Isibindi sesinye sezitho ezibalulekileyo emzimbeni wakho. Sifana nomzi-mveliso omkhulu. Senza umsebenzi omninzi obalulekileyo, njengokususa iityhefu ekutyeni esikutyayo, ukugcina amandla, nokwenza inyongo, nto leyo esinceda ekugayeni ukutya. Ngoko ke, ukugcina lo mzi-mveliso usebenza ngokufanelekileyo kubaluleke kakhulu kwimpilo yomzimba wethu wonke. Kodwa ngamanye amaxesha kukho izifo ezichaphazela isibindi buthule, izifo esingazivayo kangako ngazo. Namhlanje siza kuthetha ngesinye sezifo ezinjalo. Leyo yiPrimary Biliary Cholangitis, okanye iPBC njengoko siyibiza ngokufutshane.
Kalula nje, yintoni i-PBC?
Kulungile, masiqhubeke nale nto ilula. Njengoko benditshilo ngaphambili, isibindi sivelisa ulwelo olubizwa ngokuba yi-bile . Yile nto isinceda sigaye amafutha ekutyeni esikutyayo, sifunxe iivithamini ezithile, kwaye sisuse i-cholesterol engafunekiyo kunye neetyhefu emzimbeni.
Khawuthelekelele, ngaphakathi kwesibindi kukho uthungelwano lwemibhobho yenyongo, efana nenkqubo yetyhubhu encinci. Inyongo eyenziwa sisibindi ihamba ngale mibhobho mincinci ize igcinwe apho, inceda ekugayeni ukutya xa kuyimfuneko. Okwenzekayo kwi-PBC kukuba le mibhobho yenyongo yonakele.
Xa le mibhobho yonakele, inyongo ayikwazi ukuhamba kakuhle ize iqale ukuqokelelana ngaphakathi kwesibindi. Ifana nombhobho wamanzi oqhekekileyo ozalisa indlu ngamanzi. Inyongo eqokelelana ngale ndlela iqala ukonakalisa iiseli zesibindi. Xa lo monakalo usenzeka ngokuhamba kwexesha, izicubu ezibomvu ziqala ukwakheka endaweni yeeseli zesibindi eziphilileyo. Le meko siyibiza ngokuba yi-cirrhosis . Xa isibindi siba namanxeba ngale ndlela, ukusebenza kwaso okuqhelekileyo kuyaphazamiseka phantse ngokupheleleyo.
Amanqanaba amane esifo se-PBC
I-PBC ayibi mbi ngaxeshanye. Ikhula kancinci kancinci, idlula kumanqanaba aliqela. Ngokwesiqhelo kukho amanqanaba amane aphambili.
| Iqonga | Kwenzekani |
|---|---|
| Inqanaba 1 (Inqanaba lePortal) | Eli linqanaba lokuqala. Okwenzekayo apha kukudumba, okukudumba, okujikeleze imibhobho yenyongo. Olu tshintsho luqala kwindawo yokungena kwesibindi apho imithambo yegazi kunye nemibhobho yenyongo idibana khona. |
| Inqanaba lesi-2 (Inqanaba elingaphandle) | Ngoku ukudumba kusasazeka kancinci kwaye kuqala ukuphuma kujikeleze imibhobho yenyongo. Kukule nqanaba apho inani elincinci lezicubu ezibomvu (i-fibrosis) liqala ukwakheka. |
| Inqanaba lesi-3 (Inqanaba leSeptal) | Okwangoku, loo zicubu zesilonda zisasazeke ngakumbi, zidala unxibelelwano phakathi kwamalungu esibindi. Zifana nenethiwekhi efana nentambo yesigcawu yamanxeba asasazeka kwisibindi sonke. |
| Inqanaba lesi-4 (iBiliary Cirrhosis) | Eli lelona nqanaba linzima nelokugqibela lesi sifo. Ngeli xesha, izicubu zesilonda zisasazeke kwisibindi sonke, zenza isibindi sibe lukhuni size senze amaqhuma. Le meko ibizwa ngokuba yi-cirrhosis. Kweli nqanaba, ukusebenza kwesibindi kuyaphazamiseka kakhulu. |
Yintoni kanye kanye ebangela i-PBC?
Le yingxaki abantu abaninzi abanayo. Enyanisweni, oogqirha abakafumani unobangela ochanekileyo we-PBC. Nangona kunjalo, uluvo olwamkelweyo ngoku kukuba sisifo esibangelwa kukuzilawula komzimba esibangelwa kukudibana kwezinto zemfuza kunye neemeko ezingqongileyo .
Kulungile, yintoni esi sifo sokuzikhusela komzimba?
Ngamafutshane, oku kukungasebenzi kakuhle kwenkqubo yomzimba wethu yokuzikhusela. Ngokwesiqhelo, iiseli zethu ezimhlophe zegazi (ngakumbi iiseli ze-T) zilwa neentsholongwane ezibangela izifo. Kodwa kwi-PBC, ezi seli zokuzikhusela ziyaphazama zize ziqale ukuhlasela iiseli ze-bile duct ezisempilweni esibindini. Kufana nomkhosi wethu uhlasela abantu bethu ngempazamo.
Kuxa iiseli zethu zihlasela rhoqo imibhobho yenyongo ngale ndlela apho umonakalo endiwukhankanyileyo ngaphambili uqala ukwenzeka.
Akunakuthiwa esi sifo sidluliselwa kwizizukulwana ngezizukulwana ngeejini. Oko kukuthi, akukho mthetho wokuba ngenxa yokuba umama enaso, intombi yakhe nayo iya kuba naso. Nangona kunjalo, ukuba umntu kusapho, ingakumbi isalamane esisondeleyo (umama, udade, okanye umnakwabo), une-PBC, umngcipheko wokuba abanye bafumane esi sifo uphezulu kancinci kunomntu oqhelekileyo. Ke ngoko, kunokucingelwa ukuba kukho unxibelelwano lwejini.
Ngubani osengozini enkulu yokuhlaselwa yi-PBC?
Nangona nabani na enokuba ne-PBC, abanye abantu basengozini enkulu kancinci. Makhe sijonge ukuba bangoobani.
| Into Engumngcipheko | Iinkcukacha ezingakumbi |
|---|---|
| Isini (Isini) | Oku kuyamangalisa. I-PBC ixhaphake kakhulu kwabasetyhini. Abafazi banamathuba aphindwe kayi-9 ukuya kwi-10 okuba nesi sifo kunamadoda. |
| Ubudala | Uninzi lwabantu abafunyaniswe benesi sifo baphakathi kweminyaka engama-30 ukuya kwengama-60 ubudala , kodwa sinokuvela nakubantu abancinci okanye abadala kunoko. |
| Imbali yoSapho | Njengoko benditshilo ngaphambili, ukuba umntu kusapho lwakho (ingakumbi umama okanye udadewenu) une-PBC, usemngciphekweni omkhulu wokufumana esi sifo kunabantu ngokubanzi. |
| Imvelaphi yemfuza | Kwihlabathi liphela, esi sifo sixhaphake kakhulu kubantu abavela eMntla Yurophu (njengaseScotland nakwamanye amazwe aseScandinavia). Nangona kunjalo, sinokuvela kulo naliphi na ilizwe kunye neqela lohlanga ehlabathini. |
Zithini ke ngoko iimpawu?
Le yeyona nto ibalulekileyo. Into eyoyikisayo nge-PBC kukuba abantu abaninzi ababonisi zimpawu kwasekuqaleni. Ngamanye amaxesha ifunyanwa ngengozi xa kusenziwa uvavanyo lwegazi lwenye imeko.
Kodwa njengoko isifo siqhubeka, iimpawu ezinjalo zinokubonakala:
- Ukudinwa: Uphawu oluphambili kukuziva udiniwe kakhulu ngaphandle kwesizathu esicacileyo, nokuba ulele.
- Ulusu olurhawuzelelayo: Usenokuba nokurhawuzelela okunganyamezelekiyo emzimbeni wakho wonke, ingakumbi ezintendeni nasezinyaweni zakho.
- Amehlo nomlomo owomileyo: Ukuncipha kokuveliswa kweinyembezi emehlweni kunye namathe emlonyeni, okubangela ukuziva womile.
- Intlungu yamalungu kunye namathambo.
- Intlungu okanye ukungakhululeki okuncinci kwicala eliphezulu lasekunene lesisu.
Njengoko isifo siqhubeka (sisiya kwinqanaba le-cirrhosis), iimpawu ezinje ngokudumba kwemilenze, ulwelo esiswini, kunye nokutyheli kwamehlo nolusu (i-jaundice) nazo zinokuvela.
Ufanele uye nini kugqirha?
Ukuba wena, ingakumbi ukuba ungumfazi ophakathi kweminyaka engama-30 ukuya kwengama-60 ubudala, ufumana iimpawu ezifana nokudinwa okungapheliyo kunye nokurhawuzelelwa lulusu ngaphandle kwesizathu esicacileyo, musa ukuyithatha njengento "yokukhula nje" okanye "umsebenzi omninzi." Bona ugqirha wakho ngoko nangoko uze uthethe ngayo.
Ugqirha uza kukuxilonga aze, ukuba kuyimfuneko, acele uvavanyo lwegazi oluninzi. Esi sifo sinokuchongwa ngokulula ngokujonga ii-enzymes zesibindi kunye nee-antibodies ezithile (AMA - Antimitochondrial Antibodies). Ngoko ke musa ukuzityeshela iimpawu. Okukhona sichongwa ngokukhawuleza, kokukhona kunokwenzeka ukuba sinyangwe kwaye silawulwe.
Umyalezo Wokuya Ekhaya
- I-PBC sisifo esingapheliyo esonakalisa imibhobho yenyongo emincinci esibindini.
- Esi asisosifo esosulelayo. Sidla ngokubangelwa yimpazamo kwinkqubo yomzimba yethu yokuzikhusela (autoimmune).
- Kwinqanaba lokuqala, kusenokungabikho zimpawu konke konke. Iimpawu zokuqala eziqhelekileyo kukudinwa kunye nokurhawuzelelwa lusu.
- Esi sifo sixhaphake kakhulu phakathi kwabasetyhini, ingakumbi abo baneminyaka engama-30 ukuya kwengama-60 ubudala.
- Ukuba unamathandabuzo okanye iimpawu malunga noku, zixilonge ngokwakho (Linda, nguThai lowo. Typo kwinkqubo yam yokucinga. Kufuneka ulumke). Musa ukuzixilonga ngokwakho, kodwa ngokuqinisekileyo bonana nogqirha ofanelekileyo kwaye ucele ingcebiso.
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