Masifunde ngovavanyo lwe-ACTH Stimulation Test ngendlela elula.

Ngaba uhlala uziva udiniwe, udiniwe, okanye uncipha? Xa ubona ugqirha, unokugqiba ekubeni ajonge iihomoni zakho. Ngokukodwa, ihomoni i-cortisol. Ngoko ke, uvavanyo oluphambili olwenziwayo ukujonga ukuba amanqanaba akho e-cortisol aqhelekile na luvavanyo lwe-ACTH Stimulation. Nangona igama lisenokuvakala linzima kancinci, lilula kakhulu. Makhe sithethe ngayo yonke into namhlanje.

Kalula nje, yintoni le ACTH Stimulation Test?

Olu luvavanyo lwezonyango. Ukuchaneka, lujonga indlela amalungu akho amabini abizwa ngokuba yi-adrenal glands asabela ngayo kwi-hormone ebizwa ngokuba yi-ACTH (i-Adrenocorticotropic hormone) evela engqondweni yethu. Ngaba oku kuvakala ngathi kuyadida? Kulungile, masicinge ngale ndlela.

Khawuthelekelele ukuba i-pituitary gland esebuchotsheni bakho ifana nomphathi wenkampani enkulu. Amadlala amabini amancinci e-adrenal ngaphezulu kwezintso zakho afana nabasebenzi ababini abasebenza kuloo nkampani.

Xa umphathi (i-pituitary gland) efuna ukwenza into ethile, uthumela umyalezo obizwa ngokuba yi-'ACTH' kubasebenzi (ii-adrenal glands). Xa lo myalezo ufunyenwe, abasebenzi (ii-adrenal glands) benza i-hormone ebizwa ngokuba yi-'cortisol' baze bayikhuphele emzimbeni. Le cortisol yi-hormone ebaluleke kakhulu emzimbeni wethu. Inceda kwizinto ezininzi ezifana nokulawula uxinzelelo, ukulawula amanqanaba eswekile egazini, kunye nokulawula uxinzelelo lwegazi.

Ngoko ke, into eyenziwa luvavanyo lwe-ACTH Stimulation Test kukuba sifake i-hormone ye-ACTH eyenziwe ngaphandle (ebizwa ngokuba yi-cosyntropin) emzimbeni wakho size sibone ukuba amadlala akho e-adrenal (abasebenzi) ayasabela na kuyo aze avelise i-cortisol ngokufanelekileyo.

Olu vavanyo lusetyenziswa kakhulu ekufumaneni imeko ebizwa ngokuba yi -'adrenal insufficiency' . Oku kuthetha ukuba amadlala e-adrenal awavelisi i-cortisol eyaneleyo. Oku kwahlulwe kwaba ziintlobo ezintathu.

Kuphantsi kweziphi iimeko apho ugqirha ekuxelela ukuba wenze olu vavanyo?

Kusenokuba nezizathu ezininzi zokuba ugqirha wakho angacebisa olu vavanyo.

• Ukuba uvavanyo lwegazi lwangaphambili lubonise amanqanaba aphantsi e-cortisol: Ukuba ukhe wavavanywa igazi ngesinye isizathu esibonise amanqanaba aphantsi e-cortisol, ungacelwa ukuba wenze olu vavanyo ukuqinisekisa oko.
• Ukuba uneempawu zokungakwazi ukusebenza kakuhle kwe-adrenal: Njengoko besitshilo ngaphambili, ukuba uneempawu ezifana nokudinwa rhoqo, ukwehla kobunzima, iintlungu zesisu, isicaphucaphu, isiyezi, kunye noxinzelelo lwegazi oluphantsi, olu vavanyo lwenziwa ukuze kufunyaniswe ukuba le meko yimbangela.
• Ukuba ubusebenzisa ii-steroids ixesha elide: Xa usebenzisa amayeza e-glucocorticoid afana ne-prednisone ixesha elide, ii-pituitary glands zakho kunye nee-adrenal glands zinokuyeka ukusebenza okwethutyana. Ngoko ke, emva kokuba uyekile ukusebenzisa amayeza, olu vavanyo lwenziwa ukuze kubonwe ukuba ii-glands zisebenza kakuhle kwakhona.

Ufanele uzilungiselele njani ngaphambi kovavanyo?

Oku kubaluleke kakhulu. Ufanele ulandele imiyalelo kagqirha wakho ngokuchanekileyo. Ngokwesiqhelo, ungathetha izinto ezinje.

• Ukuzila Ukutya: Ungacelwa ukuba ungatyi okanye ungaseli nto kangangeeyure ezi-6 ngaphambi kovavanyo. Kuvumelekile amanzi kuphela.
• Imiqathango yemisebenzi: Ungacelwa ukuba uphephe imisebenzi efana nokuzilolonga okunzima iiyure ezili-12-24 ngaphambi kovavanyo.
• Ukutya: Ngamanye amaxesha unokucelwa ukuba utye ukutya okune-carbohydrate eninzi.
• Ukuyeka amayeza: Amanye amayeza owasebenzisayo (ingakumbi ii-steroid creams, iipilisi, okanye ii-inhalers) anokuchaphazela iziphumo zovavanyo. Ngenxa yoko, ugqirha wakho angakucela ukuba uyeke ukuwasebenzisa okwethutyana. Ungaze uyeke ukuthatha amayeza akho ngaphandle kokubuza ugqirha wakho kuqala.

Kulungile, masibone ukuba kuza kwenzeka ntoni ngomhla wovavanyo.

Oku akoyikisi njengoko unokucinga. Kudla ngokwenziwa esibhedlele okanye kwikliniki ye-endocrinologist. Nantsi into eyenzekayo inyathelo ngenyathelo.

1. Ukuthatha isampuli yegazi yokuqala: Okokuqala, umongikazi uza kuthatha isampuli yegazi kumthambo osengalweni yakho. Oku kuza kujonga amanqanaba akho e-cortisol asisiseko ngaphambi kokuba uvavanyo luqale.

2. Ukufaka inaliti: Okulandelayo, umongikazi uza kukunika inaliti equlethe i-ACTH (i-cosyntropin) eyenziweyo. Le naliti idla ngokunikwa kwisihlunu sengalo yakho. Iza kuvakala ngathi yimbovane encinci ekuhlabayo, kodwa iza kuphela emva kwemizuzwana embalwa.

3. Iisampulu zegazi zesibini nezesithathu: Uza kuthathwa esinye isampuli yegazi emva kwemizuzu engama-30 emva kokufakwa inaliti. Emva koko kuza kuthathwa esinye isampuli yegazi emva kwemizuzu engama-60 . Oku kuya kulinganisa ukuba ingakanani i-cortisol eveliswe zii-adrenal glands zakho ukususela oko wafakwa inaliti.

4. Ukuthumela kwilabhoratri: Iisampulu zegazi ezithathiweyo zithunyelwa kwilabhoratri.

Xa utsalwa igazi lakho, uziva nje ukuhlatywa kancinci. Oko kuyaphela emva kwexesha elithile. Usenokuva inxeba elincinci apho igazi litsalwe khona, into eqhelekileyo.

Ziza kufumaneka nini iziphumo kwaye ziza kuthini?

Kungathatha malunga neveki ukuba iziphumo zolu vavanyo zibuye. Oku kungenxa yokuba xa iziphumo zifunyenwe, ugqirha wakho uza kuzifundisisa ngononophelo aze azithelekise neempawu zakho ukuze afikelele kwisigqibo.

Iyintoni isiphumo esiqhelekileyo?

Kumntu ophilileyo, emva kokufakwa inaliti ye-ACTH, amadlala e-adrenal kufuneka akhuthazwe kakuhle kwaye amanqanaba e-cortisol egazini kufuneka anyuke kakhulu. Ugqirha wakho uza kukuchazela amaxabiso akwingxelo yakho yelebhu kunye noluhlu oluqhelekileyo.

Yintoni isiphumo esingaqhelekanga?

• Ukungasebenzi kakuhle kwe-adrenal (ukuba kukho ingxaki ngee-adrenal glands): Kumntu onesi sifo, nokuba unikwe inaliti ye-ACTH, inqanaba le-cortisol alinyuki konke konke okanye linyuke kancinci kakhulu. Oku kungenxa yokuba ingxaki ikwi-adrenal glands, kwaye nokuba ingakanani na intshukumo enikwa ngaphandle, ayinakuvelisa i-cortisol.
• Ukungasebenzi kakuhle kwe-adrenal secondary (ukuba kukho ingxaki kwi-pituitary gland): Xa i-pituitary gland ingakhuphi i-ACTH ixesha elide, i-adrenal glands iyancipha kancinci kancinci ize iqale ukungasebenzi (i-atrophy). Xa umntu onjalo enikwa inaliti ye-ACTH, i-adrenal glands engasebenziyo ayinakuphendula ngoko nangoko. Ke ngoko, amanqanaba ayo e-cortisol ayanda kancinci kakhulu okanye awanyuki kwaphela.

Ngamanye amaxesha, ukuba ingxaki ye-pituitary gland isandul’ ukwenzeka okanye ichaphazeleke kancinci, amanqanaba e-cortisol anokunyuka kancinci. Ugqirha wakho ngumntu ofanelekileyo ukwenza isigqibo ngayo yonke le nto.