Ngaba wakha wazisika umnwe wakho? Okanye walunywa sisinambuzane waza loo ndawo yaba bomvu, yadumba, yaza yaba buhlungu? Sonke siye saba namava anje. Kwaye, ukuba ungumfazi, mhlawumbi uyazi kakuhle intlungu oyivayo ngexesha lokuya esikhathini. Namhlanje, siza kuthetha ngesithunywa sekhemikhali esincinci kodwa esinamandla kakhulu esisemva kwayo yonke le nto, kodwa asithethi kakhulu ngayo, kwaye yiloo nto siza kuthetha ngayo. Ibizwa ngokuba yiProstaglandins . Nangona igama lisenokuvakala lingaqhelekanga, libandakanyeka kwimisebenzi emininzi yemihla ngemihla yemizimba yethu.
Ngamafutshane, zithini ezi prostaglandins?
Iiprostaglandins liqela lee-lipids (uhlobo lwamafutha) eziveliswa emizimbeni yethu xa izicubu zonakele, zosulelekile, okanye kwiimeko ezikhethekileyo. Nangona zisebenza njengee-hormone, azizizo ii-hormone ngokwenene.
Ngoku usenokuba ucinga, "Ngoko ke yintoni umahluko phakathi kweehomoni nezi?" Cinga ngayo, iihomoni emizimbeni yethu zifana nenkonzo yeposi yelizwe. Iihomoni, eziveliswa kwindawo enye, njenge-pituitary gland engqondweni, zihamba emzimbeni wonke ngegazi kwaye zithumela imiyalezo kwiindawo ezahlukeneyo zomzimba.
Kodwa iiProstaglandins azinjalo. Zifana nomntu osezilalini ohambisa umyalezo kwindlu elandelayo. Oko kukuthi, ziveliswa apho zifuneka khona kwaye zichaphazela kuphela iiseli ezikufutshane . Azihambi emzimbeni wonke ngegazi. Ke ngoko, ukusebenza kwazo kuhlala ixesha elifutshane kakhulu. Ezi Prostaglandins ziveliswa yi-fatty acid ebizwa ngokuba yi-arachidonic acid, efumaneka kwiiseli zomzimba wethu.
Yintoni umsebenzi oyintloko we-prostaglandins?
Kukho iintlobo ezahlukeneyo ze-prostaglandins. Kwakhona, kukho iintlobo ezahlukeneyo zee-receptors ezibopha kuzo. Ke ngoko, imisebenzi yazo yahlukile. Kuxhomekeke kwisitho, kwizicubu ezizichaphazelayo, kunye neemfuno zomzimba ngelo xesha.
Nazi ezinye zezinto eziphambili abazenzayo:
| Inkqubo | Umsebenzi we-prostaglandins |
|---|---|
| Ukuphiliswa kwamanxeba | Xa kukho ukwenzakala, iiplatelets ziyaqokelelwa kwaye zilawulwe ukuze zenze ihlwili legazi ukuze kumiswe ukopha. |
| Ukudumba | Ukukhusela izicwili ezonakeleyo, ukuhamba kwegazi kwindawo leyo kuyanda, nto leyo ebangela ukudumba, ukuba bomvu, kunye nentlungu. |
| Intlungu kunye nomkhuhlane | Iyayivuselela imithambo-luvo eva iintlungu. Ikwachaphazela neziko lokulawula ubushushu engqondweni, nto leyo ebangela umkhuhlane. |
| Inkqubo yokuzala yabasetyhini | Inceda isibeleko siqine kwaye ikhuphe ulwelo lwesibeleko (i-endometrium) ngexesha lokuya exesheni. Inceda umlomo wesibeleko uvuleke kwaye isibeleko siqine ngexesha lokubeleka. |
| Ifuthe legazi | Ukunciphisa imithambo yegazi okanye ukuvasa igazi kunceda ekulawuleni uxinzelelo lwegazi. |
| Isisu | Iyanciphisa ukukhutshwa kwe-asidi esiswini kwaye yenza kube lukhuni ulwelo lwe-mucus olukhusela udonga lwesisu. |
| Inkqubo yokuphefumla | Iindlela zomoya zinciphile (i-bronchoconstriction) okanye zibanzi (i-bronchodilation). |
Masiqonde oku ngomzekelo wokwenene.
Khawuthelekelele usekhitshini usika imifuno uze umnwe wakho unqunyulwe ngemela. Hayi bo! Kwenzeka ntoni ngoku? Nantsi indlela esebenza ngayo i-prostaglandins:
1. Ukuyeka ukopha: Iiprostaglandins zikhutshwa ngoko nangoko kwizicubu zomnwe ezonakeleyo. Ezi zinika imiqondiso kwiiplatelets egazini ukuba "zize apha ngokukhawuleza zize zinamathele ndawonye ukuze zenze ihlwili legazi." Elo hlwili legazi livala inxeba lize liyeke ukopha. Kwangaxeshanye, iiprostaglandins zikwanceda ekunciphiseni imithambo yegazi kuloo ndawo.
2. Ukudumba: Okulandelayo, olunye uhlobo lwe-prostaglandin lungena luze lubangele ukuba imithambo yegazi ivuleke. Oku kubangela ukuba igazi elininzi lihambe. Yiyo loo nto inxeba liba bomvu kwaye lidumbe kancinci . Oku kudumba kuthintela izinto ezifana neentsholongwane ezinokungena enxebeni ukuba zingafiki kwezinye iindawo zomzimba.
3. Ukungeniswa kweeseli zokhuseleko:Ezi prostaglandins zithumela olunye uphawu kwiiseli zokuzikhusela zomzimba wethu, iiseli ezimhlophe zegazi. Iiphagocytes, ngakumbi, zisabela kolu phawu kwaye "zitya" kwaye zicoce naziphi na iintsholongwane kunye neeseli ezonakeleyo ezingene ngenxeba.
4. Intlungu: Kunye nayo yonke le nto, iiProstaglandins zenza iziphelo zemithambo-luvo apho zibe buthathaka ngakumbi. Yiyo loo nto siziva iintlungu . Le ntlungu isixelela ukuba, "Umnwe wakho wenzakele, yinyamekele."
5. Emva kokuphola: Emva kokuba inxeba liphole ngokupheleleyo, olunye uhlobo lwe-prostaglandin luyangena luze lunyibilikise ihlwili legazi elakheke ngaphambili, kuba alisafuneki.
Ngaba ukhe wayibona indlela entsonkothileyo ngayo inkqubo eqhubeka ngaphakathi emizimbeni yethu nokuba kukho ukwenzakala okuncinci? Iiprostaglandins zidlala indima enkulu ekuququzeleleni konke oku.
Ngoko ke, ngaba ii-prostaglandins zilungile okanye zimbi?
Lo ngumbuzo obaluleke kakhulu. Iiprostaglandins zibalulekile kwaye zendalo emizimbeni yethu. Zibalulekile ekuphiliseni amanxeba, ekukhuseleni kwiintsholongwane, nasekulawuleni umjikelo wokuya esikhathini. Ukudumba, inkqubo ebizwa ngokuba kukudumba, yindlela umzimba ozikhusela ngayo.
Kodwa ingxaki ivela xa umzimba wethu uqala ukwenza ii-prostaglandins ezingaphezulu kunezo uzidingayo . Kulapho ke iingxaki ziqala khona.
Umzekelo, ii-prostaglandins ziyafuneka ukuze isibeleko sinciphe ngexesha lokuya exesheni. Nangona kunjalo, ukuba ziveliswa kakhulu, isibeleko sincipha kakhulu kwaye sibuhlungu. Oku sikubiza ngokuba ziintlungu zokuya exesheni . Ngamanye amaxesha le meko inokubangela ukopha kakhulu (i-menorrhagia).
Kwakhona, isizathu sokuba abantu abanezifo ezingapheliyo ezifana ne-arthritis babe neentlungu ezingapheliyo kunye nokudumba kwamalungu abo kungenxa yokuba la manqanaba e-prostaglandin ahlala ephezulu.
Zisetyenziswa njani iiprostaglandins kunyango?
Xa sele iqondwa kakuhle imisebenzi ye-prostaglandins, oogqirha bayayisebenzisa kunyango olwahlukeneyo. Basebenzisa neziyobisi ezithintela ukusebenza kwayo.
IiProstaglandins zokwenziwa
Amayeza afana ne-prostaglandins, enziwe kwilebhu, asetyenziselwa ukunyanga izifo ezahlukeneyo.
- Kwixesha lokubeleka: Oomama abakhulelweyo abalibazisekayo ekuqaliseni ukuzala banikwa amayeza afana neDinoprostone ukuze bandise umlomo wesibeleko baze banciphise isibeleko.
- I-Glaucoma: Amathontsi eliso afana neTravoprost asetyenziselwa ukunyanga i-glaucoma, imeko apho uxinzelelo lwamehlo lunyuka khona.
- Kwingxaki yokungasebenzi kakuhle ngokwesondo kwamadoda (Ukungasebenzi kakuhle kwe-Erectile):I-Alprostadil, i-dilator yegazi, isetyenziselwa ukunyanga le meko.
- Izilonda Zesisu: Ezinye iipilisi zokuphelisa iintlungu zingonakalisa ulwelo lwesisu ukuba zisetyenziswa rhoqo. Ukuthintela oku, kunikwa amayeza anjengeMisoprostol , enciphisa i-asidi yesisu.
Amachiza athintela ukusebenza kwe-prostaglandin
Uninzi lwezithomalalisi zentlungu esizisebenzisayo nesidibana nazo rhoqo zisebenza ngokuthintela ukuveliswa kwee-prostaglandins. Eli qela lamayeza libizwa ngokuba zii-nonsteroidal anti-inflammatory drugs , okanye ii-NSAIDs ngamafutshane.
Iipilisi zokubulala iintlungu ezifana ne -Ibuprofen, i-Naproxen, i-Diclofenac, i-Mefenamic Acid ozisebenzisayo zonke ziphantsi kweli qela (ii-NSAID). Xa uzisebenzisa ezi pilisi ngenxa yentlungu yokuya exesheni, iintloko ezibuhlungu, kunye nentlungu yamalungu, intlungu iyancitshiswa kuba la mayeza athintela ukuveliswa kwee-prostaglandins.
Ziziphi iingxaki ezinokunxulunyaniswa ne-prostaglandins?
Ngamanye amaxesha, imizimba yethu ivelisa ii-prostaglandins ezininzi kakhulu, okanye azanelanga. Kuzo zombini iimeko, iingxaki ezahlukeneyo zempilo zinokubakho.
Iimeko ezenzekayo xa i-prostaglandins isanda:
- Intlungu engapheliyo: Ingabangela intlungu eqhubekayo emzimbeni.
- Uvelwano olukhulu kwintlungu: Ukuziva intlungu egqithisileyo nokuba yinto encinci.
- Ukuya exesheni okubuhlungu (iDysmenorrhea): Iintlungu zokuya exesheni esithethe ngazo ngaphambili.
- Ukopha kakhulu exesheni.
- Uphando lufumanise ukuba amanqanaba aphezulu e-prostaglandins anegalelo ekukhuleni kwezinye iintlobo zomhlaza .
Xa i-prostaglandins inganelanga:
Oku akufane kudibaniswe nesifo esingapheliyo. Nangona kunjalo, kusenokubakho iimeko apho ubungakanani be-prostaglandins efunekayo ukuphilisa inxeba bunganeli. Kwakhona, kwiimeko apho umzimba ungavelisi ii-prostaglandins ezaneleyo zokuqala ukuzala, oogqirha banika ii-prostaglandins zokwenziwa ezivela ngaphandle.
Ufanele uye nini kugqirha?
Ukuba unentlungu engapheliyo okanye ukudumba emzimbeni wakho, qiniseka ukuba ubona ugqirha wakho kwaye uxoxe naye ngaloo nto. Zininzi izizathu zoku, kodwa ukungalingani kwimisebenzi ye-prostaglandins kusenokwenzeka ukuba yimbangela.
Ngokukodwa, kukho into enokuthiwa malunga nentlungu yokuya exesheni.
Ukuba iintlungu zakho zokuya exesheni zinzima kangangokuba azinakulawulwa ngee-NSAIDs ezithengiswa ngaphandle kwemvume kagqirha, musa ukuzithatha njengento "eyenzeka kumantombazana." Ngamanye amaxesha ezi ntlungu zinzima zinokubangelwa yi-endometriosis okanyeIsenokuba yingxaki yempilo efihlakeleyo, efana ne-uterine fibroids. Ngoko ke, qiniseka ukuba uthetha nogqirha wakho ngayo kwaye ufumane iingcebiso kunye nonyango olufanelekileyo.
Iiprostaglandins ziikhemikhali ezimangalisayo ezisebenza buthule kodwa ngamandla emizimbeni yethu. Nangona zibalulekile ukuze siphile, xa ibhalansi yazo iphazamisekile, zinokuchaphazela kakhulu umgangatho wobomi bethu. Ngoko ke nikela ingqalelo emzimbeni wakho. Ukuba unentlungu engapheliyo okanye iimpawu ezingaqhelekanga, ungaze ungathandabuzi ukufuna ingcebiso kagqirha.
Umyalezo Wokuya Ekhaya
- Iiprostaglandins ziikhemikhali ezisebenza njengeehomoni kwaye ziveliswa emizimbeni yethu, apho kufuneka khona.
- Ezi zibandakanyeka ngokuthe ngqo kwiinkqubo ezininzi ezifana neentlungu, ukudumba (ukudumba), umkhuhlane, ukujiya kwegazi, kunye nokuya exesheni.
- Nangona ezi zinto zibalulekile emzimbeni, ubuninzi bazo bunokubangela iingxaki ezifana neentlungu ezingapheliyo kunye neentlungu eziqatha zokuya exesheni.
- Iipilisi zokunciphisa iintlungu (ii-NSAID) ezifana ne-ibuprofen zisebenza ngokuthintela ukuveliswa kwee-prostaglandins.
- Ukuba unentlungu enzima yokuya exesheni engalawulekiyo okanye ehlala ixesha elide, musa ukuyityeshela kwaye ubone ugqirha wakho ngoko nangoko.
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