Yintoni i-AA Amyloidosis? Masifunde ngayo ngokulula!

Ngaba wakha wazibuza ukuba kunokwenzeka ntoni ukuba iiproteni ezithile emizimbeni yethu ziyaphazamiseka? Namhlanje siza kuthetha ngemeko engaqhelekanga, kodwa ebalulekileyo ekufuneka siyiqaphele. Ibizwa ngokuba yi-AA Amyloidosis.

Yintoni i-AA Amyloidosis? Masiyiqonde ngokulula!

Ngamafutshane, i-AA Amyloidosis luhlobo olunye lweqela elikhulu lezifo ezibizwa ngokuba yi-amyloidosis. Ngoku usenokuba ubuza, 'Yintoni le amyloidosis?' Kaloku, imizimba yethu inohlobo lweproteni ebizwa ngokuba yi-amyloid. Ezi proteni zinemilo ethile enobukhulu obuthathu (ulwakhiwo lwe-3D). Yile ndlela ezisebenza ngayo. Nangona kunjalo, ngamanye amaxesha ezi proteni ziyayitshintsha imilo yazo, zidibane njengebhola yomsonto, kwaye zenze imicu emincinci (ii-fibrils). Oku sikubiza ngokuba yi-'amyloid deposits'. Ukuqokelelana kwezi deposits kwizitho zethu ezahlukeneyo kunye nezicubu kuthiwa yi-amyloidosis.

Kwi-AA amyloidosis, inqanaba leproteni ye-serum A egazini liyanda kakhulu ngenxa yokuvuvukala okugqithisileyo emzimbeni wethu. Ukuba unesifo sosulelo okanye isifo sokudumba ixesha elide, eli nqanaba leproteni ye-serum A linokunyuka. Ngandlela thile, i-AA amyloidosis yingxaki enkulu yezi zifo zokudumba. Oogqirha bayayinyanga ngokunyanga isifo sokudumba esisisiseko.

I-AA amyloidosis iyichaphazela njani imizimba yethu?

Ngoku makhe sibone ukuba le AA amyloidosis ichaphazela njani imizimba yethu. Ingonakalisa kakhulu izintso zethu . Ayipheleli apho, kodwa ingonakalisa nesibindi, ipleyini, isisu, namathumbu. Ayifane ichaphazele intliziyo. Enye into kukuba le meko inokuchaphazela ubungakanani beproteni kumchamo wakho kunye nenqanaba le-cholesterol egazini lakho.

Ingaba le yimeko ebulalayo?

Ewe, le yingxaki enkulu ngokwenene. Ukuba i-AA Amyloidosis ayinyangwa kakuhle, inokubulala . Khumbula, ndithe oku kubangelwa sisifo esibangela ukudumba kwexesha elide. Ngoko ke, xa oogqirha benyanga isifo esisisiseko, banyanga ne-AA amyloidosis. Ngoko ke akukho nto ibalulekileyo, kodwa eyona nto ibalulekileyo kukuyiqaphela kwangethuba kwaye ufumane unyango .

Ngubani onokuthi abe ne-AA amyloidosis?

Ukuba ucinga ngokuba ngubani onokuba nale meko, nabani na onesifo sokudumba esingapheliyo usengozini yokufumana i-AA amyloidosis . Oko kuthetha ukuba, ukuba unesifo esinjalo, kulungile ukuba nolwazi oluncinci ngale nto.

Yintoni ebangela i-AA amyloidosis?

Masiqwalasele ngokusondeleyo ukuba yintoni ebangela oku. I-AA amyloidosis luhlobo lwe-amyloidosis. Oogqirha babiza le amyloidosis ngokuthi "yingxaki yokusongana kweeproteni." Cinga ngayo, iiproteni zethu ziimolekyuli ezinde ezineemilo ezikhethekileyo ze-three-dimensional (3D). Ezi proteni zenza umsebenzi omninzi emizimbeni yethu - ukusuka ekuboneleleni ngamandla, ukuya ekulinganiseni ulwelo, ukuya ekuncedeni ekukhuselekeni komzimba, ukuya ekwakhiweni komzimba, ekuhambiseni izinto, ukuya ekulawuleni iinkqubo zomzimba, njalo njalo.

Ngokwesiqhelo, ezi proteni ziyasuswa egazini xa umsebenzi wazo ugqityiwe. Nangona kunjalo, xa kukho iingxaki apho ezi proteni zisongeka ngendlela engafanelekanga, iiproteni zitshintsha imilo kwaye zithathe iimilo ezingaqhelekanga umzimba ongenakukwazi ukuzisebenzisa okanye ukuzisusa. Kwi-AA amyloidosis, ezi proteni ezingaqhelekanga ziyahlangana kwaye zenze 'ii-amyloid deposits', okanye 'ii-fibrils', kwizitho zethu zomzimba.

Izifundo zakutshanje zichonge inani leemeko ezinokubangela i-AA amyloidosis. Ezi ziquka iintlobo ezithile zomhlaza wegazi, usulelo lweebhaktheriya ezifana nezilonda ezingapheliyo, izifo zamathambo ezifana ne-rheumatoid arthritis, okanye izifo zamathumbu ezivuthayo ezifana nesifo sikaCrohn okanye i-ulcerative colitis. Ngamanye amaxesha, inokubangelwa zizifo ezizuzwa njengezifo zomkhuhlane ezibangelwa ziimeko ezithile ezifana ne-familial Mediterranean fever.

Zithini iimpawu ze-AA amyloidosis?

Kulungile, ngoku masibone ukuba zeziphi iimpawu ze-AA amyloidosis. Ihlala ichaphazela izintso. Ingachaphazela nezitho ezifana nesibindi, ipleen, kunye nesisu. Jonga ukuba unayo na kwezi mpawu:

• Ukudumba emilenzeni okanye emaqatheni . Oku kungaba luphawu lwengxaki yezintso. Kungaba luphawu lwesifo sezintso esingapheliyo.
• Umchamo onogwebu okanye onamagwebu.
• Ukuphuma komchamo okuncinci kunesiqhelo.
• Urhudo olungapheliyo.
• Ukwandiswa kwezintso.
• Ukwandiswa kwesibindi.
• Uxinzelelo lwegazi oluphantsi.
• Isicaphucaphu nokuhlanza.

Oogqirha bayixilonga njani i-AA amyloidosis?

Oogqirha bayixilonga njani le sifo? Benza uthotho lovavanyo. Olona luphambili yi-biopsy.

• I-biopsy ye-"Fat pad" : Oku kuquka ukuthatha inani elincinci lamafutha phantsi kolusu lwesisu uze ulihlolisise. Kulula kakhulu.
• I-biopsy yelungu : Kuthathwa isampulu encinci yezicubu kwilungu ekucingelwa ukuba lichaphazelekile kwaye lihlolwe.

Ukongeza, ezinye iimvavanyo zingenziwa ukuqinisekisa ukuba unayo na enye uhlobo lwe-amyloidosis olubizwa ngokuba yi-"AL amyloidosis." Ngenxa yokuba iimpawu ze-AL amyloidosis kunye ne-AA amyloidosis zifana kakhulu, i-AL amyloidosis luhlobo olunzima kancinci kwaye olukhula ngokukhawuleza .

Inyangwa njani i-AA amyloidosis?

Ngoku makhe sibone ukuba zeziphi iindlela zonyango zoku. I-AA amyloidosis ibangelwa yimeko yokudumba ehlala ixesha elide ebangela ukuba iiproteni ezingaqhelekanga ziqokeleleke kwizitho zakho zomzimba. Ngoko ke, oogqirha bayayinyanga ngokunyanga imeko yokudumba engaphantsi . Xa unyanga imeko engaphantsi kwaye unciphisa ukudumba, imeko ye-AA amyloidosis nayo iyalawuleka. Njengoko inqanaba lokudumba lihla, iimpawu ziyancipha kancinci kancinci.

Kukwakho namayeza akhoyo ngoku okunyanga i-AA amyloidosis. Oogqirha kunye nabaphandi bayaqhubeka nokuphonononga unyango olutsha. Umzekelo, baphanda iindlela zokususa ezi fibrils ze-amyloid egazini ngaphambi kokuba ziqokelelene kwizitho zomzimba, kwaye baphanda nee-antibodies ezenziwe elebhu ezinokujolisa kwaye zisuse ii-fibrils ze-amyloid esele ziqokelelene kwizitho zomzimba.

Ngaba i-AA amyloidosis inokuthintelwa?

Ngaba oku kungathintelwa? Enyanisweni, ukuba unesifo esingapheliyo sokudumba esifana ne-rheumatoid arthritis, sinokubangela ukwanda kweeproteni ezithile egazini kwaye sibangele i-AA amyloidosis. Ke ngoko, indlela ekuphela kwayo yokuthintela oku kukufumana unyango olukhawulezileyo nolufanelekileyo lwesifo esingapheliyo sokudumba esisisiseko onaso .

Ngaba i-AA amyloidosis inokunyangeka?

Ewe, inokunyangeka. Oogqirha banyanga i-AA amyloidosis ngokunyanga imeko yokuvuvukala ebangele oko. Njengezifo ezininzi, eyona ndlela ilungileyo yokulawula i-AA amyloidosis kukufumanisa isifo kwaye uqale unyango ngokukhawuleza .

Ndingazinyamekela njani?

Ukuba une-AA amyloidosis, eyona ndlela ilungileyo yokuzinyamekela kukusebenzisana nogqirha wakho ukuze unyange ngokufanelekileyo imeko yokudumba ebangele oko. Abaphandi bafumene inani lezifo kunye neemeko ezibangela ukudumba kwexesha elide ezinxulumene ne-AA amyloidosis. Buza ugqirha wakho ukuba imeko yakho ibangele njani i-AA amyloidosis kunye nendlela abayinyanga ngayo loo meko yokudumba.

Ngamafutshane, i-AA amyloidosis yingxaki engaqhelekanga, kodwa enzima, yezifo okanye iimeko ezininzi ezixhaphakileyo zokudumba. Ngethamsanqa, oogqirha banokuyinyanga ngokunyanga imeko engaphantsi. Rhoqo, iimpawu ze-AA amyloidosis zinokubonakala njengeengxaki eziqhelekileyo oqhelene nazo ngesifo sakho sokudumba. Kodwa, njengezinye izifo ezinzulu, oogqirha banokuthi bayinyange ukuba ifunyenwe kwangethuba.Ukuba ubona naluphi na utshintsho okanye iimpawu ezintsha kwi-arthritis yakho, xelela ugqirha wakho ngoko nangoko . Baza kuhlola iimpawu zakho baze bakuchazele ukuba zithetha ukuthini.

Ngoko ke, zeziphi izinto ezibalulekileyo ekufuneka sizikhumbule kweli bali?

Igama elithi AA Amyloidosis liyoyikisa kancinci, kodwa kubaluleke kakhulu ukuliqonda kakuhle.

Khumbula, oku kudla ngokuba yingxaki yesinye isifo sokudumba esihlala ixesha elide.

• Ukuba unesifo esingapheliyo sokudumba, esifana ne-rheumatoid arthritis, kubalulekile ukuba ufumane unyango olufanelekileyo .
• Ukuba ubonakalisa iimpawu ezintsha, ezinje ngeengxaki zezintso (ukudumba kwemilenze, utshintsho kumchamo), urhudo oluqhubekayo, okanye ukwanda kwesibindi okanye ipleyini, yazisa ugqirha wakho .
• Ukuba i-AA amyloidosis iqatshelwa kwaye inyangwa kwangethuba, iziphumo ezilungileyo zinokufumaneka . Eyona nto iphambili kunyango kukunyanga isifo esibangela ukudumba.
• Musa ukoyika, kodwa lumka . Thetha ngokukhululekileyo nogqirha wakho, mxelele iingxaki zakho. Baza kukunceda.

Ngoko ke, sinethemba lokuba olu lwazi lube luncedo kuwe. Hlala usempilweni!

I- Amyloidosis, i-AA amyloidosis, iiproteni, ukudumba, isifo sezintso, isifo esingapheliyo, isifo samathambo