Masifunde ngesitofu sokugonya iNatalizumab. Ngaba nawe unikwe eli yeza?

Xa ugqirha ecebisa isitofu esibizwa ngokuba yiNatalizumab kuwe okanye kumntu omaziyo, kuyinto eqhelekileyo ukuba nemibuzo emininzi ngaso. "Sisifo esinjani esi sinikwayo?", "Ngaba siza kunyanga ngokwenene?", "Ngaba kukho iziphumo ebezingalindelekanga?" Usenokuba uzibuza into efanayo. Ngoko ke, namhlanje, masithethe ngeli yeza elibizwa ngokuba yiNatalizumab ngendlela elula onokuyiqonda.

Luhlobo luni lonyango iNatalizumab?

Ngamafutshane, iNatalizumab lunyango. Oko kukuthi, ayinyangi ngokupheleleyo isifo, kodwa inceda ukulawula iimpawu kunye nokunciphisa ukudumba rhoqo. Eli yeza lisetyenziswa kakhulu kwiimeko ezimbini.

1. Kwimeko ye-Relapsing Multiple Sclerosis:

Cinga ngale ndlela: inkqubo yethu yemithambo-luvo ifana nocingo oluthwala imiqondiso yombane. Kwisifo esibizwa ngokuba yi-multiple sclerosis, isigqubuthelo sokukhusela (i-myelin) esijikeleze le micu yemithambo-luvo siyonakala. Emva koko ezo miqondiso zombane azihambi kakuhle. Oku kunokubangela iimpawu ezifana nobunzima bokuhamba, iingxaki zokubona, ubunzima bokuthetha, kunye nokulahlekelwa yingqondo. I-Natalizumab isebenza ngokulawula lo monakalo kunye nokunciphisa ukuphindaphindeka kokwanda kwesi sifo.

2. Kwisifo sikaCrohn:

Isifo sikaCrohn sisifo esingapheliyo sokudumba kwenkqubo yokugaya ukutya, ingakumbi amathumbu. Sinokubangela iimpawu ezifana neentlungu zesisu, ukudumba, kunye nokwehla kobunzima. Oogqirha banokucebisa iyeza iNatalizumab xa ezinye iindlela zonyango zingasebenzanga.

Eyona nto ibalulekileyo kukuba ugqirha wakho uya kugqiba ukuba eli yeza likulungele na kwaye kufuneka ulithathe ixesha elingakanani. Ngoko ke, kubaluleke kakhulu ukulandela imiyalelo yakhe.

Oogqirha banokulisebenzisa eli yeza nakwezinye iimeko. Ukuba unemibuzo ngalo, buza ugqirha wakho okanye ikhemisti. Igama lophawu lwale yeza yiTysabri.

Ndimele ndimxelele ntoni ugqirha ngaphambi kokuba ndithathe eli yeza?

Ngaphambi kokuba uqale ukuthatha iNatalizumab, kubalulekile ukuxelela iqela lakho lezempilo (oko kukuthi, oogqirha kunye nabahlengikazi) ulwazi oluthile, njengoko olo lwazi luya kubanceda bagqibe ukuba eli yeza likulungele na okanye ukuba kufuneka uthathe naziphi na izilumkiso ezikhethekileyo.

Ukuba unazo ezi zinto, ngokuqinisekileyo yitsho:

• Iingxaki zenkqubo yomzimba yokuzikhusela: Ukuba unengxaki okanye ubuthathaka kwinkqubo yomzimba wakho yokulwa nezifo (inkqubo yomzimba yokuzikhusela), sixelele ngayo. Oku kungenxa yokuba eli yeza likwachaphazela nenkqubo yomzimba yokuzikhusela, ngoko ke kubalulekile ukuba ulazi.
• Imeko ebizwa ngokuba yiProgressive Multifocal Leukoencephalopathy (PML):Olu luhlobo losulelo lobuchopho olungaqhelekanga kodwa oluyingozi kakhulu. Ukuba ukhe waba nale meko, kufuneka usixelele.
• Ukuba une-allergy kwi-Natalizumab okanye kwamanye amayeza, ukutya, iidayi, okanye izithinteli: Abanye abantu banokuba ne-allergy kumayeza athile. Ngoko ke ukuba ukhe waba ne-allergy ngaphambili kweli yeza okanye nakweyiphi na enye iyeza, xelela ugqirha wakho.
• Ukuba ukhulelwe okanye uzama ukukhulelwa: Amanye amayeza anokuba yingozi kumntwana ngexesha lokukhulelwa, ngoko ke kubalulekile ukuthetha nogqirha wakho ngale nto.
• Ukuba ungumama oncancisayo: Amanye amayeza anokudluliselwa kumntwana wakho ngobisi lwebele. Ngoko ke xelela ugqirha wakho ngale nto.

Ukongeza kwezi zinto, kubaluleke kakhulu ukuxelela ugqirha wakho malunga neminye imithi oyithathayo (eyalelwe ngugqirha, ethengiswa ngaphandle kwemvume kagqirha, amayeza esintu, iivithamini, iimveliso zezityalo).

Ulisebenzisa njani eli yeza?

I-Natalizumab inikwa njenge-infusion emthanjeni. Kufana nokunika isisombululo se-saline. Awunakukwenza oku ekhaya. Inikwa yingcali yezempilo, njengogqirha okanye umongikazi, esibhedlele okanye eklinikhi.

Eli yeza lidla ngokunikezelwa kanye ngenyanga, kodwa oku kunokwahluka ngokuxhomekeke kwimeko yakho.

Xa unikwa eli yeza, ikhemesti iya kukunika isikhokelo esikhethekileyo (iMedGuide) . Uza kuyifumana kunye nomyalelo ngamnye, ngalo lonke ixesha ufumana iyeza. Kubaluleke kakhulu ukuyifunda ngononophelo. Iqulethe ulwazi malunga neyeza, iziphumo ebezingalindelekanga, kunye nezinto ekufuneka uzilumkele. Ukuba kukho into ongayiqondiyo, ungoyiki ukubuza ugqirha wakho okanye ikhemesti.

Ngaba eli yeza linokunikwa abantwana?

Eli yeza alivumelekanga ukusetyenziswa ebantwaneni. Ukuba ucinga ngale yeza kumntwana wakho, kufuneka uthethe nogqirha wezingane ngalo.

Yintoni omawuyenze ukuba uthatha amayeza amaninzi kakhulu? (Ukusebenzisa amayeza amaninzi kakhulu)

Ekubeni oku kubonelelwa esibhedlele, amathuba okuba oku kwenzeke mancinci. Nangona kunjalo, ukuba ucinga ukuba uthathe amayeza amaninzi, fowunela iziko lokulawula ityhefu okanye igumbi longxamiseko ngokukhawuleza.

Eli yeza lelakho wedwa! Eli liyeza elichazwe ngugqirha malunga nemeko yakho kunye nomzimba wakho. Ngoko ke, ungaze wabelane ngeli yeza nomnye umntu.

Wenza ntoni ukuba uphoswe yidosi yeyeza?

Kubaluleke kakhulu ukusela eli yeza ngexesha. Ukuba uphoswe yi-aphoyintimenti ecwangcisiweyo, fowunela ugqirha wakho okanye ingcali yezempilo ngoko nangoko. Baza kukuxelela into omawuyenze ngokulandelayo. Musa ukwenza izigqibo wedwa.

Ngawaphi amanye amayeza anokungqubana (ukungqubana) nalo mayeza?

Eli linqaku elibaluleke kakhulu. Kukho amayeza athile anokubangela iingxaki xa esetyenziswa ngeNatalizumab. Ngoko ke, kubalulekile ukuba ugqirha wakho azi onke amayeza owasebenzisayo.

Musa ukuthatha iNatalizumab kunye namayeza alandelayo:

• Amayeza ebhayoloji, anjenge-adalimumab, i-certolizumab, i-etanercept, i-golimumab, kunye ne-infliximab, nawo ayayichaphazela inkqubo yomzimba yokuzikhusela, ngoko ke anokunyusa umngcipheko wosulelo olukhulu.

La mayeza anokusebenzisana neNatalizumab:

• I-Azathioprine
• I-Cyclosporine
• Ii-Interferons
• I-6-mercaptopurine
• I-Methotrexate
• Amanye amayeza anciphisa amathuba akho okulwa nosulelo
• Amayeza e-steroid - imizekelo: i-prednisone okanye i-cortisone
• Iigonyo - Lumka xa ufumana iigonyo eziphilayo, ingakumbi. Thetha nogqirha wakho ngale nto.

Olu luhlu lusenokungabandakanyi onke amayeza. Ngoko ke, xelela ugqirha wakho malunga nawo onke amayeza owasebenzisayo (kuquka amayeza aqholiweyo, amayeza angagunyaziswanga ngugqirha, kunye nezongezo zokutya), kwaye ukuba uyatshaya, usela utywala, okanye usebenzisa iziyobisi ezingekho mthethweni. Ezinye izinto zinokuchaphazela amayeza akho.

Zeziphi izinto ekufuneka uzilumkele xa usebenzisa eli yeza?

Ngelixa usela eli yeza, ugqirha wakho uza kukujonga rhoqo. Qiniseka ukuba ubona ugqirha wakho ngeentsuku ezicwangcisiweyo. Xelela ugqirha wakho ukuba iimpawu zakho aziphucuki, ukuba ziya ziba mandundu, okanye ukuba ziyaqhubeka.

Hlala kude nabantu abagulayo. Eli yeza linokuthi lichaphazele kancinci inkqubo yakho yomzimba yokuzikhusela, nto leyo enokukwenza ube namathuba amaninzi okufumana izifo. Ukuba ubonakalisa iimpawu ezifana nomkhuhlane, ukubanda, umphimbo obuhlungu, okanye impumlo egobhozayo, tsalela umnxeba ugqirha wakho ngokukhawuleza ukuze akunike ingcebiso. Musa ukuphuma uye kufuna iyeza wedwa.

Isilumkiso esibaluleke kakhulu: umngcipheko wokosuleleka kwengqondo (PML)

Oku kusenokuvakala kuyoyikisa kancinci, kodwa kubalulekile ukuba uqaphele. Kwezinye izigulana, nangona kunqabile kakhulu, iyeza iNatalizumab linokubangela usulelo olukhulu lobuchopho olubizwa ngokuba yiProgressive Multifocal Leukoencephalopathy (PML) . Oku kunokuba yingozi.

Ngoko ke, ukuba ufumana naziphi na kwezi mpawu, kufuneka uxelele ugqirha wakho ngoko nangoko:

• Utshintsho lombono (umz., umbono ofiphele ngesiquphe, umbono ophindwe kabini)
• Ubunzima bokucinga (umz., ukuphazamiseka, ukulahlekelwa yinkumbulo, ubunzima bokwenza izigqibo)
• Ubunzima bokuthetha (umz., amagama angacaciyo, ukungakwazi ukuthetha ngokucacileyo)
• Ubunzima bokuhamba (umz., ukulahlekelwa yibhalansi, ukungakwazi ukuhamba kakuhle)
• Ubunzima bokuma

Ukuba awukwazi ukufikelela kugqirha wakho, yiya kwigumbi likaxakeka ngokukhawuleza. Musa ukuyityeshela le nto. Ezi mpawu zisenokuba ziimpawu zePML okanye zingabi zona. Kodwa kungcono ukuvavanya.

Zithini iziphumo ebezingalindelekanga ezinokubakho zale yeza?

Njengayo nayiphi na iyeza, iNatalizumab inokubangela ezinye iziphumo ebezingalindelekanga. Asinguye wonke umntu ozifumanayo, kodwa kulungile ukuzazi.

Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho okanye kwingcali yezempilo ngoko nangoko:

• Iimpendulo ze-allergy: Iimpawu ezifana nokurhawuzelela kwesikhumba, ukurhawuzelela, amaqhuqhuva, ukudumba kobuso, imilebe, nolwimi.
• Ubunzima bokuphefumla.
• Utshintsho kwimbono.
• Iintlungu zesifuba.
• Ukudideka, ixhala.
• Uxinezelekile, uzive ngathi ulahlekelwa luvuyo lwakho.
• Isiyezi.
• Ukuziva utyhafile; intloko ebuhlungu; uyawa.
• Ukuziva ugula okanye iimpawu ezifana nomkhuhlane.
• Ukulahlekelwa yinkumbulo.
• Abafazi abangafikiyo kwixesha labo lokuya exesheni ngemihla yabo yokuzalwa (Abaphoswanga lixesha lokuya exesheni).
• Ubuthathaka bemisipha.
• Iingxaki zokulinganisela, ukuthetha, okanye ukuhamba. (Ezi zinokuba ziimpawu ze-PML, ngoko ke lumka ngakumbi!)
• Iimpawu kunye neempawu zokulimala kwesibindi: Umchamo otyheli okanye omdaka omnyama; ukuziva ungaphilanga, umkhuhlane; ilindle elikhanyayo; ukungabi namdla wokutya; isicaphucaphu; iintlungu kwicala eliphezulu lasekunene lesisu; ukudinwa okanye ubuthathaka obungaqhelekanga; ukutyheli kwamehlo okanye ulusu.
• Iingcinga zokuzibulala, utshintsho lweemvakalelo.
• Ukukruquka okanye ukopha okungaqhelekanga.
• Ubuthathaka okanye ukudinwa ngokungaqhelekanga.

Iziphumo ebezingalindelekanga ezihlala zingadingi ngcebiso kagqirha (kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka okanye ziyakhathaza):

• Intloko ebuhlungu
• Intlungu yamalungu
• Ukuqaqamba kwemisipha
• Intlungu yemisipha
• Isicaphucaphu, ukuhlanza
• Intlungu, ukubomvu, okanye ukurhawuzelelwa kwindawo apho kufakwe khona inaliti
• Ukudinwa

Olu luhlu lusenokungabandakanyi zonke iziphumo ebezingalindelekanga. Ukuba ubona nantoni na engaqhelekanga ukongeza kwezi, buza ugqirha wakho.

Uligcina phi eli yeza?

Awuyi kuvunyelwa ukuba uye nalo mayeza ekhaya. Liyafumaneka kwaye linikwa esibhedlele okanye ekliniki. Ngoko ke, akufuneki ukhathazeke ngendlela yokuligcina.

Okokugqibela, izinto ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ngoko ke sithethe kakhulu ngeNatalizumab. Ukuba unemibuzo engaphezulu malunga nale yeza, ungoyiki ukubuza ugqirha wakho, umongikazi, okanye ikhemisti. Baza kukunceda.

Eyona nto ibalulekileyo kukuthatha unyango kanye njengoko ugqirha wakho ekuxelela, ngexesha elifanelekileyo, nangendlela efanelekileyo. Qaphela iziphumo ebezingalindelekanga, ingakumbi iimpawu zesifo esibizwa ngokuba yi-PML. Ukuba ubona nantoni na engaqhelekanga, xelela ugqirha wakho ngoko nangoko.

Eli yeza linokukunceda ukulawula imeko yakho. Ngoko ke, hlala uqinile kwaye ujoyine ugqirha kolu hambo. Ndikunqwenelela ukuchacha ngokukhawuleza!

I- Natalizumab, i-Multiple Sclerosis, isifo sikaCrohn, i-PML, Iziphumo ebezingalindelekanga zamayeza, i-Immunotherapy, i-Tysabri