Xa oogqirha befumanisa ukuba wena okanye umntu osondeleyo kuwe unomhlaza, kuyinto eqhelekileyo ukuziva udidekile kwaye woyika neendlela zonyango. Namhlanje, siza kuthetha ngeyeza elikhethekileyo elibizwa ngokuba yi-Avelumab, elisetyenziselwa ukunyanga iintlobo ezahlukeneyo zomhlaza. Masithethe ngemiba nezinto ekufuneka uzazi ngale chiza ngendlela elula necacileyo.
Yintoni le iyeza ibizwa ngokuba yiAvelumab?
Ngamafutshane, i-Avelumab (igama lophawu: i-BAVENCIO) sisitofu sokugonya esikudidi olukhethekileyo lwamayeza abizwa ngokuba yi -monoclonal antibodies . Cinga ngaso njengejoni eliqeqeshiweyo elinceda inkqubo yomzimba wethu yokuzikhusela. Oko kwenziwa leli yeza kukunceda inkqubo yethu yokuzikhusela ikwazi ukubona iiseli zomhlaza, izihlasele, kwaye izitshabalalise.
Eli yeza lisetyenziswa kakhulu ukunyanga iintlobo ezintathu zomhlaza:
- I-Merkel cell carcinoma: Olu luhlobo lomhlaza wolusu olungaqhelekanga kodwa olusasazeka ngokukhawuleza.
- Umhlaza weeseli zezintso: Olu luhlobo lomhlaza oluvela kwizintso.
- Umhlaza we-Urothelial: Uhlobo lomhlaza oluvela kwisinyi okanye kwezinye iindawo zenkqubo yomchamo.
Ukongeza koku, ugqirha wakho angakunika eli yeza nakwezinye iimeko zonyango. Ukuba unemibuzo ngalo, buza ugqirha wakho.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale unyango
Oku kubaluleke kakhulu. Ngaphambi kokuba uqale unyango nge-Avelumab, kubalulekile ukuba uxelele ugqirha wakho ngembali yakho epheleleyo yempilo. Musa ukufihla nantoni na. Qiniseka ukuba uxelela ugqirha wakho ukuba unenye yezi meko zilandelayo.
- Ukuba unesifo sokuzikhusela komzimba: Ngamafutshane, esi sisifo apho amajoni omzimba ahlasela iiseli zomzimba ezisempilweni. Umzekelo, izifo ezifana nesifo sikaCrohn, i-ulcerative colitis, okanye i-lupus.
- Ukuba ukhe watyandwa okanye uceba utyando lwe-stem cell: ingakumbi utyando lwe-allogeneic stem cell.
- Ukuba unesifo sentliziyo, uxinzelelo lwegazi oluphezulu, okanye amanqanaba aphezulu e-cholesterol egazini.
- Ukuba kukho imbali yokufakelwa amalungu omzimba.
- Ukuba unezifo ezinxulumene nenkqubo yemithambo-luvo: Umzekelo, iimeko ezifana ne-`myasthenia gravis` okanye i-`Guillain-Barre syndrome`.
- Ukuba ukhe waba ne-allergy kwi-avelumab okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa: Oku kubaluleke kakhulu.
Ndingakunika njani eli yeza?
Eli asiloyeza onokulithatha ekhaya. I-Avelumab yinaliti efakwa kancinci emzimbeni wakho ngemithambo (ukufakwa kwimithambo) . Kufana nokukunika ityuwa. Olu nyango lunikezelwa esibhedlele okanye eklinikhi, phantsi kweliso elibukhali likagqirha okanye abasebenzi abaqeqeshiweyo bobuhlengikazi .
Ngaphambi kweseshoni nganye yonyango, uya kunikwa incwadana yolwazi ekhethekileyo (iMedGuide) malunga nale yeza. Kubalulekile ukuyifunda nokuyiqonda ngononophelo ngalo lonke ixesha.
Kuthekani ukuba uthatha amayeza amaninzi kakhulu? (Umthamo ogqithisileyo)
Oku kunikwa esibhedlele ngoko ke amathuba okuba oku kwenzeke mancinci kakhulu. Nangona kunjalo, ukuba ucinga ukuba usele amayeza amaninzi kakhulu, yazisa abasebenzi bezonyango ngoko nangoko. Ngaphandle koko, fowunela iZiko loLwazi lweePoison kwiSibhedlele sikaZwelonke saseColombo , okanye uye kwiYunithi yoNyango oluNgxamisekileyo (ETU) yesibhedlele esikufutshane.
Izinto ekufuneka ziqwalaselwe ngexesha lonyango
Ugqirha wakho uza kukubeka esweni ngokusondeleyo kulo lonke unyango lwakho, kwaye kuya kufuneka ukuba wenze uvavanyo lwegazi rhoqo ukuze ujonge iziphumo zonyango kunye nazo naziphi na iziphumo ebezingalindelekanga.
Lumka ngakumbi ngexesha lokukhulelwa nokuncancisa!
Le yingxaki ebaluleke kakhulu.
- Kuphephe ukukhulelwa ngokupheleleyo ngelixa usebenzisa eli yeza kwaye ubuncinane inyanga enye emva kokuba uyekile unyango. Abafazi kufuneka balumke kakhulu ngale nto, kuba eli yeza linokubangela ingozi enkulu kusana olungekazalwa.
- Kwakhona, kuphephe ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye ubuncinane inyanga enye emva komthamo wokugqibela.
Ukuba unemibuzo malunga noku, ungathandabuzi ukuthetha nogqirha wakho.
Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?
Njengalo naliphi na iyeza, i-Avelumab inokubangela iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye iziphumo ebezingalindelekanga zinokuba yingozi, ngoko ke kubalulekile ukuba uzazi. Masiziqonde ngokucacileyo ezi zinto kwitheyibhile engasezantsi.
| Uhlobo lwesiphumo esibi | Iimpawu |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho okanye kubasebenzi bakho bomongikazi ngoko nangoko | |
| Iingxaki ze-allergy kunye nenkqubo yomzimba yokuzikhusela | Ubunzima bokuphefumla, ukuqina kwesifuba, iintlungu zomzimba, umkhuhlane, ukuziva ubanda, ukuba bomvu kwesikhumba, amadyungudyungu (kunokwenzeka nangaphakathi emlonyeni), iintlungu zamalungu, ukudinwa kakhulu. |
| Iingxaki zenkqubo yokugaya ukutya | Intlungu yesisu, urhudo olunzima (olunegazi okanye olunamanzi), ukuqhinwa, isitulo esimnyama okanye esihlala ixesha elide, isicaphucaphu, ukuhlanza. |
| Iimpawu zomonakalo wezintso | Ukuncipha okanye ukutshintsha komthamo womchamo, ubunzima bokuchama, ukudumba emilenzeni okanye emaqatheni. |
| Iimpawu zomonakalo wesibindi | Umchamo otyheli okanye omdaka omnyama, ukutyheli kwamehlo okanye ulusu, iintlungu kwicala eliphezulu lasekunene lesisu, ukungabi namdla wokutya, kunye nokuziva udiniwe. |
| Ezinye iimpawu ezinzulu | Intlungu yomqolo, utshintsho lombono, ukubetha kwentliziyo ngokukhawuleza okanye ngokungangqalanga, ukuquleka, ukubila kakhulu, ukuncipha komzimba, ukulahleka kweenwele, indlala okanye ukoma kakhulu. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Ukulimala okuncinci | Intloko ebuhlungu, iintlungu zamathambo, iintlungu zemisipha, ukungabi namdla wokutya. |
Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ufumana nantoni na eyahlukileyo, nceda uxelele ugqirha wakho.
Umyalezo Wokuya Ekhaya
- I-Avelumab sisitofu esikhethekileyo esivuselela amajoni ethu omzimba kwaye sinikwa iintlobo ezahlukeneyo zomhlaza.
- Ngaphambi kokuba uqale unyango, xelela ugqirha wakho ngazo zonke iimeko zakho zempilo, amayeza owasebenzisayo, kunye nee-allergies ngaphandle kokufihla nantoni na.
- Kubaluleke kakhulu ukuphepha ukukhulelwa nokuncancisa ngelixa usebenzisa eli yeza kwaye ubuncinane inyanga emva kokuba uliyekile.
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngobunzima bokuphefumla, ukudumba kolusu, urhudo oluqatha, okanye ukutyheli kwamehlo.
- Ungaphoswa ziintlanganiso zikagqirha wakho. Ukuba awukwazi ukuza, mxelele kwangaphambili uze wenze elinye idinga.
- Lilungelo lakho ukuthetha ngokukhululekileyo nogqirha wakho ngayo nayiphi na imibuzo okanye iinkxalabo onokuba nazo.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Zisetyenziselwa ntoni iipilisi zeFelodipine/Plendil?
Le yipilisi yoxinzelelo lwegazi esebenza kakhulu kwaye inamandla (iCalcium Channel Blocker - CCB) ehlabathini, eyenzelwe ukulawula 'uxinzelelo lwegazi oluphezulu kakhulu'! Le pilisi yenzelwe ukuba ifunxwe kancinci (i-Extended-release), ukuze igcine uxinzelelo luphantsi imini yonke (iiyure ezingama-24).
💬 Ukusela le pilisi yoxinzelelo lwegazi (iFelodipine) kukunciphisa njani uxinzelelo lwegazi ngokukhawuleza?
Ukuze umthambo wegazi unciphe/unciphe kwaye uxinzelelo lunyuke, amasuntswana 'eCalcium' kufuneka ngokuqinisekileyo angene emthambo wegazi! Kwangoko nje le pilisi ingena egazini, onke amasango ecalcium (iitshaneli zecalcium zohlobo lwe-L) kuloo mithambo yegazi ayavalwa/avalwa nge-100% kwaye ayatshixwa. Ekubeni icalcium ingangeni, umthambo wegazi awunciphe kwaye uyakhululeka kakhulu (iVasodilation). Emva koko, igazi lihamba ngokulula njengomlambo kwaye uxinzelelo luyehla.
💬 Zithini iziphumo ezingathandekiyo zokusebenzisa eli yeza (iFelodipine)? Kutheni kusithiwa ungatyi igrapefruit?
Eyona ngxaki inkulu kukuba akufuneki usele 'ijusi yeGrapefruit/Grapefruit (uhlobo lweorenji emnandi)' ngelixa usela le pilisi! Ukuba uyisela, ukufunxwa kweyeza emzimbeni kuya kwanda ngokungaqhelekanga nge-100% kwaye uxinzelelo lunokwehla ekugqibeleni kwaye unokuwa (CYP3A4 Inhibition)! Ezinye iziphumo ebezingalindelekanga ezicaphukisayo kukuba oku ngokuqinisekileyo kuya kubangela 'Ukudumba kwamaqatha/imilenze (Peripheral Edema)' kunye nokubetha kwentliziyo ngokukhawuleza/ukubomvu kwesifuba (Ukuhluza).
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