Ngaba uyayazi le thumba (iGranulosa Cell Tumor) eyenzeka kwii-ovari?

Usenokuba awuzange uve ngeli gama elithi 'Granulosa Cell Tumor'. Olu luhlobo olungaqhelekanga lwethumba olukhula kwii-ovari. Kodwa kubaluleke kakhulu ukwazi ngalo, kuba lunokuchaphazela nezinye iihomoni emizimbeni yethu, ingakumbi kwimpilo yabasetyhini. Makhe sithethe ngale nto ngokweenkcukacha.

Yintoni iGranulosa Cell Tumor?

Ngamafutshane, eli lithumba elikhethekileyo elikhula kwii-ovari. Oogqirha balibiza ngokuba yi-"Sex Cord-Stromal Tumor". La mathumba akhula kwiithishu ezijikeleze ii-ovari. La mathumba anokubangela ukuba umzimba uvelise i-hormone yesini yabasetyhini eninzi kakhulu ``(i-estrogen)''. Ihlala ifunyaniswa imalunga neminyaka engama-50 ubudala, kodwa inokukhula nakweyiphi na iminyaka.

Zenzeka phi ezi ziqhuma?

Le `(Granulosa Cell Tumor)` ikhula ngqo ngaphakathi kwii-ovari. Njengoko usazi, ii-ovari ziyinxalenye ebaluleke kakhulu kwinkqubo yokuzala yabasetyhini. Ukongeza ekuveliseni amaqanda, ii-ovari zikwavelisa iihomoni ezimbini zokuzala `(Ova)` kunye `(Estrogen)` kunye `(Progesterone)`.

Zixhaphake kangakanani ezi zinto?

Ezi zibizwa ngokuba yi-"Granulosa Cell Tumors" kwaye azixhaphakanga kangako. Zenza malunga ne-5% kuphela yazo zonke ii-"Primary Ovarian Tumors". Leyo yipesenti ephantsi kakhulu.

Ngaba la maqhuqhuva anobungozi okanye anobungozi?

Ixesha elininzi, la maqhuqhuva, abizwa ngokuba yi-"Granulosa Cell Tumors", athathwa njengezifo ezinobungozi. Kodwa iindaba ezimnandi zezokuba adla ngokukhula kancinci. Yiyo loo nto oogqirha bekwazi ukuwabona kwasekuqaleni. Emva koko iziphumo zonyango nazo zilungile kakhulu.

Yintoni umahluko phakathi kweGranulosa Cell Tumor kubantu abadala nakubantu abancinci?

Ezi thumba zibonakala kakhulu kubafazi abadala. Enyanisweni, i-95% yeziganeko zixelwa kubafazi abadala abakhule kakuhle. Nangona kunjalo, ukuba ikhula kumntu ongaphantsi kweminyaka engama-30 ubudala, siyibiza ngokuba yi-"Juvenile GCT". Le "Juvenile GCT" inokuphinda ivele ngokukhawuleza kunokuba ikhula kumntu omdala. Kwakhona, ukuba isasazeke ngaphandle kwesibeleko kwaye ifunyanwe kamva, inokuba yingozi ngakumbi.

Kutheni le nto (iGranulosa Cell Tumor) ikhula? Yintoni unobangela?

Oogqirha abakafumani ukuba yintoni kanye kanye ebangela iiGranulosa Cell Tumors. Nangona kunjalo, uninzi lwabantu abanezi zifo banotshintsho kwijini ebizwa ngokuba yiFOXL2 gene. Le jini yeFOXL2 yiyo edla ngokunceda iiseli zegranulosa zikhule kakuhle.

Zithini iimpawu? Uyazi njani?

Ukuba eli qhuma likhona, uphawu oluphambili kukunyuka kwamanqanaba e-estrogen emzimbeni.

• Kwintombazana encinci, oku kunokubangela ukuba ifikelele kwinqanaba lokufikisa isencinci.
• Abafazi abadala banokufumana iimpawu ezifana nezi:
• Ukopha okungaqhelekanga kwesibeleko (AUB) okanye ukopha emva kokuya exesheni.
• Indawo yesisu iyadumba ize ikhule.
• Imijikelo yokuya exesheni ayiqhelekanga okanye iyeke ngokupheleleyo.
• Intlungu yebele kunye nokuxinana.
• Ngamanye amaxesha, ukuba iqhuma liyaqhambuka, linokubangela iintlungu esiswini.

Zeziphi iingxaki ezinokwenzeka ukuba azinyangwa?

Ukuba le `(Granulosa Cell Tumor)` ayinyangwa ngexesha, umngcipheko wokufumana ezinye iingxaki zempilo unokwanda. Umzekelo:

• I-Endometrial hyperplasia kukutyeba okungaqhelekanga kodonga lwangaphakathi lwesibeleko.
• Umhlaza wesibeleko.
• Umhlaza webele.
• Ubunzima bokufumana abantwana (Ukungazali).

Uyixilonga njani le nto?

Oogqirha badla ngokusebenzisa iindlela ezahlukeneyo zokuthatha imifanekiso ukuze baxilonge iGranulosa Cell Tumor. Kusenokufuneka wenze uvavanyo olufana nolu:

• Iskeni ye-CT.
• I-MRI.
• Uvavanyo lwe-ultrasound olwenziwe nge-vaginal ultrasound (i-Transvaginal ultrasound).

Ukongeza, ugqirha wakho unokuyalela uvavanyo lwegazi. Ngokukodwa, baya kukhangela into ebizwa ngokuba yi-"Tumor Markers." "Inhibin" luhlobo lwe-"Tumor Marker" oluveliswa yi-"Granulosa Cell Tumor". Kusenokufuneka novavanyo lwegazi ukuqinisekisa ukuba akukho ezinye iimeko zonyango.

Iphathwa njani?

Unyango lokuqala lwale "Granulosa Cell Tumor" lutyando. Ugqirha uzama ukususa ithumba elininzi kangangoko kunokwenzeka ngelixa egcina izicubu eziphilileyo.

Ukuba awucebi ukuba nabantwana abaninzi, okanye ukuba sele udlulile kwiminyaka yokuzala, ugqirha wakho unokucebisa ukuba ususwe ii-oophorectomy (ukususwa kwee-ovari) okanye ususwe i-hysterectomy (ukususwa kwesibeleko kunye nee-ovari). Ukususwa kwee-oophorectomy kunokufuneka ukuze kususwe ngokupheleleyo i-GCT.

Oogqirha bahlula le ``Granulosa Cell Tumor`` ngokwendawo ekuyo kunye nokuba isasazekile na, besebenzisa inkqubo ebizwa ngokuba yi``Staging.`` Le yindlela abagqiba ngayo ukuba ingaba umhlaza usasazekile okanye akunjalo.

• I-GCT yeSigaba soku-1 zezo zingasasazekanga ngaphaya kwama-ovari.
• Isigaba sesi-2 ukuya kwesesi-4 se-GCT zezo zisasazeke (ziye zasasazeka) kwezinye iindawo zomzimba.

Khawucinge ngoku: Ii-9 kwezili-10 zezi GCT zifumaneka kuphela kwi-ovary. Utyando ludla ngokucetyiswa kwezi ntlobo zeethumba, kwaye ngamanye amaxesha oko kukodwa kunokwanela.

Nangona kunjalo, kuxhomekeke kubukhulu bethumba kunye nezinto ezinokubangela ukuba liphinde libuye, ezinye iindlela zonyango zinokufumaneka ukunceda ukuthintela ukuba ithumba lingabuyi. Ugqirha wakho unokucebisa izinto ezifana nezi:

• Unyango ngamachiza.
• Unyango lwehomoni.
• Unyango ngemitha.

Ngaba ikho indlela yokuthintela oku (iGranulosa Cell Tumor) ukuba kungaveli?

Akukho siqinisekiso sokuba uya kukwazi ukuthintela ukuphuhliswa kweGranulosa Cell Tumor. Nangona kunjalo, unokunceda ngokuphila ubomi obusempilweni nokunciphisa umngcipheko wokuba nezifo ezingapheliyo :

• Ukugcina ubunzima obusempilweni obuhambelana nohlobo lomzimba wakho, isini, kunye nobudala.
• Ukuphepha ukutshaya.
• Ukutya ukutya okunesondlo.
• Ukuzilolonga rhoqo ukuze uphile kakuhle kwintliziyo namathambo.
• Ukunciphisa utywala kunye ne-caffeine.
• Ukusebenzisa iindlela ezisempilweni ezifana ``Ukuzikisa ingqondo`` okanye ``Ukucamngca``` ukulawula uxinzelelo.
• Ukulala iiyure ezisixhenxe ukuya kwezisibhozo ubusuku ngabunye.

Ungayinciphisa njani ingozi yeengxaki?

Ukuba uneempawu ezibonisa ukuba unokuba ne-GCT, bona ugqirha ngoko nangoko. Ukuba uphuma igazi ngendlela engaqhelekanga, iintlungu zebele, okanye ukopha emva kokuya exesheni, qiniseka ukuba ubona ugqirha. Ii-GCT zineziphumo ezingcono kakhulu xa zinyangwa kwangethuba.

Ngaba iGranulosa Cell Tumor inganyangeka ngokupheleleyo?

Ewe. Ii-GCT zinokunyangwa ngotyando, ingakumbi ukuba zisuswe kwangethuba.

Nangona kunjalo, ukuba ifunyenwe emva kokuba isasazeke kwezinye iindawo zomzimba, amathuba okuchacha aphantsi. Ngoko ke, ukuba uneempawu ze-GCT, bonana nogqirha ngokukhawuleza.

Yintoni onokuyilindela emva konyango?

Emva kokuba iqhuma lisusiwe, kuya kufuneka ubone ugqirha wakho rhoqo ukuze alandelelwe iminyaka eliqela. Oku kungenxa yokuba la maqhuma anokubuya nasemva kweminyaka emininzi. Ugqirha wakho uya kwenza oku kulandelayo ukujonga ukuba iqhuma libuyile na:

• Uvavanyo lwe-pelvic.
• Uvavanyo lwegazi ukukhangela iimpawu zokuba umhlaza usenokubuya.
• Uvavanyo lomfanekiso.

Iyintoni ingqikelelo yokuchacha?

Imbonakalo ye-GCT ixhomekeke kwinqanaba lesifo xa sixilongwa. Ukuba i-GCT ixilongwa ngaphambi kokuba isasazeke (i-metastasized) kwezinye iindawo zomzimba, imbonakalo ingcono kakhulu.

Yintoni enye endifanele ndiyibuze kugqirha?

Ungabuza ugqirha wakho imibuzo efana nale:

• Yintoni enokubangela ezi mpawu?
• Zeziphi iimvavanyo ekufuneka ndizenze ukuze ndifumanise ukuba `(iGranulosa Cell Tumor)`?
• Ziziphi iindlela zonyango ezikhoyo?
• Lithini ithuba lokuba i-GCT ibuye emva konyango?
• Ithini ingqikelelo yokuchacha emva kokuba `(iGranulosa Cell Tumor)` isusiwe?

Okokugqibela, izinto ezimbalwa ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, ke, nazi izinto ekufuneka uzikhumbule ngokufutshane malunga ne-`(Granulosa Cell Tumor)` esithethe ngayo:

• Olu luhlobo lwethumba olungaqhelekanga, oluhlala lukhula kancinci olujikeleza ama-ovari.
• Ezi zinokubangela ukuveliswa okugqithisileyo kwehomoni ethi ``(i-Estrogen),'' enokubangela iimpawu ezifana nokopha okungaqhelekanga kunye nemijikelo yokuya exesheni engacwangciswanga.
• Unyango oluphambili kukususwa kwesi sifo ngotyando.
• Ukuba kukho umngcipheko wokuba ithumba libuye kwakhona, ugqirha unokucebisa unyango lwe-chemotherapy, unyango lwe-hormone, okanye unyango lwe-radiation.
• Ukuba i-GCT ifunyenwe kwangethuba, amathuba okuchacha mahle kakhulu. Ngoko ke ukuba uneempawu, bonana nogqirha ngokukhawuleza.

Ithumba leseli yeGranulosa , umhlaza wesibeleko, i-estrogen, impilo yabasetyhini, iimpawu zomhlaza, utyando, iingxaki zehomoni