Ngaba unikwe iipilisi zeMercaptopurine (6-MP)? Masithethe ngale nto ngokulula!

Ngamanye amaxesha oogqirha banika amayeza kwisifo esinzima kunokuba sicinga, akunjalo? Kwimeko enjalo, kubaluleke kakhulu ukwazi ukuba yintoni kanye kanye iyeza. Namhlanje siza kuthetha ngamayeza akhethekileyo, iMercaptopurine , uhlobo lwepilisi abanye abantu abayibiza ngokuba yi-6-MP . Mhlawumbi wena okanye umntu omaziyo unikwe la mayeza. Ngoko ke masithethe ngawo ngokweenkcukacha, akunjalo?

Ngoko ke, loluphi uhlobo lonyango olu lweMercaptopurine?

Ngamafutshane, iMercaptopurine liyeza le-chemotherapy elithintela ukukhula kweeseli zomhlaza. Ngokuchanekileyo, lilawula ukwahlukana nokukhula kweeseli zomhlaza. Linokunciphisa nokusebenza kwenkqubo yomzimba yokuzikhusela.

Eli yeza lidla ngokusetyenziswa ukunyanga iintlobo ezithile ze-leukemia, njenge- acute leukemia . Nangona kunjalo, ngamanye amaxesha oogqirha banokukunika eli yeza kwezinye iimeko. Ugqirha wakho uya kuchaza isizathu sokuba unikwe eli yeza. Ukuba unemibuzo engaphezulu, zive ukhululekile ukubuza ugqirha wakho okanye ikhemisti.

Eli yeza lingafumaneka kwimarike phantsi kwegama lePurinethol .

Zeziphi izinto ezibalulekileyo ekufuneka uzixelele ugqirha ngaphambi kokuba uqale eli yeza?

Oku kubaluleke kakhulu. Ngaphambi kokuba uqale ukusebenzisa iMercaptopurine, kukho izinto ezimbalwa ekufuneka uzixelele ugqirha wakho. Kuba olu lwazi luza kusetyenziswa ngugqirha wakho ukumisela umthamo weyeza kuwe, okanye ukumisela ukuba eli yeza likulungele na okanye akunjalo.

Nazi ezo nyaniso:

• Ukuba unesifo sezintso .
• Ukuba unesifo sesibindi .
• Ukuba inani leeseli zakho zegazi liphantsi – oko kukuthi, ukuba iingxelo zibonisa ukuba unenani eliphantsi leeseli ezimhlophe zegazi, iiseli ezibomvu zegazi, okanye iiplatelets.
• Ukuba unesifo semfuza esibizwa ngokuba yi-nucleotide diphosphatase (NUDT15) deficiency (oku kungafunyaniswa ngovavanyo olukhethekileyo).
• Ukuba usandul’ ukufumana naluphi na ugonyo, okanye ucwangciselwe ukulufumana kwixesha elizayo.
• Ukuba unesinye isifo semfuza esibizwa ngokuba yi-thiopurine methyltransferase (TPMT) deficiency (oku kungafunyanwa nangovavanyo olukhethekileyo).
• Ukuba une -allergy kwi-mercaptopurine, naluphi na olunye unyango, ukutya, idayi, okanye izithinteli.
• Ukuba ukhulelwe okanye uzama ukukhulelwa, kulungile oko.
• Ukuba ungumama oncancisayo.

Kubaluleke kakhulu kwimpilo yakho ukuxelela ugqirha wakho ngezi zinto ngaphandle kokuzifihla.

Ndingayisebenzisa njani kanye kanye le yeza?

Eli yeza liza ngendlela yeepilisi. Kufuneka usele ezi pilisi ngeglasi yamanzi. Landela imiyalelo kagqirha wakho okanye imiyalelo ekwileyibhile yeyeza kanye njengoko inikwe. Thatha isixa esimiselweyo ngexesha elimiselweyo. Musa ukuthatha ngaphezulu okanye ngaphezulu kunokuba ugqirha wakho ekuxelele.

Eyona nto ibalulekileyo kukuba ungayeki ukuthatha eli yeza ngequbuliso ngaphandle kwengcebiso kagqirha wakho. Ukwenza njalo kunokuchaphazela imeko yakho.

Ukuba unika abantwana abancinci eli yeza, kufuneka uthethe nogqirha wakho wabantwana ngalo. Nangona eli yeza linikwa abantwana kwiimeko ezithile, kukho izinto ekufuneka uzilumkele.

Ungenza ntoni ukuba uthatha amayeza amaninzi kakhulu?

Ukuba ucinga ukuba ngempazamo usele eli yeza kakhulu, fowunela iziko lokulawula ityhefu okanye isebe likaxakeka lesibhedlele elikufutshane ngoko nangoko. Musa ukuchitha ixesha.

Nceda uqaphele: Eli yeza limiselwe wena wedwa. Musa ukwabelana ngeli yeza nabanye abantu nangasiphi na isizathu.

Kuthekani ukuba ndiphoswa lidosi leyeza?

Ngamanye amaxesha kunokwenzeka ukuba uphoswe yidosi, akunjalo? Ukuba oko kuyenzeka, musa ukuthatha idosi ephindwe kabini ukuze ubuyisele idosi ephosiweyo. Yeka idosi ephosiweyo uze uthathe idosi yakho elandelayo ngexesha eliqhelekileyo. Ukuba unamathandabuzo malunga noku, buza ugqirha wakho.

Ngawaphi amanye amayeza anokusebenza kunye nale mithi?

Le yingongoma ebaluleke kakhulu. Kukho amayeza athile anokubangela iingxaki xa esetyenziswa nge-mercaptopurine.

Ungaze uthathe iMercaptopurine kunye nala mayeza:

• I-Febuxostat (eli liyeza elinikwa izifo ezifana ne-gout)

La mayeza anokusebenzisana ne-mercaptopurine, oko kuthetha ukuba anokuphazamisana. Ngoko ke ukuba uwasebenzisa la mayeza, kufuneka uxelele ugqirha wakho:

• I-Allopurinol (ikwaliyeza le-gout kunye namatye ezintso)
• Amanye amayeza athintela ukujiya kwegazi, umzekelo i-warfarin
• Amanye amayeza asetyenziswa ukunyanga izifo ezifana ne-ulcerative colitis: i-balsalazide, i-olsalazine, i-mesalamine, okanye i-sulfasalazine
• Izitofu zokugonya iintsholongwane eziphilayo
• I-Trimethoprim-sulfamethoxazole (le yi-antibiotic)

Olu luhlu aluphelelanga. Xelela ugqirha wakho malunga nawo onke amayeza (abhalwe ngugqirha okanye athengiswa ngaphandle kwemvume kagqirha), amayeza esintu, iivithamini, kunye nezongezo zokutya ozisebenzisayo.Kwakhona, xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa ezinye iziyobisi. Ezi zinto zinokuchaphazela amayeza akho.

Yintoni ekufuneka uyilumkele ngakumbi xa usebenzisa eli yeza?

I-Mercaptopurine sisiyobisi esinamandla, ngoko ke kufuneka ulumke kakhulu ngezinye izinto xa usithatha.

• Ukungakhululeki kancinci: Usenokuziva ungakhululekanga kwaye ungaphilanga kakuhle xa usebenzisa eli yeza. Oku kungenxa yokuba la mayeza okulwa nomhlaza awachaphazeli kuphela iiseli zomhlaza kodwa neeseli ezisempilweni. Ukuba ufumana naziphi na iziphumo ebezingalindelekanga, xelela ugqirha wakho . Nangona kunjalo, kubalulekile ukusela iyeza njengoko kumiselweyo, nokuba alikhululeki, de ugqirha wakho akuxelele ukuba uyeke.
• Lumka kwiintsholongwane: Ukuba uneempawu zesifo ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, ukukhwehlela, okanye impumlo egobhozayo, musa ukuzinyanga. Thetha nogqirha wakho okanye ingcali yezempilo ngokukhawuleza ukuze ufumane icebiso. Eli yeza linokunciphisa amandla omzimba wakho okulwa neentsholongwane. Ke ngoko, zama ukuhlala kude nabantu abagulayo. Umzekelo, kungcono ukunciphisa ukuya kwiindawo ezixineneyo nokutyelela abantu abagulayo.
• Ukukrweleka nokuphuma kwegazi okulula: Eli yeza linokubangela ukuba ukrweleke lula, okanye uphume igazi lula ngenxa yokwenzakala okuncinci. Ukuba ufumana ukopha okanye ukukrweleka okungaqhelekanga, xelela ugqirha wakho.
• Uvakalelo lwelanga: Ulusu lwakho lusenokuba novakalelo olukhulu kwilanga ngelixa usela eli yeza. Ngoko ke, kuphephe ukukhanya kwelanga ngokuthe ngqo kangangoko unako. Ukuba uyaphuma, nxiba impahla egquma umzimba wakho kakuhle, nxiba umnqwazi, kwaye usebenzise i-sunscreen. Musa ukusebenzisa izibane zelanga okanye iibhedi/ii-booths zelanga.
• Umngcipheko womhlaza: Kuthiwa ukuthatha eli yeza kunokunyusa kancinci umngcipheko wokuba neentlobo ezithile zomhlaza. Ngoko ke, thetha nogqirha wakho ngale nto kwaye uqaphele umngcipheko wakho.
• Ukukhulelwa nokuba nabantwana: Oku kubaluleke kakhulu!
• Abafazi: Musa ukukhulelwa ngelixa usela eli yeza kwaye emva kweenyanga ezi-6 emva kokuyeka iyeza. Ukuba uzama ukukhulelwa okanye ucinga ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko.
• Amadoda: Musa ukuzama ukuba nomntwana ngelixa usela eli yeza kwaye emva kweenyanga ezi-3 uyekile ukusebenzisa eli yeza.

Eli yeza linokubangela ingozi enkulu kumntwana ongekazalwa, ngoko ke lumka kakhulu ngale nto.

• Ukuncancisa: Musa ukuncancisa umntwana wakho ngelixa usebenzisa la mayeza kwaye emva kweveki enye uyekile ukusebenzisa la mayeza.
• Iziphumo ekuNzala:Eli yeza lisenokuchaphazela amandla akho okuba nabantwana. Ukuba uneengxaki malunga noku, thetha nogqirha wakho okanye ingcali yezempilo.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengazo zonke iziyobisi, iMercaptopurine inokubangela ezinye iziphumo ebezingalindelekanga. Nangona kunjalo, ayinguye wonke umntu ozifumanayo. Ezinye zazo kufuneka zixelwe kugqirha ngoko nangoko, ngelixa ezinye zinokunyanyezelwa okwethutyana.

Xelela ugqirha wakho okanye ingcali yezempilo ngoko nangoko ukuba ufumana naziphi na kwezi ziphumo ebezingalindelekanga:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukurhawuzelela; ukudumba kobuso, imilebe, okanye ulwimi.
• Ubunzima bokuphefumla.
• Iimpawu zokubala iiseli zegazi ezisezantsi: Eli yeza linokubangela ukuba iiseli zegazi ezimhlophe ezisezantsi, iiseli zegazi ezibomvu, kunye neeplatelets zibe sezantsi. Oku kunokunyusa umngcipheko wosulelo kunye nokopha.
• Iimpawu zeeplatelets ezisezantsi okanye ukopha: ukukrweleka okulula, amabala abomvu abonakala eluswini, indle emnyama ethambileyo, kunye negazi emchameni.
• Iimpawu zeeseli ezibomvu zegazi ezisezantsi: ukuziva udiniwe ngendlela engaqhelekanga, uzive ubuthathaka, uphelelwe ngamandla, uzive unesizungu, kwaye uphelelwe ngamandla.
• Iimpawu zosulelo: umkhuhlane okanye ukubanda, ukukhohlela, umphimbo obuhlungu, iintlungu okanye ubunzima bokuchama.
• Iimpawu zokulimala kwesibindi: Umchamo otyheli okanye omdaka omnyama; ukuziva ungaphilanga okanye uneempawu ezifana nomkhuhlane okanye umkhuhlane; indle ekhanyayo; ukungabi namdla wokutya; isicaphucaphu; iintlungu kwicala eliphezulu lasekunene lesisu; ubuthathaka okanye ukudinwa okungaqhelekanga; ukutyheli kwamehlo okanye ulusu.
• Umphimbo obuhlungu kakhulu.
• Ukudumba kwesisu.

Ezi ziphumo ebezingalindelekanga azisoloko zifuneka ukuba zixelwe kugqirha wakho (kodwa ukuba ziyaqhubeka okanye ziyakukhathaza, xelela ugqirha wakho ):

• Urhudo.
• Ukulahleka kweenwele.
• Izilonda zomlomo.
• Ukuhlanza.

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga ukongeza kwezi, nceda udibane nogqirha wakho.

Uligcina njani iyeza?

Eli yeza lifanele ligcinwe kude nabantwana .

Gcina kubushushu begumbi (phakathi kwama-20 nama-25 degrees Celsius / ama-68 nama-77 degrees Fahrenheit). Khusela ekufuma. Gcina ibhotile/ipakethi yeyeza ivaliwe kakuhle. Musa ukusebenzisa amayeza aphelelwe lixesha, lilahle.

Izinto ekufuneka uzikhumbule!

Kulungile, ngoko ke sithethe kakhulu nge-mercaptopurine, akunjalo?

Eyona nto ibalulekileyo kukuba eli liyeza ekufuneka lisetyenziswe kanye njengoko kuyalelwe, phantsi kwengcebiso kagqirha.

• Mamela ngononophelo yonke into ethethwa ngugqirha wakho uze uyilandele.
• Ukuba unemibuzo okanye amathandabuzo, ungoyiki ukubuza ugqirha.
• Qaphela iziphumo ebezingalindelekanga, ingakumbi ukuba ufumana naziphi na iimpawu ezinzulu esizixubushileyo, kwaye uxelele ugqirha wakho ngoko nangoko.
• Ukuba usebenzisa amanye amayeza, ungalibali ukuxelela ugqirha wakho ngawo.
• Landela imiyalelo malunga nokukhulelwa nokuncancisa ngokuchanekileyo.

Eli yeza liluncedo ekunyangeni imeko yakho. Ngoko ke, themba oogqirha kwaye ulandele imiyalelo yabo. Ndikunqwenelela ukuchacha ngokukhawuleza!

I- Mercaptopurine, i-6-MP, i-Purinethol, umhlaza, i-leukemia, i-chemotherapy, iziphumo ebezingalindelekanga