Kunzima ukuchaza intlungu oyivayo xa ubona ilungu losapho okanye umhlobo osenyongweni elibala yonke into kancinci kancinci aze angakwazi ukwenza nemisebenzi yemihla ngemihla eyedwa. Isifo sika-Alzheimer sisifo esibuhlungu kakhulu. Kude kube ngoku, bekukho amayeza alawula iimpawu kuphela, kodwa ngoku ihlabathi lithetha ngonyango olutsha olujolise ngqo kwisizathu sesi sifo. Namhlanje sithetha ngeli themba litsha, eliyi-Anti-Amyloid therapy.
Ngamafutshane, yintoni le ndlela yonyango lwe-Anti-Amyloid?
Ebuchotsheni bomntu onesifo i-Alzheimer's, uhlobo lweproteni ebizwa ngokuba yi-'beta-amyloid' iqokelelana ngokungeyomfuneko. Cinga ngayo njengomsinga odlula kwintambo yombane, yindlela ulwazi oluhamba ngayo phakathi kwee-neurons engqondweni yethu. Loo proteni ye-'beta-amyloid' iqokelelana kwaye yenze 'iiplaque' ezifana nomhlwa phakathi kwezi seli zemithambo-luvo. Oku ke kuphazamisa ukuhamba kolwazi. Esi sesona sizathu siphambili sokulahlekelwa yinkumbulo kunye nokungakwazi ukucinga kakuhle.
Olu hlobo lutsha lwamayeza, olubizwa ngokuba yi-anti-amyloid, lusebenza ngokususa ii-plaque ze-'beta-amyloid' eziqokelelweyo ebuchotsheni. Oko kuthetha ukuba luhlasela unobangela wesifo endaweni yokucinezela nje iimpawu. Ithemba kukuba ngokususa ezi plaque, iiseli zengqondo ziya kukwazi ukusebenza kakuhle ixesha elide.
Ezi ngokwenene zezeqela lonyango olubizwa ngokuba yi-'immunotherapy'. Ngokuchanekileyo, la mayeza anikwa njengohlobo lwe-antibody (i-monoclonal antibody) eyenziwe ngokukodwa kwilebhu. Xa la ma-antibodies engena emizimbeni yethu, afumana ezo protein ziyingozi ze-'beta-amyloid', azincamathele, aze azitshabalalise.
Amayeza amabini aphambili okulwa ne-amyloid avunyiweyo okwangoku yi-'donanemab (Kisunla)` kunye ne-`lecanemab-irmb (Leqembi)`. Kukwakho neyeza elibizwa ngokuba yi-`aducanumab (Aduhelm)` kodwa ngoku lisusiwe kwimarike yinkampani eyalenzayo.
Ndingalufumana njani olu nyango? Ngaba kukho naziphi na iziphumo ebezingalindelekanga?
Eli yeza linikwa ngesisombululo setyuwa (IV infusion) emthanjeni. Oku kuthatha malunga neyure. I-`Leqembi` idla ngokunikwa rhoqo emva kweeveki ezimbini, kwaye i-`Kisunla` idla ngokunikwa rhoqo emva kweeveki ezine. Uqala ngedosi encinci uze uyinyuse kancinci kancinci ukuya kwidosi echazwe ngugqirha wakho.
Kodwa kufuneka uqaphele umngcipheko omkhulu oza nolu nyango. Lubizwa ngokuba yi-'ARIA (Amyloid-Related Imaging Abnormalities)'.
Ngamafutshane, oku kunokubangela ukudumba engqondweni okanye amabala amancinci okopha ngaphakathi kwengqondo. Nangona oku kuhlala kuphelela, kubalulekile ukukujonga oku. Yiyo loo nto kufuneka wenze i-MRI scans rhoqo yobuchopho kulo lonke ixesha lonyango.
| Uhlobo lwesiphumo esibi | Inkcazo |
|---|---|
| I-ARIA (umngcipheko omkhulu) | Ukudumba okanye ukopha kancinci engqondweni. Oku kunokubangela intloko ebuhlungu, isiyezi, isicaphucaphu, ukudideka, kunye neengxaki zokubona. |
| Ezinye iziphumo ebezingalindelekanga | - Iimpendulo ze-allergic - Ukuwa - Urhudo |
| Ingqwalasela ekhethekileyo | Izazinzulu zicinga ukuba olu nyango lunokunyusa umngcipheko wokopha ebuchotsheni ukuba lunikwa umntu othatha amayeza okunciphisa igazi. Ngokuqinisekileyo kuya kufuneka uthethe nogqirha wakho ngale nto. |
Lisebenza kangakanani eli yeza?
Nantsi inxalenye enzima. Izifundo zibonise ukuba la mayeza anokususa ii-plaque ze-'beta-amyloid' ebuchotsheni. Yinto entle leyo.
Nangona kunjalo, kusekho umahluko kwiimbono malunga nokuba inkumbulo yesigulana kunye nokukwazi kwayo ukwenza imisebenzi yemihla ngemihla kuya kuphucuka kangakanani emva kokususwa kwezo plaque. Ezinye izifundo zibonise ukuba ezi zinto zinokucothisa kancinci ukuqhubela phambili kwesi sifo. Oko akuthethi ukuba isifo sinyangekile ngokupheleleyo, kodwa kuyasicothisa isifo ekubeni sibi kakhulu.
Izazinzulu zikholelwa ukuba iziphumo ezinkulu zinokulindelwa ukuba olu nyango luqalwe kwisigaba sokuqala sesi sifo , ngaphambi kokuba kwenzeke umonakalo omkhulu engqondweni.
Ngubani onokufumana olu nyango?
Olu asilonyango olunokunikwa wonke umntu one-Alzheimer's. Okwangoku, olu nyango lucetyiswa kuphela kubantu abambalwa kakhulu.
- Kubantu abakwinqanaba lokuqala lesi sifo: Oko kukuthi, abo banesifo se-Alzheimer's esiqala kwangethuba okanye abo banesifo esibizwa ngokuba yi-'mild cognitive impairment'. Akukaziwa ukuba oku kuya kuba luncedo na kubantu abanesifo esiphucukileyo.
- Kwabo baqinisekisiweyo ukuba bane-amyloid plaques:Ngaphambi kokuba ugqirha wakho akunike eli yeza, kufuneka aqinisekise ukuba ezi plaque zikhona na engqondweni yakho. Oku kungabandakanya i-PET scan okanye i-spinal tap.
Ngubani ongenakukwazi ukufumana olu nyango?
Eli yeza alikafundwa kwiimvavanyo ezininzi zeklinikhi, ngoko ke kunokuba yingozi ukunika olu nyango kubantu abaneengxaki zempilo ezilandelayo:
- Abantu abasebenzisa amayeza athintela ukujiya kwegazi (ngaphandle kwe-aspirin).
- Abo bakha bahlaselwa sisifo sentliziyo okanye isifo sohlangothi ngaphambili.
- Abantu abaneengxaki zokopha.
- Abantu abanesifo sezintso okanye sesibindi.
Enye into kukuba, olu nyango lubiza kakhulu . Kwilizwe elifana neSri Lanka, kunokuba nzima kubantu abaninzi ukuzifumana ezi ndlela. Ezi azixhaphakanga kangako okwangoku.
Umyalezo Wokuya Ekhaya
- I-Anti-amyloid luhlobo olutsha lwamayeza olususa ii-plaque ze-'beta-amyloid' eziqokelelana engqondweni kwaye zinokubangela isifo se-Alzheimer.
- Oku kujoliswe ekunyangeni unobangela wesifo endaweni yokunyanga iimpawu.
- Oku kunokunikwa kuphela izigulane ezikwinqanaba lokuqala lesi sifo kwaye kuqinisekiswe ukuba zine-plaque engqondweni.
- Ngenxa yomngcipheko wokudumba okanye ukopha kwengqondo okubizwa ngokuba yi-ARIA, ukubekwa esweni rhoqo nge-MRI scans kubalulekile ngexesha lonyango.
- Qonda ukuba olu nyango lusesekwinqanaba lophando, lubiza kakhulu, kwaye lufumaneka kubantu abambalwa kuphela .
- Ukuba umntu omthandayo uneempawu ze-Alzheimer's, eyona nto ingcono onokuyenza kukuthetha nogqirha wakho ngolwazi oluthe kratya kunye neendlela zonyango ezifanelekileyo kuwe.
💬 Comments (0)
Akukho zimvo zithunyelweyo okwangoku. Faka uluvo lwakho apha okokuqala.
Faka uluvo lwakho