Ingaba igazi lakho liyawa ngaphandle kwesizathu? Masifunde ngakumbi ngeFactor V Leiden Thrombophilia!

Ayifani yonke imizimba yethu, akunjalo? Ngamanye amaxesha sinokuba nomahluko omncinci emizimbeni yethu esingawuqondiyo. Namhlanje siza kuthetha ngenye imeko enjalo esiyifumana njengelifa, ebangela ukuba igazi lethu lijijeke kakhulu, nto leyo ethetha ukuba kunokwenzeka ukuba lijijeke ngokungeyomfuneko. Oku kubizwa ngokuba yiFactor V Leiden Thrombophilia .

Ngoko ke yintoni iFactor V Leiden?

Ngamafutshane, esi sisifo sokugalela igazi esizuzwe njengelifa . Oko kukuthi, uzalwa unotshintsho kwizakhi zofuzo zakho. Olu tshintsho lwenza igazi lakho libe namahlwili ngakumbi kunesiqhelo. Oku kukubeka emngciphekweni omkhulu wokufumana iimeko ezifana nezi:

• I-Deep Vein Thrombosis (DVT): Oku kwenzeka xa amahlwili egazi eyenzeka kwimithambo enzulu yomzimba wakho, ingakumbi emilenzeni okanye ezingalweni zakho. Nangona kunjalo, ngamanye amaxesha anokwenzeka kwimithambo kwiindawo ezifana nesibindi, izintso, ingqondo, kunye namehlo.
• I-Pulmonary Embolism (PE) : Oku kuyingozi ngakumbi. Okwenzekayo apha kukuba elinye lamahlwili egazi elikhankanyiweyo apha ngasentla, okanye ihlwili legazi elenziwe kwenye indawo, liqhekeke, lihambe egazini, lize libambeke kwenye yemiphunga yakho.

Kodwa nantsi into, ukuba nje unale meko akuthethi ukuba ngokuqinisekileyo uza kufumana i-DVT okanye i-PE . Enyanisweni, malunga nabantu abalithoba kwabalishumi abanale meko abayi kuze babe ne-blood clot engaqhelekanga ebomini babo. Nangona kunjalo, kubalulekile ukuqonda ukuba usemngciphekweni omkhulu kunabanye.

Ukwanda kwesi sifo se-'Factor V Leiden' kuyahluka phakathi kwamaqela eentlanga ezahlukeneyo. Ngokuqhelekileyo sibonakala rhoqo phakathi kwabantu abamhlophe eMelika naseYurophu.

• Malunga nabantu aba-5 kwabayi-100 abaphuma eYurophu.
• Malunga nabantu ababini kwabayi-100 abanemvelaphi yaseHispanic.
• Malunga nomntu omnye kwabayi-100 abamnyama okanye abangamaNdiya aseMelika.
• Kubantu baseAsia, bangaphantsi komntu omnye kwabayi-100.

Nangona kunjalo, malunga nomntu omnye kwabahlanu abanegazi eliqhekekileyo emithanjeni yakhe bafunyenwe bene-'Factor V Leiden' gene variant. Oku kubizwa ngokuba yi-'Factor V Leiden.'' Unobumba u-V umele inani lesiRoma elithetha isihlanu.

Zithini iimpawu zale meko?

Nantsi into ekufuneka uyikhumbule: Olu tshintsho lwemfuza lodwa alubangeli zimpawu . Ungaba nalo ubomi bakho bonke ungazi. Nangona kunjalo, njengoko bekutshiwo ngaphambili, iimpawu zibonakala kuphela xa kuvela ihlwili legazi.

Kubalulekile: Ukuba ucinga ukuba uneempawu ze-'DVT' okanye 'PE', fowunela u-911 okanye inombolo yakho yongxamiseko yasekuhlaleni ngoko nangoko . Kungenjalo, yiya kwicandelo lezonyango ezingxamisekileyo lesibhedlele elikufutshane ngokukhawuleza nomntu. Asinto yokuyichitha ixesha.

Iimpawu ze-deep vein thrombosis (DVT) zingabandakanya:

• Ukudumba komlenze okanye ingalo, ukuziva ushushu xa uyichukumisa, kunye notshintsho kumbala wolusu (mhlawumbi utshintshe ube bomvu okanye ube luhlaza okwesibhakabhaka).
• Ukuziva intlungu xa uchukumisa loo mlenze okanye ingalo, intlungu xa ucinezela .
• Imithambo engaphantsi kolusu emikhulu kuneqhelekileyo kwaye ibonakala ngaphezulu .
• Ukuba igazi liqhekeka emithanjeni engaphakathi esiswini, unokufumana iintlungu zesisu okanye iintlungu ephangweni .
• Ukuba igazi liqhekeka engqondweni, linokubangela intloko ebuhlungu ngequbuliso kunye/okanye ukuxhuzula .

Iimpawu ze-pulmonary embolism (PE) zingabandakanya:

• Ubunzima bokuphefumla ngequbuliso .
• Intlungu ebukhali esifubeni xa uphefumla nzulu, ukhohlela, okanye uthimla.
• Ukukhohlela, ngamanye amaxesha igazi elincinci liphuma kunye nomkrwelo .
• Isandi sokuphefumla xa uphefumla.
• Ukubetha kwentliziyo okukhawulezayo kakhulu (i-tachycardia) .
• Ukuziva uxhalabile kwaye ungaphumli .
• Ukuziva unesizungu, uzive ngathi uza kulahlekelwa zingqondo (kunqabile, usenokulahlekelwa zingqondo) .

Yintoni ebangela iFactor V Leiden?

Eyona sizathu siphambili soku yi -gene variant . Kukho iproteni emzimbeni wethu enceda ukujiya kwegazi, ibizwa ngokuba yi -'Coagulation factor V' . Ngokuchanekileyo, inceda ekumiseni ukopha xa kukho ukwenzakala. Ngoko ke, umzimba wethu uyalelwa ukuba wenze le proteni yi-gene ebizwa ngokuba yi-'F5' .

Ngokwesiqhelo, sonke sizuza iikopi ezimbini eziqhelekileyo zale gene ye-`F5`. Nangona kunjalo, ukuba ufumana ikopi enye okanye ezingaphezulu ezingaqhelekanga zale gene, kuthiwa une-`Factor V Leiden` variant (ngamanye amaxesha ibizwa ngokuba yi-`mutation`). Igama elithi `Leiden` livela kwisixeko saseLeiden eNetherlands apho abaphandi bafumanise khona le gene variant.

Olu tshintsho lwe-gene lwe-'Factor V Leiden' lubangela utshintsho oluncinci kwisakhiwo seproteni ye-'factor V' eveliswa emizimbeni yethu. Ngenxa yolu tshintsho, le protein ye-'factor V' etshintshileyo ayimelani nesenzo sezinye iiproteni ezimbini ezibalulekileyo ezilawula ukujiya kwegazi , iProteni C ('Proteni C') kunye neProteni S ('Proteni S') . Ngamafutshane, ezo proteni zilawulayo azikwazi ukuyimisa. Emva koko, iproteni ye-'factor V' iba namandla ngakumbi kunokuba kufanele, kwaye igazi liqala ukujiya ngokungeyomfuneko, nokuba alifuneki.

Ingaba le yinto edluliselwa kusapho olunye ukuya kolunye?

Ewe, ngokuqinisekileyo. Ungayizuza le meko kumama wakho okanye kutata wakho, okanye zombini. I-Factor V Leiden izuzwe njengelifa kwi-autosomal dominant inheritance pattern.Oko kuthetha ukuba, nokuba ufumana olu hlobo lwezakhi zofuzo olungaqhelekanga komnye wabazali bakho, usenokufumana esi sifo njengelifa.

Uninzi lwabantu (abaneFactor V Leiden) bafumana ikopi enye engaqhelekanga yejini. Oku kubizwa ngokuba yi -heterozygous . Kunqabile kakhulu ukuba ufumane iikopi ezingaqhelekanga zejini kumama nakutata wakho. Oku kubizwa ngokuba yi-homozygous .

Ziziphi ezinye izinto ezibangela umngcipheko wokuqhekeka kwegazi?

Umntu one-Factor V Leiden unokuba namathuba amaninzi okufumana igazi elijiyileyo ukuba:

• Ukuba uzuze zombini iikopi ze-`F5` gene engaqhelekanga njengoko bekutshiwo ngaphambili (ukuba ungumntu ofana nowesifazana`) .
• Ukuba izalamane zakho zegazi (ezifana nomama, utata, abantakwenu) zinembali ye-DVT okanye i-PE .
• Ukuba unezinye iimeko zokujiya kwegazi .
• Ukuba utyando (ingakumbi emva kotyando olukhulu, njengoko uza kuba kwindawo enye ixesha elide).
• Ukuba ukhulelwe (ngeli xesha, utshintsho lweehomoni kunye nomntwana lunokubangela uxinzelelo kwimithambo).
• Ukuba uthatha iintlobo ezithile zeepilisi zokulawula ukuzala (eziqulethe i-estrogen) okanye unyango lokutshintshwa kweehomoni (unyango lokutshintshwa kweehomoni) .

Ukuba unayo nayiphi na kwezi zinto zinobungozi, kubaluleke kakhulu ukuthetha nogqirha wakho uze ufunde ngomngcipheko wokuqhekeka kwegazi kunye namanyathelo okhuseleko onokuwathatha.

Ziziphi iingxaki ezinokwenzeka ngenxa yale meko?

Ukuba une-Factor V Leiden Thrombophilia, unokufumana oku kulandelayo:

• Ukuphuhlisa i-'DVT' okanye i-'PE' ngaphambi kokuba ufikelele kwiminyaka engama-50 .
• Ngaphezu kwesihlandlo esinye, oko kuthetha ukwenzeka kaninzi kwe-`DVT` okanye `PE`.
• Amahlwili egazi ayenzeka kwimithambo yegazi edla ngokwenza amahlwili egazi ambalwa , umzekelo, kwimithambo yesibindi, ingqondo, kunye nezintso.
• I-DVT okanye i-PE ngexesha lokukhulelwa okanye emva kokubeleka .
• I-DVT okanye i-PE zinokwenzeka kwixesha elifutshane emva kokuqalisa iipilisi zokulawula ukuzalwa .

Oogqirha bayixilonga njani le meko?

Oogqirha banokufumanisa ukuba unale meko ngovavanyo lwegazi . Oku kungabandakanya novavanyo lwemfuza . Ugqirha wakho unokucebisa ukuba uvavanye le meko, ingakumbi:

• Ukuba ukhe wakha wane-DVT okanye i-PE ngaphambili , ingakumbi ukuba kwenzeke usemncinci kunokuba bekulindelwe.
• Ukuba omnye okanye ngaphezulu kwizalamane zakho zegazi unembali yokuqhekeka kwegazi .

Iphathwa njani iFactor V Leiden?

I-Factor V Leiden yimeko yobomi bonkeOko kuthetha ukuba okwangoku akukho nyango okanye unyango oluthile lwale gene variant. Endaweni yoko, unyango lusebenza ekunyibilikiseni amahlwili egazi akhoyo kwaye lunciphise umngcipheko wamahlwili egazi kwixesha elizayo . Ugqirha wakho unokucebisa unyango olufana nolu:

• Amayeza okulwa nokugabha kwegazi (akwaziwa ngokuba zizinto ezinciphisa igazi) : La mayeza anceda ekunyibilikiseni amahlwili egazi akhoyo kwaye athintele ukwakheka kwamahlwili amatsha.
• Iikawusi zokucinezelwa : Ezi ziikawusi ezikhethekileyo eziqinileyo ezinxitywa emilenzeni ukuphucula ukujikeleza kwegazi nokunciphisa umngcipheko wokuqhekeka kwegazi.
• Ukubekwa kwesihluzo seVena cava : Esi sisixhobo esincinci esifakwa kumthambo omkhulu ukuthintela amahlwili egazi ukuba angahambi aye emiphungeni. Asinguye wonke umntu osidingayo.
• Ukususwa kwamahlwili egazi ngotyando : Kwezinye iimeko, utyando lunokufuneka ukuze kususwe amahlwili egazi amakhulu.

Ixesha omele ulithathe ukuze unciphise igazi lixhomekeke kumngcipheko wakho wokuba nelinye ihlwili legazi. Abanye abantu kufuneka balithathe eli yeza iinyanga ezimbalwa kuphela. Abanye banokufuna ukulithatha ixesha elide, kwanabo bonke ubomi babo. Ugqirha wakho uza kukuchazela isicwangciso sonyango esikulungeleyo.

Ufanele uye nini kugqirha?

Ukuba uyazi ukuba unale meko, kubalulekile ukuba uhlale unxibelelana nogqirha rhoqo.

• Yiya kuvavanyo lwezonyango oluqhelekileyo ubuncinane kanye ngonyaka .
• Ukuba une-DVT okanye i-PE kwaye ufumana unyango, kuya kufuneka ubone ugqirha wakho rhoqo ukuze ufumane amadinga okulandela ukuze ubone ukuba unyango luhamba njani.
• Ukuba uthatha iyeza lokunciphisa igazi elifana neWarfarin , kufuneka uhlolwe igazi (uvavanyo lwexesha leProthrombin - uvavanyo lwePT/INR) rhoqo ukuze kuhlolwe ukuba iyeza lisebenza kakuhle na kwaye idosi ichanekile.

Kwakhona, kubalulekile ukuthetha nogqirha kwiimeko ezinjalo:

• Ngaphambi kokusebenzisa ucwangciso-nzala (ingakumbi ezo zine-estrogen).
• Ngaphambi kokuba uqale unyango lokutshintshwa kwehomoni .
• Ukuba uceba ukukhulelwa, ngaphambi koko .

Ithini le nto malunga nolindelo lobomi?

Kwabaninzi abantu, ukuba neFactor V Leiden akuchaphazeli ubomi babo obuqhelekileyo . Nokuba uphuma igazi elijiyileyo, ukuba ufumana unyango olukhawulezileyo nolufanelekileyo, unokuthintela iziphumo ezibi . Ukuba unenkxalabo malunga neminyaka yakho yokuphila okanye iingxaki zexesha elizayo, thetha nogqirha wakho ngazo.

Yintoni esifanele siyiphephe ukuba sineFactor V Leiden?

Ugqirha wakho uza kukunika iingcebiso ngokusekelwe kwimeko yakho, kodwa ngokubanzi, kungcono ukuziphepha ezi zinto:

• Ukutshaya, ukutshaya i-vape, kunye nokusebenzisa ezinye iimveliso zecuba .
• Ukuhlala kwindawo enye ixesha elide (umz., ukusebenza eofisini, ukuhamba ngebhasi okanye ngololiwe ixesha elide, okanye ukundiza iiyure ezininzi). Ukuba kunokwenzeka, vuka uhambehamba ubuncinane kanye ngeyure.
• Kuphephe ukusela utywala obuninzi , ingakumbi xa uhamba ngenqwelo moya ezinde.
• Iipilisi zokulawula ukuzala kunye nonyango lokutshintshwa kweehomoni olune-estrogen (ngokuqinisekileyo kufuneka uthethe nogqirha wakho ngaphambi kokuba uzisebenzise ezi).

Ngaba ukunqongophala kweFactor V kunye neFactor V Leiden ziyafana?

Ewe, musa ukubhidanisa ezi zimbini. Ezi ziimeko ezimbini zemfuza ezahluke ngokupheleleyo . Nangona kunjalo, zombini ezi meko zinxulunyaniswa nokwahluka kwi-'F5' gene.

Kwi-Factor V Leiden Thrombophilia, utshintsho lwemfuza lubangela ukuba igazi lakho lijiye lula.

Nangona kunjalo, kwimeko ebizwa ngokuba yi -'Factor V deficiency' , utshintsho lwemfuza luthintela igazi lakho ekujiyeni ngokufanelekileyo xa kufuneka. Oku kuthetha ukuba usemngciphekweni wokopha. ''Factor V deficiency' sisifo esophayo esingaqhelekanga (malunga nesinye kwisigidi). Sinokubangela izinto ezifana nokopha rhoqo, ukopha kakhulu ngexesha lokuya exesheni, kunye nokopha okungapheliyo emva kotyando.

Okokugqibela, izinto ekufuneka uzikhumbule

Ngoko ke, ukuba ufumanisa ukuba wena okanye umntu omaziyo une-Factor V Leiden Thrombophilia, musa ukoyika ngoko nangoko. Khumbula, uninzi lwabantu abanale meko banokuphila ubomi obusempilweni ngaphandle kokuphuma kwamagazi .

Nangona kunjalo, ukuba unesifo sokuwa kwegazi, kukho unyango olusebenzayo olufumanekayo . Eyona nto ibalulekileyo kukulandela imiyalelo kagqirha wakho ngononophelo, ufumane uvavanyo nonyango olufunekayo, kwaye uphile ubomi obuqhelekileyo, obonwabisayo nale meko, uyilawule kakuhle ngaphambi kokuba ibe yingxaki.

I- Factor V Leiden, i-Thrombophilia, ukujiya kwegazi, i-DVT, i-PE, isifo semfuza, ukujiya kwegazi, ukuphazamiseka kwemfuza