Iipilisi zeMifepristone zeCushing's syndrome? Masithethe ngale nto!

Ngaba une -Cushing Syndrome ? Okanye ngaba kukho umntu omaziyo onayo le meko? Okwenzekayo kule meko kukuba umzimba wethu uvelisa i- cortisol engaphezulu kunokuba kuyimfuneko, nto leyo ebangela ukuba amanqanaba eswekile egazini, oko kukuthi, i-glucose, anyuke. Ngoko ke, elinye lamayeza acetyiswa ngoogqirha ngamaxesha anje yiMifepristone. Namhlanje, siza kuthetha ngezi pilisi zeMifepristone ngokweenkcukacha.

Luhlobo luni lonyango iMifepristone?

Ngamafutshane, iipilisi zeMifepristone zisetyenziswa kakhulu ukulawula amanqanaba eglucose egazini kwimeko yeCushing 's Syndrome , imeko eyenzeka xa i-hormone cortisol emzimbeni wakho inyuka kakhulu.

Uyazi na ukuba le hormone ebizwa ngokuba yi-cortisol ibaluleke kakhulu emzimbeni wethu? Xa sixinezelekile, umzimba wethu uzilungiselela ukujongana nayo ngale hormone. Umzekelo, xa umzimba ufuna amandla angakumbi ngoko nangoko, le cortisol inceda ekukhupheleni iswekile engaphezulu egazini. Nangona kunjalo, xa oku kusanda ngendlela engalawulekiyo, kuvela iingxaki ezahlukeneyo. Iipilisi zeMifepristone zinciphisa impembelelo yehomoni ye-cortisol, ngaloo ndlela zinciphisa amanqanaba eswekile egazini.

Eli yeza ngamanye amaxesha linokunikwa ngoogqirha kwezinye iimeko. Ke ngoko, ukuba awuqinisekanga ukuba le yeza lenzelwe ntoni kanye kanye, kungcono ubuze ugqirha wakho okanye ingcali yezemithi kwikhemesti apho uthenga khona amayeza akho. Eli yeza likwaziwa kwimarike ngegama lophawu iKorlym .

Zeziphi izinto ekufuneka ndizixelele ugqirha ngaphambi kokuba ndithathe eli yeza?

Ngaphambi kokuba uqale ukusebenzisa iipilisi zeMifepristone, kukho izinto ezibalulekileyo ekufuneka uzixelele ugqirha wakho. Kuba, abantu abaneengxaki ezithile zempilo okanye abo basebenzisa amanye amayeza kufuneka balumke kakhulu xa benika iMifepristone. Jonga ukuba oku kulandelayo kuyasebenza na kuwe:

• Ngaba unesifo sokopha ?
• Ngaba okwangoku unomhlaza okanye unyangwa ngenxa yawo?
• Ngaba unesifo sengqondo esifana nokudakumba ?
• Ingaba unesinye isifo seswekile esingahambelani nesifo sikaCushing?
• Isifo sentliziyoNgaba unesifo sentliziyo?
• Ingaba unalo ifuthe eliphezulu ?
• Ingaba unayo nayiphi na isifo sesibindi?
• Ngaba oogqirha bakuxelele ukuba amanqanaba e-potassium egazini lakho aphantsi?
• Ngaba wakha wafakelwa amalungu omzimba?
• Ngaba okwangoku usebenzisa ii-steroids ezifana ne-dexamethasone okanye i-prednisone?
• Ngaba unesifo sokopha esingaphantsi komlomo esingachazekiyo?
• Ngaba wakha waba ne-allergy kwi-mifepristone, naluphi na olunye unyango, ukutya, iidayi zokutya, okanye izithinteli?
• Ngaba okwangoku uzama ukukhulelwa? Okanye sele ukhulelwe?
• Ingaba ungumama oncancisayo? (Uyancancisa)

Ukuba unemeko efana nale, kungcono ukuxelela ugqirha wakho ngayo ngaphandle kokufihla nantoni na .

Ndingayisebenzisa njani le yeza?

Ezi pilisi zeMifepristone kufuneka zithathwe ngamanzi. Kubaluleke kakhulu ukusela eli yeza ngexesha elinye yonke imihla , njengoko kuyalelwe kwileyibhile kagqirha. Musa ukuphula, ukutyumza, okanye ukuhlafuna ezi pilisi. Ginya ipilisi yonke ngamanzi.

Enye into ebalulekileyo kukuba eli yeza lifanele lithathwe kunye nokutya. Kwakhona, musa ukulisebenzisa eli yeza kunye nejusi yegrapefruit nangasiphi na isizathu. Kufuneka uqhubeke nokusebenzisa eli yeza njengoko kuyalelwe de ugqirha wakho akuxelele ukuba uyeke.

Xa unikwa eli yeza yikhemesti, uza kunikwa incwadana enemiyalelo ekhethekileyo malunga neli yeza, ebizwa ngokuba yiMedGuide . Kubaluleke kakhulu ukulifunda nokuliqonda ngononophelo eli ncwadana yeMedGuide ngalo lonke ixesha usela iyeza, naxa uphinda ulizalise.

Ukuba unika abantwana abancinci eli yeza, qiniseka ukuba uthetha nogqirha wakho ngalo, kuba lisenokufuna ulwalathiso olukhethekileyo lwezonyango kunye nokhathalelo.

Yintoni omawuyenze ukuba ugqithisile?

Ukuba ucinga ukuba usele kakhulu eli yeza, fowunela ngokukhawuleza iziko lokulawula ityhefu elikufutshane okanye igumbi likaxakeka lesibhedlele sikarhulumente ukuze ufumane ingcebiso.

Kwakhona khumbula: Eli yeza limiselwe wena kuphela. Musa ukulinika umhlobo okanye ilungu losapho nangasiphi na isizathu, nokuba baneempawu ezifanayo nezakho.

Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?

Ukuba ulibele ukusela ipilisi yeMifepristone ngenye imini, yisele kwangoko xa ukhumbula. Nangona kunjalo, ukuba sele kusondele ixesha lokusebenzisa idosi yakho elandelayo xa ukhumbula, yeka idosi ongayisebenzisanga kwaye uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini okanye ezongezelelweyo, oko kukuthi, thatha zombini idosi ongayisebenzisanga kunye neyo ubufanele ukuba uyithathe ngexesha elinye. Ukwenza njalo kwandisa umngcipheko weziphumo ebezingalindelekanga.

Ngawaphi amanye amayeza angafanele asetyenziswe kunye nale mithi?

Ukuba okwangoku usebenzisa naliphi na kula mayeza alandelayo, ungaze uwasebenzise kunye neMifepristone. La mayeza anokubangela ukudibana okunzulu nokuyingozi okunokuba yingozi ebomini:

• Amanye amayeza asetyenziswa ukunyanga izifo zefungus, umzekelo, i-fluconazole, i-ketoconazole, kunye ne-posaconazole.
• Amanye amayeza anikwa ukunciphisa amanqanaba e-cholesterol egazini, umzekelo i-lovastatin kunye ne-simvastatin.
• I-Cisapride
• I-Cyclosporine
• I-Dronedarone
• Ii-alkaloids ze-Ergot ziluhlobo lwamayeza, umzekelo, i-dihydroergotamine kunye ne-ergotamine.
• I-Fentanyl
• I-Pimozide
• I-Quinidine
• ISirolimus
• I-Tacrolimus
• I-Thioridazine

Olu luhlu aluphelelanga, ngoko ke kubaluleke kakhulu ukuxelela ugqirha wakho malunga namayeza onke owasebenzisayo, kuquka neevithamini.

Amanye amayeza nezinto ezinokusebenzisana

Kukho amanye amayeza nezinto ezinokusebenzisana neMifepristone, ngoko ke kulungile ukuba uzazi ezi zinto:

• Ezinye iintlobo zee-antibiotics, umzekelo i-clarithromycin, i-erythromycin, i-telithromycin.
• Amanye amayeza okulwa neentsholongwane anikwa abantu abasulelekileyo yi-HIV okanye izifo zesibindi ezifana ne-hepatitis.
• Amayeza asetyenziselwa ukunyanga iimeko zenkqubo yemithambo-luvo ezifana nokuxhuzula, umzekelo i-carbamazepine, i-phenytoin, kunye ne-phenobarbital.
• Amanye amayeza athintela ukujiya kwegazi, umzekelo i-warfarin.
• I-Conivaptan
• Ijusi yegrapefruit – Njengoko bekutshiwo ngaphambili, le yinto engalunganga ukuyitya ngelixa usela iMifepristone.
• Iipilisi zokulawula ukuzalwa, iinaliti, iipatches kunye nezixhobo eziqulethe iihomoni.
• I-Itraconazole
• Amayeza eengxaki zengqondo ezifana nokudakumba okanye ukuxhalaba okukhulu.
• Amanye amayeza e-narcotic anikwa njengeentlungu zokuthomalalisa iintlungu.
• Amanye amayeza anokubangela isigqi sentliziyo esingaqhelekanga, njengalawo andisa ixesha le-QT.
• I-Repaglinide
• I-Rifabutin, i-Rifampin, i-Rifapentine.
• I-St. John's wort sisongezelelo semifuno.
• Amayeza e-steroid, anjenge-prednisone okanye i-cortisone.
• Iihomoni ze-thyroid.
• I-Voriconazole.

Olu luhlu lusenokungabandakanyi yonke into. Ngoko ke, qiniseka ukuba uxelela ugqirha wakho malunga nawo onke amayeza, iziqholo, amayeza angagunyaziswanga ngugqirha, kunye nezongezo zokutya ozithathayo . Kwakhona, xelela ugqirha wakho ukuba uyatshaya, usela utywala, okanye usebenzisa iziyobisi ezingekho mthethweni. Ezi zinokudibana neMifepristone oyithathayo.

Zeziphi izinto ekufuneka uzilumkele xa usebenzisa eli yeza?

Ngelixa usela iMifepristone, kuya kufuneka ubone ugqirha wakho rhoqo ukuze ahlolwe impilo yakho. Ugqirha wakho angacebisa ukuba wenze umsebenzi wegazi.

Eli yeza linokuthi lichaphazele amanqanaba eswekile egazini. Ukuba unesifo seswekile, qiniseka ukuba uthetha nogqirha wakho ngaphambi kokuba wenze naluphi na utshintsho kwindlela otya ngayo okanye umthamo wamayeza akho eswekile.

Gcina incwadana yemiyalelo ekhethekileyo yale yeza, ebizwa ngokuba yiMedGuide, ngononophelo. Ukuba ufuna unyango olungxamisekileyo, bonisa iqela lezonyango incwadana yeMedGuide. Baxelele nokuba uthatha iMifepristone.

Izinto ekufuneka ziqwalaselwe ngakumbi ngabasetyhini:

• Kufuneka wenze uvavanyo lokukhulelwa ukuqinisekisa ukuba ukhulelwe na ngaphambi kokuba uqale eli yeza leMifepristone. Musa ukukhulelwa ngelixa usela eli yeza okanye inyanga enye emva kokuba uyekile ukusebenzisa eli yeza.
• Ukuba uceba ukukhulelwa okanye ucinga ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko. Eli yeza linokubangela iziphumo ebezingalindelekanga ezibi kakhulu kusana olungekazalwa. Cela ugqirha wakho ukuba akunike ulwazi oluthe kratya.
• Kufuneka usebenzise uthintelo lokuzala olusebenzayo ngelixa usebenzisa iMifepristone. Uthintelo lokuzala olungelulo olwehomoni lungcono xa usebenzisa eli yeza kwaye emva kwenyanga enye uyekile ukusebenzisa eli yeza. Thetha nogqirha wakho ngeyona ndlela ingcono yokuthintela ukukhulelwa. Ukuba ukrokrela ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko.

Kwabomama abancancisayo: Musa ukuncancisa umntwana wakho ngelixa usebenzisa eli yeza leMifepristone.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengazo zonke iziyobisi, iMifepristone inokubangela ezinye iziphumo ebezingalindelekanga. Kukho ezinye iziphumo ebezingalindelekanga ekufuneka uxelele ugqirha wakho ngoko nangoko ukuba ziyavela. Nazi:

• Iimpendulo ze-allergy: Ukurhawuzelela kwesikhumba, ukurhawuzelela, amaqhuqhuva, ukudumba kobuso, imilebe, ulwimi, okanye umqala. Ezi zinokuba yingozi.
• Utshintsho lwesingqi sentliziyo: ukubetha kwentliziyo ngokukhawuleza okanye ukubetha kwentliziyo okungahambelaniyo, isiyezi, ukuziva ubuthathaka okanye ubuthathaka, iintlungu zesifuba, ubunzima bokuphefumla.
• Kwabasetyhini: Ukuya exesheni okungaqhelekanga okanye ukopha okungaqhelekanga (ukubonakala amabala) ngexesha lokuya exesheni.
• Iimpawu zokungasebenzi kakuhle kwe-adrenal gland: isicaphucaphu, ukuhlanza, ukuphelelwa ngumdla wokutya, ubuthathaka okanye ukudinwa okungaqhelekanga, isiyezi.
• Iimpawu zamanqanaba aphantsi e-potassium egazini: iintlungu zemisipha okanye ukuqaqamba, ukuziva ubuthathaka okanye udiniwe ngendlela engaqhelekanga, ukubetha kwentliziyo okukhawulezayo okanye okungahambelaniyo, ukuqhina.

Iziphumo ebezingalindelekanga ezidweliswe ngezantsi azisoloko zimbi kakhulu, kodwa ukuba ziyaqhubeka okanye ziyakukhathaza, xelela ugqirha wakho:

• Isiyezi
• Ukudinwa
• Intloko ebuhlungu
• Intlungu yamalungu
• Ukulahlekelwa ngumdla wokutya
• Isicaphucaphu
• Ukudumba kwamaqatha, izandla, okanye iinyawo.

Olu luhlu alubandakanyi zonke iziphumo ebezingalindelekanga zeMifepristone. Ukuba ufumana naziphi na iimpawu ezingaqhelekanga, xelela ugqirha wakho. Ungaxela neziphumo ebezingalindelekanga kwi-US Food and Drug Administration (FDA) ku-1-800-FDA-1088.

Ndingawagcina njani amayeza am?

Gcina eli yeza leMifepristone kwindawo ekhuselekileyo kude nabantwana abancinci kunye nezilwanyana zasekhaya . Ligcine kubushushu begumbi, phakathi kwama-20 kunye nama-25 degrees Celsius (ama-68 kunye nama-77 degrees Fahrenheit). Jonga umhla wokuphelelwa kweli yeza kwaye ungaze usebenzise naliphi na iyeza eliphelelwe lixesha. Lilahle ngokufanelekileyo.

Ulahla njani amayeza angasafunekiyo okanye aphelelwe lixesha ngaphandle kokonakalisa okusingqongileyo?

• Ezinye iikhemesti okanye izibhedlele zineenkqubo zokuthatha amayeza kwakhona. Ukuba kunokwenzeka, thatha amayeza akho uye kwenye yezi ndawo. Ungafumana ulwazi oluthe kratya malunga noku kwikhemesti yakho okanye kwiofisi yokuhlolwa kwezempilo yoluntu yasekuhlaleni.
• Ukuba akukho ndlela yokuyibuyisela, jonga ipakethi yamayeza okanye imiyalelo engaphakathi ukuze ubone ukuba ifanele ilahlwe kwinkunkuma okanye ihlanjwe kwindlu yangasese. Ukuba awuqinisekanga, buza ugqirha wakho okanye ikhemisti.
• Ukuba ungazilahla enkunkuma, khupha iipilisi ebhotileni okanye epakethini, uzixube kakuhle nenkunkuma yekati esele isetyenzisiwe, umhlaba, ikofu egayiweyo, okanye ezinye izinto ezifanayo ezingafunekiyo. Emva koko, beka lo mxube kwingxowa yepolythene ephinda ivalwe okanye kwisikhongozeli seplastiki, uyivale kakuhle, uze uyilahle kwinkunkuma.

Okokugqibela, izinto ekufuneka uzikhumbule

Kulungile, ngoku uyaqonda ukuba iMifepristone liyeza elibalulekileyo elinokunceda ukulawula amanqanaba eswekile egazini kumntu onjengawe oneCushing Syndrome. Kodwa uyabona nokuba zininzi izinto ekufuneka uzilumkele xa uyisebenzisa.

Ngokukodwa, kubaluleke kakhulu ukuxelela ugqirha wakho ngokucacileyo ngamanye amayeza owasebenzisayo kunye nezinye izifo onazo, ukuthatha amayeza kanye njengoko ugqirha etshilo, ngexesha nangobungakanani obumiselweyo, ukuqaphela iziphumo ebezingalindelekanga ezinokubakho, kwaye uqaphele ngakumbi malunga nokukhulelwa kunye nolawulo lokuzalwa.

Ukuba unemibuzo okanye amathandabuzo malunga nale yeza, ungaze ungathandabuzi ukubuza ugqirha wakho okanye ingcali yezemithi kwikhemesti ukuba ayisombulule. Khumbula, impilo yakho ibaluleke kakhulu kuwe!

I- Mifepristone, i-Cushing's syndrome, i-cortisol, iswekile yegazi, i-adrenal gland, ukusebenzisana kwamayeza, iziphumo ebezingalindelekanga