Ngaba wakha waba neentlungu zomqolo ukususela usemncinci, okanye waziva umqolo uqinile xa wawuvuka kusasa? Ngaba iintlungu zibonakala ziphela emva kokuhamba okufutshane okanye xa uqala umsebenzi wakho wosuku? Usenokucinga ukuba le yintlungu nje yomqolo. Kodwa ngamanye amaxesha ezi mpawu zinokuba ziimpawu zokuqala zesifo esibizwa ngokuba yi-Ankylosing Spondylitis, esithetha ngaso namhlanje. Ungakhathazeki, siza kuthetha ngale nto ngokucacileyo nangokulula.
Yintoni kanye kanye i-Ankylosing Spondylitis (AS)?
Ngamafutshane, i-Ankylosing Spondylitis (AS) luhlobo lwe-arthritis. Kodwa ichaphazela ngokukodwa amalungu omqolo wethu . Umqolo wethu wenziwe ngamathambo amaninzi amancinci adibanayo, kwaye amalungu aphakathi kwala mathambo ayavuvukala, adumbe, kwaye abe buhlungu. Ekuhambeni kwexesha, oku kuvutha kunokubangela ukuba amalungu omqolo adibane, kunciphisa ukuguquguquka komqolo.
Iimpawu eziqhelekileyo zesi sifo zezi:
- Intlungu nokuqina komqolo: Oku kuvakala ngakumbi xa uvuka kusasa okanye emva kokuma ixesha elide.
- Ukuncipha kwentlungu ngexesha lokuzilolonga: Okumangalisayo kukuba, intlungu iyanda xa uphumle kwaye iyancipha xa usebenza, njengokuhamba, ukubaleka, okanye ukutsiba.
- Iintlungu kwamanye amalungu: Abanye abantu banokuva iintlungu kumalungu afana nezinqe, amadolo, kunye nezithende.
- Ndiziva ndidiniwe kakhulu.
Esi sifo sidla ngokuqala kubantu abaselula abaphakathi kweminyaka eli-15 nengama-30 ubudala. Yiyo loo nto abantu abaninzi besenokusijonga njengentlungu nje yomqolo.
Ngaba ke ngoko kukho unxibelelwano lwemfuza koku?
Ewe. Le yeyona ngongoma ibalulekileyo kweli nqaku. I-Ankylosing Spondylitis sisifo esidluliselwa kakhulu kwilifa, oko kukuthi, sinefuthe lemfuza . Ukuba umntu kusapho lwakho, oko kukuthi, abazali, abantakwenu, unaso esi sifo, ngoko ke nawe usemngciphekweni omkhulu wokufumana esi sifo kunabanye.
Njengoko izazinzulu ziphanda oku, ziye zagxila kakhulu kwijini enye ethile: ijini ye-HLA-B27 .
Khawucinge nje, ngaphezu kwama-85% ezigulana ezifunyaniswe zine-Ankylosing Spondylitis zifunyenwe zine-gene ebizwa ngokuba yi-HLA-B27. Ngaba oko akubonisi unxibelelwano oluqinileyo phakathi kwesi gene nesi sifo?
Le jini ye-HLA-B27 inceda inkqubo yomzimba wethu yokuzikhusela. Ngamafutshane, iyaziqonda kwaye ilwa nabahlaseli bamanye amazwe njengeentsholongwane kunye neebhaktheriya. Kodwa ngamanye amaxesha, ngenxa yotshintsho kule jini, inkqubo yomzimba yokuzikhusela iyaphazamiseka ize iqale ukuhlasela amalungu asempilweni omzimba wethu, kwimeko enjalo, amalungu omqolo wethu. Izazinzulu zikholelwa ukuba oku kuvutha kubangelwa koku.
Ngaba i-HLA-B27 kuphela enoxanduva loku?
Hayi. Lo ngumbuzo obaluleke kakhulu. Nangona i-HLA-B27 ingumlinganiswa ophambili kweli bali, kukho abanye abadlali abambalwa abaxhasayo. Izazinzulu zithi malunga ne-30% yomngcipheko wemfuza opheleleyo wokufumana esi sifo uvela kwi-HLA-B27 gene. Eminye impembelelo ithonyelwa zezinye ii-gene ezincinci.
Ngenxa yokuba iziphumo zezi jini zincinci, kunzima ukuzichonga nganye nganye. Nangona kunjalo, ezinye iijini ezininzi zichongiwe ngophando olwenziwe ngoososayensi kwihlabathi liphela abaye basebenzisana kwaye babelane ngolwazi.
| Ijini | Ingcaciso elula |
|---|---|
| I-HLA-B27 | Le yeyona jini iphambili. Inxulumene nenkqubo yomzimba yokuzikhusela. Uninzi lwezigulane ze-AS zinale jini. |
| I-ERAP1 | Le yijini ebandakanyekayo ekusebenzeni kwenkqubo yomzimba yokuzikhusela. Iyandisa umngcipheko wesifo xa idityaniswe ne-HLA-B27. |
| IL23R kunye ne -IL1A | Ezi zikwayi-genes ezibandakanyekayo ekuphuhlisweni nasekulawuleni ukudumba emzimbeni. Utshintsho kwezi genes lunokwandisa umngcipheko we-AS. |
Abaphandi basakhangela ezinye ii-genes ezingaziwayo ezinokuthi zichaphazele oku.
Ngaba wonke umntu ufumana esi sifo kuba nje ene-gene?
Hayi. Ngokuqinisekileyo akunjalo.Le yinto ekufuneka uyikhumbule. Ukuba ne-HLA-B27 gene emzimbeni wakho akuthethi ukuba uza kuba ne-Ankylosing Spondylitis. Kuthetha nje ukuba usemngciphekweni omkhulu wokufumana esi sifo kunabanye.
Cinga ngale ndlela. Olunye uphando lufumanise ukuba ama-75% abantwana abafumana i-HLA-B27 gene kubazali abane-Ankylosing Spondylitis, okanye abathathu kwabane, abasayi kuze babe nesifo.
Oku kuthetha ukuba ii-genes zodwa azanele ukubangela esi sifo. Ukongeza kwiimpembelelo ze-genetic , kufuneka kubekho izinto ezingqongileyo . Nangona kungaziwa ukuba zeziphi ezi zinto, kukholelwa ukuba izinto ezithile, ezifana nosulelo oluthile, zinokudlala indima. Ngamafutshane, ii-genes zifana nompu olungele ukuvutha, kwaye zifuna intlantsi ukuze zivuthe.
Ngoko ke ndimele ndenze ntoni?
Ukuba uneempawu ezifana nezo zikhankanyiweyo kweli nqaku (iintlungu zomqolo eziqala usemncinci, ziba mandundu kusasa, kwaye zithomalalisa umthambo), okanye ukuba umntu kusapho lwakho une-Ankylosing Spondylitis, akufuneki ukhathazeke.
Eyona nto ingcono onokuyenza kukubona ugqirha ofanelekileyo, ugqirha wakho, ngoko nangoko . Uza kumamela iimpawu zakho, akuhlole, kwaye ukuba kuyimfuneko, acele uvavanyo lwegazi kunye nee-X-ray. Banokucebisa novavanyo ukuze babone ukuba unayo na i-HLA-B27 gene.
Khumbula, eyona nto ibalulekileyo kukuchonga nokulawula ezi meko kwangethuba . Ukuba wenza njalo, ungazilawula iintlungu, uthintele iintlungu zomqolo, kwaye uphile ubomi obuqhelekileyo nobonwabisayo.
Umyalezo Wokuya Ekhaya
- I-Ankylosing Spondylitis (AS) luhlobo lwe-arthritis oluchaphazela kakhulu umqolo. Ixhaphake kakhulu kubantu abancinci.
- Esi sifo sinxulumene kakhulu nemfuza, ingakumbi i-HLA-B27 yejini ibe yeyona nto iphambili.
- Nangona kunjalo, ukuba ne-HLA-B27 gene emzimbeni wakho akuthethi ukuba uza kuba nesifo. Yinto nje ebangela umngcipheko.
- Ukongeza kwizakhi zofuzo, izinto ezingqongileyo nazo zichaphazela ukuvela kwesi sifo.
- Ukuba uneentlungu zomqolo ezihlala ixesha elide, ukuqina kwasekuseni, okanye imbali yokugula kwintsapho yakho, musa ukoyika kwaye qhagamshelana nogqirha wakho ukuze akunike icebiso elifanelekileyo.
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