Masifunde ngeHuman Growth Hormone (HGH) ngokulula.

Ngaba uvakalelwa kukuba umntwana wakho akakhuli ngendlela afanele ukuba mde ngayo? Okanye uhlala uziva udiniwe kwaye udiniwe? Mhlawumbi isizathu soku sisithunywa sekhemikhali esincinci emzimbeni wakho. Enye ye-hormone ebalulekileyo ekukhuleni kwemizimba yethu kunye nezinye izinto ezininzi ibizwa ngokuba yi -human growth hormone . Siyibiza ngokuba yi -HGH (Human Growth Hormone) ngamafutshane. Abanye bayibiza ngokuba yi -somatotropin . Ke namhlanje, masithethe ngale HGH ngokweenkcukacha, ngokulula.

Yintoni i-HGH? Yenziwa njani emizimbeni yethu?

Ngamafutshane, i-HGH yi-hormone yendalo eveliswa yimizimba yethu. Iveliswa yi-gland encinci engaphantsi kwengqondo yethu, malunga nobukhulu bethambo elincinci. Siyibiza ngokuba yi-pituitary gland . Le hormone ye-HGH ichaphazela iindawo ezininzi zomzimba wethu. Ibaluleke kakhulu ekukhuleni kwabantwana . I-HGH inceda kakhulu kwizinto ezifana nokwenza umntwana wakho abe mde kwaye aqinise amathambo akhe.

Nangona kunjalo, xa sikhulile, oko kukuthi, emva kokuba iipleyiti zokukhula emathanjeni ethu (ii-epiphyses) zivaliwe, i-HGH ayisasenzi sibe bade. Kodwa ayikuko konke okwenziwa yi-HGH. Kwanasemva kokuba sikhulile, i-HGH inceda ukugcina ulwakhiwo oluqhelekileyo lwemizimba yethu kwaye igcine imetabolism yethu isebenza ngokufanelekileyo. Le metabolism yiyo eguqula ukutya esikutyayo ibe ngamandla. I-HGH ikwanceda ukugcina amanqanaba eswekile yegazi (iglucose) kwinqanaba elithile.

Iihormone ziikhemikhali emizimbeni yethu. Zisebenza njengabathunywa. Zihamba ngegazi zize zixelele amalungu ethu, izihlunu, kunye nezinye izicwili zethu into ekufuneka siyenze kunye nexesha ekufuneka siyenze ngalo. Kukho iihormone ezingaphezu kwama-50 emizimbeni yethu!

I-pituitary gland endikhankanyileyo ngaphambili ikwisiseko sobuchopho, ngaphantsi kwe -hypothalamus . Le hypothalamus ilawula izinto ezininzi ezifana noxinzelelo lwegazi, isantya sentliziyo, ubushushu bomzimba, kunye nokugaya ukutya. Ngoko ke, le hypothalamus yiyo exelela i-pituitary gland ukuba ikhuphe i-HGH. I-hormone enceda ngaloo nto ibizwa ngokuba yi -GHRH (i-growth hormone-releasing hormone) . Kwakhona, enye i-hormone (somatostatin) ivela kwi-hypothalamus ukuze iyeke ukukhutshwa kwe-HGH. Le yindlela i-HGH elawulwa ngayo.

Ngamanye amaxesha oogqirha basebenzisa i-HGH yokwenziwa ukunyanga izifo ezithile. Kodwa khumbula, ungaze usebenzise i-HGH yokwenziwa ngaphandle kwemvume kagqirha.

Ziziphi izinto ezichaphazela ukukhutshwa kwe-HGH?

I-pituitary gland yethu idla ngokukhupha i-HGH ngobuninzi bayo imini yonke, ebizwa ngokuba yi-pulses . Oku kulawulwa ikakhulu ziihomoni ezimbini ezivela kwi-hypothalamus ebizwa ngokuba yi-GHRH kunye ne-somatostatin.

Ayipheleli apho, kodwa nezinye iihomoni ziyabandakanyeka. Umzekelo,I-insulin-like growth factor 1 (IGF-1) yehlisa imveliso ye-HGH, ngelixa ii-hormone ezifana ne -thyroxine , i-glucocorticoids , kunye ne -ghrelin zonyusa ukukhululwa kwe-HGH.

I-IGF-1, ekhutshwa sisibindi sethu, yimveliso ephambili yomsebenzi we-HGH. Le IGF-1 yiyo elawula ukuveliswa okugqithisileyo kwe-HGH. Oko kukuthi, i-HGH ibangela ukuba kuveliswe i-IGF-1, kwaye i-IGF-1 eveliswayo iphinda inciphise ukuveliswa kwe-HGH. Kufana nomjikelo.

Kumntu ophilileyo, ukukhululwa kwe-HGH kuthintelwa ngamanqanaba aphezulu eswekile egazini (i-hyperglycemia) . Ukongeza, ukukhululwa kwe-HGH kukhuthazwa zizinto ezifana nokulala, uxinzelelo, umthambo, amanqanaba aphantsi eswekile egazini (i-hypoglycemia) , kunye nee-amino acids .

Ziziphi imisebenzi ephambili ye-hormone ye-HGH?

I-HGH inemisebenzi emibini ephambili:

1. Ukukhuthaza ukukhula (ingakumbi ebantwaneni)

2. Ukuchaphazela imetabolism (indlela esiguqula ngayo ukutya esikutyayo kube ngamandla)

I-HGH kunye nokukhula

I-HGH inceda zonke izicwili kunye namalungu omzimba wethu ukuba akhule. Kodwa idume kakhulu ngokunceda i-cartilage kunye namathambo akhule. Oku kubaluleke kakhulu ngexesha lokufikisa. Iiseli ezibizwa ngokuba zii-chondrocytes kwi-cartilage kunye ne -osteoblasts emathanjeni zifumana imiqondiso evela kwi-HGH ukuze zahlukane kwaye zikhule zibe nkulu.

Nangona kunjalo, njengoko benditshilo ngaphambili, i-HGH ayinyusi ubude emva kokuba ii-growth plates (ii-epiphyses) emathanjeni omntwana zivaliwe. Endaweni yoko, i-HGH inceda ukugcina ulwakhiwo lomzimba oluqhelekileyo ubomi bonke.

I-HGH kunye ne-metabolism

I-metabolism yinkqubo yeekhemikhali eguqula ukutya esikutyayo kube ngamandla. Yonke iseli emzimbeni wethu ifuna amandla ukuze isebenze kakuhle.

I-HGH ichaphazela imetabolism ikakhulu ngokunyusa imveliso ye-IGF-1, etshintsha indlela echaphazela ngayo iiseli zomzimba wethu. I-IGF-1 yihomoni enesakhiwo esifana ne -insulin . I-insulin yihomoni ebalulekileyo eveliswa yipancreas yethu ehlisa amanqanaba eswekile yegazi (i-glucose) . I-IGF-1 ikwanako nokunciphisa iswekile yegazi.

Ngokwesiqhelo, imizimba yethu ilawula ngononophelo amanqanaba eglucose egazini lethu. Iglucose egazini, okanye iswekile, lolona hlobo luphambili lweswekile egazini lethu. Siyifumana ekutyeni okune-carbohydrate esikutyayo. Le swekile yiyo enika amandla kumalungu ethu, kwimisipha, nakwinkqubo yemithambo-luvo.

I-insulin yeyona hormone iphambili ehlisa iswekile yegazi xa iphezulu. Kwaye i-hormone i-glucagon inyusa iswekile yegazi xa iphantsi. Nangona kunjalo, i-HGH idla ngokunyusa iswekile yegazi xa iphantsi. Nangona kunjalo,Ukuba ubungakanani be-HGH emzimbeni wakho buyanda kakhulu, bunokuphazamisana nesenzo se-insulin kwaye bubangele ukuba amanqanaba eswekile egazini anyuke.

Ngaba i-HGH ikwenza ube mde ngokwenene?

Ewe, i-HGH inokunyusa ubude babantwana. Kodwa oko kwenzeka ngaphambi kokuba iipleyiti zokukhula emathanjeni abo zihlangane. I-HGH ayinakukwenza ube mde emva kokuba iipleyiti zokukhula zidibene. Endaweni yoko, emva kokuba ufikelele kubude bakho obuphezulu, i-HGH inceda ekugcineni ulwakhiwo lomzimba wakho kunye nemetabolism.

Zithini iinqanaba eziqhelekileyo zeHGH?

Njengoko benditshilo ngaphambili, i-pituitary gland ikhupha i-HGH ngokuqhuma imini yonke. La manqanaba ayahluka ngokuxhomekeke kwixesha losuku, ubudala, kunye nesini. Ke ngoko, uvavanyo olunye lwegazi lokulinganisa i-HGH aluluncedo kakhulu ekuxilongeni imeko. Endaweni yoko, oogqirha bajonga amanqanaba e-HGH ngokusebenzisa iimvavanyo ezikhethekileyo (uvavanyo lokukhuthaza okanye lokunciphisa).

Amanqanaba aqhelekileyo e-HGH ngala alandelayo:

• Amadoda amadala: 0.4 ukuya 10 nanograms ngemililitha nganye (ng/mL)
• Abafazi abadala: 1 ukuya kwi-14 nanograms nge-milliliter (ng/mL)
• Abantwana: iinanogram ezili-10 ukuya kuma-50 ngemililitha nganye (ng/mL)

Kodwa khumbula, la maxabiso anokwahluka kancinci kwilabhoratri nganye. Ngoko ke thelekisa la maxabiso noluhlu oluqhelekileyo kwingxelo yakho yelabhoratri. Ukuba uneengxaki, qiniseka ukuba uthetha nogqirha wakho.

Kwenzeka ntoni ukuba amanqanaba e-HGH ehla? (Ukunqongophala kweHormone yoKhula)

Xa amanqanaba e-HGH esezantsi kunesiqhelo, siwabiza ngokuba yi -Growth Hormone Deficiency . Oku kudla ngokubangelwa yingxaki ethile okanye umonakalo kwi-pituitary gland. Oku kunokukhokelela kwimeko ebizwa ngokuba yi -hypopituitarism . Oku kuthetha ukuba i-hormone enye okanye ezingaphezulu eziveliswa yi-pituitary gland ziyancitshiswa. I-HGH ikwayi-hormone enokuchaphazeleka ngale ndlela.

Oku kunqongophala kwe-HGH kuchaphazela abantu abadala nabantwana ngeendlela ezahlukeneyo.

Ukuba amanqanaba e-HGH ehla kubantu abadala:

Ukuba amanqanaba e-HGH kumntu omdala ehla, ezi ngxaki zilandelayo zinokwenzeka:

• Ukuncipha kolonwabo nolwaneliseko ebomini.
• Ukwanda kwamafutha emzimbeni.
• Umngcipheko okhulayo wesifo sentliziyo.
• Ubuthathaka bentliziyo, izihlunu kunye namathambo.

Kubantu abadala, le meko inokubangelwa yi -pituitary adenoma (oku akusiso umhlaza, kodwa sisimila) okanye umonakalo kwi-pituitary gland/hypothalamus.

Ukuba abantwana bane-HGH ephantsi:

Ukuba amanqanaba e-HGH omntwana ehla, ukukhula kuya kudodobala. Uphawu oluphambili kukunyuka kancinci kobude emva kokuzalwa komntwana okwesithathu. Oko kukuthi, ngaphantsi kwe-1.4 intshi ngonyaka. Umzekelo, ukuba umntwana wakho ubonakala mfutshane kakhulu kunabanye abantwana eklasini, kufuneka ukhathazeke.

Ukongeza, umntwana onesifo se-HGH unokuba neempawu ezifana nezi:

• Ubuso obubonakala buncinci kakhulu kunobudala balo.
• Ukukhula kweenwele okungahambi kakuhle.
• Ukufikisa okulibazisekileyo.

Abantwana banokuzalwa benale meko. Ngamanye amaxesha imbangela ayaziwa (idiopathic), ingaba yimfuza, okanye inokubangelwa kukonakala kwe-pituitary gland ngexesha lokukhulelwa okanye ekuzalweni. Ngamanye amaxesha inokubangelwa nangumonakalo kwi-pituitary gland okanye kwi-hypothalamus kamva ebomini.

Kuthekani ukuba amanqanaba e-HGH ayanda?

Imeko ephambili enxulunyaniswa namanqanaba aphezulu e-HGH kunesiqhelo yi -acromegaly . Oku kuchaphazela abantu abadala nabantwana ngeendlela ezahlukeneyo. Yimeko engaqhelekanga kakhulu.

I-Acromegaly kubantu abadala

Abantu abadala abane-acromegaly badla ngokuba nezandla neenyawo ezinkulu okanye ezidumbileyo kunye notshintsho kwimbonakalo yobuso .

Basenokuba namathambo atyebileyo kunye nezitho zangaphakathi ezinkulu. Banamathuba amaninzi okuba neemeko ezifana noxinzelelo lwegazi , isifo seswekile sohlobo lwesibini, kunye nesifo sentliziyo. Ngaphezulu kwe-99% yeemeko ze-acromegaly zibangelwa zizilonda ezingezizo zomhlaza kwi-pituitary gland ezibizwa ngokuba yi-pituitary adenomas . Ezi zilonda zinokuvelisa i-HGH eninzi kakhulu. I-Acromegaly ixhaphake kakhulu emva kweminyaka ephakathi, emva kokuba ukukhula kugqityiwe. Ke ngoko, abantu abadala abane-acromegaly abakhuli bade. Endaweni yoko, amathambo abo anokutyeba.

I-Acromegaly (i-Gigantism) ebantwaneni

Kunqabile kakhulu ukuba abantwana babe namanqanaba aphezulu e-HGH ngaphambi kokuba bafikelele kubude babo obupheleleyo. Oku kunokubangela ukukhula okugqithisileyo kwamathambo amade, okukhokelela kubantwana abade ngokungaqhelekanga. Le meko ibizwa ngokuba yi -juvenile acromegaly . Ngamanye amaxesha ibizwa ngokuba yi-gigantism . Ukuba ayinyangwa, aba bantwana banokukhula babe ziimitha ezimbini okanye ngaphezulu. Banokufumana neempawu ezifana nokudinwa, ukufikisa okulibazisekileyo, kunye nentloko ebuhlungu.

Oku kudla ngokubangelwa yi-pituitary adenoma.

Amanqanaba e-HGH alinganiswa njani?

Ukuba wena okanye umntwana wakho nineempawu ezibonisa ukuba uneengxaki ezinxulumene ne-HGH, ugqirha wakho unokuyalela uvavanyo lwegazi oluninzi ukujonga amanqanaba akho e-HGH.

Njengoko benditshilo ngaphambili, i-pituitary gland ikhupha i-HGH egazini imini yonke kwaye ngamaxesha athile ebusuku. Ke ngoko, kunzima ukuyiqonda ngokuchanekileyo imeko ngokuthatha igazi nokujonga i-HGH kube kanye kuphela.

Ngoko ke, oogqirha badla ngokusebenzisa iindlela ezibizwa ngokuba kukukhuthaza ukukhula kwehomoni kunye novavanyo lokucinezela ukuze kuchongwe iimeko ezibangelwa kukungabikho kwe-HGH okanye ukugqithisa.

Ukongeza, uvavanyo lwegazi lunokwenziwa ukujonga amanqanaba e -IGF-1 (i-insulin-like growth factor 1) .

I-HGH isetyenziswa njani njengeyeza?

I-United States Food and Drug Administration (FDA) ivumile i-HGH yokwenziwa ukunyanga iimeko ezithile. Le HGH yokwenziwa inokufumaneka kuphela ngomyalelo kagqirha, kwaye inikwa njengenaliti.

I-HGH imiselwe abantwana kwezi meko zilandelayo:

• Ukungabikho kwehomoni yokukhula.
• Iimeko ezibangela ukuba umntu abe mfutshane, ezifana nesifo sezintso esinganyangekiyo , i-Turner syndrome , kunye ne -Prader-Willi syndrome .

I-HGH imiselwe abantu abadala kwezi meko zilandelayo:

• Ukungabikho kwehomoni yokukhula.
• Ukulahlekelwa bubunzima bemisipha ngenxa ye -HIV .
• Isifo samathumbu amafutshane .

Kubaluleke kakhulu: Ungaze usebenzise i-HGH yokwenziwa ngaphandle kokuba ugqirha wakho ekunike yona.

Zithini iziphumo ebezingalindelekanga ze-HGH yokwenziwa?

Ezinye iziphumo ebezingalindelekanga zinokwenzeka xa kusetyenziswa i-HGH yokwenziwa njengonyango lwezonyango. Nazi:

• I-Carpal tunnel syndrome (umthambo ocinezelweyo esihlahleni).
• Ukwanda kokumelana ne-insulin kunye/okanye isifo seswekile sohlobo lwesibini.
• Ukudumba kwezandla neenyawo (i-edema) .
• Intlungu yamalungu kunye nemisipha.
• Ukwanda kwezicubu zebele kumadoda (i-gynecomastia) .
• Umngcipheko okhulayo wezinye iintlobo zomhlaza.

Abaphandi abasenalo ulwazi olwaneleyo malunga nemiphumo yexesha elide yonyango lwe-HGH oludibeneyo.

Ndifanele ndimbone nini ugqirha malunga namanqanaba e-HGH?

Ukuba wena okanye umntwana wakho nineempawu ezinxulumene nokungabikho kwe-HGH okanye ukugqithisa (umz., ukukhula kancinci, ukwandiswa kwamalungu omzimba), qiniseka ukuba ubona ugqirha wakho.

Ukuba sele unyangwa ngenxa yokungaqheleki kwamanqanaba e-HGH, kubaluleke kakhulu ukubona ugqirha wakho rhoqo ukuqinisekisa ukuba unyango lwakho lusebenza kakuhle.

I-HGH yihomoni enamandla ebaluleke kakhulu kwiinkqubo ezininzi ezibalulekileyo emzimbeni wethu. Ngamanye amaxesha i-pituitary gland yethu inokwenza okuninzi okanye okuncinci kakhulu. Ukuba wena okanye umntwana wakho unezinye zezi mpawu, kungcono ukuthetha nogqirha. Bakhona ukukunceda.

Umyalezo Wokugqibela Wokuya Ekhaya

Kulungile, ngoko ke sithethe kakhulu nge-HGH namhlanje, akunjalo? Masiphinde sichaze ngokufutshane:

• I-HGH yi-hormone ebaluleke kakhulu ekukhuleni kwethu, ingakumbi ngexesha lobuntwana, nakwimetabolism yomzimba wethu.
• Oku kuveliswa yi-pituitary gland esebuchotsheni bethu.
• Ukuba amanqanaba e-HGH ayancipha, abantwana banokuba nokukhula okukhawulezileyo, kwaye abantu abadala banokuba neengxaki ezahlukeneyo zempilo.
• Ukuba amanqanaba e-HGH ayanda, iimeko ezifana ne-acromegaly zinokwenzeka.Kubantwana, oku kunokubonakala njengobugorha, nto leyo ethetha ukukhula ngokungaqhelekanga.
• Ukuba ukrokrela ukuba wena okanye umntwana wakho unokuba nengxaki nge-HGH, ungathandabuzi ukufuna ingcebiso kagqirha.
• Ungaze usebenzise i-HGH yokwenziwa ngaphandle kwemvume kagqirha.

Khumbula, konke oku kwenzelwe ukukufundisa. Ukuba uneengxaki zempilo, ngugqirha wakho kuphela onokukunika isisombululo esifanelekileyo. Hlala usempilweni!

IHormone Yokukhula Komntu , iHGH, iGland yePituitary, Ukukhula Komntwana, Ukwanda Kobude, iMetabolism, Ukungalingani Kwehomoni