe chinhu, uye kunzwa kufinhwa nehupenyu.
• Pfari nepfari: Zvirwere zvakaita sekugwinha nepfari zvinoitika mumuviri nekuda kwekusashanda zvakanaka kwemasero etsinga muuropi kamwe kamwe.

Kuwedzera kune izvi zvirwere zvikuru, kune zvimwe zvirwere zvinofungidzirwa kuti zvine chekuita nekusawirirana kweGABA:

• Kushaikwa kwePyridoxine:Ichi chirwere chisingawanzoitiki. Chinokonzerwa nekushaikwa kwevhitamini B6 (pyridoxine), iyo inokosha pakugadzirwa kweGABA. Izvi zvinowanzo kukonzera pfari muvana vadiki. Kupfari uku kwakaoma kudzora nemishonga yekudzivirira pfari, asi kunogona kurapwa nemishonga yekuwedzera mavitamini.
• Hepatic encephalopathy: Chirwere chakakomba chechiropa chinokanganisa mashandiro europi.
• Chirwere cheHuntington: Chirwere chinogara nhaka chinoparadza masero europi zvishoma nezvishoma.
• Kusagadzikana uye kusimba kwemhasuru: Zvirwere zvinoonekwa nekuomarara kwetsandanyama uye kugwinha-gwinha.
• Kunzwa hope dzakanyanya kana kurara zvakanyanya masikati.

Kuwedzera mazinga eGABA kunopa mabhenefiti ehutano here?

Vaongorori vachiri kudzidza nezvemigumisiro yekuwedzera kwemazinga eGABA. Kunyangwe humbowo husati hwanyatsojeka, zviri kuferefetwa kana GABA ingabatsira kurapa kana kudzivirira mamwe matambudziko ehutano. Semuenzaniso:

• Kukwira kweropa
• Kushaya hope
• Chirwere cheshuga

Kutsvagurudza kwakawanda kunodiwa pane izvi.

Mhando dzemishonga inotarisa GABA

Nekuda kwekukosha uku kweGABA, vagadziri vemishonga vakagadzira mishonga yakawanda inotarisa GABA "receptors". Iyi inoshanda nekubatsira kana kuwedzera mhedzisiro yeGABA yekudzikamisa. Ungave wakambonzwa nezveizvi:

• Benzodiazepines: Iyi mishonga inosanganisira diazepam (inozivikanwawo seValium) uye alprazolam (inozivikanwawo seXanax) uye inoshandiswa kurapa kuzvidya mwoyo, kushaya hope, pfari, uye kurega doro. Inoshandiswawo senzira yekunyaradza panguva yekuvhiyiwa.
• Barbiturates: Iyi mishonga inonyaradzawo inokonzera hope. Zvisinei, kushandiswa kwayo kwava kushoma.
• Vigabatrin (Sabril®): Mushonga unoshandiswa kurapa pfari uye kugwinha kwetsandanyama muvana vadiki.
• Flumazenil (Romazicon®): Inoshandiswa kurapa overdose yebenzodiazepine. Inoshandiswawo kuvandudza mamiriro epfungwa mu hepatic encephalopathy, chirwere chinokonzerwa nechirwere chechiropa.
• Valproic acid: Uyu mushonga unodzikamisa mafungiro unodzora pfari.
• Zolpidem (inozivikanwawo seAmbien® kana Edluar®): Uyu mushonga mukuru wekushaya hope.
• Propofol (inozivikanwawo seDiprivan®): Mushonga unoshandiswa kunyaradza uye kurarisa murwere panguva yekunzwa kuneta.
• Baclofen (`Baclofen (Lioresal®, Gablofen®)`): Kuzorodza tsandanyama.

Yeuka: Mishonga iyi nemimwe yakafanana inofanira kushandiswa chete pasi pekutarisirwa nachiremba. Kuishandisa wega, kana kuti nekuda kwekuti mumwe munhu ari pedyo newe akakuudza kudaro, kunogona kukonzera kukuvara kukuru. Saka chenjera.

Mishonga yeGABA inobatsira here?

Vamwe vangabvunza kuti, 'Saka sei tisingakwanise kutenga GABA sechinowedzera?' Ehe, GABA inowanikwa sechinowedzera pakudya. Asi pane dambudziko diki pano. Hazvisati zvanyatsojeka kuti GABA yakawanda sei yatinonwa nemuromo inopinda muuropi hwedu.

Nekuti, uropi hwedu hwakakomberedzwa neganda rekudzivirira rakakosha rinonzi "blood-brain barrier". Izvi zvakafanana negedhi, risingabvumire makemikari ese kupinda muuropi zviri nyore, rinongobvumira akasarudzwa chete. Saka, hapasisina humbowo hwakakwana hwesainzi hwekutaura kana mishonga iyi yeGABA ine simba pauropi kana kwete. Saka, tsvakiridzo yakawanda inofanira kuitwa pane izvi uchishandisa boka guru revanhu. Tichifunga nezvemamiriro ezvinhu aripo iye zvino, hazvina kunaka kushandisa mishonga yeGABA usina kutaura nachiremba.

Pane zvekudya zvine GABA here?

GABA inowanikwawo mune zvimwe zvekudya. Semuenzaniso:

• Zvekudya zvakaviriswa: zvinhu zvakaita sekimchi (muto wekuKorea), miso (soy paste yekuJapan), uye tempeh (chigadzirwa chesoya chekuIndonesia).
• Mhando dzetii: Tii yegirini, tii nhema, uye tii yeoolong zvinewo GABA.
• Zvimwe zvekudya: Zvokudya zvakaita semupunga webrown, soya, nyemba, chestnuts (rudzi rwenzungu), howa, madomasi, sipinachi, broccoli, kabichi, cauliflower, Brussels sprouts (rudzi rwekabheji kadiki), tsanga dzakamera (semuenzaniso, bhinzi dzegirini kana dzamera), uye mbatatisi dzinewo GABA kana kuti dzinobatsira muviri kugadzira GABA.

Asi sezvataurwa nezvezvekudya zvinovaka muviri, hapasati pave netsananguro yakajeka yekuti GABA yakawanda sei inobva muzvikafu izvi inosvika kuuropi. Zvakanaka kuzviisa mukudya kune hutano, asi hazvikurudzirwi kuvimba nezvikafu izvi chete senzira chaiyo yekurapa chirwere chakati. Uyewo, tsvaga mazano echiremba nezveizvi.

Pakupedzisira, zvinhu zvekurangarira (Mharidzo Yekuenda Kumba)

Saka, pamwe wava kunzwisisa kuti GABA (gamma-aminobutyric acid) yatataura nezvayo nhasi ineurotransmitter inodzikamisa uropi hwedu uye inokosha zvikuru pahutano hwedu hwepfungwa, kurara, uye kushanda kwemuviri wedu wese.

Inobatsira kudzora kuzvidya mwoyo, kushushikana, uye kushaya hope. Kuderera kweGABA kunogona kukonzera matambudziko akasiyana-siyana etsinga nepfungwa. Mimwe mishonga inoshanda nekutarisa system yeGABA.

Kutsvagurudza kwakawanda kwesainzi kunodiwa pamusoro pemabhenefiti eGABA supplements nechikafu chine GABA. Saka, kana uine zvinokunetsa, kusava nechokwadi, kana mibvunzo nezveGABA, chinhu chakanakisa uye chakachengeteka chekuita ndechekuona chiremba wemhuri yako, kukurukura nezvemamiriro ako ezvinhu, uye kuwana mazano akakodzera.Usaende kubasa zvichibva pakufungidzira kana makuhwa. Hutano hwako hwakakosha kwauri.

GABA , gamma-aminobutyric acid, neurotransmitter, uropi, hutano hwepfungwa, kuzvidya mwoyo, kurara