Ukuba kukho umntu kusapho lwakho, mhlawumbi umama wakho othandekayo, utata, umakhulu okanye umakazi, onesifo se-Alzheimer, siyazi ukuba kunokuba nzima kangakanani. Amazwi awanakuchaza usizi kunye nokungabi namandla okuziva njengoko ulahlekelwa yinkumbulo yakho kancinci kancinci kwaye ufumana kunzima ukwenza imisebenzi yemihla ngemihla. Nangona kungekho nyango lwesifo se-Alzheimer, kukho amayeza anokunceda ukulawula iimpawu kwaye enze ubomi bube lula kancinci. Ngoko ke, namhlanje sithetha ngodidi olukhethekileyo lwamayeza oogqirha abadla ngokuwacebisa oku.
Masiqonde nje indlela eli yeza elisebenza ngayo, akunjalo?
Ukuze siqonde oku, masiqale sijonge indlela esebenza ngayo ingqondo yethu. Iiseli zemithambo-luvo ezikwiingqondo zethu, ezibizwa ngokuba zii-neurons, ziyathetha kwaye zitshintshiselana ngolwazi ngee-chemical messengers, njengokuba umntu othumela iileta ehambisa iileta.
Esinye isithunywa esibalulekileyo yi -acetylcholine . Inceda ngezinto ezininzi ezibalulekileyo ezifana nenkumbulo yethu, ukufunda, kunye nengqalelo.
Nangona kunjalo, xa isifo sika-Alzheimer sikhula, iiseli zemithambo-luvo ezivelisa ezi zithunywa ezibizwa ngokuba yi-acetylcholine ziyatshatyalaliswa kancinci kancinci. Emva koko inani lezi zithunywa engqondweni liyancipha. Eziseleyo ziyaqhekeka ngokwemvelo xa zigqibile umsebenzi wazo.
Kulapho ke amayeza abizwa ngokuba yiCholinesterase Inhibitors angena khona. La mayeza asebenza ngokunciphisa isantya sokuqhekeka kwe-acetylcholine messengers eseleyo. Oku kuthetha ukuba ayagcinwa kwaye avunyelwe ukusebenza engqondweni ixesha elide kangangoko kunokwenzeka. Oku kuphumela ekuphuculeni okwethutyana kwimemori nakwizakhono zokucinga.
Ngamafutshane, la mayeza awanyangi isifo. Endaweni yoko, alawula iimpawu aze anike isiqabu sexeshana kumguli.
Amayeza e-Cholinesterase Inhibitor asetyenziswa rhoqo
Kukho amayeza amaninzi e-Cholinesterase Inhibitor avunyiweyo ukunyanga isifo se-Alzheimer kwihlabathi liphela naseSri Lanka. Ugqirha wakho uza kukhetha amayeza afanelekileyo ngokusekwe kuhlobo lwesifo kunye nemeko yesigulana.
| Igama leyeza (igama lophawu) | Iimeko zokusetyenziswa | Iziphumo ebezingalindelekanga eziqhelekileyo |
|---|---|---|
| I-Donepezil (i-Aricept) | Kwimeko zesifo ezibuthathaka, eziphakathi, nezinzima. Ithathwa njengepilisi enye kanye ngemini. | Isicaphucaphu, ukuhlanza, ukuqunjelwa, ukuqaqamba kwemisipha, ukudinwa, ukungabi namdla wokutya. |
| I-Rivastigmine (i-Exelon) | Kwizigulana ezincinci ukuya kweziphakathi (iipilisi). Ikwafumaneka njenge-patch yesikhumba kwizigulana ezinzima. | Isicaphucaphu, ukuhlanza, ukuqunjelwa, ukuphelelwa ngumdla wokutya, kunye nentlungu yesisu (ezi azixhaphakanga xa usebenzisa i-patch). |
| IGalantamine (iRazadyne) | Kwiimeko ezingephi ukuya kweziphakathi zesifo, thatha kabini ngemini okanye njengekhaphu esebenza ixesha elide kanye ngemini. | Isicaphucaphu, ukuhlanza, ukuqunjelwa, ukungabi namdla wokutya, intloko ebuhlungu , isiyezi. |
| I-Donepezil + iMemantine (iNamzaric) | Yenziwa kunye nelinye iyeza (i-NMDA agonist) kwiimeko eziphakathi ukuya kwezinzima zesifo. | Intloko ebuhlungu , ukudideka, isiyezi, ukuqhina, isicaphucaphu, ukuhlanza. |
Kuthekani ukuba ndineziphumo ebezingalindelekanga xa ndiqala ukuthatha amayeza?
Abanye abantu banokufumana iziphumo ebezingalindelekanga xa beqala ukuthatha eli yeza. Kodwa ungakhathazeki. Uninzi lwexesha, ezi ziphumo bezingalindelekanga ziya kuphela njengoko umzimba wakho uqhelana neyeza. Ugqirha wakho uhlala eqala ngedosi ephantsi kakhulu aze anyuse idosi kancinci kancinci.
Ukuba unesicaphucaphu, ukuthatha iyeza kunye nokutya kunokunceda ekulawuleni. Eyona nto ibalulekileyo kukuthetha nogqirha wakho ngayo nayiphi na ingxaki onayo. Uya kukwazi ukukunika isisombululo esifanelekileyo.
Lisebenza kangakanani eli yeza?
Le yingxaki kubantu abaninzi. Ukuba ndithetha inyani, iziphumo zala mayeza zezexeshana. Abanye abaguli banokubona ukwehla okukhulu kweempawu. Bayakwazi ukucinga ngokucacileyo, ukukhumbula izinto, nokwenza imisebenzi yemihla ngemihla ngokulula. Le meko ngamanye amaxesha inokuhlala iminyaka eliqela.
Kodwa kufuneka siqonde ukuba oku kufana nokubeka iplasta okwethutyana phezu kwetanki evuzayo. Kuya kuyithintela amanzi ekuvuzeni okwethutyana, kodwa ibala aliyi kusetyenziswa njengoko umngxuma osetankini ukhula. Ngokufanayo, la mayeza awanakumisa okanye abuyisele umonakalo engqondweni obangelwe sisifo sika-Alzheimer. Njengoko isifo siqhubeka, kwaye ukuveliswa kwe-acetylcholine engqondweni kuyeka ngokupheleleyo, la mayeza nawo awasebenzi.
Ngaba kukho abantu abangafanele bawasebenzise la mayeza?
Ewe. Eli yeza alifanelekanga kuye wonke umntu. Izithinteli ze-cholinesterase zinokunciphisa ukubetha kwentliziyo kunye noxinzelelo lwegazi. Ke ngoko, oogqirha balumkile kakhulu xa benika abantu abaneengxaki ezithile zempilo.
- Abantu abane-asthma
- Abantu abaneengxaki zesingqisho sentliziyo
- Abantu abanesifo sezintso okanye sesibindi
- Abantu abanezilonda zesisu
Ukuba umntu omthandayo unenye yezi meko, qiniseka ukuba wazisa ugqirha wakho ngayo.
Kubaluleke kakhulu: Xelela ugqirha wakho malunga namayeza , iivithamini, izongezo zesondlo, kwanamayeza e-Ayurvedic okanye e-Sinhala asetyenziswa ngumntu omthandayo. Amanye amayeza (umz., amanye amayeza omkhuhlane kunye ne-allergy) anokusebenzisana nala ma-Cholinesterase Inhibitors, nto leyo eyenza omabini la mayeza angasebenzi kakuhle okanye abangele iziphumo ebezingalindelekanga eziyingozi.
Umyalezo Wokuya Ekhaya
- Izithinteli ze-cholinesterase azilonyango lwesifo sika-Alzheimer. Zilawula okwethutyana kuphela iimpawu ezinxulumene nenkumbulo nokucinga.
- Eli yeza lisebenza ngokunyusa amanqanaba esithunywa sekhemikhali esibizwa ngokuba yi-acetylcholine engqondweni.
- Iziphumo ebezingalindelekanga ezifana nokucaphuka nokuhlanza zinokwenzeka ekuqaleni kokuthatha iyeza, kodwa zihlala zincipha ngokuhamba kwexesha.
- Ungaze uyeke ukuthatha amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
- Kubalulekile ukwazisa ugqirha wakho ngazo zonke ezinye iziyobisi ezisetyenziswa ngumntu omthandayo.
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