Yintoni i-calcitonin? Masifunde ngayo ngokulula!

Ngaba wakha waliva igama elithi calcitonin? Mhlawumbi waliva kugqirha, okanye mhlawumbi walifunda ndaweni ithile. Le yi-hormone ekhethekileyo emizimbeni yethu. Kodwa kunokuthiwa yi-hormone engaqondakaliyo kancinci. Makhe sibone ukuba yintoni le calcitonin kwaye yintoni eyenzayo emizimbeni yethu ngendlela elula.

Yintoni i-calcitonin? Ivela phi?

Ngamafutshane, i-calcitonin yi-hormone eveliswa yi-thyroid gland yethu. Uyazi ukuba i-thyroid gland yi-gland encinci efana nebhabhathane ebekwe ngaphambili entanyeni yethu, phantsi nje kolusu. Uhlobo olukhethekileyo lweseli kwi-thyroid gland, olubizwa ngokuba zii-C-cells okanye ii-parafollicular cells, lwenza le hormone ye-calcitonin kwaye luyikhuphele egazini lethu.

Kodwa into engaqhelekanga kukuba, izazinzulu azikayiqondi ngokupheleleyo indlela esebenza ngayo le hormone, i-calcitonin. Oko kukuthi, siyazi ukuba yenza ntoni, kodwa asazi ukuba kutheni sinayo. Nokuba kukho ukungaqheleki kwamanqanaba e-calcitonin, akwenzeki ukuba kubekho naziphi na iimpawu ezinkulu, okanye ngamanye amaxesha azibangeli kwaphela.

Ngaphambili, oogqirha babesebenzisa iintlobo ze-calcitonin ezenziwe ngokwenziwa njengonyango lweemeko ezithile. Umzekelo, ukunyanga iimeko ezifana nesifo sikaPaget sethambo, okanye i-hypercalcemia, imeko apho i-calcium egazini iphezulu kakhulu. Kodwa ngoku, ngokufika kwamayeza amatsha, ngakumbi ii-bisphosphonates, i-calcitonin ayisetyenziswa rhoqo njengonyango.

Yintoni eyenziwa yi-calcitonin emizimbeni yethu?

Umsebenzi ophambili wehomoni i-calcitonin kukunciphisa amanqanaba e-calcium egazini lethu. Khumbula, oku malunga ne-calcium egazini, hayi i-calcium emathanjeni. Ikwenza oku ngeendlela ezimbini eziphambili:

1. Iyayimisa imisebenzi yeeseli ezivuselela amathambo: Kukho uhlobo lweseli olubizwa ngokuba yi-osteoclasts emathanjeni ethu. Ezi seli ziqhekeza amathambo ethu zize zongeze i-calcium egazini. I-hormone i-calcitonin iyayimisa okwethutyana imisebenzi yezi osteoclasts. Oku kunciphisa ubungakanani be-calcium eyongezwa egazini.

2. Inciphisa ukufunxwa kwakhona kwekhalsiyam kwizintso iye egazini: Ikhalsiyam ikhutshwa ngomchamo ohluzwe zizintso zethu. Nangona kunjalo, ikhalsiyam ethile ifunxwa kwakhona zizintso iye egazini. Ihomoni i-calcitonin inciphisa ukufunxwa kwakhona kwekhalsiyam kwizintso iye egazini ngale ndlela. Ngenxa yoku, amanqanaba ekhalsiyam egazini ayancipha.

Cinga ngale ndlela: inqanaba le-calcium egazini lethu lifana nenqanaba lamanzi etankini yamanzi. I-Calcitonin ifana nomntu onceda ekwehliseni elo nqanaba lamanzi xa linyuka.

Kutheni i-thyroid yethu ivelisa i-calcitonin?

I-thyroid gland yethu ivelisa i-calcitonin ngokusekelwe kwinqanaba le-calcium egazini lethu. Xa inqanaba le-calcium egazini lisanda, i-thyroid gland ivelisa i-calcitonin engakumbi. Ngokufanayo, xa inqanaba le-calcium egazini lincipha, ubungakanani be-calcitonin eveliswa yi-thyroid gland nabo buyancipha. Oku kufana nolawulo oluzenzekelayo.

Ungayijonga njani inqanaba le-calcitonin? Kutheni le nto kwenziwa olu vavanyo?

Ugqirha wakho angenza uvavanyo lwegazi ukujonga amanqanaba e-calcitonin yakho.

Nangona kunjalo, ngenxa yokuba amanqanaba angaqhelekanga e-calcitonin adla ngokungabangeli iimpawu ezinkulu, oogqirha badla ngokuyalela olu vavanyo ngenxa yezizathu ezimbalwa ezithile. Ezi ziquka:

• Ukunceda ekuxilongeni izifo ezifana neMedullary Thyroid Cancer (MTC) okanye i-C-cell hyperplasia .
• Jonga impumelelo yonyango lomhlaza we-thyroid obizwa ngokuba yi-medullary thyroid cancer (MTC).
• Ukuba kukho umntu kusapho lwakho onesifo esibizwa ngokuba yiMultiple Endocrine Neoplasia (MEN type 2) .

Ithini inqanaba eliqhelekileyo le-calcitonin?

Ngokubanzi, amaxabiso aqhelekileyo e-calcitonin ngala alandelayo:

• Kumadoda: Ngaphantsi kwee-picogram ezingama-25 kwi-milliliter nganye (Ngaphantsi kwe-25 pg/mL)
• Kwabasetyhini: Ngaphantsi kwee-picogram ezingama-20 kwi-milliliter nganye (Ngaphantsi kwe-20 pg/mL)

Kodwa into enye ekufuneka uyikhumbule kukuba la maxabiso aqhelekileyo anokwahluka kancinci kwilabhoratri nganye. Ke ngoko, kufuneka uhlale ujonga amaxabiso aqhelekileyo kwilabhoratri kwingxelo yakho yegazi.

Ukuba une-calcitonin, ugqirha wakho uza kukuchazela iziphumo aze akuxelele ukuba ngaba kufuneka olunye uvavanyo.

Kuthekani ukuba amanqanaba e-calcitonin ayanda?

Ukuba namanqanaba aphezulu e-calcitonin akubonakali ngathi kunemiphumo emibi kakhulu emizimbeni yethu. Kwaye akubanga naziphi na iimpawu ezinkulu. Nangona kunjalo, amanqanaba aphezulu e-calcitonin angaba luphawu lweemeko ezimbini ezingaqhelekanga. Zithini ezo?

1. Umhlaza we-Medullary Thyroid (MTC): Olu luhlobo lomhlaza olungaqhelekanga oluvela kwi-thyroid gland. Luqala kwii-C-cells ezivelisa i-calcitonin. Lo mhlaza ubangela ukuba ezi seli zivelise i-calcitonin eninzi kakhulu.

2. I-hyperplasia yeeseli ze-C:Lo asingomhlaza (ongengomhlaza). Kodwa okwenzekayo koku kukuba ii-C-cells zikhula ngendlela engaqhelekanga. Le tissue ikhuliswe kakhulu inokuvelisa i-calcitonin eninzi. Ngamanye amaxesha le meko, ebizwa ngokuba yi-C-cell hyperplasia, inokujika kamva ibe ngumhlaza we-thyroid medullary (MTC).

Ukuba uneempawu zezinye zezi meko, ugqirha wakho unokucebisa uvavanyo lwe-calcitonin.

Kuthekani ukuba amanqanaba e-calcitonin ehla?

Amanqanaba aphantsi e-calcitonin abonakala engenampembelelo ingako emizimbeni yethu. Kwanabantu abasuswe i-thyroid yabo ngokupheleleyo, kwaye ngenxa yoko banamanqanaba angabonakaliyo e-calcitonin, abafumani zimpawu ezinxulumene namanqanaba e-calcium egazini labo. Le yinto engaqhelekanga ngale hormone.

Yintoni umahluko phakathi kweHormone yeParathyroid kunye neCalcitonin?

I-Parathyroid Hormone (PTH) kunye neCalcitonin zombini zinceda ekulawuleni inqanaba le-calcium egazini lethu. Nangona kunjalo, umahluko ukho kwindlela ezisebenza ngayo kunye nokuba zichaphazela kangakanani amanqanaba ethu e-calcium.

• I-Parathyroid hormone (PTH) inyusa amanqanaba e-calcium egazini lethu. I-PTH ikwanceda ekulawuleni amanqanaba e-phosphorus egazini nasemathanjeni ethu. Ikwavuselela i-vitamin D.
• ICalcitonin yehlisa inqanaba lecalcium egazini lethu.

Nangona kunjalo, izazinzulu zikholelwa ukuba i-parathyroid hormone (PTH) idlala indima enkulu kune-calcitonin ekulawuleni amanqanaba e-calcium egazini lethu. Oku kungenxa yokuba amanqanaba e-PTH angaqhelekanga anokukhokelela kwiimeko ezinzulu ezifana ne-hypercalcemia (i-calcium ephezulu egazini) okanye i-hypocalcemia (i-calcium ephantsi egazini). Nangona kunjalo, amanqanaba e-calcitonin angaqhelekanga akanayo impembelelo ibalulekileyo emzimbeni.

Ngaba i-calcitonin kunye ne-calcitriol ziyafana?

Hayi, i-calcitonin kunye ne-calcitriol zizinto ezimbini ezahlukeneyo. Nangona zombini ezi homoni zichaphazela amanqanaba e-calcium, zinemisebenzi eyahlukileyo.

• ICalcitriol lelinye igama levithamini D esebenzayo. Yonyusa inqanaba lecalcium egazini. Ikwenza njani oko? Yonyusa ubungakanani becalcium enokufunxwa emathunjini ethu ekutyeni esikutyayo. Loo calcium ingena egazini. ICalcitriol ikwathintela izintso ekulahlekelweni yicalcium. I-Parathyroid hormone (PTH) ivuselela i-enzyme eguqula ivithamini D ibe yi-calcitriol.
• ICalcitonin isebenza ngokunciphisa amanqanaba e-calcium egazini.

Ngoko ke, ekugqibeleni, izinto ekufuneka sizikhumbule (Umyalezo Wokuya Ekhaya)

I-Calcitonin yi-hormone engaqhelekanga neyimfihlakalo.

• Nokuba inqanaba liphantsi okanye liphezulu, akunakwenzeka ukuba libangele naziphi na iziphumo okanye iimpawu ezimbi ezinkulu.
• Nangona kunjalo, amanqanaba aphezulu e-calcitonin angaba luphawu lwemeko efana nomhlaza we-thyroid obizwa ngokuba yi-medullary thyroid cancer (MTC) okanye i-C-cell hyperplasia.
• Ukuba uneempawu zezi meko, okanye ukuba unemibuzo malunga nomngcipheko wakho wokuba nazo, qiniseka ukuba uthetha nogqirha wakho. Bakho ukuze bakuncede. Musa ukoyika, eyona nto ibalulekileyo kukuthetha ngokucacileyo ngayo yonke into.

Uyivile? Ndiyathemba ukuba olu lwazi luluncedo kuwe.

I- Calcitonin, iCalcitonin, iThyroid, iHormone, iCalcium, iCalcium yegazi, umhlaza weThyroid ophakathi