Ngaba uhlala uziva udiniwe okanye urhawuzelelwa ngaphandle kwesizathu? Ngamanye amaxesha sisenokungazinaki kakhulu ezi zinto njengezinto eziqhelekileyo kubomi bethu bemihla ngemihla. Nangona kunjalo, ezi ngamanye amaxesha zinokuba luphawu lwesilumkiso oluvela ngaphakathi emzimbeni wethu. Ngokukodwa, zinokuba luphawu lokuqala lwengxaki yesibindi sethu. Namhlanje siza kuthetha ngesifo esinokuchaphazela umzimba buthule. Oko yiPrimary Biliary Cholangitis, okanye iPBC ngamafutshane.
Ngamafutshane, yintoni iPrimary Biliary Cholangitis (PBC)?
Khawuthelekelele ngaphakathi kwesibindi sakho kukho inkqubo yeetyhubhu ezincinci nezincinci nezincinci. Kufana namasebe omthi akhula. Ezi zizinto esizibiza ngokuba yi-bile ducts. Umsebenzi ophambili wale ducts kukuthwala ulwelo olubizwa ngokuba yi-'Bile' oluveliswa sisibindi luphume esibindini, oko kukuthi, lungene kwinkqubo yethu yokugaya ukutya. Le bile ibaluleke kakhulu kuthi, kuba yile bile enceda ekunyibilikiseni amafutha ekutyeni esikutyayo.
Ngoku, kwisifo esibizwa ngokuba yiPrimary Biliary Cholangitis (PBC), inkqubo yethu yomzimba yokuzikhusela ihlasela ngempazamo le mibhobho yenyongo. Oku kubangela ukudumba, okanye ukudumba, kwimibhobho yenyongo. Ekuhambeni kwexesha, oku kudumba konakalisa imibhobho yenyongo kwaye kuyitshabalalisa kancinci kancinci.
Kwenzeka ntoni ke ngoko? Njengombhobho wamanzi ovalekileyo, inyongo ayikwazi ukuhamba kwaye inamathele ngaphakathi kwesibindi. Inyongo ebambekileyo iqala ukonakalisa iiseli zesibindi. Njengoko lo monakalo uqhubeka, izicubu ezibomvu ziqala ukwakheka endaweni yezicubu zesibindi eziphilileyo. Ekugqibeleni, isibindi siba nzima kancinci kwaye umsebenzi waso uyehla. Le meko siyibiza ngokuba yi-cirrhosis . Ngaphambili, esi sifo sasibizwa ngokuba yi-Primary Biliary Cirrhosis.
Ingaba esi sifo sibi ngokwenene?
I-PBC sisifo esiqhubekayo nesingapheliyo. Oku kuthetha ukuba asibi ngcono ngobusuku obunye, kwaye iimpawu zinokuba mandundu ngokuhamba kwexesha. Kwinqanaba lokuqala, kusenokungabikho zimpawu konke konke. Nangona kunjalo, ukuba esi sifo asilawulwa, ekugqibeleni sinokukhokelela ekungasebenzini kwesibindi. Ngelo xesha, sinokubeka ubomi esichengeni ukuba ukufakelwa isibindi akwenziwa.
Kodwa ungoyiki apha. Ngethamsanqa, kukho amayeza amaninzi alungileyo namhlanje anokunciphisa isantya kwaye alawule isantya sesi sifo. Ngoko ke ayinguye wonke umntu ofikelela kwinqanaba lokugqibela lesi sifo. Eyona nto ibalulekileyo kukufumanisa isifo kwangethuba kwaye uqale unyango.
Ngubani onokuthi afumane esi sifo?
Into ephawulekayo xa kuthethwa ngesi sifo kukuba sixhaphake kakhulu phakathi kwabasetyhini.Oko kukuthi. Kumadoda onke afumana esi sifo, malunga nabafazi abali-10 bayasifumana. Kukho umsantsa onjalo.
- Esi sifo sidla ngokufunyaniswa emva kweminyaka engama-40 ubudala.
- Kwakhona, ukuba umntu kusapho lwakho unezinye izifo ezibangelwa kukuzikhusela komzimba , usenokuba sengozini enkulu yokuba nesinye, nto leyo ebonisa ukuba kusenokwenzeka ukuba kukho unxibelelwano olubangelwa yimfuza.
Ziziphi iimpawu kunye neengxaki ze-PBC?
Abantu abaninzi abanazo iimpawu ekuqaleni kwesi sifo. Ngamanye amaxesha sifunyanwa ngengozi xa uvavanyo lwegazi lwenziwa ngesizathu esithile. Kodwa njengoko isifo siqhubeka, iimpawu ziqala ukubonakala.
Iimpawu eziqhelekileyo eziza kuqala
- Ukudinwa: Olu lolona phawu luqhelekileyo. Nokuba ulala okanye uphumle kangakanani na, ukudinwa okuvayo akupheli.
- Ulusu olurhawuzelelayo: Ukurhawuzelela kunokwenzeka, ingakumbi ezintendeni zezandla nasezinyaweni. Nangona kunjalo, kunokwenzeka naphi na emzimbeni. Kwabanye abantu, ukurhawuzelela akunakunyamezeleka.
Ezi mpawu azibonakali ngendlela efanayo kuye wonke umntu. Kwabanye, zibonakala kanye ekuqaleni kwesi sifo, ngelixa kwabanye, zibonakala kamva kakhulu.
Iingxaki ezinokwenzeka njengoko isifo siqhubeka
Xa inyongo ingakwazi ukuhamba kakuhle, iqala ukuqokelelana egazini lethu. Kwakhona, kuvela iingxaki kuba inkqubo yokugaya ukutya ayifumani inyongo. Njengoko amanxeba esibindi esanda, uxinzelelo luyanda kwimithambo yegazi edlula esibindini. Oku kunokukhokelela kwiingxaki ezahlukeneyo. Masijonge ezi kwitheyibhile.
| Uhlobo lwengxaki | Iimpawu kunye neengxaki ezinokwenzeka |
|---|---|
| Ukungafunxwa kwamafutha Ukungakwazi ukugaya ioyile ekutyeni ngenxa yokungabikho kwenyongo. |
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| Uxinzelelo lwegazi oluphezulu lwePortal Uxinzelelo oluphezulu kumthambo wegazi ophambili odlula esibindini ngenxa yokuvaleka kwesibindi. |
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Yintoni unobangela wokwenene we-PBC?
Njengoko besitshilo ngaphambili, i-PBC sisifo esibangelwa kukuzikhusela komzimba . Ngamafutshane, "umkhosi" womzimba wethu (amajoni omzimba) uhlasela iiseli zethu ezilungileyo ngempazamo. Kufana nokuhlasela abantu bakuthi, sicinga ukuba baziintshaba. Kwi-PBC, olu "hlaselo" lwenzeka kwimibhobho yenyongo esibindini.
Oogqirha abakayazi kakuhle ukuba kutheni oku kusenzeka, kodwa bakholelwa ukuba kukho izizathu ezininzi ezinokwenzeka:
1. I-genetic factor: Ukuba kukho umntu kusapho onale zifo, nabanye banokuba nazo.
2. Izinto ezisingqongileyo: Xa intsholongwane, ibhaktheriya, okanye ikhemikhali ingena emzimbeni, inkqubo yomzimba yokuzikhusela yomntu onesifo semfuza inokubangela ukuba isebenze gwenxa.
Sifunyaniswa njani esi sifo? (Ukuxilongwa)
Xa uxelela ugqirha wakho ngeempawu zakho, uza kukuhlola aze akuyalele iimvavanyo ezininzi ukuqinisekisa ukuba unesifo.
1. Uvavanyo lwegazi: Olu lolona vavanyo lubalulekileyo. Kukho izinto ezimbini ezijongwa ngokukodwa.
- Ii-antibodies: Malunga nama-95% abantu abane-PBC bane-antibody ethile ebizwa ngokuba yi -Antimitochondrial Antibody (AMA) egazini labo.
- Ii-Enzymes zeSibindi: Xa isibindi sonakele, ii-enzyme ezithile (ingakumbi i-Alkaline Phosphatase - ALP ) ziyanda egazini.
2. Uvavanyo lweMifanekiso: Ukuba uvavanyo lwegazi lubonisa ukuba kukho i-PBC, ugqirha wakho unokuyalela ukuba kwenziwe iskeni ukuze kujongwe isibindi sakho kunye nenyongo. Oku kunokunceda ekuthinteleni ezinye izizathu zeempawu zakho. Iskeni ye-ultrasound idla ngokuba luvavanyo lokuqala olwenziweyo. Iskeni ye-MRI inokwenziwa ukuze kufunyanwe imifanekiso ecacileyo.Ungabhekisa kwenye.
3. I-Biopsy yeSibilini: Ngamanye amaxesha (ingakumbi kubantu abangenazo ii-antibodies ze-AMA egazini labo), iqhekeza elincinci kakhulu lesicubu sesibindi liyathathwa lize lihlolwe phantsi kwemakroskopu ukuqinisekisa ukuxilongwa nokufumanisa ubungakanani bomonakalo wesibindi.
Ziziphi iindlela zonyango ze-PBC?
Akukho nyango lwe-PBC okwangoku. Nangona kunjalo, kukho unyango olusebenzayo kakhulu lokunciphisa umonakalo kwisibindi obangelwa sisifo, ukulawula ukuqhubela phambili kwesifo, kunye nokulawula iimpawu.
Amayeza
- I-Ursodeoxycholic acid (UDCA): Eli liyeza eliphambili le-PBC. Liyi-bile acid yendalo. Eli yeza linceda ukususa i-bile esibindini kwaye linciphise umonakalo wesibindi. Lingasebenza kakhulu xa liqalwe kwangethuba kwesi sifo.
- Amanye amayeza: Kwabo bangasabeli kakuhle kwi-UDCA, ugqirha wakho unokucebisa amanye amayeza, anjenge -obeticholic acid . Ukongeza, amayeza amatsha, anjenge -seladelpar kunye ne -elafibrinor, ngoku asetyenziswa.
- Amayeza okuthintela iimpawu:
- Kwisikhumba esirhawuzelelwayo: Kusetyenziswa amayeza anjengeCholestyramine, ii-antihistamines, kunye nonyango lokukhanya kwe-ultraviolet.
- Xa kukho ukunqongophala kweevithamini: Kunikwa izongezo eziqulethe iivithamini A, D, E, kunye ne-K.
- Ngokudinwa: Abanye abantu banokufumana isiqabu kwiimithi ezivuselelayo ezifana ne-modafinil.
Utyando
Ukuba ukusebenza kwesibindi sakho kuyaqhubeka nokuwohloka kwaye akulawuleki ngamayeza, ugqirha wakho angakubeka kuluhlu lokulinda ukufakelwa isibindi . Ukufakelwa isibindi kwi-PBC kuyaphumelela kakhulu. Ungaphila ubomi obuqhelekileyo emva kokufakelwa. Nangona kunokwenzeka ukuba i-PBC ibuyele kwisibindi esitsha, kunqabile kakhulu.
Yintoni endifanele ndiyazi ngokuphila nesi sifo?
I-PBC idla ngokuqhubeka kancinci kakhulu. Kungathatha iminyaka eli-15-20 ukuba isifo sifikelele kwinqanaba lokugqibela. Ukuba isifo sifunyenwe kwaye sinyangwa kwangethuba, iimeko ezinzima zesifo zinokuthintelwa okanye zilibaziseke. Abantu abaninzi balawula iimpawu zabo ngamayeza baze baphile iminyaka emininzi ngaphandle kokuphazamiseka okukhulu kubomi babo bemihla ngemihla.
Nangona kunjalo, abanye abantu banokuba nokukhula ngokukhawuleza kwesi sifo. Ukudinwa kakhulu kunye namanqanaba aphezulu e-bilirubin egazini kunokuba ziimpawu zokuba isifo siqhubeka ngokukhawuleza.
Izinto onokuzenza ukukhusela isibindi sakho
Ukulandela indlela yokuphila elungileyo kunye nemikhwa yokutya kuya kunceda ukugcina isibindi sakho sisempilweni ixesha elide kangangoko kunokwenzeka.
- Yeka ngokupheleleyo ukutshaya, utywala, kunye nokusebenzisa iziyobisi ngokungeyomfuneko.Ezi ziyingozi kakhulu kwisibindi.
- Yitya ukutya okupheleleyo okufana nemifuno emitsha, iziqhamo, kunye nemifuno endaweni yokutya okulungisiweyo, okupakishwe kwiipakethe.
- Nciphisa amafutha agcweleyo kwaye ukhethe ukutya okuqulethe amafutha angenamafutha okanye "alungileyo" (umz. ii-avokhado, amantongomane, ioyile yomnquma).
- Yenza umthambo yonke imihla. Nokuba yinto elula njengokuhamba ilungile. Umthambo wokuthwala ubunzima unceda ukugcina amathambo eqinile.
Ukuphila nesifo esinganyangekiyo esifana nesi kunokuba nzima engqondweni. Thetha nogqirha wakho ngeendlela zokunciphisa uxinzelelo lwakho lomzimba, lwengqondo nolweemvakalelo. Funa ingcebiso ukuba kuyimfuneko. Khumbula, impilo yakho iyonke inkulu kakhulu kunesi sifo.
Umyalezo Wokuya Ekhaya
- I-Primary Biliary Cholangitis (PBC) sisifo esingapheliyo esonakalisa imibhobho yenyongo emincinci esibindini.
- Oku kubangelwa kukuba inkqubo yethu yokuzikhusela komzimba ihlasela ngempazamo imibhobho yenyongo (isifo sokuzikhusela komzimba).
- Iimpawu zokuqala zingabandakanya ukudinwa kunye nokurhawuzelelwa lusu, okanye kusenokungabikho zimpawu konke konke.
- Ukufunyanwa kwangoko kubalulekile. Esi sifo sinokufunyanwa rhoqo ngovavanyo lwegazi.
- Amayeza anokulawula ngempumelelo umonakalo kwisibindi obangelwa sisifo kunye nesantya sokuqhubeka kwesifo.
- Ukuphepha utywala nokutshaya kunye nokulandela indlela yokuphila esempilweni kubaluleke kakhulu kwimpilo yesibindi.
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