Ngaba wakha waphawula ukuba inkumbulo kamama, katata, kamakhulu, okanye katatomkhulu wakho iyancipha kancinci kancinci njengoko bekhula? Ngamanye amaxesha, nokulibala amagama nokungakwazi ukufumana indlela yabo yokuya ekhaya kunokuba yinto eyoyikisayo nexhalabisayo, akunjalo? Xa ucinga ukuba oku kukuqala kwesifo esifana ne-Alzheimer's, kwaye xa ucinga ngovavanyo ekufuneka uye esibhedlele ukuze uqinisekise ukuba kunjalo, kuvakala kunzima. Kodwa khawucinge ukuba bekuya kuba lula kangakanani ukuba bekukho indlela yokuthatha ithontsi elincinci legazi emnweni wakho ekhaya kwaye ufunde ulwazi olubalulekileyo malunga nesi sifo kuso. Yiloo nto sithetha ngayo namhlanje, uphando olutsha olusinika ithemba.
Yintoni le mva nje yovavanyo lwegazi?
Ngamafutshane, yindlela elula kakhulu, njengokuthatha ithontsi legazi elivela kwiminwe yakho ukuze kuvavanywe isifo seswekile. Xa sixilonga isifo sika-Alzheimer, sikhangela iintlobo ezithile zeeproteni (umzekelo , i-amyloid ) ezifakwa engqondweni. Ezi sizibiza ngokuba zii-biomarker . Okwangoku, nangona sithatha isampuli yegazi ukulinganisa ezi biomarker, yinkqubo enzima kakhulu.
Le ndlela yangoku ifuna ukuba igazi lithathwe emthanjeni, lithuthwe liye kwilebhu phantsi kolawulo lobushushu olukhethekileyo, kwaye ngexesha elithile. Isampuli yegazi kufuneka ijikeleziswe ngesantya esiphezulu (i-centrifugation) ukuze kwahlulwe izinto kwaye igcinwe kwiifriji. Oku kufuna izixhobo ezikhethekileyo, abasebenzi abaqeqeshiweyo, kunye neendleko eziphezulu. Oku kwenza kube nzima kubantu abaninzi ukwenza olu vavanyo.
Kodwa olu phando lutsha lufumanise ukuba, ngaphandle kobunzima obunjalo, ithontsi elincinci legazi elithathwe kwincam yomnwe lingathambisa ikhadi elikhethekileyo (ikhadi legazi), lishiywe lome kubushushu begumbi, lize lithunyelwe kwilabhoratri ngeposi eqhelekileyo. Hayi umahluko, akunjalo?
Luchane kangakanani olu vavanyo?
Umbuzo ophambili esijongene nawo ngalo naluphi na uvavanyo olutsha ngulo, "Inokuthenjwa kangakanani le nto?" Ukuze bafumane impendulo, abaphandi basebenzise amavolontiya angama-77 afike kwikliniki yenkumbulo eSpain.
Bathathe iisampulu zegazi kumntu ngamnye kwaba bantu ngeendlela ezimbini:
1. Indlela yesintu: Ukuthatha igazi emthanjeni.
2. Indlela entsha: Thabatha ithontsi legazi kwincam yomunwe wakho.
Xa sisiya nzulu ngakumbi, abangama-28 kwaba bantu bathathe iisampulu zolwelo lwe-cerebrospinal ezithathwe ebuchotsheni nakwi-spinal cord. Olu vavanyo luthathwa njengo "mgangatho ogqwesileyo" wokufumanisa isifo se-Alzheimer. Oko kukuthi, lolona vavanyo lubalaseleyo lokuba iziphumo zichanekile na.
Isampuli yegazi leminwe ethathwe ngolu hlobo ithunyelwe kwilebhu yophando eSweden ubusuku bonke, ngaphandle kwefriji.
Iziphumo ziyamangalisa ngokwenene. Kukho ukuvumelana okukhulu phakathi kolwazi olufunyenwe kwisampulu yegazi yesiqhelo yemithambo yegazi kunye nolwazi olufunyenwe kwisampulu yegazi elula ethathwe kwincam yomnwe.Baqinisekisile ukuba ikho.
Ngamafutshane, olu phando lubonise ukuba ulwazi olufanayo olunokufunyanwa ngaloo nkqubo inzima nebiza kakhulu lunokufunyanwa ngale ndlela ilula nelula.
Makhe sijonge umahluko phakathi kwezi ndlela zimbini kwitheyibhile.
| Uphawu | Indlela yendabuko ekhoyo | Uvavanyo olutsha lweminwe olucetywayo |
|---|---|---|
| Indawo yokuqokelelwa kwegazi | Ngokusebenzisa umthambo (iVein) | Incam yeminwe |
| Indawo efunekayo | Isibhedlele okanye ilebhu | Naphi na (nokuba sekhaya) |
| Ukugcina kunye nokuthuthwa | Ulawulo lwefriji/lobushushu lubalulekile. | Kwiqondo lobushushu begumbi, kwikhadi elomileyo |
| Ubunzima | Iphezulu kakhulu (ifuna izixhobo ezikhethekileyo kunye noqeqesho) | Iphantsi kakhulu (kwanesigulana siyakwazi ukuzenzela ngokwaso) |
Ziziphi iingenelo eziphambili zale ndlela?
Ukuba olu vavanyo luqinisekiswa luphando olongezelelekileyo, kwaye luza kwiikliniki zethu kwixesha elizayo, iingenelo oluza kuzizisa azinakucingelwa.
- Ukukwazi ukubona isifo kwangethuba:Umntu oneengxaki zokukhumbula unokukhawuleza afumane uvavanyo olulula olufana nolu ngaphandle kokuya esibhedlele aze alinde uvavanyo oluntsonkothileyo. Okukhona isifo sifunyanwa ngokukhawuleza, kokukhona amathuba onyango oluphumelelayo esanda.
- Ubuchule bokuvavanya ukude: Khawuthelekelele ukuba ugqirha wakho ebenokukunika uvavanyo lwememori olukwi-intanethi aze kwangaxeshanye akucele ukuba ugcwalise kwaye uthumele eli khadi lokuqokelelwa kwegazi eliza kuthunyelwa ekhaya? Oku bekuya kuba lula kangakanani kwabo bahlala kwiindawo ezikude abanengxaki yokuya ezibhedlele?
- Ukubeka esweni impendulo kunyango: Le yeyona nto ibalulekileyo. Iindidi ezintsha zamayeza anokulawula ukuqhubela phambili kwesifo sika-Alzheimer ngoku ziyaziswa kwihlabathi liphela. Umntu othatha iyeza elinjalo angenza olu vavanyo ekhaya, nokuba yiveki nganye, ngaphandle kokulinda ukuza ekliniki rhoqo kwiinyanga ezi-6, kwaye ugqirha unokujonga indlela eli yeza elichaphazela ngayo umzimba. Ngoko ke, kukho ithuba lokutshintsha unyango ukuze lufanele isigulana ngasinye (amayeza obuqu).
- Ukuxilongwa okuphuculweyo: Ngamanye amaxesha, ukuxilongwa kwesifo ngokusekelwe kwiimpawu zodwa kunokukhohlisa. Kodwa uvavanyo oluchanekileyo lwe-biomarker olufana nolu luvumela oogqirha ukuba baxilonge isifo ngokuchanekileyo baze banike unyango olufanelekileyo .
Ngaba kukho izinto esisafuna ukuzixhalabela?
Ngezo ndaba zimnandi zonke, kufuneka sikhumbule into enye. Olu luluphononongo oluyimvavanyo . Nangona iziphumo zikhuthaza kakhulu, kufuneka ziphindwe kwizifundo ezinkulu ngaphambi kokuba le ndlela isetyenziswe njengovavanyo oluqhelekileyo kwihlabathi liphela.
Kwakhona, xa isigulana senza olu vavanyo sodwa ekhaya, kunokuba nzima ngandlela thile ukuqinisekisa ukuba lwenziwa ngokuchanekileyo.
Ngoko ke, nangona oku kusinika ithemba elikhulu ngekamva, akulona uvavanyo olusele lufumaneka kwizibhedlele zethu.
Umyalezo Wokuya Ekhaya
- Uphando luyaqhubeka kuvavanyo olutsha olusebenzisa ithontsi elilula legazi elithathwe kwincam yomunwe ukuze kufunyanwe isifo se-Alzheimer.
- Le ndlela ilula kakhulu kunendlela yangoku enzima nebiza kakhulu, kwaye ayifuni zixhobo zikhethekileyo zokukhenkcisa.
- Ukuba olu vavanyo luphumelele, luya kuba luncedo olukhulu ekufumaneni isifo kwangethuba, ukujonga izigulane kude, kunye nokulinganisa impumelelo yonyango.
- Oku kusesekwinqanaba lophando, kwaye kuza kuthatha ixesha ngaphambi kokuba kusetyenziswe ngokubanzi.
- Ukuba wena okanye umntu osondeleyo kuwe uneengxaki zenkumbulo, nantsi into omawuyenze:Eyona nto ibalulekileyo kukubona ugqirha wakho ngoko nangoko ukuze nixoxe ngale nto. Angakunika iingcebiso kunye nonyango olufanelekileyo olufumanekayo.
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