Xa ugqirha wakho ekuxelela ukuba unesifo seswekile, into yokuqala onokuthi uyinikwe yipilisi ebizwa ngokuba yiMetformin. Namhlanje, siza kuthetha ngokulula nangokucacileyo ngale chiza liqhelekileyo elinikwa abantu abaninzi besifo seswekile sohlobo lwesibini, kungekuphela nje eSri Lanka, kodwa nakwihlabathi liphela. Siza kujonga yonke into ukususela kwinto eyiyo, into eyenzayo emzimbeni, kunye nento ekufuneka siyilumkele.
Zithini ii-biguanides? Ngaba ziyafana ne-metformin?
Ngamafutshane, iiBiguanides ligama elinikwa iqela lamayeza asetyenziselwa ukunyanga isifo seswekile. Njengokuba kukho iintlobo zezithuthi. Njengokuba kukho iintlobo zeemoto, iiveni, kunye neebhasi, kukho amaqela ahlukeneyo amayeza esifo seswekile. IiBiguanides zezinye zezo qela.
Okwangoku, iyeza elisetyenziswa kolu didi kumazwe amaninzi ehlabathi yiMetformin . Oku kuthetha ukuba ukuba uthatha iMetformin, uthatha iyeza elikwiklasi yeBiguanide. Eli liyeza elithathwa ngomlomo ngendlela yepilisi. Eli yeza linokuba phantsi kwamagama eempawu ezahlukeneyo ezifana neGlucophage®, Fortamet®, kodwa zonke ziqulathe iMetformin.
Ziziphi iimeko ezisetyenziselwa iMetformin?
Ukusetyenziswa okuphambili nokuvunyiweyo ngokusemthethweni kwe-metformin kukulawula isifo seswekile sohlobo lwesibini . Enyanisweni, i-metformin idla ngokuba lolona nyango lokuqala oogqirha abaqala ngalo isifo seswekile sohlobo lwesibini.
Kodwa ukongeza, oogqirha bakwanika eli yeza kwezinye iimeko zempilo ezininzi. Oku kubizwa ngokuba kukusetyenziswa "okungekho kwileyibhile". Oko kukuthi, eli yeza linikwa ezinye iindlela eziluncedo kunezo lalivunyiwe ekuqaleni.
| Ezinye iindlela zokusetyenziswa kweMetformin | Ingcaciso elula |
|---|---|
| Isifo Seswekile Sokukhulelwa | Lawula isifo seswekile esibakho kwabanye oomama ngexesha lokukhulelwa. |
| I-prediabetes | Lawula amanqanaba eswekile egazini kubantu abasengozini yokufumana isifo seswekile kwaye ulibazise okanye uthintele ukuphuhliswa kwesifo seswekile. |
| I-Polycystic ovary syndrome (i-PCOS) | Inceda ekulawuleni ukungalingani kwamahomoni kunye nemijikelo yokuya esikhathini kwabasetyhini abane-PCOS. |
| Amanye amayeza engqondo abangela ukutyeba | Lawula ukunyuka kobunzima okubangelwa ngamayeza kwezinye izifo zengqondo. |
Ukongeza, ezinye izifundo zifumanise ukuba abantu abasebenzisa i-metformin banokuba nomngcipheko omncinci wokuba nomhlaza, kodwa oku kusesekwinqanaba lophando.
Isebenza njani le mithi yeMetformin emzimbeni?
I-Metformin inceda ekulawuleni amanqanaba eswekile emzimbeni wethu ngeendlela ezimbini eziphambili.
1. Inciphisa ubuninzi beswekile eyongezwa egazini sisibindi: Ngokwesiqhelo, isibindi sethu sikhupha iswekile (iglucose) egazini ukuze sifumane amandla. I-Metformin ilawula le nkqubo kwaye inciphisa ukuqokelelwa kweswekile egazini ngokungeyomfuneko.
2. Yonyusa Uvakalelo lwe-Insulin kwiMisipha: Omnye wemisebenzi ephambili yehomoni i-insulin emzimbeni wethu kukunceda iiseli zithathe iswekile egazini zize ziyisebenzisele amandla. Kwisifo seswekile, le nkqubo ayisebenzi kakuhle. I-Metformin yenza imisipha yethu iphendule ngcono kwi-insulin. Emva koko, imisipha inokufunxa lula kwaye isebenzise iswekile egazini.
Zombini ezi ndlela zinceda ekulawuleni amanqanaba aphezulu eswekile egazini. Kwi-PCOS, eli yeza lehlisa amanqanaba e-insulin, nto leyo enceda ekulinganiseni iihomoni kunye nokulawula umjikelo wokuya esikhathini.
Ziziphi iingenelo eziphambili zeMetformin?
- Ulawulo olungcono lweswekile: Izifundo zibonise ukuba i-metformin inokunciphisa ixabiso lakho lovavanyo lwe-HbA1c, elibonisa amanqanaba akho aqhelekileyo eswekile egazini kwiinyanga ezintathu ezidlulileyo, malunga ne-1% .
- Ukuthintela isifo seswekile: Kufunyaniswe ukuba ukuthatha iMetformin kunye nokutshintsha indlela yokuphila kunokunciphisa umngcipheko wokuba nesifo seswekile malunga ne-31% kubantu abanesifo seswekile esingaphambi kokuba sivele.
- Ukunciphisa umngcipheko wesifo sentliziyo: Ezinye izifundo zibonisa ukuba i-metformin inokunciphisa umngcipheko wesifo sentliziyo kunye neengxaki ezinxulumene nayo (isifo sentliziyo).
Ngaba kukho naziphi na iziphumo ebezingalindelekanga kweli yeza?
Ewe, njengayo yonke imithi, iMetformin inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, kubantu abaninzi, oku kwenzeka kuphela xa beqala ukuthatha amayeza baze baphele xa umzimba uqhelana nawo.
| Imiphumela | Funda ngale nto |
|---|---|
| Iziphumo ebezingalindelekanga eziqhelekileyo abantu abaninzi abanokuzifumana | |
| Ukungagayi kakuhle ukutya, urhudo | Le yeyona miphumo ixhaphakileyo. Idla ngokuphela emva kweentsuku ezimbalwa. Unganciphisa oku ngokuthatha amayeza kunye nokutya. |
| Isicaphucaphu nokuhlanza | Oku kuqhelekile nakwizigaba zokuqala. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga | |
| Ukungakhululeki esifubeni, intloko ebuhlungu, ukubila kakhulu (diaphoresis), kunye nokuziva udiniwe. | Ezi aziqhelekanga, kodwa ukuba uqhubeka unale mpawu, xelela ugqirha wakho. |
| Iswekile ephantsi egazini (iHypoglycemia) | Oku akunakwenzeka ukuba kwenzeke ukuba uthatha i-metformin yodwa, kodwa kunokwenzeka xa uyithatha kunye namanye amayeza eswekile. |
Zeziphi iingozi ezithile ekufuneka uzazi nge-metformin?
I-Metformin ngokubanzi liyeza elikhuselekileyo kakhulu. Nangona kunjalo, kukho iingozi ezithile ekufuneka sonke siziqaphele.
Ukunqongophala kweVithamini B12
I-Metformin ixesha elideXa isetyenziswa, ukufunxwa kwevithamini B12 emzimbeni kunokuncipha kancinci. Ke ngoko, ugqirha wakho unokujonga amanqanaba evithamini B12 yakho, aze, ukuba kuyimfuneko, akunike isongezelelo sevithamini B12.
I-Lactic Acidosis
Le yeyona nto ibalulekileyo ekufuneka wonke umntu ayiqaphele xa ethetha ngeMetformin. Kodwa okokuqala, kufuneka kuthiwe le yimeko engaqhelekanga kakhulu , kodwa imbi kakhulu enokuba yingozi nakubomi ukuba iyenzeka. Malunga nomntu omnye kwabangama-30,000 abasebenzisa iMetformin unale ngozi.
- Yintoni iLactic Acidosis? Ngamafutshane, kukuqokelelana okungeyomfuneko kwekhemikhali ebizwa ngokuba yi-lactic acid emzimbeni.
- Ngubani osengozini enkulu yoku?
- Kwabo banesifo sezintso okanye sesibindi.
- Kwabo baneminyaka engaphezu kwama-65 ubudala.
- Kwabo basandula utyando.
- Kwabo basela utywala kakhulu.
- Iimpawu zeLactic Acidosis:
- Ukudinwa okugqithisileyo kunye nobuthathaka ngequbuliso.
- Isicaphucaphu, ukuhlanza, kunye nentlungu yesisu.
- Ukuphefumla ngokukhawuleza okanye ukuphefumla nzulu, ixesha elide.
Isilumkiso: Ukuba usebenzisa iMetformin kwaye ufumana enye okanye ngaphezulu kwezi mpawu, yiya kwicandelo lezonyango ezingxamisekileyo esibhedlele (ETU) elikufutshane ngoko nangoko. Oku akuyonto yokulibazisa.
Ukusebenzisana neziyobisi
Ukuba usebenzisa iMetformin, kubaluleke kakhulu ukuxelela ugqirha wakho malunga nazo zonke ezinye iindlela ozisebenzisayo (kuquka amayeza ezinye izifo, iivithamini, kwanezongezo zesondlo). Amanye amayeza anokunyusa umngcipheko we-lactic acidosis okanye iswekile ephantsi egazini (hypoglycemia) xa esetyenziswa neMetformin.
Ndifanele ndithethe nini nogqirha?
Ukuba usebenzisa iMetformin, kubalulekile ukubona ugqirha wakho rhoqo ukuqinisekisa ukuba iyeza liyasebenza kwaye iswekile yakho egazini iphantsi kolawulo. Ukongeza, thetha nogqirha wakho ngezi zinto.
- Ukuba iziphumo ebezingalindelekanga zininzi kakhulu ukuba ungakwazi ukuzisingatha.
- Ukuba uvakalelwa kukuba izifo zakho ezifana nesifo seswekile okanye i-PCOS azilawulwa ngokufanelekileyo nangona usela amayeza.
- Ukuba uziva ngathi kufuneka uyeke ukusebenzisa eli yeza ( ungaze uyeke ukusebenzisa eli yeza ungabuzanga kugqirha wakho ).
Umyalezo Wokuya Ekhaya
- I-Metformin liyeza eliqhelekileyo, elikhuselekileyo, nelisebenzayo kwisifo seswekile sohlobo lwesibini.
- Oku kusebenza kakhulu ngokunciphisa ukuveliswa kweswekile sisibindi kunye nokwandisa uvakalelo lwe-insulin kwimisipha.
- Iziphumo ebezingalindelekanga eziqhelekileyo, ezinje ngokudumba, zinokwenzeka ekuqaleni zize ziphele njengoko umzimba uqhele.
- I-Lactic Acidosis yimeko engaqhelekanga kodwa enzulu. Qaphela iimpawu zayo kwaye uye kwi-ETU ngokukhawuleza ukuba ufumana nayiphi na kwezi mpawu.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iziyobisi ozisebenzisayo.
- Ungaze uyeke ukuthatha iMetformin ngaphandle kwengcebiso kagqirha. Ukuba unemibuzo, ungathandabuzi ukubuza ugqirha wakho.
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