Ngaba nawe unengxaki yokuphefumla ngenxa yesifuba okanye i-allergies? Ngoko makhe sifunde ngezi Leukotriene Modifiers!

Ngamanye amaxesha, nokuba luthuli oluncinci, ipollen, okanye ukutya kunokukwenza uzive uphelelwa ngumoya, uxinene esifubeni, okanye ukhohlela rhoqo. Mhlawumbi unempumlo egobhozayo , uthimla, okanye umphimbo okrwelekayo. Ezi zinto ziyacaphukisa ngokwenene, akunjalo? Uninzi lwexesha, ezi mpawu zibangelwa kukusabela emzimbeni wethu. Namhlanje, siza kuthetha ngohlobo oluthile lwamayeza anokunceda ukulawula ubunzima bokuphefumla obubangelwa ziimeko ezifana ne-asthma kunye ne-allergies. Zibizwa ngokuba yi -Leukotriene Modifiers .

Zithini ii-leukotrienes? Kutheni zisikhathaza?

Ngamafutshane, ii-leukotrienes ziikhemikhali eziveliswa yimizimba yethu. Aziveliswa nje ngengozi. Khawuthelekelele, xa une-allergy kwinto ethile, oko kukuthi, xa into ingena emzimbeni wakho, umzekelo, uthuli, i-pollen, ukutya okuthile, inkqubo yethu yomzimba yokuzikhusela ivele isebenze ngequbuliso ize ikhuphe ezi leukotrienes.

Kuxa ezi leukotrienes zikhutshwa apho siqala ukuba neengxaki. Inkqubo yokuphefumla ichaphazeleka kakhulu. Makhe sibone ukuba kwenzeka ntoni:

• Ukukhwehlela: Ukukhwehlela okungapheliyo, ngamanye amaxesha okubuhlungu, kunokubakho.
• Ukwanda kwe-mucus: Ulwelo olufana ne-mucus kunye ne-phlegm luqala ukuqokelelana esifubeni nasemqaleni. Oku kunokubangela isandi somlozi xa uphefumla.
• Ukudumba kweendlela zomoya: Iindlela zethu zomoya, iindawo esiphefumla kuzo, ziqala ukudumba ngaphakathi. Njengokuba umbhobho wamanzi udumba ngaphakathi, indawo yokuba amanzi adlule kuyo iba ncinci.
• Ukuxinana kwemisipha yomoya: Izihlunu ezincinci ezijikeleze iindlela zomoya ziyaqina kwaye zinciphe, nto leyo eyenza iindlela zomoya zibe ncinci nangakumbi.
• Ukuqina kwesifuba: Kusenokuvakala ngathi kukho umntu ocinezela isifuba sakho, ngokungathi uyacinezelwa.
• Ubunzima bokuphefumla okanye ukuphefumla: Xa zonke ezi zinto zingasentla zidityanisiwe, ukuphefumla kuba nzima kakhulu. Abanye abantu banokuba nokuphefumla.

Uyabona, la makhemikhali mancinci abizwa ngokuba yi-leukotrienes asibangela ingxaki enkulu.

Ngoko ke zithini ezi leukotriene modifiers? Zinceda entwenini ezi medicine?

Kulungile, ngoku siyazi ukuba ii-leukotrienes zihlala zibangela ezi ngxaki zokuphefumla. Ii-leukotriene modifiers luhlobo lwamayeza alawula kwaye atshintshe ukusebenza kwezo leukotrienes. Zikwabizwa ngokuba zii-leukotriene receptor antagonists okanye ii-leukotriene synthesis inhibitors.Kulungile. Nangona eli gama liyinkimbinkimbi kancinci, la mayeza enza into ebaluleke kakhulu.

La mayeza asetyenziswa kakhulu kwezi zinto zilandelayo:

• I-Allergies, ingakumbi i-Allergic Rhinitis: Oku sidla ngokukubiza ngokuba yi-allergies kwiincukuthu zothuli okanye iikati. Iimpawu ziquka impumlo egobhozayo, ukuthimla, ukuxinana kweempumlo, kunye namehlo arhawuzelelayo.
• I-Allergic Asthma: Ukuba iimpawu ze-asthma ziyanda ngenxa ye-allergy, eli yeza linokunceda.
• Isifuba esibangelwa kukuzilolonga: Abanye abantu banokufumana ukwanda kweempawu zabo zesifuba xa bezilolonga, bebaleka, okanye betsiba. Eli yeza likwaluncedo kwiimeko ezinjalo.

Into ebalulekileyo kukuba la mayeza awasetyenziselwa ukunciphisa ngokukhawuleza i-allergy okanye uhlaselo lwe-asthma olusele lwenzekile. Asetyenziselwa ukuthintela ezo meko ukuba zingabikho okanye ukunciphisa iimpawu zazo . Kufana nesambulela, ukuba uyiphakamisa ngaphambi kokuba ine, awuyi kumanzi. Kunjalo ke.

Ziziphi iintlobo zeLeukotriene Modifiers ezikhoyo?

Kukho iintlobo ezahlukeneyo zamayeza kolu didi. Xa ugqirha wakho ekunike elinye, lingabizwa ngokuba lelinye lala magama:

• IMontelukast - Usenokuba ukhe weva ngale nto phantsi kwegama lophawu elithi `Singulair®`.
• I-Zafirlukast - Le iphantsi kwegama lophawu elithi `Accolate®`.
• I-Zileuton - Le ifumaneka phantsi kwegama lophawu elithi `Zyflo®`.

Zonke ezi zintathu zisetyenziselwa ukunyanga isifo sesifuba. Nangona kunjalo, yiMontelukast kuphela evunyiweyo ukunyanga isifo se-allergy rhinitis , oko kukuthi, i-allergies yempumlo.

Asebenza njani la mayeza? Kuyamangalisa, akunjalo?

La mayeza asebenza ngeendlela ezimbini. Kufana nokuba kukho izisombululo ezimbini kwingxaki.

1. I-Montelukast kunye ne -Zafirlukast zezinye zeqela lamayeza abizwa ngokuba yi-leukotriene receptor antagonists . Khawuthelekelele ukuba kukho 'iitshixo' ezincinci emzimbeni wakho, kwaye xa ezi khemikhali zibizwa ngokuba yi-leukotrienes zifika zingene kweli tshixo 'njengesitshixo', loo ngxaki yokuphefumla iyenzeka. Into eyenziwa leli chiza kukuba, ngaphambi kokuba eli sitshixo se-leukotriene singene kwelo tshixo, livala elo tshixo ngokufaka esinye isitshixo 'esingeyonyani'. Emva koko ezo leukotrienes azikwazi ukusebenza. Oko kukuthi, iyayimisa impembelelo ye-leukotrienes.

2. I-Zileuton yahlukile kancinci. Ikwiqela lamayeza abizwa ngokuba yi-leukotriene synthesis inhibitors.Yile nto iyenzayo ngokwenza ezo khemikhali 'zibangela ingxaki' ezibizwa ngokuba yi-leukotrienes ngaphakathi emzimbeni, oko kukuthi, ukunciphisa imveliso yazo. Kufana nokuyeka ukuveliswa kweempahla kumzi-mveliso. Emva koko inani le-leukotrienes emzimbeni liyancipha.

Ngaba uyaqonda? Ngandlela thile, ayivumeli ii-leukotrienes ukuba zisebenze, kwaye ngenye indlela, inciphisa ukuveliswa kwee-leukotrienes.

Ndingayisebenzisa njani le yeza? Yintoni endifanele ndiyilumkele?

Ezi modifiers ze-leukotriene zihlala ziza ngendlela yeepilisi, oko kuthetha ukuba zithathwa ngomlomo .

Eyona nto ibalulekileyo kukuthatha eli yeza yonke imihla njengoko ugqirha wakho ekuyalele . Kubalulekile ukulithatha ngexesha, nokuba unengxaki yokuphefumla ngaloo mini okanye akunjalo. Kuba, njengoko besitshilo ngaphambili, ezi zisetyenziselwa ukuthintela ubunzima bokuphefumla. Njengevithamini yemihla ngemihla, kufuneka uyithathe yonke imihla ukuze ugcine ukhuseleko oluyinikayo.

Ugqirha wakho uza kukunika imiyalelo ethile malunga nale yeza:

• Idosi: Oku kuthetha ukuba kufuneka uthathe malini kwaye kangaphi ngemini.
• Ixesha lokusela iyeza: Kusasa, kabini ngemini, okanye ebusuku. Oku kunokuxhomekeka ekubeni iimpawu zakho zinzima kangakanani na.
• Nokuba uyisebenzisela ukutya okanye ngaphandle kwayo: Amanye amayeza kufuneka athathwe ngaphambi kokutya, amanye emva kokutya. Cela ngononophelo.

Ungaze uthathe eli yeza lingaphezulu okanye lingaphantsi kunelo ulinikwe ngugqirha wakho. Ukwenza njalo kunokunciphisa ukusebenza kakuhle kweli yeza kwaye kubangele iziphumo ebezingalindelekanga.

Zithini iingenelo zokusebenzisa iiLeukotriene Modifiers?

Ukuba uwasebenzisa ngokuchanekileyo la mayeza, ungafumana isiqabu esikhulu. Nazi iingenelo:

• Ukuphefumla kuba lula: Ukuqina kwesifuba kunye nokuphefumla kuyancitshiswa, kwaye unokuphefumla ngokukhululekileyo.
• Ungazilolonga nangona unengxaki yokuphefumla: Ukuba ukhe wanengxaki yokuphefumla xa uzilolonga, eli yeza liza kukuvumela ukuba ulawule imeko kwaye wenze umthambo.
• Inceda ukugcina iindlela zomoya zivulekile: Sithe iindlela zomoya ziyadumba kwaye ziyaqina, ngoko ke ziyanciphisa ezo meko.
• Inciphisa i-mucus esifubeni nasemqaleni: I-mucus iyancipha, nto leyo eyenza ukuphefumla kube lula.
• Inceda ekuthinteleni iingxaki zokuphefumla, ezifana nee-allergy kunye nokuhlaselwa sisifo sesifuba.
• Inciphisa inani kunye nobunzima beempendulo kunye nohlaselo.

Oku kungenza ubomi bakho bemihla ngemihla bube lula kakhulu.

Ngaba kukho naziphi na iingozi ngala mayeza?

Njengayo nayiphi na imithi, ezi modifiers ze-leukotriene zinokuba neengozi ezithile.

Umonakalo wesibindi obangelwa zii-leukotriene modifiers ezithileKunokwenzeka. Ngoko ke, ukuba sele uneengxaki zesibindi, usenokungakwazi ukusebenzisa la mayeza. Ngelixa usebenzisa la mayeza, ugqirha wakho angenza uvavanyo lwegazi ukujonga ukuba isibindi sakho sisebenza kakuhle na. Oku kungenxa yokhuseleko lwakho.

Zithini iziphumo ebezingalindelekanga ezinokubakho?

Ii-Leukotriene modifiers zihlala zithathwa njengezikhuselekileyo. Nangona kunjalo, abanye abantu banokufumana iziphumo ebezingalindelekanga. Musa ukukhathazeka, ezi zihlala zingekho mbi kakhulu.

Iziphumo ebezingalindelekanga eziqhele ukubonwa:

• Iimpawu zomkhuhlane: ukukhwehlela, umphimbo obuhlungu, impumlo egobhozayo.
• Ukuphazamiseka kwesisu: Urhudo, iintlungu zesisu.
• Usulelo lwendlebe.
• Ukudinwa: Kuthetha ukuziva udiniwe.
• Iimpawu ezifana nomkhuhlane: umkhuhlane.
• Intloko ebuhlungu .
• Isitshiso sentliziyo: Kuvakala ngathi kukho into etshisayo esifubeni.
• Ukurhawuzelela okanye ukurhawuzelela.
• Ukutya akunancasa.
• Isicaphucaphu: Ukuziva ngathi uhlanza.

Ukuba ufumana isiphumo esiqhelekileyo esifana nesi, ukuba asipheli kwiintsuku ezimbalwa, okanye ukuba kunzima ukusinyamezela, thetha nogqirha wakho.

Nangona kunjalo, ngamanye amaxesha iziphumo ebezingalindelekanga ezinzulu zinokubakho. Ukuba ubona nayiphi na kwezi, kufuneka ubone ugqirha okanye uye esibhedlele ngoko nangoko:

• Utshintsho kwimpilo yengqondo: Oku kubaluleke kakhulu. Ukuba ufumana uxinzelelo , iingcinga zokuzibulala , okanye ukuba ndlongondlongo ngequbuliso , musa ukulibazisa. Abanye abantu abasebenzisa eli yeza baye baxela ukuba bahlangabezana nale miphumo yengqondo. Ngoko ke, ukuba wena okanye umntu kusapho lwakho ubona utshintsho olukhulu kwindlela yokuziphatha okanye kwimo yeemvakalelo ngelixa usebenzisa eli yeza, xelela ugqirha ngoko nangoko.
• Ukudumba, ukuxobuka, okanye ukurhawuzelela okukhulu okufana nokudumba.
• Ukurhawuzelela okanye umphimbo obuhlungu.
• Ukubetha kwentliziyo.
• Ukungaziva mnandi okanye ukurhawuzelelwa ziingalo.
• Ukudumba kobuso, amehlo, umlomo, okanye umqala.
• Ubunzima bokuphefumla okanye ukuginya.
• Ukuhlanza.
• Ukutyheli kolusu okanye amehlo (i-Jaundice): Oku kungaba yingxaki yesibindi.

Ukuba ubona into enzulu ngolu hlobo, kungcono ukufuna ingcebiso kagqirha ngaphandle kokuchitha ixesha.

Ngaba kukho naluphi na unxibelelwano olukhoyo namanye amayeza?

Ewe, iiLeukotriene Modifiers zinokusebenzisana nezinye iiyeza ozisebenzisayo. Kungoko ke, kubaluleke kakhulu ukuxelela ugqirha wakho ngazo zonke iiyeza ozisebenzisayo, kuquka amayeza kagqirha, amayeza okuphelisa iintlungu athengiswa ngaphandle kwemvume kagqirha, iivithamini, kunye namayeza emifuno.

Amanye amayeza anokusebenzisana nala mayeza ngala:

• Amanye amayeza omhlaza (umz. `Alpelisib`, `dabrafenib`, `enzalutamide`).
• Ezinye iintlobo zee-antibiotics (umz. `Erythromycin`, `rifapentine`).
• Amanye amayeza okugula ngengqondo (umz. iLoxapine - iyeza leemeko ezifana ne -schizophrenia ).
• Amayeza e-cystic fibrosis (umz. iLumacaftor).
• Amanye amayeza okulwa neentsholongwane (umz. iTerfenadine - iyeza elisetyenziselwa ukuthintela okanye ukunyanga iimpawu ze-allergy).
• Izithibisi zegazi (umz. `iWarfarin` - iyeza elinceda ekuthinteleni ukuqhekeka kwegazi, isifo sohlangothi, kunye nokuhlaselwa yintliziyo).

Olu luhlu aluphelelanga. Ngoko ke, qiniseka ukuba uxoxa ngayo yonke imithi oyithathayo nogqirha wakho ukuze akwazi ukucebisa unyango olukhuselekileyo nolufanelekileyo kuwe.

Umyalezo Wokuya Ekhaya

Kulungile, ngoko ke ndiyathemba ukuba ngoku uyiqonda ngcono iLeukotriene Modifiers esithethe ngayo namhlanje.

Ngamafutshane, la mayeza anceda ekuthinteleni iingxaki zokuphefumla ezibangelwa yi-allergies okanye i-asthma. Afanele athathwe yonke imihla, nokuba uneempawu okanye awunazo, kwaye njengoko kuyalelwe ngugqirha wakho. Ugqirha wakho ngumntu ongcono ukwazi ukuba eli yeza likulungele na kwaye liza kukunceda na.

Ngoko ke, ukuba uneengxaki zokuphefumla ezinje, ungoyiki ukuthetha nogqirha ubuze ngezi ntlobo zonyango. Wonke umntu ufanelwe kukukwazi ukuphefumla ngokukhululekileyo nokuphila ubomi obusempilweni!

IiLeukotrienes , izilungisi ze-leukotriene, i-asthma, ii-allergies, ubunzima bokuphefumla, i-montelukast, i-zafirlukast, i-zileuton, izifo zokuphefumla