Ingaba usoloko unxaniwe kwaye uchama malunga namaxesha angamashumi amabini ngemini? Ingaba le yi-Arginine Vasopressin Disorders / Diabetes Insipidus?

Ngaba nawe unxaniwe kakhulu? Ngaba uziva ngathi awukwazi ukusela amanzi aneleyo? Ngaba kufuneka uye kwigumbi lokuhlambela amaxesha amaninzi ngemini, ngamanye amaxesha kube kanye okanye kabini ngeyure? Ukuba kufuneka uvuke ebusuku ukuze uchame ungalali kakuhle, oku akuyonto ithathwa lula. Namhlanje siza kuthetha ngemeko engaqhelekanga kodwa enyangekayo ebonisa iimpawu ezifanayo. Ngaphambili, oku kwakubizwa ngokuba yi-'Diabetes Insipidus'.

Yintoni i-Arginine Vasopressin Disorder?

Ngamafutshane, le meko iyenzeka xa umzimba wakho uvelisa umchamo omninzi kakhulu. Oku kuthetha ukuba umzimba wakho awukwazi ukugcina amanzi aneleyo. Isizathu esiphambili soku yingxaki yehomoni ebizwa ngokuba yi -Arginine Vasopressin (AVP) . Oogqirha bakwabiza le homoni ngokuthi yi-"AVP" ngokuba yi-Antidiuretic Hormone (ADH) . Le homoni "AVP" idlala indima ebaluleke kakhulu ekugcineni ubungakanani bolwelo emzimbeni bulungelelene kwizintso zethu.

Kukho iintlobo ezimbini eziphambili zezi meko:

1. Ukunqongophala kwe-AVP (AVP-D): Oku kwenzeka xa umzimba wakho ungavelisi ngokwaneleyo i-hormone ye-AVP.

2. Ukumelana ne-AVP (AVP-R): Oku kwenzeka xa izintso zakho zingasabeli kakuhle kwi-hormone i-AVP. Oku kuthetha ukuba nangona i-hormone ikhona, izintso aziyisebenzisi.

Zithini iimpawu zale meko?

Iimpawu eziphambili zokungabikho kwe-AVP kunye nokuxhathisa kwe-AVP zezi:

• Ukufuna ukuchama rhoqo: Uphawu oluphambili lwale nto kukufuneka uvuke ukuze uchame kungekuphela nje emini kodwa nasebusuku (Nocturia) .
• Ukuchama kakhulu ngombala okhanyayo okanye omanzi: Ngokwesiqhelo, umntu uchitha phakathi kwe-1 kunye ne-3 yelitha yomchamo ngosuku. Nangona kunjalo, umntu onesi sifo unokukhupha ukuya kuthi ga kwiilitha ezingama-20 zomchamo ngosuku. Khawucinge ukuba ingakanani loo nto!
• Unxano olugqithisileyo (iPolydipsia): Ukuziva ngathi awulucimi unxano lwakho nokuba usela amanzi angakanani na.

Ezi mpawu ziluphawu oluqinileyo lokuba kukho into engasebenzi kakuhle emzimbeni wakho. Kubaluleke kakhulu ukufuna ingcebiso kagqirha ngokukhawuleza.

Ezi mpawu zibachaphazela njani abantwana abancinci?

Ukuba le meko iyenzeka kubantwana abancinci, iimpawu zinokwahluka kancinci. Ezinye zazo ziquka:

• Ukuphelelwa ngamanzi emzimbeni kakhulu.
• Ukuqhinwa.
• Ukuhlanza.
• Umkhuhlane oqhelekileyo.
• Ubonakalisa isimo sengqondo sokucaphuka kakhulu nokungakhululeki.
• Ukukhula kuyawohloka / Ukungaphumeleli ukukhula.

Ukuba iintsana okanye abantwana abancinci banezi mpawu, ngokuqinisekileyo kufuneka babonwe ngugqirha ngoko nangoko.

Kutheni le nto ezi ngxaki ze-arginine vasopressin zenzeka?

Izizathu zahlukile, kuxhomekeke kuhlobo olukhankanyiweyo ngaphambili.

Izizathu zokungabikho kwe-AVP `(AVP-D)`

Ngaphambili yayibizwa ngokuba yi-central diabetes insipidus , oku kubangelwa kukungabikho kwe-hormone i-arginine vasopressin (AVP). Olu lolona hlobo luqhelekileyo.

Oku kusenokuba kungenxa yezi zinto zilandelayo:

• Ukonakala kwi -hypothalamus okanye kwi-pituitary gland (ezi ziindawo ezibalulekileyo zobuchopho ezilawula iihomoni). Lo monakalo unokwenzeka ngenxa yotyando okanye ukwenzakala entloko.
• Ezinye iinguqulelo zemfuza (Ukwahluka kwemfuza okuzuzwe njengelifa)
• Ukwakheka kweethumba .
• Ukudumba/iiGranulomas ezibangelwa ziimeko ezithile zempilo, ezifana ne-sarcoidosis okanye isifo sephepha.
• Ngamanye amaxesha, unobangela usenokungafumaneki (idiopathic) . Oku kuthetha ukuba malunga nesiqingatha sezigulane, unobangela awukaziwa.

Izizathu zokuxhathisa i-AVP (AVP-R)

Olu hlobo lwalubizwa ngokuba yi -nephrogenic diabetes insipidus ngaphambili. Kwimeko enjalo, i-pituitary gland ivelisa i-hormone i-AVP, kodwa izintso aziphenduli kakuhle kuyo.

Kukho izizathu ezahlukeneyo zoku:

• Utshintsho oluthile kwimfuza.
• Indlela yomchamo evalekileyo .
• Ukusetyenziswa ixesha elide kwamayeza athile, ingakumbi i-lithium .
• Ukwanda kwamanqanaba e-calcium egazini (i-Hypercalcemia) .
• Amanqanaba aphantsi e-potassium egazini (i-Hypokalemia) .

Uhlobo olukhethekileyo oluvela ngexesha lokukhulelwa

Oku kubizwa ngokuba yiGestational Arginine Vasopressin Disorder (gAVP-d) . Oku kunqabile kakhulu. Ngexesha lokukhulelwa, i-placenta ivelisa i-enzyme eninzi kakhulu ephula i-hormone ye-AVP.

Unamathuba amaninzi okuba nale meko, ngesizathu esithile :

• Ukuba uthwele amawele okanye abantwana abaninzi .
• Ukuba unemeko echaphazela ukusebenza kwesibindi, efana ne -preeclampsia okanye i-HELLP syndrome .

Iindaba ezimnandi zezokuba le meko ye-'gAVP-d' idla ngokuphela emva kweeveki ezimbini ukuya kwezintathu emva kokubeleka.

Zithini iingxaki zale meko?

Ingxaki ephambili ye-AVP-D kunye ne-AVP-R kukuphelelwa ngamanzi emzimbeni , oku kukulahlekelwa zizinto ezifunekayo ukuze umzimba usebenze.

Ngokwesiqhelo ungalawula ukuphuma komchamo wakho ngokusela amanzi amaninzi kunalawo uwadingayo, kodwa ukuba awukwenzi oko, ungaphelelwa ngamanzi emzimbeni ngokukhawuleza.

Ukuphelelwa ngamanzi emzimbeni kunokuba yingozi ebomini. Ukuba uneempawu zokuphelelwa ngamanzi emzimbeni, ezifana nesiyezi, isicaphucaphu, okanye ukudinwa kakhulu, yiya esibhedlele esikufutshane ngokukhawuleza.

Oogqirha bayibona njani le nto?

Ngenxa yokuba iimpawu zokunxanwa rhoqo kunye nokuchama zinokubangelwa zezinye iimeko eziqhelekileyo, oogqirha baqala ngokuzikhupha ezinye iimeko xa befumanisa ukuba unayo i-'AVP-D` okanye i-'AVP-R`. Ukuba unale mpawu, ugqirha wakho usenokuyalela iimvavanyo ezininzi.

Xa kuchongwa le meko, kuyimfuneko ukufumanisa ukuba ingaba yi-`AVP-D` okanye yi-`AVP-R` kwaye yintoni unobangela.

Uvavanyo lokuxilonga

• Uvavanyo lokungafumani manzi: Le yeyona ndlela ithembekileyo yokufumanisa i-AVP-D okanye i-AVP-R. Uza kuhlolwa ngokusondeleyo ngeli xesha lovavanyo, kuba oku kunokukhokelela ekuphelelweni ngamanzi emzimbeni. Olu vavanyo lubandakanya ukungaseli naluphi na ulwelo kangangeeyure ezininzi nokubona indlela umzimba wakho osabela ngayo. Ukuba unale meko, uya kuqhubeka ukhupha umchamo omninzi onombala okhanyayo. Ukuba awunale meko, uya kudlula umchamo omncinci oxineneyo, otyheli obumnyama.
• Uvavanyo lwegazi lweCopeptin: ICopeptin yimveliso ephuma kwihomoni i-AVP.
• Uvavanyo lweglucose egazini: Oku kwenzelwa ukujonga isifo seswekile, esineempawu ezifanayo.
• Uhlalutyo lomchamo: Oku kuvavanya i-osmolality ( uxinzelelo lomchamo) kunye nee-ketones kumchamo.
• Uvavanyo lwemifanekiso olufana ne-MRI scans (MRI - Magnetic Resonance Imaging): Olu lwenziwa ukuze kubonwe ukuba kukho nawuphi na umonakalo kwi-pituitary gland okanye kwi-hypothalamus.

Ziphathwa njani ezi `AVP-D` kunye ne`AVP-R`?

Unyango luxhomekeke ekubeni unayo na i-`AVP-D` okanye i-`AVP-R`. Nokuba unyango lunjani na, kubalulekile ukusela amanzi amaninzi ukuze uphephe ukuphelelwa ngamanzi emzimbeni.

Unyango lwe-AVP-D (Ukunqongophala)

I-Desmopressin lolona nyango luphambili lwe-AVP-D. Liyeza elisebenza ngendlela efanayo ne-hormone ye-AVP. Lingasetyenziswa ngeendlela ezahlukeneyo (umz., njenge-spray yempumlo, njengepilisi).

Ngamanye amaxesha iDesmopressin isetyenziselwa imeko yokukhulelwa engaqhelekanga ``(gAVP-d)''. Nangona kunjalo, ngamanye amaxesha ngexesha lokukhulelwa, inokulawulwa ngokusela amanzi amaninzi.

Unyango lwe-AVP-R (Ukumelana)

Ukunyanga i-`AVP-R` kunzima kancinci. Ngamanye amaxesha kufuneka kusetyenziswe iindlela ezininzi kunye. Umzekelo:

• I-Thiazide diuretics(Nangona ezi zihlobo zamayeza anyusa ukuchama, zisebenza ngendlela eyahlukileyo kule meko)
• Amayeza angengowe-steroidal alwa nokuvuvukala (ii-NSAID)

Ukuba imeko ye-`AVP-R` ibangelwa yimithi oyiselayo, ugqirha wakho unokukwazi ukunyanga le meko ngokukutshintshela kwenye imithi.

Ndifanele ndimbone nini ugqirha?

Ukuba une-`AVP-D` okanye `AVP-R`, kubaluleke kakhulu ukubona ugqirha wakho rhoqo ukuze akunike ingcebiso. Ngale ndlela, ugqirha wakho angenza uvavanyo lokujonga imeko yakho aze aqinisekise ukuba unyango lwakho lusebenza kakuhle.

Unokufumana kuluncedo ukubuza ugqirha wakho le mibuzo:

• Ngaba ndine-`AVP-D` okanye `AVP-R`?
• Yintoni isizathu soku?
• Ingaba le yimeko engapheliyo (ehlala ixesha elide) okanye yeyokwexeshana?
• Ziziphi iindlela zonyango endinazo?
• Ndifanele ndisele amanzi angakanani ngosuku?
• Yintoni enye endinokuyenza ukulawula le meko?
• Ingaba intsapho yam isengozini yokuba nesifo se-arginine vasopressin?

Ndingalindela ntoni ukuba ndine-`AVP-D` okanye `AVP-R`?

Imbono (isiphumo) seemeko ze-`AVP-D` kunye ne-`AVP-R` ngokubanzi zilungile. Ukuba uthatha unyango olufanelekileyo kwaye usela amanzi aneleyo, akufanele ube neengxaki ezinkulu.

Nangona kunjalo, aba bantu basengozini enkulu yeengxaki:

• Iintsana
• Abantu abangaphezu kweminyaka engama-65 ubudala
• Abantu abaneengxaki ezithile zempilo yengqondo okanye ukukhubazeka kokukhula

Aba bantu banokuba nobunzima bokuqaphela unxano lwabo, okanye basenokungakwazi ukuthatha inyathelo ngalo.

Kutheni le nto ingabizwa ngokuba yi-'Diabetes Insipidus' ngoku?

Ngowama-2022, imibutho emininzi yezonyango yagqiba ekubeni itshintshe igama elithi `Diabetes Insipidus` libe yi `Arginine Vasopressin Deficiency` kunye ne `Arginine Vasopressin Resistance`. Isizathu esiphambili soku yayikukudideka okubangelwe ligama elithi `diabetes` kunye nemiphumo emibi yempilo ebangelwe yiyo.

Xa uninzi lwabantu lusithi "isifo seswekile", bathetha isifo seswekile . Sibangelwa ngamanqanaba aphezulu eswekile egazini. Sikwaba neempawu ezifana nokunxanwa rhoqo kunye nokuchama. Nangona kunjalo, siqheleke kakhulu kunezi meko `AVP-D` kunye `AVP-R` (ezaziwa ngokuba yi`Diabetes Insipidus`). Kwakhona, unyango lwesifo seswekile lwahlukile ngokupheleleyo kunyango lwe`AVP-D` kunye ne`AVP-R`.

Igama elithi "diabetes" livela kwigama lesiGrike elithi "diabetesine," elithetha "ukudlula." Elo gama lisetyenziswa kuba, njengakwisifo seswekile, ulwelo ludlula emzimbeni ngokukhawuleza, nto leyo eyenzekayo kwezi ngxaki ze-arginine vasopressin.

Okokugqibela, kufuneka ndikuxelele... (Umyalezo Wokuya Ekhaya)

Ukuba une-`AVP-D` (ukungabikho kwe-arginine vasopressin) okanye i-`AVP-R` (ukumelana ne-arginine vasopressin), ungaziva ngathi uchitha uninzi lobomi bakho kwigumbi lokuhlambela, awukwazi ukuthomalalisa unxano lwakho nokuba usela amanzi angakanani na. Kodwa iindaba ezimnandi zezokuba ezi meko zinokulawulwa.

Ugqirha wakho uza kuyila isicwangciso sonyango esikusebenzelayo, aze akuxelele nokuba kufuneka usele amanzi angakanani ngosuku ukuze uhlale unamanzi aneleyo. Musa ukoyika. Fumana inkxaso nolwalathiso kugqirha wakho. Khumbula, oku akusiyo "isifo seswekile." Yiyo loo nto kubalulekile ukufumana uxilongo olufanelekileyo kunye nonyango. Awuwedwa, hlala unolwazi, kwaye uhlale uqinile.

Iingxaki zeArginine Vasopressin, iDiabetes Insipidus, iAVP, iADH, unxano olugqithisileyo, ukuchama rhoqo, ukuphelelwa ngamanzi emzimbeni, iPolydipsia, iNocturia, iDesmopressin, izintso, iiHormones