Masifunde ngeepilisi ze-Imatinib? Zincede ekulweni kwakho nomhlaza!

Ngaba wena okanye umntu omaziyo wakha walwa nomhlaza? Ngamaxesha anjalo, oogqirha basinika amayeza ahlukeneyo, akunjalo? I-Imatinib liyeza elikhethekileyo elinceda ukulawula iiseli zomhlaza ezinjalo. Makhe sithethe ngeli yeza ngokweenkcukacha namhlanje, akunjalo?

Luhlobo luni lonyango oluyi-Imatinib?

Ngamafutshane, i-Imatinib liyeza eliphambili elijolise kwiiseli zomhlaza kwaye linceda ekumiseni ukukhula kwazo. Njengesixhobo sokudubula, ijolise kwiiproteni ezithile kwiiseli zomhlaza ngelixa igcina iiseli ezisempilweni kangangoko kunokwenzeka. Oku kucothisa iiseli zomhlaza ekubeni zahlukane kwaye zisasazeke.

Elinye igama lale chiza elithengiswayo yiGleevec . Ugqirha wakho angalibiza eli chiza ngeli gama.

Zeziphi izifo ezisetyenziselwa eli yeza?

Eli yeza, elibizwa ngokuba yi-Imatinib, lisetyenziswa kakhulu ukunyanga iintlobo ezithile ze -leukemia , ezizii-cancer ezikhula egazini. Ukongeza, li:

• I-Myelodysplastic Syndromes zizifo ezinxulumene nomongo wethambo.
• Kwezinye iintlobo zomhlaza.
• Ikwasetyenziswa kwiintlobo ezikhethekileyo zeethumba ezikhula kwinkqubo yethu yokugaya ukutya (oko kukuthi, amathumbu), ezibizwa ngokuba yi-GISTs (Gastrointestinal Stromal Tumors) .

Kodwa khumbula, oogqirha ngamanye amaxesha banokulisebenzisa eli yeza kwezinye iimeko, ngoko ke ukuba unemibuzo malunga nokuba kutheni unikwe eli yeza, kungcono ukubuza ugqirha wakho okanye ikhemisti.

Zeziphi izinto ekufuneka uzixelele ugqirha ngaphambi kokuba usebenzise amayeza?

Ngaphambi kokuba uqale ukuthatha i-Imatinib, kukho izinto ezimbalwa ekufuneka uzixelele ugqirha wakho. Ukuba awumxeleli, zisenokungakulungeli, okanye zinokubangela ezinye iingxaki. Ngoko ke qiniseka ukuba umxelele:

• Ukuba unengxaki yokopha.
• Ukuba okwangoku unayo nayiphi na intsholongwane - ingakumbi intsholongwane efana ne-chickenpox kunye ne-herpes.
• Ukuba unesifo sentliziyo okanye ukusilela kwentliziyo.
• Ukuba unesifo sezintso.
• Ukuba unesifo sesibindi.
• Ukuba unesifo semiphunga.
• Ukuba uneengxaki zesisu.
• Ukuba ukhe waba ne-allergy kwi-Imatinib ngaphambili, okanye nakweyiphi na enye iyeza, ukutya, iidayi, okanye izithinteli.
• Ukuba ukhulelwe okanye uzama ukukhulelwa.
• Ukuba ungumama oncancisayo.

Kubaluleke kakhulu ukuze ukhuseleke ukunika ugqirha olu lwazi!

Ungayisebenzisa njani le yeza ngokuchanekileyo?

Kubaluleke kakhulu ukwazi kakuhle indlela yokusebenzisa eli yeza. Ufanele ulandele ngqo oko kuthethwa ngugqirha.

• Le pilisi kufuneka ithathwe neglasi enkulu yamanzi . Musa ukuyithatha nenani elincinci lamanzi.
• Kungcono ukuyithatha kunye nokutya. Oku kunokunceda ekunciphiseni ukucaphuka kwesisu kunye nokucaphuka.
• Musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit nangasiphi na isizathu. Ijusi yegrapefruit inokuphazamisa ukusebenza kweli yeza.
• Sela amayeza kanye njengoko ugqirha wakho ekuyalele, ngexesha elifanelekileyo, ngomlinganiselo ofanelekileyo. Ungaze uthathe ngaphezu koko ugqirha akuxelele kona, okanye uwasele rhoqo.
• Musa ukuyeka ukuthatha eli yeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho.

Abanye abantu banengxaki yokuginya iipilisi, akunjalo? Ukuba unengxaki enjalo, thetha nogqirha wakho, usokhemesti, okanye ingcali yezempilo. Banokukunceda ngaloo nto. Kusenokubakho iindlela zokunyibilikisa ipilisi emanzini uze uyisele, kodwa oko kufanele kwenziwe kuphela phantsi kwengcebiso kagqirha.

Kuthekani ukuba eli yeza linikwa abantwana...?

Ewe, kwezinye iimeko ezikhethekileyo, i-Imatinib inokunikwa abantwana abaneminyaka eli-1 ubudala. Kodwa oko kugqitywa ngugqirha wabantwana. Kukho izinto ezimbalwa ekufuneka uzilumkele xa uzinika abantwana. Ke ngoko, ukuba unika umntwana eli yeza, kubalulekile ukuthetha nogqirha ngalo uze umchazele yonke into.

Wenza ntoni ukuba usela amayeza amaninzi ngempazamo?

Ukuba oko kuyenzeka, oko kukuthi, ukuba ucinga ukuba uthathe okungaphezulu kunokuba ubucinga, kuya kufuneka ufowunele iziko lokulawula ityhefu ngokukhawuleza okanye kwigumbi likaxakeka lesibhedlele esikufutshane. Musa ukuchitha ixesha. Eli liyeza elinikiweyo, ungalabelani nabani na.

Wenza ntoni ukuba uphoswe yintlanganiso yamayeza?

Ukuba ngempazamo ulibele ukuthatha idosi, yithathe kwangoko xa ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha ledosi yakho elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini ukuze ubuyisele idosi oyilibeleyo. Ukwenza njalo kunokunyusa inani lamayeza owathathayo.

Ngawaphi amanye amayeza anokusebenza kunye nale mithi?

Oku kubaluleke kakhulu . I-Imatinib inokunxibelelana namanye amayeza owasebenzisayo. Oku kuthetha ukuba xa isetyenziswa kunye naloo mayeza, iziphumo ze-Imatinib zinokutshintsha, okanye iziphumo zamanye amayeza zinokutshintsha, okanye iziphumo ebezingalindelekanga zinokunyuka.

Ngoko ke, xa uthatha i-Imatinib, kufuneka uxelele ugqirha wakho ngawo onke amayeza owathathayo (achazwe ngugqirha wakho, lawo uwathengayo kwikhemesti, amayeza esintu, iimveliso zezityalo, iivithamini). Kufuneka uxelele ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi.

I-Imatinib inokusebenzisana namayeza alandelayo:

• Amanye amayeza okulwa neentsholongwane ze -HIV okanye i-AIDS
• IBosentan
• I-Cisapride
• IClarithromycin
• I-Cyclosporine
• I-Dexamethasone
• I-Diltiazem
• Ii-alkaloids ze-Ergot (umz., i-dihydroergotamine, i-ergonovine, i-ergotamine, i-methylergonovine)
• I-Erythromycin
• Ijusi yegrapefruit okanye igrapefruit - Njengoko bekutshiwo ngaphambili, oku kufanele kuphetshwe ngokuqinisekileyo.
• Amayeza okunciphisa i-cholesterol (umz. i-atorvastatin, i-lovastatin, i-simvastatin)
• Amayeza okudakumba, ixhala, okanye ukugula ngengqondo
• Amayeza okulwa nefungus (umz. i-ketoconazole, i-itraconazole)
• Amayeza okubetha kwentliziyo ngendlela engacwangciswanga (umz. i-amiodarone, i-bepridil, i-dofetilide, i-encainide, i-flecainide, i-propafenone, i-quinidine)
• Amayeza okuxhuzula (umz. i-carbamazepine, i-phenobarbital, i-phenytoin)
• Iipilisi zokulala
• Ii-NSAID (umzekelo, ibuprofen, naproxen)
• I-Pimozide
• I-Rifabutin
• I-Rifampin
• I-Sildenafil
• ISirolimus
• Imifuno yeSt. John's wort
• I-Tacrolimus
• Isitofu
• I-Verapamil
• I-Warfarin - iyeza elithintela ukujiya kwegazi

Olu luhlu aluphelelanga. Kungoko ke , kungcono ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo. Ingakumbi thetha nogqirha wakho ngaphambi kokuba usebenzise amayeza anjenge-paracetamol, i-aspirin, i-ibuprofen, i-ketoprofen, kunye ne-naproxen.

Zeziphi izinto ekufuneka uzilumkele xa usebenzisa amayeza?

Ugqirha wakho uza kujonga impilo yakho rhoqo ngelixa usela i-Imatinib. Oku kuza kuquka uvavanyo lwegazi rhoqo ukuze kubonwe indlela eli chiza elichaphazela ngayo umzimba wakho kunye nokuba kukho naziphi na iziphumo ebezingalindelekanga. Ukuba ufumanisa naziphi na iimpawu ezintsha, kufuneka uxelele ugqirha wakho ngoko nangoko.

Qaphela ukuba kukho iimpembelelo eziqatha ezinokubakho kulusu.

Eli yeza linokubangela ukusabela okukhulu kwesikhumba kwabanye abantu. Oku kungenzeka kwiiveki okanye kwiinyanga emva kokuba uqalile iyeza. Ukuba ufumana irhashalala eluswini enomkhuhlane okanye isifo esifana nomkhuhlane, xelela ugqirha wakho ngoko nangoko.Irhashalala lisenokuba bomvu okanye mfusa, emva koko libe namaqhubu kwaye lixobuke. Okanye, irhashalala ebomvu linokuba kunye nee-lymph nodes ezivuvukileyo ebusweni, emilebeni, entanyeni, okanye emakhwapheni.

Zikhusele kwiintsholongwane

Ukuba uneempawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, okanye umkhuhlane, musa ukuzenza unyango. Fowunela ugqirha wakho ngoko nangoko ukuze ufumane icebiso. Eli yeza linokunciphisa amandla omzimba wakho okulwa nosulelo. Ngoko zama ukuhlala kude nabantu abagulayo kangangoko unako.

Ingozi yokopha

Eli yeza linokukwandisa umngcipheko wakho wokopha okanye ukukrweleka. Xelela ugqirha wakho ukuba ufumana imikrwelo rhoqo, ukopha impumlo, ukopha iintsini xa uhlamba amazinyo akho, okanye naluphi na olunye ukopha okungaqhelekanga.

Ukozela kunye nesiyezi

Eli yeza lingakwenza uzive ulele okanye unesizungu. Ngoko ke, de wazi kakuhle indlela eli yeza elikuchaphazela ngayo, kuphephe ukuqhuba, ukusebenzisa oomatshini, okanye ukwenza nantoni na efuna ukuqwalaselo.

Injani le yeza kumama abakhulelweyo nabancancisayo?

Le yingxaki ebaluleke kakhulu .

• Musa ukukhulelwa ngelixa usebenzisa eli yeza kwaye emva kweentsuku ezili-14 emva kokuyeka ukusebenzisa eli yeza.
• Ukuba umfazi uceba ukukhulelwa, okanye ucinga ukuba ukhulelwe, kufuneka axelele ugqirha wakhe. Eli yeza linokubangela iziphumo ebezingalindelekanga ezibi kakhulu kusana olungekazalwa. Buza ugqirha wakho okanye ikhemisti ukuze ufumane ulwazi oluthe kratya.
• Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza kwaye emva kwenyanga enye uyekile ukusebenzisa eli yeza.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengalo naliphi na iyeza, i-Imatinib inokubangela iziphumo ebezingalindelekanga kwabanye abantu. Asinguye wonke umntu ozifumanayo, kodwa abanye abantu bayazifumana. Ezinye zezi zinto kufuneka uxelele ugqirha wakho ngoko nangoko , ngelixa ezinye zingabi yingozi kangako kwaye ziya kuphela kwiintsuku ezimbalwa. Kodwa ukuba ziyaqhubeka okanye ziyakhathaza, kufuneka uxelele ugqirha wakho .

Iziphumo ebezingalindelekanga ekufuneka uzixelele ugqirha wakho ngoko nangoko:

• Iimpawu ze-allergy: ukurhawuzelela kwesikhumba, ukurhawuzelela okanye ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi.
• Iingxaki zokuphefumla.
• Utshintsho kwimbono.
• Umchamo omnyama.
• Ukuziva ugula okanye iimpawu ezifana nomkhuhlane.
• Izitulo ezinombala okhanyayo.
• Ukulahlekelwa yintliziyo.
• Ukwehla kokubala kwegazi: Eli yeza linokubangela ukwehla kwenani leeseli ezimhlophe zegazi, iiseli ezibomvu zegazi, kunye neeplatelets. Oku kunokunyusa umngcipheko wakho wokufumana usulelo kunye nokopha.
• Izilonda zomlomo.
• Urhawuzelelo, umkhuhlane, kunye nokudumba kwama-lymph nodes.
• Ububomvu, ukudumba, ukuxobuka okanye ukukhululeka kolusu, kwaye ezi zinokwenzeka nangaphakathi emlonyeni.
• Intlungu yesisu esingentla ngasekunene.
• Iimpawu zeeplatelets ezisezantsi okanye ukopha: ukukrweleka, amabala abomvu acacileyo eluswini, umnyama, indle ethambileyo, igazi emchameni, ukopha empumlweni.
• Iimpawu zeeseli ezibomvu zegazi ezisezantsi: ubuthathaka obungaqhelekanga, ukudinwa, ukuquleka, kunye nokuba nomsindo ophantsi.
• Iimpawu zosulelo: umkhuhlane okanye ukubanda, ukukhohlela, umphimbo obuhlungu, iintlungu okanye ubunzima bokuchama.
• Ukudumba kwemilenze okanye amaqatha.
• Ubunzima bokuchama okanye ukutshintsha ubungakanani bomchamo.
• Ukuhlanza.
• Ukutyheli kwamehlo okanye ulusu.

Iziphumo ebezingalindelekanga ezihlala zingadingi nyango (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza):

• Ukuncipha komnqweno wokutya.
• Urhudo.
• Ukungalali (ubunzima bokulala).
• Intloko ebuhlungu.
• Isitshiso sentliziyo.
• Intlungu yamalungu.
• Ukuqaqamba kwemisipha okanye iintlungu.
• Isicaphucaphu.
• Isisu esimoshakele.

Olu luhlu lusenokungabandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga, buza ugqirha wakho ngayo. Ungaxela iziphumo ebezingalindelekanga kwi-FDA (Food and Drug Administration) ku-1-800-FDA-1088 (eSri Lanka, ungazixela kwigunya elifanelekileyo lolawulo lwamayeza ngogqirha wakho).

Ndingaligcina njani eli yeza?

Eli yeza lifanele ligcinwe kude nabantwana . Oko kubaluleke kakhulu.

• Gcina iipilisi kubushushu begumbi, phakathi kwe-15 kunye ne-30 degrees Celsius (59 kunye ne-86 degrees Fahrenheit).
• Yikhusele ekufumeni. Oko kuthetha ukuba ungayigcini kwiindawo ezifumileyo njengegumbi lokuhlambela.
• Gcina ibhotile ivaliwe kakuhle.
• Musa ukusebenzisa amayeza aphelelwe lixesha. Walahle.

Le ncwadana sisishwankathelo kuphela. Isenokungabi nalo lonke ulwazi. Ukuba unemibuzo engaphezulu malunga nale yeza, thetha nogqirha wakho, usokhemesti, okanye ingcali yezempilo.

Umyalezo Wokuya Ekhaya:

Kulungile, ngoko ke, ngokwezinto esizithethileyo nge-Imatinib, kukho izinto ezimbalwa ekufuneka uzikhumbule ngokuqinisekileyo :

• I-Imatinib liyeza elikhethekileyo elinceda ekumiseni ukukhula kweeseli zomhlaza. Lithathe kanye njengoko ugqirha wakho ekuxelela, ngexesha elifanelekileyo, ngomlinganiselo ofanelekileyo.
• Yithathe nokutya namanzi amaninzi. Ungaze uyithathe nejusi yegrapefruit.
• Xelela ugqirha wakho ngazo zonke ezinye iindlela ozithathileyo kunye nazo zonke iimeko zakho zempilo . Oku kubaluleke kakhulu ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa.
• Kuya kufuneka uhlolwe igazi rhoqo. Qaphela utshintsho lolusu, iimpawu zosulelo, kunye nokopha okungaqhelekanga. Ukuba ubona into efana naleyo , xelela ugqirha wakho ngoko nangoko.
• Sithethe ngento omawuyenze ukuba usela amayeza amaninzi okanye uphoswe kukutya, akunjalo? Khumbula ezo zinto.
• Gcina eli yeza kwindawo epholileyo neyomileyo kude nabantwana.

Idabi nomhlaza alilula. Kodwa ngamayeza aphucukileyo anje, nangokulandela imiyalelo kagqirha ngononophelo, uya kufumana amandla amakhulu okuphumelela kweli dabi. Nokuba unengxaki enjani na, ungoyiki ukuthetha nogqirha. Ndikunqwenelela ukuchacha ngokukhawuleza!

imatinib , i-gleevec, umhlaza, i-leukemia, i-GIST, amayeza, iziphumo ebezingalindelekanga