Ukuba kukho umntu kusapho lwakho, mhlawumbi umama othandekayo, utata, umakhulu okanye umakazi, onesifo se-Alzheimer, siyazi ukuba kunokuba buhlungu kangakanani. Kunzima ukuchaza intlungu oyivayo njengoko ubukela inkumbulo yakho iphela kancinci kancinci kwaye ulahlekelwa kukukwazi kwakho ukuzazi. Nangona amayeza angoku esi sifo enokulawula iimpawu ukuya kuthi ga kwinqanaba elithile, akukho nyango. Nangona kunjalo, isayensi yezonyango ayiyeki. Ngoku, izazinzulu kwihlabathi liphela ziphanda ngesitofu esinokunyanga, silawule kwaye sithintele esi sifo. Ngoko masithethe ngeli themba litsha namhlanje.
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Zeziphi izitofu ezinokunceda kwisifo sika-Alzheimer?
Enyanisweni, ezinye izifundo zibonise ukuba abantu abadala abafumana imijovo ethile yezifo ezifana ne-chickenpox (umzekelo, imijovo ye-shingles) kunye nemijovo yezifo ezifana ne-masisi banomngcipheko ophantsi wokufumana isifo se-Alzheimer. Kodwa ezi ayizizo imijovo ezijolise ngqo kwisifo se-Alzheimer.
Xa besenza isitofu esithile sokugonya isifo sika-Alzheimer, izazinzulu zigxile kakhulu kutshintsho oluphambili oluthathu engqondweni olubangelwa sesi sifo. Ngamafutshane, kukho "izinto ezintathu" eziphambili ngaphakathi kwengqondo yomguli one-Alzheimer's.
1. Iiproteni zeTau zidibana: Ezi ziqokelelana ngaphakathi kwiiseli zemithambo-luvo engqondweni.
2. Ii-Beta-amyloid plaques: Ezi ziqokelelana phakathi kweeseli zemithambo-luvo, oko kukuthi, kwiindawo eziphakathi kweeseli ezimbini.
3. Ukudumba ebuchotsheni: Ezi zinto zimbini zibangela ukudumba okungapheliyo, okanye ukudumba, ebuchotsheni.
Injongo yogonyo ngalunye oluphuhliswayo ngoku kukulawula enye okanye ezingaphezulu kwezi zinto zibangela le ngxaki. Makhe sijonge uhlobo ngalunye logonyo ngokwahlukeneyo.
| Uhlobo lwegonyo kunye nenjongo yalo | Inkqubo kunye nefuthe |
|---|---|
| Iigonyo ezijolise kwiiproteni zeTau | Khawuthelekelele ngaphakathi kwiiseli zemithambo-luvo zobuchopho bakho, kukho isakhiwo esifana nenkqubo kaloliwe yokuthutha izondlo ukuya phambili. Le protein ibizwa ngokuba yi-'tau' yiyo egcina ezo 'mizila kaloliwe' zizinzile. Kwisifo sika-Alzheimer, ezi protein ze-tau ziba yimilo engafanelekanga, endaweni yokuba zibe njengemizila, zidityaniswe zibe 'ziibhola zentambo'. Emva koko uthutho olungaphakathi kwiiseli luyayeka, kwaye iiseli ziqala ukufa. Ezi zitofu zizama ukumisa olu xinano. Izitofu ezikwisigaba sovavanyo okwangoku yi -AADvac1 kunye ne -ACI-35.030/JACI-35.054 . |
| Izitofu zokugonya ezijolise kwi-beta-amyloid | Oku kufana 'nenkunkuma' okanye 'inkunkuma efana neglue' eqokelelana phakathi kweeseli zemithambo-luvo engqondweni. Ezi ziqwenga zeproteni ebizwa ngokuba yi-beta-amyloid ziyaqokelelana kwaye zenze iidiphozithi ezibizwa ngokuba yi-'plaques'. Oku kuthintela iiseli zemithambo-luvo ukuba zinganxibelelani kakuhle, oko kuthetha ukuba zithintelwa ekuthumeleni 'iimpawu'. Oko kwenziwa zezi zitofu kukuvuselela inkqubo yomzimba yokuzikhusela ukuba isuse le 'nkunkuma'. Izitofu ezifana ne -ALZ-101, i-ABvac40, kunye ne-UB-311 zezo zikolu didi. |
| Iigonyo ezijolise ekuvuvukeni kwengqondo | Kwingqondo ephilileyo, kukho iiseli ezikhethekileyo ezibizwa ngokuba yi-microglia. Zifana 'neqela lokucoca' lobuchopho. Umsebenzi wazo kukususa inkunkuma engafunekiyo kunye neetyhefu. Kodwa kwisifo sika-Alzheimer, aba basebenzi bayacaphuka. Endaweni yokususa inkunkuma, bavelisa iikhemikhali eziyingozi ezibangela ukudumba rhoqo engqondweni. Oku konakalisa neeseli zemithambo-luvo ezisempilweni. Ezi zitofu zizama ukubuyisela le 'nkqubo yokucoca engcolileyo'. I-GV1001 kunye neProtollin zezinye zezi zitofu zovavanyo. |
Ngoko ke, siza kufumana nini isitofu sokugonya i-Alzheimer's?
Lo ngumbuzo omkhulu engqondweni yomntu wonke. Ukuba ndithetha inyani, oku kuza kuthatha ixesha. Zonke ezi gonyo sithethe ngazo zisekwinqanaba lovavanyo lweklinikhi. Oko kuthetha ukuba zisavavanywa ukuze kubonwe ukuba zikhuselekile na ukuba zinganikwa abantu kwaye zisebenza kangakanani na.
Eyona nto ibalulekileyo kukuba ukuba olu phando luphumelele, isifo sika-Alzheimer sinokuthintelwa okanye sinyangeke kwasekuqaleni kwixesha elizayo.
Ngokweenkcukacha zangoku, phakathi kwezitofu ezikhankanyiweyo apha ngasentla, i-GV1001Olu gonyo luphucuke kancinci kwiimvavanyo zeklinikhi, kodwa ezi azikabi ziziphumo zokugqibela okwangoku.
Siza kwenza ntoni de kube ngoko?
Kulungile ukuba nethemba ngale gonyo intsha. Kodwa kude kube ngoko, ukuba wena okanye umntu kusapho lwakho unesifo esi, eyona nto ilungileyo onokuyenza kukulandela unyango olucetyiswa ngugqirha wakho okwangoku.
Amayeza akhoyo ngoku, anjengeAducanumab kunye neLecanemab, abonakalisiwe ukuba ayayicothisa inkqubela yesi sifo ukuya kuthi ga kwinqanaba elithile ukuba ifunyenwe kwangethuba. Ke ngoko, kubalulekile ukuhlala unxibelelana rhoqo nogqirha wakho kwaye ulandele imiyalelo yakhe.
Ukuba unomdla wokuthatha inxaxheba kuvavanyo lweklinikhi olufana nolu, ungathetha nogqirha wakho ngalo mba. Uya kukwazi ukukunika isikhokelo esichanekileyo sokuba kukho ithuba elifanelekileyo kuwe na nokuba uyalifanelekela na.
Umyalezo Wokuya Ekhaya
- Isifo sika-Alzheimer sisifo esibangelwa lutshintsho oluntsonkothileyo engqondweni (ii-tau protein tangles, ii-beta-amyloid deposits, ukudumba).
- Izazinzulu zisebenza nzima ukuphuhlisa imigonyo enokuthi ijolise kolu tshintsho kwaye ithintele, iphilise, okanye ilawule esi sifo.
- Ekubeni la machiza esekwinqanaba lophando, kuya kuthatha ixesha ukuba afumaneke ngokubanzi.
- Eyona nto ingcono onokuyenza ngeli xesha kukuqhuba unyango olucetyiswe ngugqirha wakho uze ulandele imiyalelo yakhe.
- Xa isitofu sokugonya siphuhlisiwe ngempumelelo kwixesha elizayo, iqela lakho lezonyango liya kukwazisa ngaso.
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