Ngaba ukhe weva ngalo mhlaza ungaqhelekanga? Masifunde ngeSignet Ring Cell Carcinoma

Ngaba wakha weva ngohlobo lomhlaza olubizwa ngokuba yi-"Signet Ring Cell Carcinoma"? Mhlawumbi eli gama livakala lingaqhelekanga. Kodwa olu luhlobo lomhlaza ekufuneka sonke silwazi. Kuba luhlobo lomhlaza olusasazeka ngokukhawuleza, oko kukuthi, olunobundlongondlongo . Ngoko ke, masiqonde oku ngokweenkcukacha namhlanje, ngokungathi sithetha nomhlobo.

Yintoni iSignet Ring Cell Carcinoma?

Ngamafutshane, i-Signet Ring Cell Carcinoma (SRCC) luhlobo lomhlaza. Idla ngokuqala kwindlela yakho yokugaya ukutya , ingakumbi esiswini sakho. Ifumana igama layo elingaqhelekanga ngenxa yendlela ezi seli zomhlaza ezibonakala ngayo phantsi kwe-microscope. Zifana neringi, kodwa icala elinye lide kancinci, njenge-"signet ring" eyayisetyenziswa ukuvala oonobumba ngemihla yakudala.

Lo mhlaza, obizwa ngokuba yi-"SRCC", ungowodidi lomhlaza olubizwa ngokuba yi-"Adenocarcinoma." Oku kuthetha ukuba lo mhlaza uvela kwiiseli ezifumaneka kumadlala omzimba wethu, esizibiza ngokuba ziiseli ze-glandular . Ezi ngokwenene luhlobo lweseli eqhelekileyo efumaneka kwizicubu ezingaphakathi kwamalungu ethu omzimba.

Nangona kunjalo, ukufunyanwa une-SRCC kunokuba nzima kancinci. Lo ngumhlaza okhula ngokukhawuleza, ngoko ke unyango kufuneka luqale ngokukhawuleza. Nangona kunjalo, abaphandi basasebenza ukufumana unyango olufanelekileyo lwale meko. Ukuba unale meko, kuya kufuneka usebenzisane nogqirha wakho we-oncologist ukuze kuchongwe isicwangciso sonyango esifanelekileyo.

Ngaba kukho iintlobo ezahlukeneyo zalo mhlaza?

Ewe, oogqirha bahlula le `(SRCC)` ngokwelungu lomhlaza eliqala ngalo. Uninzi lwexesha, oko kukuthi, malunga nama-90 ekhulwini `(SRCC)` kwenzeka njengomhlaza wesisu . Kunqabile kakhulu, iqala kwezinye iindawo zomzimba apho kukho iiseli zedlala.

Umzekelo, i-1% okanye ngaphantsi yomhlaza kwizitho ezilandelayo ifunyenwe iyi-``(SRCC)'':

• Umhlaza wamathumbu amakhulu
• Umhlaza wamathumbu
• Umhlaza wePancreatic
• Umhlaza wesinyi
• Umhlaza wenyongo
• Umhlaza wesisu
• Umhlaza wesihlomelo
• Umhlaza weprostate
• Umhlaza webele

Ixhaphake kangakanani le mhlaza ebizwa ngokuba yi-``(SRCC)''?

Ngoku khangela, ama-90-95 ekhulwini omhlaza wesisu aluhlobo lwe-"Adenocarcinomas". Kuloo mhlaza wesisu uphakathi kwama-35% nama-40% yi-"SRCC" .

Umhlaza wesisu ngumhlaza wesihlanu oxhaphakileyo ehlabathini. Nangona kunjalo, ukwanda komhlaza wesisu kuye kwehla xa kuthelekiswa nexesha elidlulileyo. Oku kungenxa yokufumaneka konyango olutsha olunokuthintela izinto ezifana nokosulelwa yintsholongwane iHelicobacter pylori (H. pylori), eyingozi yomhlaza wesisu.

Kodwa okumangalisayo kukuba, inani lomhlaza wesisu ofunyaniswe njenge-``(SRCC)`` liyanda. Izazinzulu azikaqiniseki ukuba kutheni.

Zithini iimpawu zalo mhlaza? Ngaba kunzima ukuzibona kwangethuba?

Nantsi into ekufuneka uyiqaphele. Iimpawu ze-SRCC zihlala zibonakala emva kokuba umhlaza usasazekile . Ngoko ke, abantu abaninzi abaqondi ukuba banengxaki kwizigaba zokuqala. I-SRCC eqala esiswini idla ngokusasazeka iye kwi-peritoneum, emathanjeni, nakubasetyhini, kwii-ovari.

Iimpawu ze-`(SRCC)` zingabandakanya:

• Ukudumba, ukungagayi kakuhle kokutya
• Intlungu zesisu
• Isicaphucaphu nokuhlanza
• Urhudo
• Indle enegazi
• Ukudinwa rhoqo
• Intlungu yamalungu
• Ukubetha kwentliziyo ngokukhawuleza, ukubetha kwentliziyo okukhawulezayo, kunye nobunzima bokuphefumla

Khawucinge nje, umhlobo wakho usoloko ebuhlungu esiswini kwaye ephazamisekile emva kokutya. Usenokucinga, "Owu, le kufuneka ukuba yi-gastritis eqhelekileyo." Kodwa uninzi lwezi mpawu zinokubonwa nakwizifo zesisu ezingabalulekanga kangako njengomhlaza. Ngoko ke ungoyiki ukuba ngumhlaza kuba nje unazo ezi mpawu. Nangona kunjalo, ukuba uneempawu ezingapheliyo nezinganyangekiyo, kusoloko kububulumko ukubona ugqirha.

Kutheni olu hlobo lomhlaza luvela? Yintoni unobangela?

I-SRCC ikhula xa iiseli ze-glandular ezingaqhelekanga ziqala ukwenza iikopi zazo. Ezi seli ezingaqhelekanga zinokwenza iithumba, zisasazeke, kwaye zitshabalalise izicubu eziphilileyo. Nangona kunjalo, abaphandi abakaqiniseki ukuba kutheni iiseli ezibandakanyekayo kwi-SRCC ziba zingaqhelekanga kwasekuqaleni.

Ezinye izifundo zibonise ukuba utshintsho kwi-gene ebizwa ngokuba yi-CDH1, eyenza iproteni ebalulekileyo kwiiseli ze-glandular, lunokudlala indima. Nangona kunjalo, kusekho okuninzi okusamele kufunyanwe malunga nendlela iiseli ze-glandular (SRCC) eziba ngayo zi-malignant.

Oogqirha bayixilonga njani le `(SRCC)` yomhlaza?

Ukuxilongwa kwe-(SRCC) kudla ngokuqala ngogqirha ebuza ngeempawu zakho aze enze uvavanyo lomzimba. Oku kunokubanceda bafumane umbono wokuba ingxaki ikuphi emzimbeni wakho. Emva koko banokugqiba ukuba zeziphi iimvavanyo abamele bazenze. Ezi mvavanyo zingabandakanya:

• Uvavanyo lomfanekiso:I-computed tomography (CT) scan isetyenziswa kakhulu ekufumaneni iithumba kwindlela yokugaya ukutya. Ukuba ugqirha wakho ufumene ithumba elirhanelekayo, unokuyalela i-PET scan ukuze abone ukuba iiseli zomhlaza zisasazekile na.
• Uvavanyo lwegazi: Kuza kuthathwa isampulu yegazi lakho kwaye kwenziwe uvavanyo oluninzi. Olu vavanyo lungabandakanya uvavanyo lokujonga impilo yakho ngokubanzi, kunye novavanyo lokujonga iimpawu zezifo ezifana nomhlaza.
• I-Biopsy: Olu lolona vavanyo lubalulekileyo . Ugqirha kuya kufuneka athathe isampuli yethumba okanye izicubu zonke aze azihlole. Le yindlela ugqirha aza kuqinisekisa ngayo ukuba yi-SRCC. Ingcali yezifo iza kujonga isampuli phantsi kwe-microscope ukuze ibone ukuba kukho na iiseli "zendandatho yesayini". Banokwenza uvavanyo olukhethekileyo olubizwa ngokuba yi-immunohistochemistry kwisampuli ukuqinisekisa ukuba iiseli zinomhlaza.

Inganyangwa njani le nto? Ngaba inganyangeka?

Unyango olufumanayo luxhomekeke kwizinto ezininzi. Ezona ziphambili kukuba umhlaza uqale phi (uhlobo) kwaye usasazeke kangakanani (inqanaba). Konke oku kugqitywa emva kokuthetha nogqirha wakho. Abantu abaninzi abane-(SRCC) bafuna unyango olungaphezulu kolunye, okanye indibaniselwano yonyango . Oku kungabandakanya:

• Utyando lwe-Endoscopic: Ukuba umhlaza awukasasazeki, utyando lunokwenziwa kusetyenziswa indlela ebizwa ngokuba yi-esophagogastroduodenoscopy. Oku kubandakanya ukususwa kwethumba ngetyhubhu efakwe ngomlomo. Le yinkqubo engenasihlaselo.
• Ukususwa ngokupheleleyo: Le yindlela yotyando eqhelekileyo kwi-SRCC. Oku kungenxa yokuba umhlaza uhlala sele uqhubele phambili xa ufunyaniswa. Oku kubandakanya ukususa lonke ithumba kunye nezicubu ezijikelezileyo. Ekubeni i-SRCC idla ngokusasazeka kwiindawo ze-lymph nodes, oogqirha basusa nezinye iindawo ze-lymph nodes.
• I-Hyperthermic Intraperitoneal Chemotherapy (HIPEC): Le yindibaniselwano yotyando kunye ne-chemotherapy yokunyanga umhlaza osasazeke ngaphakathi kwisisu. Emva kokuba ugqirha esuse ithumba, amayeza e-chemotherapy afakwa ngqo kwisisu. Emva koko la mayeza ayafudunyezwa. Ubushushu benza amayeza e-chemotherapy abe yingozi ngakumbi kuzo naziphi na iiseli zomhlaza eziseleyo.
• I-chemotherapy esetyenziswa ngokwenkqubo: Ugqirha wakho unokucebisa olu khetho. Apha, unikwa amayeza e-chemotherapy, nokuba ziipilisi okanye njenge-IV. La mayeza ahamba emzimbeni wakho wonke aze abulale iiseli zomhlaza. Nangona i-chemotherapy ilunyango oluqhelekileyo kwi-(SRCC), isenokungasebenzi kakuhle kwixesha elide.
• Unyango ngemitha:Abanye oogqirha bacebisa unyango lwemitha kunye ne-chemotherapy ukubulala naziphi na iiseli zomhlaza eziseleyo emva kotyando. Unyango lwemitha (SRCC) lusebenzisa umatshini ongaphandle komzimba ukuhambisa amandla kwiiseli zomhlaza.
• Uvavanyo lwezonyango: Olu vavanyo lwenzelwe ukuvavanya ukhuseleko kunye nokusebenza kakuhle konyango olutsha lomhlaza. Izazinzulu ziyaqhubeka nokufunda utshintsho lweeseli olukhokelela kwi (SRCC), ngenjongo yokuphuhlisa unyango olunokuthintela olu tshintsho. Ukuthatha inxaxheba kuvavanyo lwezonyango kunokukunika ithuba lokufumana olu nyango lutsha.

Ukuba ndine `(SRCC)`, zeziphi izinto endiza kujongana nazo?

Enyanisweni, akukho mntu unokuqikelela ngokuthe ngqo ukuba amava omntu nge-SRCC aya kuba njani. Kodwa esikwaziyo kukuba xa kuthelekiswa nezinye iintlobo ze-carcinoma, i-SRCC ngumhlaza odlamkileyo nokhula ngokukhawuleza . Kunokwenzeka ukuba iphinde ibuye emva kotyando. Kunzima nokulawula ixesha elide ngonyango oluqhelekileyo lomhlaza olufana ne-chemotherapy.

Amava akho aya kuxhomekeka kakhulu kwiinjongo zakho. Ukuba umhlaza usekwinqanaba lokuqala, injongo isenokuba kukuwunyanga ngokupheleleyo umhlaza kwaye uwugcine "uphilile." Ukuba umhlaza usasazekile, njengakwinqanaba lesi-4, unyango lunokukunceda uphile ubomi obutofotofo ngakumbi.

Buza ugqirha wakho ukuba ulindele ntoni ngokusekelwe kwisifo sakho.

Ndingazinyamekela njani? Ndingenza ntoni?

Kubalulekile ukufunda kangangoko unako malunga nokuxilongwa kwakho (SRCC). Kungcono ukufumana iimpendulo zemibuzo (nokuba inzima) kunokukhathazeka ngento eyenzekayo emzimbeni wakho. Buza ugqirha wakho ukuba ukuxilongwa kwakho kuya kuyichaphazela njani impilo yakho iyonke kunye nobomi bakho bemihla ngemihla.

Kwakhona, buza ugqirha wakho ukuba ungazuza na kwiinkonzo zokhathalelo lokudambisa iintlungu. Injongo yokhathalelo lokudambisa iintlungu kukubonelela ngoncedo kwiimpawu. Nokuba umhlaza wakho ukwinqanaba elingakanani na, ezi nkonzo zinokunceda ekunciphiseni iimpawu zomhlaza kunye nemiphumo emibi yonyango.

Ndifanele ndimbone nini ugqirha?

Ukuba uneempawu zesisu ezingapheliyo nezingenakuchazwa - umzekelo, iintlungu zesisu okanye urhudo - bona ugqirha. Amaxesha amaninzi, ezi zinokuba ziimpawu zesifo esingesibi kangako. Amaxesha amaninzi , zinokuba ziimpawu zethumba esiswini.

Ndingaya nini kwiYunithi yoNyango oluNgxamisekileyo (i-ETU) ?

Ukuba uneempawu ezifana nesiyezi, umkhuhlane, kunye nobunzima bokuphefumla (ukuphelelwa ngamandla), yiya kwigumbi likaxakeka ngokukhawuleza. Ezi mpawu ziqhelekile kwiimeko ezininzi ezifuna unyango olungxamisekileyo, kuquka noluqatha (SRCC).

Ndingayibuza yiphi imibuzo ugqirha wam?

Kubalulekile ukuqonda yonke into malunga nokuxilongwa kwakho, kuquka nendlela ekuchaphazela ngayo ubomi bakho bemihla ngemihla. Ungabuza imibuzo efana nale:

• Luhlobo luni lomhlaza endinalo?
• Umhlaza wam ukuliphi inqanaba?
• Ucebisa luphi unyango?
• Zeziphi iziphumo ebezingalindelekanga endinokuzilindela kunyango?
• Ithini i-prognosis yam (iziphumo ngonyango)?
• Ngawaphi amanyathelo endingawathatha ukuze ndiphile ubomi obulula ne-`(SRCC)`?

Okokugqibela, izinto ekufuneka uzikhumbule

Ukwazi ukuba umhlaza wakho yi-signet ring cell carcinoma (SRCC) kubalulekile koogqirha abacebisa unyango olusekelwe kuhlobo lomhlaza. Kodwa umbuzo omkhulu kubantu abaninzi usenokuba ngulo: "Oku kuya kuyichaphazela njani impilo yam?" Impendulo ayilula. Ukuba nayo (SRCC) kuthetha ukuba kusenokufuneka wenze izigqibo ezinzima malunga neendlela zakho zonyango. Ungadinga uncedo lokuqonda indlela ukuxilongwa kwakho okuya kutshintsha ngayo ubomi bakho bemihla ngemihla.

Musa ukoyika, thetha nogqirha wakho ucele uncedo. Nguye umntu ofanelekileyo ukucacisa amanyathelo onokuwathatha ukulawula okuzayo. Khumbula, awuwedwa.

I - Carcinoma yeSeli yeRingi yeSiginesha, i-SRCC, umhlaza wesisu, iimpawu zomhlaza, unyango lomhlaza, i-Adenocarcinoma, umhlaza wesisu