Izifo kunye neemekoJulayi 16, 2026🔄 Updated: Jul 16, 2026⏱ 4 min

Ngaba uyayazi iRenal Medullary Carcinoma (RMC), umhlaza ongaqhelekanga kodwa onzima okhula kwizintso?

Creator: Dr. Priya Sammani
Published: 2026-07-15T22:50:48.000Z

Dr. Priya Sammani, MBBS, PG Dip. FMMedical Verification

Ngaba wakha weva ngohlobo lomhlaza olungaqhelekanga nolunzima oluvela kwizintso, ingakumbi kubantu abancinci? Mhlawumbi akunjalo. Le yiRenal Medullary Carcinoma, okanye iRMC ngamafutshane. Nangona ingaqhelekanga kakhulu, kunokuba yinto ebalulekileyo ukuyiqonda, ingakumbi kwabanye abantu. Nangona le yingongoma enzulu, musani ukoyika. Masithethe ngayo ngendlela elula neqondakalayo namhlanje.

Yintoni kanye kanye iRMC?

Ngamafutshane, iRenal Medullary Carcinoma (RMC) luhlobo lomhlaza wezintso. Kodwa ayiqhelekanga, inobundlongondlongo kakhulu, kwaye isasazeka ngokukhawuleza. Ixhaphake kakhulu kubantu abancinci, ingakumbi abo baneengxaki zegazi ezibizwa ngokuba yi-'sickle cell disease' okanye 'sickle cell trait'.

Xa sithetha ngomhlaza wezintso, uhlobo oluqhelekileyo yi-'renal cell carcinoma'. I-RMC ikwaluhlobo lwe-'renal cell carcinoma'. Kodwa akukho namnye kwizigulane ezili-100 ezinomhlaza wezintso ofumana le meko ye-RMC. Ayiqhelekanga kangako.

Yintoni ebangela lo mhlaza?

Izazinzulu kunye noogqirha abakafumani unobangela opheleleyo woku, kodwa kukho into enye ephambili esele ichongiwe.

Izintso zethu zinenxalenye ebizwa ngokuba yi-'renal medulla'. Umntu onesifo se-'sickle cell' ngamanye amaxesha uneeseli ezibomvu zegazi ezitshintsha zibe yi-sickle shape. Xa oku kusenzeka, iiseli zinokunamathelana kwaye zivale imithambo yegazi kwinxalenye ye-'renal medulla' yezintso.

Oku kuthintelwa kokunikezelwa kwegazi konakalisa iiseli ezikuloo ndawo. Ngokukodwa, ijini ebizwa ngokuba yi-`INI1` (ekwabizwa ngokuba yi-`SMARCB1`) kwezo seli yonakele. Le jini ye-`INI1` isebenza njengomkhuseli othintela iiseli ekubeni zibe ngumhlaza. Xa iiseli zomhlaza ze-RMC zihlolwa, le jini ye-`INI1` ayifumaneki kuzo. Ngoko ke oogqirha bajonga ukuba ikhona na le jini ye-`INI1` ukuqinisekisa ukuba ithumba liyi-RMC okanye akunjalo.

Ngaba nam ndisemngciphekweni wokuba ne-RMC?

Kunzima ukutsho ngqo ukuba ngubani oza kuphuhlisa oku. Ukuba nomntu kusapho lwakho one-RMC akunyusi umngcipheko wokuba nakho. Oko kuthetha ukuba asiyonto iqhubekayo kwiintsapho.

Eyona nto iphambili ebangela umngcipheko sisifo segazi esibizwa ngokuba yi-'sickle hemoglobinopathy'. Oko kukuthi, ukuba nesifo se-sickle cell okanye 'uphawu lwe-sickle cell'. Kodwa kunqabile kakhulu ukuba abantu abangenazo ezi meko banokuba ne-RMC. Ibizwa ngokuba yi-"renal cell carcinoma, engachazwanga nge-medullary phenotype" (RCCU-MP).

Ukuba ujonga izibalo:

Ixhaphake kakhulu kumadoda kunabafazi.
Idla ngokuchaphazela izintso ezichanekileyo.
Esi sifo sidla ngokufunyaniswa sisebancinci, phakathi kweminyaka eli-11 nengama-39 ubudala.

Kubalulekile ukuba abantu abaselula, ingakumbi abo banesifo se-sickle cell okanye uphawu lwe-sickle cell, bazi ezi mpawu, njengoko ukubonwa kwangethuba kunokwenza unyango lube lula. Ukuba kuvela iimpawu, bonana nogqirha ngokukhawuleza.

Zithini iimpawu ze-RMC?

Kukho iimpawu ezininzi eziqhelekileyo zesi sifo. Ukuba unenye okanye ngaphezulu kwezi, kungcono ukufuna ingcebiso kagqirha ngokukhawuleza.

Uphawu	Inkcazo
Intlungu kwindawo yezintso	Intlungu engapheliyo evakala kumacala omabini esisu nakumqolo ongezantsi (ngaphezulu nje kwengquza).
Igazi kumchamo	Umchamo opinki, obomvu, okanye omdaka. Ngamanye amaxesha kunokubakho igazi elingabonakaliyo emehlweni.
Ithumba lesisu	Iqhuma okanye ubunzima obuvakala ngathi liqhuma kwicala elinye lesisu.
Ukunciphisa umzimba ngaphandle kwesizathu	Ukunciphisa umzimba ngokukhawuleza ngexesha elifutshane, ngaphandle komzamo.
Umkhuhlane oqhelekileyo kunye nokubila ebusuku	Ukuba usoloko unefiva ngaphandle kwesizathu esinye kwaye ubila kakhulu ebusuku kangangokuba amashiti akho ayamanzi.

Ugqirha uyixilonga njani le nto?

Xa usixelela ngeempawu zakho, into yokuqala ugqirha aza kuyenza kukuxilonga. Emva koko ungalandela la manyathelo.

1.I-ultrasound scan: Oku kunokunika umbono ocacileyo wokuba kukho into efana nethumba kwizintso.

2. I-CT okanye i-MRI scan: Ukuba kurhanelwa ukuba kukho ithumba, i-CT scan okanye i-MRI ingayalelwa ukuze kufunyanwe umfanekiso ocacileyo wethumba. Ngokusekelwe kwezi mifanekiso, ugqirha unokufumanisa ukuba kunokwenzeka kangakanani ukuba libe ngumhlaza.

3. I-Biopsy: Ukuba kukho umhlaza okrokrelwayo kakhulu, olu vavanyo lwenziwa ukuqinisekisa ukuba ukhona. Oku kuquka ukufaka inaliti encinci kwindawo yethumba lezintso, ukuthatha iqhekeza elincinci kakhulu lesicwili uze ulihlole phantsi kwe-microscope.

4. Uvavanyo lwemfuza: Iiseli ezithathwe kwi-biopsy zijongwa ukuba zikhona na i-gene `INI1` elwa nomhlaza esithethe ngayo ngaphambili.

Ukuba i-gene ethi `INI1` ayikho , ichongwa njenge-RMC.
Ukuba i-gene ethi `INI1` ayikho kwaye isigulane asinayo imeko ye-`sickle cell`, sichongwa njenge-`RCCU-MP`.
Ukuba i-gene ethi `INI1` ikhona , ayisiyo i-RMC, kodwa luhlobo olwahlukileyo lwethumba.

Zithini iindlela zonyango zoku?

Ngenxa yokuba i-RMC ngumhlaza osasazeka ngokukhawuleza nonobundlongondlongo, unyango kufuneka lukhawuleze kwaye lube nobundlongondlongo ngokulinganayo.

Unyango lweKhemotherapy: Olu lolona nyango lokuqala luqhelekileyo. Lubandakanya ukunika umzimba amayeza abulala iiseli zomhlaza.
Utyando: Ukususwa kwethumba elinomhlaza kunye nezintso ezichaphazelekileyo.
Unyango lweMisebe: Ukutshabalalisa iiseli zomhlaza kusetyenziswa imisebe enamandla yemitha.

Ngenxa yokuba esi sifo sinqabile, uphando lusaqhubeka. Izazinzulu zihlala zikhangela unyango olutsha nolusebenzayo lwe-RMC.

Ngaba ikho indlela yokuthintela i-RMC?

Ngelishwa, okwangoku akukho ndlela eyaziwayo yokuthintela i-RMC ukuba ivele, kwaye akukho vavanyo lokuyifumanisa ngaphambi kokuba kuvele iimpawu.

Eyona nto ingcono onokuyenza kukwazi . Ukuba uyazi ukuba unesifo se-sickle cell okanye uphawu lwe-sickle cell, jonga iimpawu ezichazwe apha ngasentla. Ukuba unenkxalabo, bonana nogqirha wakho ngoko nangoko.

Amaxesha amaninzi, xa esi sifo sifunyanwa, umhlaza sele usasazeke kwiindawo ze-lymph nodes okanye kwezinye izitho ezifana nemiphunga, isibindi, kunye namathambo. Ngoko ke, ukufunyanwa kwangethuba yeyona ndlela ilungileyo yokufumana iziphumo ezilungileyo.

Umyalezo Wokuya Ekhaya

I-Renal Medullary Carcinoma (RMC) luhlobo lomhlaza wezintso olungaqhelekanga kodwa olunzima kakhulu oluchaphazela kakhulu abantu abancinci.

Eyona nto iphambili ebangela oku kukuba nesifo segazi esibizwa ngokuba sickle cell disease okanye sickle cell trait .

Intlungu yomqolo/yesisu, igazi emchameni, iqhuma esiswini, kunye nokuncipha kobunzima ngendlela engachazekiyo zezona mpawu ziphambili.

Ukuba unesifo se-sickle cell kwaye ufumana enye okanye ngaphezulu kwezi mpawu zingasentla, bona ugqirha wakho ngokukhawuleza ngaphandle kokulibazisa.

Kwesi sifo, ukuxilongwa kwangoko kunye nokuqaliswa konyango yeyona ndlela ilungileyo yokusindisa ubomi.

Umhlaza wezintso, i-Renal Medullary Carcinoma, i-RMC, isifo se-sickle cell, isifo sezintso, iimpawu zomhlaza, igazi kumchamo

⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.

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Izifo kunye neemekoJulayi 16, 2026
Ngaba uyayazi iRenal Medullary Carcinoma (RMC), umhlaza ongaqhelekanga kodwa onzima okhula kwizintso?
Dr. Priya SammaniMedical Verification
⏱ 4 min read
📋Table of Contents
1. Yintoni kanye kanye iRMC?
2. Yintoni ebangela lo mhlaza?
3. Ngaba nam ndisemngciphekweni wokuba ne-RMC?
4. Zithini iimpawu ze-RMC?
5. Ugqirha uyixilonga njani le nto?
6. Zithini iindlela zonyango zoku?
7. Ngaba ikho indlela yokuthintela i-RMC?
8. Umyalezo Wokuya Ekhaya
Ngaba wakha weva ngohlobo lomhlaza olungaqhelekanga nolunzima oluvela kwizintso, ingakumbi kubantu abancinci? Mhlawumbi akunjalo. Le yiRenal Medullary Carcinoma, okanye iRMC ngamafutshane. Nangona ingaqhelekanga kakhulu, kunokuba yinto ebalulekileyo ukuyiqonda, ingakumbi kwabanye abantu. Nangona le yingongoma enzulu, musani ukoyika. Masithethe ngayo ngendlela elula neqondakalayo namhlanje.
Yintoni kanye kanye iRMC?
Ngamafutshane, iRenal Medullary Carcinoma (RMC) luhlobo lomhlaza wezintso. Kodwa ayiqhelekanga, inobundlongondlongo kakhulu, kwaye isasazeka ngokukhawuleza. Ixhaphake kakhulu kubantu abancinci, ingakumbi abo baneengxaki zegazi ezibizwa ngokuba yi-'sickle cell disease' okanye 'sickle cell trait'.
Xa sithetha ngomhlaza wezintso, uhlobo oluqhelekileyo yi-'renal cell carcinoma'. I-RMC ikwaluhlobo lwe-'renal cell carcinoma'. Kodwa akukho namnye kwizigulane ezili-100 ezinomhlaza wezintso ofumana le meko ye-RMC. Ayiqhelekanga kangako.
Yintoni ebangela lo mhlaza?
Izazinzulu kunye noogqirha abakafumani unobangela opheleleyo woku, kodwa kukho into enye ephambili esele ichongiwe.
Izintso zethu zinenxalenye ebizwa ngokuba yi-'renal medulla'. Umntu onesifo se-'sickle cell' ngamanye amaxesha uneeseli ezibomvu zegazi ezitshintsha zibe yi-sickle shape. Xa oku kusenzeka, iiseli zinokunamathelana kwaye zivale imithambo yegazi kwinxalenye ye-'renal medulla' yezintso.
Oku kuthintelwa kokunikezelwa kwegazi konakalisa iiseli ezikuloo ndawo. Ngokukodwa, ijini ebizwa ngokuba yi-`INI1` (ekwabizwa ngokuba yi-`SMARCB1`) kwezo seli yonakele. Le jini ye-`INI1` isebenza njengomkhuseli othintela iiseli ekubeni zibe ngumhlaza. Xa iiseli zomhlaza ze-RMC zihlolwa, le jini ye-`INI1` ayifumaneki kuzo. Ngoko ke oogqirha bajonga ukuba ikhona na le jini ye-`INI1` ukuqinisekisa ukuba ithumba liyi-RMC okanye akunjalo.
Ngaba nam ndisemngciphekweni wokuba ne-RMC?
Kunzima ukutsho ngqo ukuba ngubani oza kuphuhlisa oku. Ukuba nomntu kusapho lwakho one-RMC akunyusi umngcipheko wokuba nakho. Oko kuthetha ukuba asiyonto iqhubekayo kwiintsapho.
Eyona nto iphambili ebangela umngcipheko sisifo segazi esibizwa ngokuba yi-'sickle hemoglobinopathy'. Oko kukuthi, ukuba nesifo se-sickle cell okanye 'uphawu lwe-sickle cell'. Kodwa kunqabile kakhulu ukuba abantu abangenazo ezi meko banokuba ne-RMC. Ibizwa ngokuba yi-"renal cell carcinoma, engachazwanga nge-medullary phenotype" (RCCU-MP).
Ukuba ujonga izibalo:
Ixhaphake kakhulu kumadoda kunabafazi.
Idla ngokuchaphazela izintso ezichanekileyo.
Esi sifo sidla ngokufunyaniswa sisebancinci, phakathi kweminyaka eli-11 nengama-39 ubudala.
Kubalulekile ukuba abantu abaselula, ingakumbi abo banesifo se-sickle cell okanye uphawu lwe-sickle cell, bazi ezi mpawu, njengoko ukubonwa kwangethuba kunokwenza unyango lube lula. Ukuba kuvela iimpawu, bonana nogqirha ngokukhawuleza.
Zithini iimpawu ze-RMC?
Kukho iimpawu ezininzi eziqhelekileyo zesi sifo. Ukuba unenye okanye ngaphezulu kwezi, kungcono ukufuna ingcebiso kagqirha ngokukhawuleza.
Uphawu Inkcazo
Intlungu kwindawo yezintso Intlungu engapheliyo evakala kumacala omabini esisu nakumqolo ongezantsi (ngaphezulu nje kwengquza).
Igazi kumchamo Umchamo opinki, obomvu, okanye omdaka. Ngamanye amaxesha kunokubakho igazi elingabonakaliyo emehlweni.
Ithumba lesisu Iqhuma okanye ubunzima obuvakala ngathi liqhuma kwicala elinye lesisu.
Ukunciphisa umzimba ngaphandle kwesizathu Ukunciphisa umzimba ngokukhawuleza ngexesha elifutshane, ngaphandle komzamo.
Umkhuhlane oqhelekileyo kunye nokubila ebusuku Ukuba usoloko unefiva ngaphandle kwesizathu esinye kwaye ubila kakhulu ebusuku kangangokuba amashiti akho ayamanzi.
Ugqirha uyixilonga njani le nto?
Xa usixelela ngeempawu zakho, into yokuqala ugqirha aza kuyenza kukuxilonga. Emva koko ungalandela la manyathelo.
1.I-ultrasound scan: Oku kunokunika umbono ocacileyo wokuba kukho into efana nethumba kwizintso.
2. I-CT okanye i-MRI scan: Ukuba kurhanelwa ukuba kukho ithumba, i-CT scan okanye i-MRI ingayalelwa ukuze kufunyanwe umfanekiso ocacileyo wethumba. Ngokusekelwe kwezi mifanekiso, ugqirha unokufumanisa ukuba kunokwenzeka kangakanani ukuba libe ngumhlaza.
3. I-Biopsy: Ukuba kukho umhlaza okrokrelwayo kakhulu, olu vavanyo lwenziwa ukuqinisekisa ukuba ukhona. Oku kuquka ukufaka inaliti encinci kwindawo yethumba lezintso, ukuthatha iqhekeza elincinci kakhulu lesicwili uze ulihlole phantsi kwe-microscope.
4. Uvavanyo lwemfuza: Iiseli ezithathwe kwi-biopsy zijongwa ukuba zikhona na i-gene `INI1` elwa nomhlaza esithethe ngayo ngaphambili.
Ukuba i-gene ethi `INI1` ayikho , ichongwa njenge-RMC.
Ukuba i-gene ethi `INI1` ayikho kwaye isigulane asinayo imeko ye-`sickle cell`, sichongwa njenge-`RCCU-MP`.
Ukuba i-gene ethi `INI1` ikhona , ayisiyo i-RMC, kodwa luhlobo olwahlukileyo lwethumba.
Zithini iindlela zonyango zoku?
Ngenxa yokuba i-RMC ngumhlaza osasazeka ngokukhawuleza nonobundlongondlongo, unyango kufuneka lukhawuleze kwaye lube nobundlongondlongo ngokulinganayo.
Unyango lweKhemotherapy: Olu lolona nyango lokuqala luqhelekileyo. Lubandakanya ukunika umzimba amayeza abulala iiseli zomhlaza.
Utyando: Ukususwa kwethumba elinomhlaza kunye nezintso ezichaphazelekileyo.
Unyango lweMisebe: Ukutshabalalisa iiseli zomhlaza kusetyenziswa imisebe enamandla yemitha.
Ngenxa yokuba esi sifo sinqabile, uphando lusaqhubeka. Izazinzulu zihlala zikhangela unyango olutsha nolusebenzayo lwe-RMC.
Ngaba ikho indlela yokuthintela i-RMC?
Ngelishwa, okwangoku akukho ndlela eyaziwayo yokuthintela i-RMC ukuba ivele, kwaye akukho vavanyo lokuyifumanisa ngaphambi kokuba kuvele iimpawu.
Eyona nto ingcono onokuyenza kukwazi . Ukuba uyazi ukuba unesifo se-sickle cell okanye uphawu lwe-sickle cell, jonga iimpawu ezichazwe apha ngasentla. Ukuba unenkxalabo, bonana nogqirha wakho ngoko nangoko.
Amaxesha amaninzi, xa esi sifo sifunyanwa, umhlaza sele usasazeke kwiindawo ze-lymph nodes okanye kwezinye izitho ezifana nemiphunga, isibindi, kunye namathambo. Ngoko ke, ukufunyanwa kwangethuba yeyona ndlela ilungileyo yokufumana iziphumo ezilungileyo.
Umyalezo Wokuya Ekhaya
I-Renal Medullary Carcinoma (RMC) luhlobo lomhlaza wezintso olungaqhelekanga kodwa olunzima kakhulu oluchaphazela kakhulu abantu abancinci.
Eyona nto iphambili ebangela oku kukuba nesifo segazi esibizwa ngokuba sickle cell disease okanye sickle cell trait .
Intlungu yomqolo/yesisu, igazi emchameni, iqhuma esiswini, kunye nokuncipha kobunzima ngendlela engachazekiyo zezona mpawu ziphambili.
Ukuba unesifo se-sickle cell kwaye ufumana enye okanye ngaphezulu kwezi mpawu zingasentla, bona ugqirha wakho ngokukhawuleza ngaphandle kokulibazisa.
Kwesi sifo, ukuxilongwa kwangoko kunye nokuqaliswa konyango yeyona ndlela ilungileyo yokusindisa ubomi.
Umhlaza wezintso, i-Renal Medullary Carcinoma, i-RMC, isifo se-sickle cell, isifo sezintso, iimpawu zomhlaza, igazi kumchamo
⚠️ Important: The medical articles and information on Nirogi Lanka are for general awareness only, and are by no means a substitute for professional medical advice, diagnosis, or treatment. For any medical problem you have, consult a qualified physician immediately.
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