Sonke siyazi ukuba ukulwa nomhlaza akuyonto ilula. Ngeli xesha lohambo, ugqirha wakho unokukunika amayeza ahlukeneyo. Umzekelo, iPonatinib liyeza elithile, lanamhlanje elijolise kuphela kwiiseli zomhlaza kwaye lithintele ukukhula kwazo. Ngoko ke, ukuba unikwe eli yeza, kubaluleke kakhulu ukuba impilo-ntle yakho nokhuseleko lwakho lufumane ulwazi olupheleleyo ngalo. Masithethe ngayo yonke into ngokulula nangokucacileyo.
Yintoni iPonatinib?
Ngamafutshane, olu luhlobo lonyango olubizwa ngokuba yi-'targetted therapy'. Oku kuthetha ukuba olu nyango luchonga iiproteni ezithile kwiiseli zomhlaza kwaye luzithintele ekusebenzeni, ngaphandle kokubangela umonakalo omkhulu kwiiseli eziphilileyo emzimbeni. Oku kuthintela iiseli zomhlaza ukuba zahlukane kwaye zikhule. Kufana nokufumana utshaba nokuzihlasela.
Eli yeza lisetyenziswa kakhulu ukunyanga iintlobo ezahlukeneyo ze-leukemia. Ezi zezi:
- I-Chronic Myelogenous Leukemia (CML)
- Ezinye iintlobo ze-acute lymphoblastic leukemia (YONKE)
Ugqirha wakho uya kugqiba ukuba eli yeza lifanelekile na kuwe ngokusekelwe kwimeko yakho yempilo.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Kubalulekile ukuba ugqirha wakho ayazi imbali yakho epheleleyo yempilo ngaphambi kokuba anike eli yeza. Oku kungenxa yokuba ezinye iimeko zonyango zinokwenza ukusetyenziswa kweli yeza kube yingozi. Ke ngoko, ukuba unembali yenye yezi zilandelayo, kufuneka uxelele ugqirha wakho ngaphandle kokuyifihla .
- Izifo zokopha okanye amahlwili egazi
- Isifo seswekile
- Ukuba usandul' utyando okanye uceba ukulutyanda kwixesha elizayo
- Ukuba ukhe wahlaselwa yintliziyo
- Nasiphi na esinye isifo sentliziyo (isifo sentliziyo okanye ukusilela kwentliziyo)
- Igazi elonyukayo
- I-cholesterol ephezulu
- Ukubetha kwentliziyo okungaqhelekanga
- Isifo sesibindi
- Ukuba une-pancreatitis
- Ukuba ukhe waba nesifo sohlangothi
- Ukuba une-allergy kwi-ponatinib okanye naliphi na elinye iyeza, ukutya, okanye idayi.
- Ukuba ukhulelwe okanye uzama ukukhulelwa
- Ukuba umntwana uncanciswa
Kubaluleke kakhulu kukhuseleko lwakho ukuzixela ngokuchanekileyo ezi zinto.
Ndingayisebenzisa njani le yeza?
Njengoko ugqirha esitsho, kubaluleke kakhulu ukuthatha idosi echanekileyo ngexesha elifanelekileyo.
- Ginya ipilisi yonke ngeglasi yamanzi.
- Ungayithatha ngaphambi okanye emva kokutya. Nangona kunjalo, ukuba uziva uphazamisekile esiswini okanye unesicaphucaphu, kungcono ukuyithatha kunye nokutya.
- Kubaluleke kakhulu: Musa ukuphula, ukutyumza, okanye ukuhlafuna le pilisi. Yiginye yonke.
- Kubaluleke kakhulu: Ungaze ulisebenzise eli yeza kunye nejusi yegrapefruit okanye yegrapefruit. Ezi zimbini zinokubangela impendulo enzima.
- Ziqhelise ukusela amayeza akho malunga nexesha elifanayo yonke imihla.
- Musa ukuyeka ukuthatha amayeza akho ngaphandle kwengcebiso kagqirha wakho.
Uza kufumana incwadana yolwazi ekhethekileyo (iMedGuide) xa unikwa eli yeza. Lifunde ngononophelo rhoqo. Liqulethe ulwazi oluninzi olubalulekileyo kuwe.
Kuthekani ukuba umthamo weyeza unyusiwe? (Umthamo ogqithisileyo)
Ukuba ucinga ukuba usenokuba uthathe amayeza amaninzi kakhulu, ungalibazisi. Tsalela umnxeba iZiko loLwazi lweTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo ngoko nangoko okanye uye kwiSebe leNgxamiseko (ETU) lesibhedlele esikufutshane.
Kuthekani ukuba ndiphoswe yidosi? (Idosi ephoswe yidosi)
Ukuba ulibele ukuthatha idosi, yithathe kwangoko xa ukhumbula. Nangona kunjalo, ukuba sele kuza kufuneka uthathe idosi yakho elandelayo, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe idosi ephindwe kabini.
Izinto ekufuneka uzilumkele xa usebenzisa amayeza
Kufuneka unikele ingqalelo engakumbi emzimbeni wakho ngelixa usebenzisa eli yeza.
Uvavanyo lwezonyango olucwangcisiweyo
Yiya kwiikliniki ngeentsuku ezicwangcisiweyo njengoko uyalelwe ngugqirha wakho. Yenza uvavanyo lwegazi lwakho kunye nezinye iimvavanyo ngexesha. Xelela ugqirha wakho ngokukhawuleza ukuba iimpawu zakho aziphucuki okanye azibi mandundu.
Ingqalelo kumehlo
Umbono wakho ungajongwa ngaphambi kokuba uqale ukusebenzisa eli yeza kwaye ngelixa ulisebenzisa. Ukuba ufumana naluphi na utshintsho, olufana nombono ofipheleyo, amehlo omileyo, iintlungu zamehlo, okanye ukuva ukukhanya, xelela ugqirha wakho ngoko nangoko.
Ngaphambi kotyando
Ukuba uza kwenziwa utyando, kufuneka uxelele ugqirha wakho we-oncologist kunye nogqirha. Eli yeza linokucothisa inkqubo yokuphiliswa kwamanxeba. Ngoko ke, kufuneka uyeke ukuthatha eli yeza kwiintsuku ezisi-7 ngaphambi kotyando . Emva kotyando, kufuneka ulinde ubuncinane iiveki ezi-2 ngaphambi kokuba uqale kwakhona iyeza. Eli yeza kufuneka liqalwe kwakhona kuphela emva kokuba inxeba lipholile ngokupheleleyo.
Ingozi yokopha kunye nosulelo
Eli yeza linokubangela ukukrweleka okulula kunye nomngcipheko owongezelelekileyo wokopha. Xelela ugqirha wakho ukuba ubona ukopha okungaqhelekanga (umz. okuvela kwiintsini, empumlweni) okanye ukukrweleka. Kukwakho nomngcipheko wokosuleleka ngenxa yenkqubo yomzimba yokuzikhusela ebuthathaka. Umkhuhlane, ukubandaUkuba uziva ungaphilanga, uneempawu ezifana nomphimbo obuhlungu okanye ukukhwehlela, funa ingcebiso kagqirha ngokukhawuleza. Ziphephe iindawo apho abantu bagula khona.
Ukukhulelwa kunye nokuncancisa
Le yingxaki ebaluleke kakhulu.
- Kuphephe ukukhulelwa ngokupheleleyo ngelixa usebenzisa eli yeza.
- Kuphephe ukukhulelwa ubuncinane iiveki ezi-3 emva kokuyeka ukusebenzisa ipilisi.
- Ukuba uceba ukukhulelwa, okanye ukrokrela ukuba ukhulelwe, xelela ugqirha wakho ngoko nangoko, kuba oku kunokubangela ingozi enkulu kumntwana ongekazalwa.
- Musa ukuncancisa umntwana wakho ngelixa usela iyeza kwaye emva kweentsuku ezi-6 uyekile.
Iziphumo ebezingalindelekanga ezinokubakho zeyeza
Njengalo naliphi na iyeza, i-ponatinib inokubangela iziphumo ebezingalindelekanga. Ezinye zinzima, ngelixa ezinye zixhaphakile. Kubalulekile ukuzazi ezi zinto.
| Imiphumela | Inkcazo/Iimpawu |
|---|---|
| Iziphumo ebezingalindelekanga ezinzulu ekufuneka zixelwe kugqirha wakho okanye esibhedlele ngoko nangoko | |
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi. |
| Ukopha | Indle emnyama okanye enegazi, umchamo omdaka okanye obomvu, ukuhlanza into efana nekofu egayiweyo, amabala abomvu eluswini, ukopha okungaqhelekanga emehlweni, kwiintsini, okanye empumlweni. |
| Ihlwili legazi | Intlungu esifubeni, ubunzima bokuphefumla, intlungu yemilenze, ukudumba, okanye ukufudumala. |
| Ukuhlaselwa yintliziyo okanye iingxaki zentliziyo (Ukuhlaselwa yintliziyo / Ukusilela kwentliziyo) | Ukuqina kwesifuba, umqolo, neengalo, ubunzima bokuphefumla, ukunyuka kobunzima ngequbuliso, ukudumba kwamaqatha, iinyawo, nezandla, kunye nokudinwa kakhulu. |
| Istroke | Ukutshintsha kombono, ukudideka, ubunzima bokuthetha okanye ukuqonda, intloko ebuhlungu, ukudinwa okanye ubuthathaka ngequbuliso ebusweni, engalweni, okanye emlenzeni. |
| Ukulimala kwesibindi | Umchamo otyheli okanye omdaka omnyama, ukutyheli kwamehlo okanye ulusu, iintlungu kwinxalenye ephezulu ngasekunene yesisu, ukungabi namdla wokutya. |
| I-Pancreatitis | Intlungu yesisu isasazeka emqolo, intlungu eba mandundu emva kokutya, umkhuhlane, isicaphucaphu, ukuhlanza. |
| Iziphumo ebezingalindelekanga ezingaqhelekanga, kodwa kufuneka zixelwe kugqirha ukuba ziyaqhubeka | |
| Ukuqhinwa | |
| Ulusu olomileyo | |
| Intlungu yamalungu | |
| Intlungu yemisipha | |
| Isicaphucaphu | |
Ukuba ufumana naziphi na ezinye iimpawu ezingaqhelekanga ezingakhankanywanga kolu luhlu, thetha nogqirha wakho ngazo.
Umyalezo Wokuya Ekhaya
- Sela amayeza akho kanye njengoko ugqirha wakho ekuyalele, ngedosi echanekileyo, nangexesha elifanelekileyo.
- Musa ukuthatha eli yeza kunye nejusi yegrapefruit nangasiphi na isizathu.
- Nika ugqirha wakho uluhlu olupheleleyo lwazo zonke ezinye iziyobisi ozisebenzisayo (kuquka ezo zezinye izifo, iivithamini, kunye namayeza e-Ayurvedic).
- Funa uncedo lwezonyango ngokukhawuleza ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngeentlungu zesifuba, intloko ebuhlungu kakhulu, ubunzima bokuthetha, okanye ukopha okungaqhelekanga.
- Kuphephe ukukhulelwa ngelixa usebenzisa eli yeza kwaye emva kweeveki ezi-3 uyekile.
- Ukuba uneengxaki okanye amathandabuzo, thetha nogqirha wakho ngazo. Musa ukukhathazeka nganto.
👩🏽⚕️ Imibuzo eyongezelelweyo (Ii-FAQ)
💬 Iipilisi zeBenazepril (Benazepril / Lotensin) zimiselwe isifo sasiphi?
Eli lelinye lamayeza e-ACE Inhibitor aphumelele kakhulu emhlabeni alawula uxinzelelo lwegazi oluphezulu! Linciphisa uxinzelelo lwegazi kwaye lithintele ukuhlaselwa yintliziyo/ukubetha kwentliziyo, kwaye likwamiselwa ngoogqirha njengeyeza lokukhusela kwakhona ukulawula i-nephropathy yesifo seswekile kunye nokukhusela izintso kubantu abanesifo seswekile.
💬 Ndingawunciphisa njani uxinzelelo lwegazi kwaye ndisindise izintso zam ngokuthatha le pilisi yoxinzelelo lwegazi (iBenazepril)?
Uxinzelelo luyanyuka luze lubeke uxinzelelo kwizintso ngekhemikhali eyingozi ebizwa ngokuba yi-'Angiotensin II' eyenziwa ngumzimba wethu! Xa ipilisi yeBenazepril ingena emzimbeni, i-enzyme eyenza loo khemikhali (ACE) ivalwe/ivalwe kwaye itshixwe ngokupheleleyo! Emva koko yonke imithambo yegazi iyaphumla (iVasodilation) kwaye uxinzelelo luyehla. Kwakhona, izintso ziyakhuseleka kuba uxinzelelo kwimithambo yegazi ethambileyo ngaphakathi kwezintso luyancitshiswa.
💬 Zithini iziphumo ezicaphukisayo neziyingozi (iBlack Box Warning) zokuthatha eli yeza (iBenazepril)?
Ukususela ekuqaleni, ingozi enkulu yolu sapho (lwe-ACE) lwamayeza kukuba awavumelekanga ngokungqongqo 'ekukhulelweni' (okubulalayo kwimveku)! Enye ingxaki enkulu 'kukukhwehlela okomileyo' okwenzeka xa usela amayeza, ukuba awukwazi ukumelana nawo, kufuneka utshintshele kwenye ipilisi (ARB). Kwakhona, abanye abantu kufuneka baye esibhedlele ngoko nangoko ukuba bafumana 'i-angioedema, ukudumba kobuso/imilebe kunye nokuphelelwa ngumphefumlo'.
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