Zithini ezi prostaglandins? Kutheni zibaluleke kangaka emizimbeni yethu?

Namhlanje siza kuthetha ngento encinci yekhemikhali eveliswa ngaphakathi emzimbeni wethu kwaye isebenza ngendlela engaqhelekanga. Oku kubizwa ngokuba yi -prostaglandins . Usenokuba awukaze uve eli gama ngaphambili. Kodwa, uyazi ukuba ezi zinto zincinci ziyichaphazela kangakanani impilo yomzimba wethu kunye neenkqubo zemihla ngemihla! Ngoko ke, namhlanje siza kuthetha ngezi prostaglandins ngendlela elula neqondakala lula.

Zithini kanye kanye ii-prostaglandins?

Ngamafutshane, ii-prostaglandins liqela lee-lipids eziveliswa emizimbeni yethu xa kukho umonakalo kwizicubu okanye usulelo, kwaye zisebenza njengee-hormone. Kukho iintlobo ezininzi ezahlukeneyo zazo, kwaye zinceda ukulawula iinkqubo ezininzi ezibalulekileyo emizimbeni yethu.

Cinga ngabo njengabathunywa abancinci ngaphakathi emizimbeni yethu. Xa kukho ingxaki kwenye indawo, aba bathunywa bakhiwa kanye apho baze banike abanye iiseli imiqondiso yokuba benze oko kufunekayo.

Ingaba le yihormone efanayo?

Usenokuba ucinga, "Ngoko ke olu luhlobo lwehomoni?" Enyanisweni, iiprostaglandins luhlobo lwe-lipid oluneempawu ezifana neehomoni. Ii-lipids zii-fatty acids okanye izinto eziphuma kuzo. Imizimba yethu yenza ezi prostaglandins kwi-fatty acid ebizwa ngokuba yi-arachidonic acid.

Ezi zibizwa ngokuba ziihormone kuba zilungelelanisa imisebenzi eyahlukeneyo emzimbeni wethu kwaye zixelela umzimba into ekufuneka uyenze kunye nexesha ekufuneka uyenze ngalo.

Kodwa, ezi zahlukile kwiihomoni zokwenyani. Uyazi njani? Iiprostaglandins azisebenzi njengeehomoni eziveliswa ziindlala kwinkqubo yethu ye-endocrine kwaye zikhutshwe egazini. Endaweni yoko, ziveliswa zizicubu zethu kwindawo yomonakalo okanye usulelo, apho isenzo senzeka khona. Yiloo nto ezenza zibe zezikhethekileyo.

Yeyiphi inkonzo enikezelwa zii-prostaglandins emizimbeni yethu?

Enyanisweni, kukho iintlobo ezahlukeneyo ze-prostaglandins, kwaye ii-receptors ezisabela kuzo nazo zahlukile. Oku kuthetha ukuba iziphumo zazo zinokubonakala phantse kuwo onke amalungu omzimba wethu. Impembelelo ye-prostaglandin ixhomekeke kwizinto ezahlukeneyo:

• Isitho okanye izicubu esidityaniswe nazo.
• I-receptor ebopha kuyo.
• Inkqubo okanye imeko yempilo eyenzekayo emzimbeni.

Makhe sijonge eminye yemisebenzi ephambili yale prostaglandins:

• Inceda ekuqaliseni ukwakheka kwamahlwili egazi kwindawo yokwenzakala, okanye ingayimisa.
• Imithambo yegazi iyanda (i-vasodilation) okanye inciphe (i-vasoconstriction), nto leyo echaphazela ukuhamba kwegazi .
• Inceda inkqubo yokuphiliswa .
• Ukudumba (Yile nto ibangela ukudumba nokubomvu xa unenxeba .
• Inceda ekuqaliseni ukuzala ngexesha lokukhulelwa (ukuqaliswa kokubeletha) .
• Ngexesha lokuya exesheni, ibangela ukuba isibeleko sinciphe kwaye inceda ekukhupheni ulwelo lwesibeleko (i-endometrium).
• Inxulumene ne -ovulation .
• Ingabangela umkhuhlane .
• Ukulawula indlela oziva ngayo iintlungu .
• Inceda ekunciphiseni uxinzelelo ngaphakathi kweliso.
• Inciphisa ukukhutshwa kwe-asidi esiswini.
• Izihlunu ezigudileyo kwindlela yethu yokugaya ukutya ziyancitshiswa okanye ziphumle.
• Ilawula umsebenzi wezinye iihomoni ezininzi.

Eyona nto ibalulekileyo kukuba ii-prostaglandins zinobomi obufutshane kakhulu. Oko kuthetha ukuba zisebenza ixesha elifutshane kakhulu. Ngoko ke, zinokuchaphazela kuphela iiseli ezikufutshane. Zinokwenziwa ziithishu ezahlukeneyo emzimbeni wethu.

Masithathe umzekelo kubomi bemihla ngemihla?

Khawucinge ukuba usika umnwe wakho. Kwanesilonda esincinci sinokwenza umsebenzi omninzi. Nantsi indlela ii-prostaglandins ezinceda ngayo:

1. Iyeka ukopha: Okokuqala, ii-prostaglandins zikhutshwa kwizicubu zesilonda. Ezi zixelela ii-platelet egazini ukuba "zihlangane ngokukhawuleza zize zivale inxeba, ziyeke ukopha." Emva koko kwakheka ihlwili legazi apho.

2. Ilawula imithambo yegazi: Okulandelayo, olunye uhlobo lwe-prostaglandin luvela kwizicubu ezikwindawo yokwenzakala kwaye lubangela ukuba imithambo yegazi inciphe kancinci. Oku kubizwa ngokuba yi-vasoconstriction . Oku kunciphisa ukopha nangakumbi.

3. Ukudumba (ukudumba): Emva koko, ii-prostaglandins ziyakhutshwa, ezibangela ukudumba. Ezi zibangela ukuba ulwelo luphume kwimithambo yegazi luye kwiithishu, nto leyo ebangela ukuba inxeba lidumbe, libe bomvu, kwaye live lishushu. Ungakhathazeki, oku kudumba kulungile. Oku kungenxa yokuba kuthintela izinto ezifana neentsholongwane ebezinokungena enxebeni ukuba zingayi kwezinye iindawo zomzimba. Ezi prostaglandins ezidumbayo zenza enye into. Oko kukuthi, zizisa iiseli ezimhlophe zegazi ezibizwa ngokuba zii-phagocytes enxebeni. Ezi seli zezo 'zitya' iintsholongwane kunye neeseli ezifileyo kwaye zicoce inxeba.

4. Ihlwili legazi liyasuswa xa liphola: Ekugqibeleni, xa inxeba lipholile ngokupheleleyo, ii-prostaglandins ziyabuya zize zinyibilikise ihlwili legazi zize zilisuse. Kuba akusekho mfuneko yokuba liphinde libe lapho.

Ngaba ukhe wayibona indlela esebenza ngayo i-prostaglandins nokuba inxeba elincinci?

Ngoko ke, ngaba ii-prostaglandins zilungile okanye zimbi?

Lo ngumbuzo obaluleke kakhulu. Phantsi kweemeko eziqhelekileyo, ii-prostaglandinsKubalulekile, kuyinto yendalo emizimbeni yethu. Zidlala indima enkulu ekulawuleni iinkqubo zendalo zomzimba ezifana neentlungu kunye nokudumba. Inkqubo eqhelekileyo yokudumba yindlela imizimba yethu eyisebenzisayo ukuzikhusela ekonakaleni okungakumbi.

Nangona kunjalo, ngamanye amaxesha inani lee-prostaglandins emzimbeni wethu linokunyuka ngokungeyomfuneko. Kulapho ke iingxaki ziqala khona. Xa oko kusenzeka, ukudumba okungapheliyo kunye nentlungu enganyamezelekiyo kunokwenzeka. Kwiimeko ezinjalo, ii-prostaglandins ezigqithisileyo zinokukhokelela kwizifo ezingapheliyo kunye neempawu ezingathandekiyo.

Umzekelo, nangona ii-prostaglandins zibalulekile xa usexesheni, ukuba zinyuka kakhulu, ukopha okubuhlungu nokukhulu ngexesha lokuya exesheni (i-menorrhagia) kunokwenzeka.

Indima ye-prostaglandins ngexesha lokukhulelwa

Ngexesha lokukhulelwa nokubeleka, iiseli ezikwisibeleko zivelisa ii-prostaglandins. Ezi zinceda ukwandisa umlomo wesibeleko kwaye zibangele ukubhitya kwesibeleko. Ezi zibhitya zinceda ukutyhala umntwana emjelweni wokuzala.

Kwakhona, oogqirha ngamanye amaxesha basebenzisa ii-prostaglandins zokwenziwa ukuze babangele ukuzala ukuba bacebisa ukuba ukuzala kuqale ngaphambi kokuba kuqale ngokwemvelo.

Zisetyenziswa njani iiprostaglandins kunyango?

Oogqirha basebenzisa iintlobo ezahlukeneyo ze-prostaglandins zokwenziwa ukunyanga iimeko ezahlukeneyo. Makhe sijonge imizekelo embalwa.

• I-Travoprost: Isetyenziselwa ukunyanga i-glaucoma kunye noxinzelelo lwegazi lwamehlo.
• I-Dinoprostone: Inceda ukwandisa umlomo wesibeleko koomama abasondela ekupheleni kokukhulelwa kwabo kwaye iqalise ukuzala.
• I-Alprostadil: Le yeyodidi lwamayeza abizwa ngokuba yi-vasodilators. Yonyusa ukuhamba kwegazi. Inceda ekunyangeni ezinye iingxaki zentliziyo kwiintsana (umz., isifo sentliziyo esibizwa ngokuba yi-cyanotic) kunye nokungasebenzi kakuhle kwe-erectile (ED) kumadoda.
• I-Misoprostol: Kwezinye iimeko, eli yeza linikwa nge-rectally ukuze kuthintelwe ukopha kakhulu emva kokubeleka (i-postpartum hemorrhage).
• I-Iloprost: Isetyenziselwa ukunyanga uxinzelelo lwegazi oluphezulu emaphaphu kunye nemeko ebizwa ngokuba yi-CREST syndrome.

Ngenxa yokuba i-prostaglandin eninzi inokubangela iintlungu nokudumba okungeyomfuneko, oogqirha basebenzisa amayeza anciphisa imiphumo ye-prostaglandins, okanye ayithintele. Amayeza asetyenziswa kakhulu athintela i-prostaglandins ngala:Amayeza Angalwiyo Nee-steroidal Alwa Nokuvuvukala (ii-NSAID). La adla ngokubizwa ngokuba zii-painkillers. Imizekelo ibandakanya i-aspirin (umz. i-Excedrin®), i-ibuprofen (umz. i-Advil®, i-Motrin®), kunye ne-naproxen sodium (umz. i-Aleve®).

Ziziphi iingxaki ezinokubangelwa yi-prostaglandins?

Ngamanye amaxesha imizimba yethu ivelisa ii-prostaglandins ezininzi kakhulu, okanye zinganeli. Oku kunokukhokelela kwiingxaki ezithile zempilo kunye neempawu.

I-prostaglandins engaphezulu

Ukuba inani le-prostaglandins emizimbeni yethu liyanda ngokungeyomfuneko, linokubangela ukudumba okungeyomfuneko nokungancediyo emzimbeni. Nazi ezinye zeengxaki zempilo ezinokubangela oku:

• Intlungu engapheliyo.
• Ukwanda kovakalelo kwiintlungu.
• Ukuya exesheni okubuhlungu okanye iintlungu zokuya exesheni (i-dysmenorrhea).
• Ukopha kakhulu exesheni.
• Ezinye iintlobo zomhlaza.

Ukungabikho kwe-prostaglandins

Ngamanye amaxesha, umzimba usenokungavelisi ii-prostaglandins ezaneleyo zokuphilisa inxeba okanye ukuqala ukuzala emva kokukhulelwa okupheleleyo. Nokuba ezi meko azinxulumananga neemeko ezingapheliyo, ii-prostaglandins zokwenziwa zinokunceda. Oogqirha basebenzisa ii-prostaglandins zokwenziwa ukunyanga izilonda zesisu kunye ne-glaucoma. Zinokunceda nokuqala ukuzala.

Ufanele uye nini kugqirha malunga neengxaki ezinxulumene ne-prostaglandins?

Ukuba unentlungu engapheliyo kunye/okanye ukudumba okungapheliyo , qiniseka ukuba ubona ugqirha. Nangona zininzi izizathu zezi meko, enye imbangela enokubakho kukusebenza kweeprostaglandins emzimbeni wakho.

I-Dysmenorrhea yimeko eqhelekileyo enxulunyaniswa ne-prostaglandins kwaye yimeko yezonyango efuna unyango. Ukuba unexesha elibuhlungu lokuya exesheni elingaphumliyo ngokuthatha ii-painkillers (NSAIDs), thetha nogqirha wakho. Ngamanye amaxesha, ixesha elibuhlungu lokuya exesheni lingabangelwa yimeko yezonyango engabonakaliyo, efana ne -endometriosis okanye i-uterine fibroids .

Iiprostaglandins zizinto ezifumaneka ngokwemvelo, zizinto ezinamandla ezichaphazela iinkalo ezininzi zomzimba wethu. Nangona zibalulekile kwiinkqubo zomzimba ezifana nokuphiliswa, i-prostaglandin eninzi inokubangela iintlungu ezingapheliyo, ukudumba, kunye nomgangatho wobomi ophantsi. Ukuba unentlungu engapheliyo okanye ukudumba, bona ugqirha ukuze ufumane unobangela kwaye ufumane isicwangciso sonyango esifanelekileyo.

Umyalezo Wokuya Ekhaya

Kulungile, ngoko ke sithethe kakhulu ngee-prostaglandins namhlanje, akunjalo? Eyona nto ibalulekileyo ekufuneka siyikhumbule kukuba ezi zifana nezithunywa ezincinci zeekhemikhali eziveliswa emizimbeni yethu kwaye zenza umsebenzi obaluleke kakhulu.

• Ezi zinceda kwizinto ezininzi, ezinje ngokuphilisa amanxeba, ukunqanda ukopha, ukulawula ukudumba, ukunceda ekubelekeni, kunye nokulawula ukuya exesheni.
• Kwakhona, ukuba ezi zinto zikhula kakhulu, iingxaki ezifana neentlungu kunye nokudumba okungapheliyo zinokubakho.
• Ukuba unentlungu engapheliyo, ukudumba, okanye iintlungu eziqatha zokuya exesheni, kubalulekile ukufuna ingcebiso kagqirha ngaphandle kokuzityeshela, njengoko zinokubangelwa kukungalingani kwezi prostaglandins.

Ngoko ke, ukwazi ezi zinto zimangalisayo ezenzekayo emizimbeni yethu kuya kunceda kakhulu ekugcineni impilo yethu.

Iiprostaglandins , iihomoni, iintlungu, ukudumba, ukudumba, ukuya exesheni, ukukhulelwa