Ngaba uziva ngathi umzimba wakho ulwa nawe ngaphakathi? Isenokuba yi-Antisynthetase Syndrome!

Ngaba ngamanye amaxesha ukhe uzive ngathi kukho into ekukhathazayo ngaphakathi? Kusenokwenzeka ukuba amalungu akho ayabuhlungu nje, unengxaki yokuphefumla, okanye ubona utshintsho oluncinci eluswini lwakho. Musa ukuzithatha nje njengento eyenzekayo. Ngamanye amaxesha kukho ibali eliyinkimbinkimbi emva kwazo. Namhlanje siza kuthetha ngemeko engaqhelekanga kodwa elawulekayo ebizwa ngokuba yi-Antisynthetase Syndrome.

Yintoni i-Antisynthetase Syndrome? Ngamafutshane...

I-Antisynthetase Syndrome yimeko engaqhelekanga kakhulu. Okwenzekayo koku kukuba kukho ukudumba emzimbeni wonke, oko kukuthi, imeko efana nokudumba. Esi sisifo esibangelwa kukuzimela komzimba. Ngoku ubuza ukuba yintoni isifo esibangelwa kukuzimela komzimba.

Khawuthelekelele, umzimba wethu unenkqubo yokuzikhusela . Ifana nomkhosi okhusela ilizwe lethu. Iiseli kunye namalungu ale nkqubo asikhusela kwiintsholongwane, iibhaktheriya, kunye neentsholongwane ezibangela izifo. Nangona kunjalo, kwisifo sokuzikhusela komzimba, le nkqubo yokuzikhusela iyaphazama. Icinga ukuba iiseli zethu eziphilileyo kunye nezicubu "ziintshaba" kwaye iqala ukuzihlasela. Kufana nomkhosi wethu ohlasela amakhaya ethu. Kwanoogqirha abakakwazi ukuqonda ukuba kutheni oku kusenzeka.

Kwi-Antisynthetase Syndrome, inkqubo yethu yomzimba yokuzikhusela inokuchaphazela ezi ndawo zilandelayo zomzimba wethu:

• Izihlunu
• Amalunga
• Imiphunga
• Ulusu
• Ivazi yegazi

Eyona nto ibalulekileyo kukubona ugqirha ukuba ubona nayiphi na intlungu entsha yamalungu, utshintsho lolusu, okanye ubunzima bokuphefumla.

Ingaba esi sifo sinqabile kangakanani?

Esi (i-Antisynthetase Syndrome) sisifo esingaqhelekanga kakhulu. Kunzima ukutsho ngokuthe ngqo ukuba bangaphi abantu abanaso. Kuba zimbalwa kakhulu iimeko ezixelwayo minyaka le. Ngamanye amaxesha, ezi mpawu ziyafana neempawu zezinye izifo, kwaye zinokungabonwa.

Zithini iimpawu ze-Antisynthetase Syndrome?

Iimpawu ozifumanayo ziya kuxhomekeka ekubeni inkqubo yakho yokuzikhusela yomzimba isebenza kakuhle kangakanani na kwaye iwonakalisa kangakanani.

Amaxesha amaninzi, abantu abane-Antisynthetase Syndrome baneempawu ezidityaniswe nezinye izifo ezininzi. Makhe sijonge ukuba zithini na:

• I-Myositis: Oku kukudumba kwemisipha okuhlala ixesha elide. Oku kubangela iintlungu zemisipha kunye nobuthathaka.Kuyenzeka. Khawucinge nje, uzive ubuthathaka kangangokuba awukwazi nokuphakamisa iingalo zakho. Ngamanye amaxesha izihlunu zomqala wakho ziba buthathaka, nto leyo eyenza kube nzima ukuginya ukutya nokusela. Siyibiza loo nto ngokuba yi-dysphagia .

• "Izandla zoMechanic": Asilogama lingaqhelekanga eli? Kulapho ulusu olusezintendeni nasemacaleni eminwe luqina khona kwaye luqhekeka. Lufana nezandla zomkhandi osebenza ngamafutha neoyile imini yonke.

• Isifo semiphunga esiphakathi kwemithambo yegazi (ILD): Oku kwenzeka xa izicubu eziphakathi kweengxowa zomoya ezincinci (i-alveoli) emiphungeni yethu kunye nemithambo yegazi ejikeleze zonakala. Oku kunokubangela ukuphefumla okufutshane (ukuphelelwa ngumoya) , ukukhohlela okomileyo , ukudinwa , kunye nokungonwabi esifubeni . Kufana nokuwa phantsi kwezinyuko.

• I-Polyarthritis: Oku kwenzeka xa amalungu amahlanu okanye ngaphezulu echaphazeleka ngaxeshanye. Oku kubangela iintlungu, ukuqina, kunye nokudumba kwamalungu . Ungaziva uqinile xa uvuka kusasa.

• Isiganeko sikaRaynaud (isifo sikaRaynaud sesibini): Kule meko, iminwe neenzwane ziyatshintsha umbala (zibe mthubi, zibe luhlaza okwesibhakabhaka, zibe bomvu) kwaye zibe ndindisholo, ingakumbi xa zibekwe emakhazeni. Kufana nokuba iminwe yakho iya ndindisholo emva kokukhupha iqhekeza lomkhenkce efrijini.

• Umkhuhlane: Abanye abantu banokuba nomkhuhlane nje ngaphandle kosulelo emizimbeni yabo. Oku kuthetha ukuba ubushushu bomzimba buyanyuka ngenxa yalo msebenzi wokuzikhusela komzimba.

Yintoni ebangela i-Antisynthetase Syndrome?

Isizathu esichanekileyo sesi sifo asikaziwa okwangoku . Kodwa oogqirha bafumanise ukuba abantu abaninzi abanale sifo banohlobo oluthile lwee-antibodies egazini labo. Ezi antibodies zibonisa ukuba inkqubo yabo yokuzikhusela ihlasela imizimba yabo endaweni yokuyikhusela. Sizibiza ngokuba zii -autoantibodies , oko kuthetha "ii-self-antibodies".

Ngoku, khangela, ii-antibodies ziiproteni ezisikhuselayo xa into embi ingena emizimbeni yethu. Zifana nemiqondiso yeekhemikhali esetyenziswa yinkqubo yethu yokuzikhusela komzimba. Ezi antibodies ziphawula abahlaseli abayingozi njengeebhaktheriya kunye neentsholongwane "njengengozi." Kodwa ukuba unesifo sokuzikhusela komzimba, inkqubo yakho yokuzikhusela komzimba ivelisa kwaye ikhuphe ii-antibodies ezihlasela izicubu eziphilileyo ngempazamo.

Abantu abane-Antisynthetase Syndrome badla ngokuba nama-autoantibodies ahlasela ii-enzymes ezibizwa ngokuba yi-tRNA synthetases . Ezi tRNA synthetases zii-enzymes ezibalulekileyo neziluncedo ezifunekayo emizimbeni yethu ukuze isebenze kakuhle.

Kusengummangaliso ukuba kutheni inkqubo yethu yomzimba iqala ukwenza ezi autoantibodies. Nangona kunjalo, ukuba unobungqina bezi autoantibodies egazini lakho, kusenokwenzeka ukuba une-Antisynthetase Syndrome.

Kunje, khawucinge ngomntu oqhumisa iifirecracker phambi kwendlu yakho. Xa uzijonga kusasa, kukho iziqwenga zeefirecracker kunye neendlela ezitshileyo ezisasazeke emhlabeni wonke. Usenokungazi ukuba ngubani oqhumise iifirecracker, ukuba zaqhumiswa nini, okanye kutheni. Kodwa kukho ubungqina bokuba zenzekile. Kwi-Antisynthetase Syndrome, endaweni yengxolo oyivayo xa uqhumisa iifirecracker kunye nezinja zisoyika, ufumana iimpawu esithethe ngazo ngaphambili.

Ngubani osengozini enkulu yokuhlaselwa sesi sifo?

Nabani na unokufumana i-Antisynthetase Syndrome. Nangona kunjalo, abafazi kunye nabantu abaneminyaka engaphezu kwama-50 ubudala banamathuba amaninzi okufumana esi sifo. Abafazi banamathuba aphindwe kabini okufumana esi sifo kunamadoda.

Ifunyanwa njani i-Antisynthetase Syndrome?

Ugqirha uxilonga esi sifo ngokusekelwe kwiimpawu zakho, uvavanyo lomzimba, kunye nezinye iimvavanyo ezininzi.

Kusenokufuneka ubonane nogqirha ochwephesha kwizifo ezibangelwa kukuzikhusela komzimba, obizwa ngokuba yi- rheumatologist . Uza kukuhlola aze akubuze ngeempawu zakho. Kuya kufuneka uxelele ugqirha ukuba zeziphi iimpawu zakho, ukuba uziqaphele nini okokuqala, nokuba kukho into ebangela ukuba zibe mandundu na.

Ukongeza, kuya kufuneka wenze iimvavanyo ezininzi ukuqinisekisa ukuba une-Antisynthetase Syndrome kwaye ukhuphe ezinye iimeko ezinokubangela iimpawu ezifanayo.

Zeziphi iimvavanyo ezisetyenziswayo ukufumanisa isifo?

Olu ayilovavanyo olunye olunokuqinisekisa ngokuqinisekileyo ukuxilongwa. Oku kudla ngokuba yinxalenye yenkqubo ebizwa ngokuba yi-differential diagnosis . Oku kuthetha ukuba ugqirha wakho uza kwenza uvavanyo oluninzi ukuze afumanise ukuba yintoni ebangela iimpawu zakho, asuse ezinye iimeko, aze ekugqibeleni akuxilonge nge-Antisynthetase Syndrome. Ezinye zeemvavanyo onokuba nazo zezi:

• Uvavanyo lwegazi: Ukujonga indlela esebenza ngayo inkqubo yakho yomzimba yokuzikhusela kunye nokujonga ukuba unayo na i-autoantibodies, eziluphawu lwe-Antisynthetase Syndrome. Uvavanyo lwegazi lunokujonga na amanqanaba aphezulu ee-enzyme ezithile ezikhutshwa egazini xa izihlunu zonakele.
• Uvavanyo lomchamo: Ukujonga ukusebenza kwezintso nokujonga usulelo okanye ezinye iingxaki kumchamo ezinokubangela iimpawu zakho.
• Uvavanyo lokusebenza kwephaphu: Jonga ukuba imiphunga yakho okanye inkqubo yokuphefumla ichaphazelekile na.
• Iiskeni ze-CT ezisebenzisa ikhompyutha okanye ezinye iimvavanyo zokuthatha imifanekiso: Thatha imifanekiso yezicubu kunye namalungu omzimba ngaphakathi emzimbeni.
• (I-Electromyography - EMG):Jonga ukusebenza kwezihlunu.
• Iskeni ye-magnetic resonance imaging (MRI) yezihlunu ezichaphazelekayo: ukujonga ukudumba.
• I-biopsy luvavanyo olubandakanya ukuthathwa kwenxalenye encinci yezicubu zemisipha okanye zemiphunga.

Inyangwa njani i-Antisynthetase Syndrome?

Akukho nyango lwe- Antisynthetase Syndrome. Nangona kunjalo, ugqirha wakho unokukunceda ufumane indibaniselwano yonyango olunokukunceda ukulawula iimpawu zakho, ukunciphisa impembelelo yazo kubomi bakho bemihla ngemihla, kunye nokunciphisa umonakalo kwizitho zakho zomzimba.

Uhlobo lonyango olufunekayo luya kuxhomekeka ekubeni iimpawu zakho zikuphi kwaye zinzima kangakanani. Nazi ezinye zezona ndlela zonyango zisetyenziswa kakhulu:

• IiCorticosteroids: La ngamayeza akhutshwa ngugqirha anciphisa iintlungu nokudumba. Oogqirha badla ngokunika ii-corticosteroids kunye namayeza abizwa ngokuba yi-immunosuppressants.
• Ii-immunosuppressants: La mayeza asebenza ngokuthintela amasosha omzimba wakho ekuhlaseleni iiseli kunye nezicubu ezisempilweni. Uhlobo lwamayeza olufunayo luya kuxhomekeka ekubeni zeziphi izitho zomzimba ezichaphazelekileyo. Ii-immunosuppressants eziqhelekileyo yi -methotrexate, i-azathioprine, kunye ne-mycophenolate . Ungadinga ne -cyclophosphamide, i-rituximab, okanye i-tacrolimus .
• Unyango lweSifo seMiphunga esiPhakathi (ILD): Unganikwa amayeza okwenza kube lula ukuphefumla, okanye unyango lweoksijini ukuba ufuna ioksijini eyongezelelweyo. Kuya kufuneka usebenzisane nogqirha wemiphunga ukulawula iingxaki zakho zokuphefumla.
• Unyango lomzimba: Ingcali yonyango lomzimba inokukunceda uphucule indlela umzimba wakho ohamba ngayo. Banokukunceda ukulawula iimpawu ezinxulumene nemisipha okanye bacebise umthambo wokuphefumla ukuze uqinise imiphunga yakho. Ungadinga nonyango lonyango lokuphefumula .

Kuza kwenzeka ntoni ukuba ndine-Antisynthetase Syndrome?

Ugqirha wakho unokukunceda ufumane indibaniselwano yonyango olunokulawula iimpawu zakho.

I-Antisynthetase Syndrome sisifo esingapheliyo . Oku kuthetha ukuba kuya kufuneka ulawule iimpawu ixesha elide (mhlawumbi ubomi bakho bonke).

Ngaba i-(Antisynthetase Syndrome) iyabulala?

I-Antisynthetase Syndrome ayidli ngokubulala . Ubomi obulindelekileyo babantu abaphila nesi sifo abusoloko buchaphazeleka kakhulu. Abantu abaninzi baphila nesi sifo ubomi babo bonke, kodwa banokuzilawula iimpawu zabo ngonyango.

Nangona kunjalo, ukuba unesifo esibi kakhulu semiphunga okanye enye ingxaki echaphazela inkqubo yakho yokuphefumla, inokubulala. Kodwa ayiqhelekanga kakhulu. Ugqirha wakho uza kukuxelela into omawuyilindele, kunye neempawu ezitshintshayo ezinokuba ziimpawu zokuqala zeengxaki ezinzima zokuphefumla.

Ngaba ndingayithintela i-Antisynthetase Syndrome?

Akukho ndlela yokuthintela i-Antisynthetase Syndrome, njengoko iingcali zingaqinisekanga ncam ukuba yintoni ebangela oko okanye yintoni eyonyusa umngcipheko.

Ndifanele ndimbone nini ugqirha?

Ukuba ufumanisa iimpawu ezintsha, ingakumbi ukuba ziya zisiba mandundu, bona ugqirha . Ukuba uziva ngathi iimpawu zakho azilawuleki njengoko bezinjalo kunyango lwakho, okanye ukuba iimpawu zakho zenza kube nzima ukwenza imisebenzi yakho yemihla ngemihla, thetha nogqirha wakho.

Ndingaya nini kwigumbi likaxakeka?

Ukuba unayo nayiphi na kwezi mpawu, yiya kwigumbi likaxakeka ngoko nangoko okanye utsalele umnxeba ku-911 (okanye inombolo yakho kaxakeka yasekuhlaleni) :

• Ubunzima bokuphefumla ngequbuliso.
• Ukuphefumla nzima (ukuziva ngathi awukwazi ukuphefumla).
• Umbala oluhlaza okwesibhakabhaka wesikhumba, imilebe, okanye iinzipho (i-cyanosis).
• Intlungu yesifuba okanye ubunzima.

Ndingayibuza yiphi imibuzo ugqirha wam?

• Ngaba ndine-Antisynthetase Syndrome okanye esinye isifo esizilawulayo?
• Luhlobo luni lovavanyo oluza kufuneka ndilwenze?
• Zeziphi iindlela zonyango ezilungileyo zokulawula iimpawu zam?
• Ngaba ndiza kufuna unyango lomzimba okanye ukuvuselelwa kokuphefumla?
• Ndisengozini kangakanani yeengxaki ezinkulu zemiphunga?

Ngawaphi amanye amagama e-Antisynthetase Syndrome?

Ngamanye amaxesha oogqirha babiza i-Antisynthetase Syndrome ngamanye amagama. Umzekelo:

• (Isifo sokungabikho kwe-Antisynthetase)
• (i-AS syndrome)
• (Isifo se-Anti-Jo1)

La magama ahlukeneyo axhomekeke kwimeko efanayo.

Okokugqibela, yintoni ekufuneka uyikhumbule (Umyalezo Wokuya Ekhaya)

I-Antisynthetase Syndrome yimeko engaqhelekanga apho amajoni akho omzimba ahlasela umzimba wakho endaweni yokukukhusela. Thetha nogqirha wakho malunga nonyango olunokunceda ukunciphisa impembelelo yeempawu zakho kubomi bakho bemihla ngemihla.

Ukuphila nesifo sokuzikhusela komzimba kunokuba yinto ecaphukisayo kakhulu - kunokuvakala ngathi umzimba wakho uyakhohlisa. Ukuba ufuna uncedo lokuziqhelanisa notshintsho ebomini bakho okanye ukumelana nale meko, buza ugqirha wakho ngeendlela zokufumana ingcebiso ngempilo yengqondo. Ukuziva ulusizi kwaye udandathekile kuyinto eqhelekileyo, kodwa akufuneki udlule kuko wedwa.

"I-Antisynthetase Syndrome, isifo sokuzikhusela komzimba, i-myositis, isifo semiphunga esiphakathi kwemithambo yegazi, isiganeko sikaRaynaud, ii-autoantibodies, iintlungu zamalungu, ubuthathaka bemisipha