Eyona nto isisiseko eyenzekayo emizimbeni yethu kukuba ukutya esikutyayo kusinika amandla. Kufana nokufaka igesi emotweni. Apha, imizimba yethu ifumana amandla kwiswekile (iglucose). Le nkqubo ilawulwa yihomoni ebizwa ngokuba
yi-insulin . Yile insulin exelela iswekile egazini ukuba ithunyelwe kwiiseli ezifuna amandla. Kufana nokuvula iingcango zeeseli nokuvumela iswekile ingene. Nangona kunjalo, emzimbeni womntu oneRabson-Mendenhall Syndrome, le nkqubo ayenzeki kakuhle. Oko kukuthi, imizimba yabo ayinakuyisebenzisa kakuhle i-insulin. Le yimeko engaqhelekanga kakhulu.
Ngoko ke yintoni kanye kanye le syndrome?
Xa i-insulin ingakwazi ukwenza umsebenzi wayo ngokufanelekileyo, ichaphazela ngqo ukukhula komntwana. Khawuthelekelele, isiphumo sale nto siqala nangaphambi kokuba umntwana azalwe, oko kukuthi, ngoxa esesesibelekweni sikanina. Iintsana ezinale meko zihlala zincinci ngobukhulu. Kwanasemva kokuzalwa,
ukunyuka kwazo ubunzima nokukhula komzimba kwenzeka kancinci kakhulu. Ngokwezonyango, i-Rabson-Mendenhall syndrome sisifo esikwiqela elikhulu elibizwa ngokuba yi-severe insulin resistance syndromes. I-Donohue syndrome kunye ne-type A insulin resistance syndrome zezinye izifo ezimbini ezikweli qela.
Yintoni unobangela wale meko?
Ngamafutshane, le yimeko yemfuza. Oko kukuthi,
ifunyanwa ngabazali ukuya emntwaneni . Oku kubangelwa yimpazamo kwijini ebizwa ngokuba yi-'INSR' emzimbeni wethu. Ngoku makhe sibone ukuba oku kwenzeka njani. Kwiseli nganye yomzimba wethu, kukho iikopi ezimbini zejini nganye. Enye ivela kumama, kwaye enye ivela kutata. Ukuze umntwana abe neRabson-Mendenhall syndrome, zombini iikopi zejini ye-'INSR' umntwana azifumanayo kufuneka zibe nesiphako esikhankanyiweyo. Ukuba ikopi enye kuphela enesiphako, esi sifo asiyi kuvela. Ngamanye amazwi, ukuze umntwana abe nesi sifo, umama notata kufuneka babe nekopi enye yale jini inesiphako kunye nekopi enye yejini ephilileyo. Emva koko, umntwana kufuneka afumane zombini iikopi ezinesiphako kubo bobabini ngengozi. Yingakho kunqabile kuba akwenzeki kathathu kane.
Zithini iimpawu zale meko?
Iimpawu zihlala ziqala ukubonakala
kunyaka wokuqala wobomi bomntwana. Kwakhona, ubunzima bezi mpawu bungahluka kumntu nomntu. Makhe sijonge iimpawu eziphambili ezinokubonwa.
| Inxalenye/inkqubo yomzimba | Iimpawu ezibonakalayo |
|---|
| Intloko nobuso | Ulusu olurhabaxa, umsantsa omkhulu phakathi kwamehlo, imingxunya enzulu elulwimini, inkulu kuneendlebe eziqhelekileyo, imilebe, kunye nomhlathi. |
| Izikhonkwane | Ityebile kunesiqhelo. |
| Ulusu | Ulusu olomileyo. Ukufiphala nokutyeba kweendawo ezithile zesikhumba (ingakumbi kwiindawo ezigobileyo ezifana namakhwapha nentamo). Oku kwaziwa ngokwezonyango njenge- acanthosis nigricans . Ezi ndawo zinokuvakala ngathi zithambile xa uzichukumisa. |
| Amazinyo | Ukuba mkhulu kunesiqhelo, ukuxinana, okanye ukudumba kwamazinyo ngaphambi kwexesha. |
| Izitho zangaphakathi | Izintso, intliziyo, kunye namalungu esini (ipenis kumakhwenkwe, i-vagina kumantombazana) zikhulu kunesiqhelo. |
| Ezinye iimpawu eziqhelekileyo | Ukukhula kweenwele emzimbeni ngokugqithisileyo, ukukhula kancinci ngaphambi nasemva kokuzalwa, ukudumba kwesisu, amafutha amancinci kakhulu phantsi kolusu, kunye nobuthathaka bemisipha. |
Ezinye izifo ezinokwenzeka ngenxa yesi sifo
Ukongeza kwezi mpawu zisisiseko, esi sifo sinokubangela nezinye izifo ezinzulu.
- Ii-cysts kwii -ovari zamantombazana.
- Isifo seswekile . Oku ngamanye amaxesha kunokukhokelela kwimeko esongela ubomi ebizwa ngokuba yi-ketoacidosis .
- Iingxaki zezintso .
Yenziwa njani le nto yokuxilonga?
Enye yeengxaki ekuchongeni le meko kukwahlula kwezinye iimeko ezifana nayo (njenge-Donahue syndrome).
Ugqirha womntwana wakho uza kwenza uvavanyo olucokisekileyo lomzimba, abuze ngeempawu zomntwana wakho kunye nembali yempilo yosapho, kwaye mhlawumbi uza kuyalela uvavanyo lwegazi oluninzi ukujonga
amanqanaba eswekile yegazi lomntwana wakho kunye ne-insulin . Le yindlela kuphela yokwenza uxilongo oluchanekileyo.
Iphathwa njani?
Unyango lwesifo sikaRabson-Mendenhall ludla ngokufuna uncedo lweqela elikhulu, kuquka iingcali ezahlukeneyo, oogqirha botyando, kunye noogqirha bamazinyo. Ukunika iingcebiso kunokuba yinto ebaluleke kakhulu kwiintsapho ukulawula uxinzelelo kunye neemvakalelo eziza nokuba nomntwana onesi sifo singaqhelekanga.
Okwangoku akukho nyango luhlala luhleli lwale meko. Unyango lujolise ekulawuleni nasekulawuleni iimpawu.
Unyango ludla ngokuba lolona lukhethekileyo kwimpawu nganye. Umzekelo, utyando lokususa ii-cysts ze-ovarian, unyango lwamazinyo kwiingxaki zamazinyo, njl. Kwezinye iimeko, oogqirha banika iidosi eziphezulu ze-insulin okanye ezinye iziyobisi ezikhuthaza ukusetyenziswa kwe-insulin, kodwa ezi zihlala zingasebenzi ixesha elide.
Unyango olutsha oluphantsi kophando
Iingcali ziyaqhubeka nokuphanda iindlela zonyango ezingcono zamanqanaba aphezulu eswekile egazini (i-hyperglycemia) enxulunyaniswa nokuxhathisa kakhulu i-insulin. Nangona olu nyango lubonise iziphumo ezithembisayo, uphando olongezelelweyo luyafuneka.
- IiBiguanides: Ezi luhlobo lwamayeza anciphisa ukuveliswa kweswekile emzimbeni kwaye anyuse ukusetyenziswa kwe-insulin .
- I-Leptin: Le protein ifunyenwe inceda ukulawula iswekile egazini kunye namanqanaba e-insulin.
- rhIGF-I (Recombinant insulin-like growth factor I): Le protein isetyenziselwa ukunyanga i-ketoacidosis, imeko ebangelwa kukunganyamezelani kakhulu kwe-insulin .
Umyalezo Wokuya Ekhaya
- Isifo sikaRabson-Mendenhall sisifo esingaqhelekanga kakhulu esibangelwa yimfuza apho umzimba ungakwazi ukusebenzisa i-insulin ngokufanelekileyo.
- Oku kubangelwa yijini enesiphene (ijini ethi `INSR`) efunyanwa ngumntwana kubazali bobabini.
- Iimpawu ziqala ebuntwaneni kwaye zichaphazela ukukhula komzimba , inkangeleko yobuso , ulusu, amazinyo kunye nezitho zangaphakathi.
- Akukho nyango luhlala luhleli loku, kwaye unyango lujolise ekulawuleni iimpawu. Oku kufuna inkxaso yeqela loogqirha abaziingcali.
- Ukuba umntwana wakho ubonakalisa naziphi na kwezi mpawu, kubaluleke kakhulu ukubona ugqirha ofanelekileyo (ugqirha) ngokukhawuleza ukuze akunike ingcebiso.
Isifo sikaRabson-Mendenhall, ukuxhathisa i-insulin, izifo zemfuza, izifo zabantwana, i-acanthosis nigricans, i-ketoacidosis, isifo seswekile
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