Nokuba sisiva igama elithi umhlaza, sonke siziva sisoyika kakhulu. Kodwa namhlanje, isayensi yezonyango iqhubele phambili kakhulu. Kufunyenwe unyango olumangalisayo lokulwa neeseli zomhlaza. Namhlanje siza kuthetha ngolunye unyango olukhethekileyo. Ngamafutshane, ezi zisebenza ngokunciphisa izondlo, oko kukuthi, ukuhanjiswa kwegazi, kweeseli zomhlaza kunye nokucothisa ukukhula kwazo.
Zithini kanye kanye ezi Angiogenesis Inhibitors?
Ukuze siqonde oku, masithathe umzekelo omncinci. Khawucinge nje, ukuze nawuphi na umthi ukhule ube mkhulu, kufuneka ufumane amanzi kunye nezondlo rhoqo. Ngokufanayo, ukuze ithumba likhule libe likhulu lize lisasazeke kwamanye amalungu omzimba, kufuneka kubekho igazi elineleyo.
Ithumba lomhlaza lincinci kakhulu ekuqaleni. Ngelo xesha, lifunxa izondlo elizifunayo kwizicubu eziphilileyo ezijikelezileyo. Kodwa xa ithumba likhula libe malunga ne-1-2 milimitha, kufuneka livelise inkqubo entsha yemithambo yegazi. Kanye njengesityalo sikhula amasebe amatsha. Kukule mithambo yegazi mitsha apho ithumba lomhlaza 'liyondla' khona, likhule libe likhulu nangakumbi, lize liqale ukusasazeka.
La mayeza akhethekileyo, abizwa ngokuba yi -Angiogenesis Inhibitors , asebenza ngokuthintela iiseli zomhlaza ekwenzeni imithambo yegazi emitsha. Oku kucothisa ukukhula kweeseli zomhlaza, kwaye ngamanye amaxesha iiseli zinokuncipha. Nangona olu nyango lungenakuwunyanga ngokupheleleyo umhlaza, lunokulawula ukukhula komhlaza kwaye lukuvumele ukuba ube nabantu obathandayo ixesha elide.
Lisebenza njani eli yeza?
La mayeza athintela inkqubo ebizwa ngokuba yi -Angiogenesis eyenzeka emizimbeni yethu. Ngokwesiqhelo, le yinkqubo ebaluleke kakhulu emzimbeni wethu. Khawuthelekelele ukuba unenxeba esandleni sakho. Emva koko ezo seli zonzakeleyo zikhupha isignali ekhethekileyo (isignali ye-SOS) zisithi, 'Sincede!'. Ngenxa yesi signali, ii-capillaries ezintsha zegazi zivela kwimithambo yegazi ejikeleze inxeba, zinika inxeba igazi elifunekayo kwaye liliphilise.
Eyona nto imbi kakhulu apha kukuba iiseli zomhlaza nazo zisebenzisa le nkqubo ilungileyo emizimbeni yethu ukuze zizuze. Zikwathumela imiqondiso efanayo kwaye zenze imithambo yegazi emitsha ukuze zondle.
Oko kwenziwa yi-Angiogenesis Inhibitors kukuphazamisa loo nkqubo yokubonisa.
- Isignali ephambili kule nkqubo yokubonisa yiproteni ebizwa ngokuba yiVEGF (Vascular Endothelial Growth Factor) .
- Xa le protein, i-VEGF, ibopha kwii-receptors ezikumphezulu weeseli, ithumela umyalezo wokuba kwenziwe imithambo yegazi emitsha.
- La mayeza ayayimisa le nkqubo ngeendlela ezahlukeneyo.
| Ingaba isebenza kanjani | Imizekelo yeentlobo zamachiza |
|---|---|
| Ibopha kwiproteni yeVEGF kwaye iyithintele ekubophaneni kwii-receptors. | Amayeza e-antibody e-Monoclonal afana ne-Bevacizumab (Avastin®). |
| Ithintela ngokuthe ngqo ukuhanjiswa kwemiyalezo evela kwii-receptors ze-VEGF. | IiTyrosine Kinase Inhibitors ezifana neSorafenib (Nexavar®) kunye neSunitinib (Sutent®). |
| Ithintela ezinye iinkqubo zokubonisa ezibandakanyeka ekwakhiweni kwemithambo yegazi kwiithumba zomhlaza. | Ii-immunomodulators ezifana neThalidomide kunye neLenalidomide (Revlimid®). |
Zeziphi iimeko ezisetyenziswa leli yeza?
Oogqirha badla ngokucebisa olu nyango kubantu abanomhlaza abasele bekhulile okanye abaye baphinda bavela emva konyango. Umzekelo:
- Umhlaza wobuchopho
- Umhlaza webele
- Umhlaza womlomo wesibeleko
- Umhlaza wamathumbu amakhulu
- Umhlaza wezintso
- Umhlaza wesibindi
- Umhlaza wemiphunga
- I-Lymphoma kunye ne-Multiple Myeloma
- Umhlaza wePancreatic
- Umhlaza wesisu
- Umhlaza we-thyroid
- Umhlaza wesibeleko
Ukongeza, olu hlobo lweyeza, olubizwa ngokuba yi-VEGF inhibitors, lukwasetyenziselwa ukunyanga izifo ezithile zamehlo ezibangelwa kukukhula okungaqhelekanga kwemithambo yegazi emehlweni.
Kwenzeka ntoni ngexesha lonyango?
La mayeza awanikwa rhoqo ewodwa. Adla ngokunikezelwa kunye nezinye iindlela zonyango lomhlaza, ezifana ne-chemotherapy okanye i-immunotherapy. Ngamafutshane, i-angiogenesis inhibitors iyawubulala umhlaza ngokuwuncisha ukutya, ngelixa ezinye iindlela zonyango zibulala ngokuthe ngqo iiseli zomhlaza.
Ngokuxhomekeke kuhlobo lonyango olunikwayo, ungalunikwa njengepilisi kanye okanye kabini ngemini, okanye lunokunikwa ngemithambo yegazi (IV) kunye ne-saline kanye emva kweentsuku ezimbalwa.
Ubude bonyango buxhomekeke kuhlobo lwamayeza owanikwayo kunye nemeko yakho yempilo. Abanye abantu bayaqhubeka nokuwasela logama nje esebenza. Abanye kufuneka bayeke xa bengakwazi ukunyamezela iziphumo ebezingalindelekanga. Konke oku kugqitywa ngokuthetha nogqirha wakho kunye nokuvavanya izinto ezilungileyo nezingalunganga zonyango.
Zithini iingozi kunye nemiphumo emibi?
Kubaluleke kakhulu ukuba uzazi iingozi kunye nemiphumo emibi yokusebenzisa eli yeza kwangethuba, ukuze ukwazi ukubona naluphi na utshintsho emzimbeni wakho ngokukhawuleza.
Eminye yemiphumo emibi yala mayeza inokuba yingozi, ngoko ke kubalulekile ukukwazi oku.
| Isiphumo/umngcipheko | Yintoni ekufuneka uyazi |
|---|---|
| Igazi elonyukayo | Kubalulekile ukujonga uxinzelelo lwegazi rhoqo ngexesha lonyango. |
| Ukopha ngaphakathi | Lumka ngeempawu ezinje ngokugruzuka naphi na emzimbeni kunye negazi elisesitulweni. |
| Ukuphola kwenxeba okulibazisekileyo | Ugqirha ulumke kakhulu xa enika la mayeza ngaphambi okanye emva kotyando. |
| Ukugqobhoza kwamathumbu | Nangona oku kungaqhelekanga, ukuba ufumana iintlungu zesisu eziqatha ngequbuliso, yazisa ugqirha wakho ngoko nangoko. |
| Amahlwili egazi | Le yimeko eyingozi kakhulu kwaye inokukhokelela kwiimeko ezifana nokuhlaselwa yintliziyo okanye isifo sohlangothi. |
| Ezinye iziphumo ebezingalindelekanga | Ukungasebenzi kakuhle kwe-thyroid kunye nomonakalo wesibindi nakho kunokwenzeka. |
Ezi zisenokuvakala zisoyikisa, kodwa ugqirha wakho uya kuhlala ejonga impilo yakho kunye novavanyo lwegazi, ukuze ezi ngozi zichongwe kwaye zilawulwe ngokubanzi.
Ndingazinyamekela njani? Ndingamfowunela nini ugqirha?
Eyona nto ibalulekileyo onokuyenza kukwazi kakuhle ngemiphumo emibi enokubakho ngaphambi kokuba uqale eli yeza. Emva koko, ukuba ubona naluphi na utshintsho emzimbeni wakho, ungalubona ngokukhawuleza uze uxelele ugqirha wakho. Ugqirha wakho angakunika amanye amayeza okulawula loo miphumo emibi, okanye atshintshe umthamo wamayeza owasebenzisayo.
Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana naziphi na iimpawu ezingaqhelekanga nezingalindelekanga. Ingakumbi ukuba ufumana iimpawu zestroke okanye ukuhlaselwa yintliziyo (umz., iintlungu eziqatha esifubeni, ubunzima bokuphefumla, ukungaziva mnandi ebusweni okanye emacaleni), yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) elikufutshane nawe ngokukhawuleza.
Ngaba kukho izinto eziyekisa le nkqubo ngokwendalo?
Ewe, ezinye ukutya ziqulathe izinto ezinokuthintela ezinye zeempawu ezibandakanyekayo kule nkqubo ye-angiogenesis. Ezi zinto zokutya zihlala zifumaneka kukutya kweMeditera. Umzekelo:
- Iti eluhlaza
- I-oyile ye-olivu
- Imidiliya ebomvu
- Iinati
- I-asparagus
Oogqirha baphanda ngamayeza amatsha besebenzisa la mayeza endalo, kodwa olo phando lusekwinqanaba lokuqala.
Kubalulekile ukukhumbula into ebalulekileyo apha. Ukutya ezi zinto zokutya akuyi kuyinyanga umhlaza okanye kuyithintele ukukhula kweethumba ezinomhlaza. Ezi azinakuthatha indawo yamayeza omhlaza anikwe ngugqirha.
Nangona kunjalo, ukutya ukutya okunesondlo kunokunceda kakhulu ekuncedeni umntu ofumana unyango lomhlaza ukuba ahlale enamandla. Ngoko ke, qiniseka ukuba utya ukutya okunesondlo.
Umyalezo Wokuya Ekhaya
- I-Angiogenesis inhibitors luhlobo lweyeza elithintela ukwakheka kwemithambo yegazi ehambisa igazi kwiithumba zomhlaza, lilawula ukukhula kwazo.
- Nangona ezi zingenakunyanga umhlaza ngokupheleleyo, zinokunceda ekulawuleni ukuqhubela phambili kwesi sifo kwaye zandise ixesha lokuphila.
- Amaxesha amaninzi la mayeza anikwa kunye nezinye iindlela zonyango, ezifana ne-chemotherapy.
- Njengoko iziphumo ebezingalindelekanga ezinobungozi ezifana noxinzelelo lwegazi oluphezulu kunye nokuqhekeka kwegazi zinokwenzeka, yazisa ugqirha wakho ngoko nangoko ngazo naziphi na iimpawu ezingaqhelekanga ezenzeka ngexesha lonyango.
- Ungaze usebenzise izongezo zokutya zendalo endaweni yonyango. Hlala ulandela icebiso likagqirha wakho.
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