Yintoni iSpindle Cell Sarcoma? Masithethe ngayo ngokulula!

Ngaba wakha wakhathazeka ngento engaqhelekanga, njengentlungu okanye ukudumba emathanjeni akho okanye iindawo ezithambileyo njengemisipha yakho? Ngamanye amaxesha ezi zinto zinokuba yinto eqhelekileyo. Kodwa, kunqabile, ezi mpawu zinokuba luphawu lwento enzulu. Ngoko ke, namhlanje siza kuthetha ngohlobo lomhlaza olungaqhelekanga, kodwa olubalulekileyo ukwazi ngalo. Olu lubizwa ngokuba yiSpindle Cell Sarcoma.

Yintoni kanye kanye iSpindle Cell Sarcoma?

Ngamafutshane, iSpindle Cell Sarcoma luhlobo olungaqhelekanga lomhlaza oluvela emathanjeni nakwizicwili ezithambileyo zomzimba wethu. Ubusazi ukuba igama elithi 'sarcoma' libhekisa kwiiseli ezingaqhelekanga, okanye iithumba, ezikhula kuloo mathambo nakwizicwili ezidibana nawo?

Ngoku, into ekhethekileyo ngeSpindle Cell Sarcoma kukuba xa ujonga ezo seli zingaqhelekanga usebenzisa imakroskopu, zifana 'nespindle'. Ispindle sisimo esifana nekhandlela, amacala ayo abhityile kwaye umbindi wayo utyebile kancinci. Yiyo loo nto yafumana igama layo.

Ngenxa yovavanyo oluphambili lwelabhoratri, oogqirha baye bakwazi ukubona iintlobo ezingaphezu kwama-75 ze-sarcoma. I-Spindle cell sarcoma yenye yeentlobo ezinjalo. Enyanisweni, igama elithi 'spindle cell sarcoma' lisetyenziselwa ukuchaza ii-sarcomas ezingenakuhlelwa ngokuchanekileyo ziimvavanyo ezithile zelabhoratri, ezifana namabala okanye iimpawu zemfuza. Ngoko ke, ligama elibanzi kancinci.

Zivela phi ezi thumba?

I-Spindle Cell Sarcoma idla ngokukhula emathanjeni amade omzimba wethu. Umzekelo:

• Ithambo lakho lethanga (`femur`)
• Ithambo lesifuba (tibia)
• Ithambo lengalo ephezulu (ihumerus)

Nangona kunjalo, ayizizo ezi ndawo zodwa. Abanye abantu bane-spindle cell sarcomas kwi-pelvis, entloko nasentanyeni, nakwezinye iindawo zomzimba.

Ziziphi iintlobo eziphambili zeSpindle Cell Sarcoma?

Ngoku, khangela, zonke ii-sarcomas ziqala kwizicubu ezithambileyo. Oko kukuthi, kwizinto ezinje ngamafutha, izihlunu, imithambo yegazi, imithambo-luvo, kunye nezicubu ezijikeleze amathambo. Oogqirha baphinda bahlele ii-sarcomas ze-spindle cell ngokusekelwe kuhlobo lweseli apho umhlaza uqala khona.

Ngokuqonda uhlobo lweseli kunye neempawu zalo ngale ndlela, oogqirha banokuvavanya ukuba umhlaza usasazeka kangakanani. Oku kubanceda ukuba babone unyango olufanelekileyo.

Nangona igama elithi 'spindle cell sarcoma' lithetha lukhulu, kukho iintlobo ezininzi eziphambili:

• I-Sarcoma yePleomorphic engahlukanisiweyo:Njengoko igama lisitsho, iiseli ezikule hlobo lomhlaza 'azinamahluko'. Oku kuthetha ukuba akucaci ukuba loluphi uhlobo lweseli umhlaza owaqala kulo. Iiseli ezinesifo kwi-tumor 'zi-pleomorphic', oko kuthetha ukuba ziza ngeemilo ezahlukeneyo kunye nobukhulu obahlukeneyo. Ngamanye amazwi, i-tumor yingqokelela yeeseli ezivela kwiintlobo ezahlukeneyo.
• I-Fibrosarcoma: Ezi zivela kwiiseli ezibizwa ngokuba yi-fibroblasts. Ii-Fibroblast zezona zinto ziphambili zokwakha izicwili ezidityanisiweyo emizimbeni yethu.
• I-Leiomyosarcoma: Ezi ziqala kwiiseli zemisipha ezithambileyo. Ezi zahlukile kwiiseli ezikwizicubu zemisipha yamathambo, esizisebenzisa ukuhambisa imizimba yethu nokufumana amandla. Iiseli zemisipha ezithambileyo zifumaneka kwizitho zethu zangaphakathi, kwimingxunya yomzimba, nakwamanye amathambo njengezicubu ezithambileyo.

Ixhaphake kangakanani le meko?

Njengezinye iintlobo ze-sarcoma, i-spindle cell sarcoma ayifumaneki lula . Enyanisweni, ibangela ngaphantsi kwe-10% yazo zonke iintlobo zomhlaza wamathambo kunye nezicubu ezithambileyo. Khumbula, kunqabile kangangokuba ugqirha wakho usenokungacingi ukuba olu hlobo lomhlaza lukhona ekuqaleni. Kusenokufuneka uye kwiingcali ezininzi, ubone iingcali ezahlukeneyo, kwaye wenze iimvavanyo ezininzi ngaphambi kokuba ufumane ukuxilongwa.

I-Spindle cell sarcoma inokukhula nakubani na. Nangona kunjalo, ixhaphake kakhulu kubantu abangaphezu kweminyaka engama-40 ubudala. Abantu abakhula i-pleomorphic sarcoma engachazwanga ngaphambili badla ngokuba phakathi kweminyaka engama-60 ukuya kwengama-70 ubudala.

Zithini iimpawu zoku?

Iimpawu ze-spindle cell sarcoma zingahluka. Zixhomekeke kubukhulu be-tumor, inani le-tumor, kunye namathambo (okanye amanye amalungu omzimba) iiseli zomhlaza ezikuwo. Nazi ezinye iimpawu ekufuneka uziqwalasele ngokukodwa :

• Intlungu yamathambo: Le ntlungu inokuba yinto engapheliyo okanye ifike ize idlule. Ingavakala ngathi kukho umntu okuhlabayo ngaphakathi.
• Ukuphuka kwethambo kwindawo ebuthathaka ngenxa yomhlaza: Oku kubizwa ngokuba 'kukwaphuka kwethambo'. Ithambo linokwaphuka nokuba liwile kancinci.
• Ukuthamba okanye ukudumba xa ucinezelwe kwindawo apho kukho khona ithumba: Kusenokubakho nethumba elikhulu ngokwaneleyo ukuba libanjwe esandleni.
• Ukungakwazi ukuhambisa ilungu kufutshane nethumba ngokufanelekileyo: Khawuthelekelele ukuba idolo likufutshane, kuya kuba nzima ukugoba okanye ukwandisa idolo.
• Ukudinwa: Oku akukokudinwa nje okuqhelekileyo. Kukudinwa okugqithisileyo okungapheliyo nokuba ulala okanye uphumle kangakanani.
• Ukungabi namdla: Ukuziva ungaphilanga , ngaphandle kwesizathu esicacileyo, ngokungathi umntu akanawo amandla okanye umdla kwinto ethile.

Yintoni ebangela i-spindle cell sarcoma?

Njengazo zonke ezinye iintlobo zomhlaza, i-spindle cell sarcoma iqala xa iiseli eziphilileyo ziba zizifo ezinobungozi. Ezi seli zinobungozi zikhula zingalawuleki, zenze iithumba. Ezi zifo zingonakalisa izicubu eziphilileyo ezijikeleze izicubu. Eyona nto iyingozi kukuba ezi seli zomhlaza zinokuqhekeka kwithumba lokuqala zize zisasazeke emzimbeni wonke, zonakalisa ezinye izicubu kunye namalungu omzimba. Oku kubizwa ngokuba yi-metastasis, okanye umhlaza osasazekayo.

Kodwa, nantsi into ekufuneka uyazi. Ngokwesiqhelo, ii-spindle cells (xa zikhula kakuhle) ziyinto elungileyo. Ii-spindle cells zenzeka apho izicubu zonakaliswe khona. Ngoko ke, ukuba nee-spindle cells luphawu lokuba inxeba lakho liyaphola. Ezi seli ziyanyamalala xa inxeba liphola.

Nangona kunjalo, kwi-spindle cell sarcoma, ezi spindle cells ziyaqhubeka zikhula kwaye ziphindaphindeka. Izazinzulu azikafumani sizathu sithile sokuba ezi cells zibe yingozi kangaka.

Nangona kunjalo, abaphandi bafumanise ukuba utshintsho oluthile lwezakhi zofuzo lunokunyusa umngcipheko womntu wokuba nomhlaza. 'Uguquko' yimpazamo kwizakhi zofuzo zethu, inkqubo exelela iiseli zethu indlela yokusebenza. Kwimeko ye-spindle cell sarcoma, olu tshintsho ludla ngokudluliselwa kwilifa, oko kuthetha ukuba lunokusebenza kwiintsapho.

Ziziphi izinto ezibangela umngcipheko wokufumana lo mhlaza?

Kukho izinto ezininzi ezinokunyusa umngcipheko wokuba ne-spindle cell sarcoma. Makhe sijonge ukuba zeziphi:

• Ukufa Kwamathambo: Oku kwenzeka xa izicubu zethambo zisifa kuba zingafumani gazi laneleyo. Njengoko usazi, izicubu zethambo zifuna igazi ukuze ziphile, nto leyo eyenziwa yioksijini.
• I-Fibrous Dysplasia: Kule meko, izicubu zamathambo eziphilileyo zithathelwa indawo zizicubu ezifana nethambo. Oku kwandisa umngcipheko wokuqhekeka kwaye (kunqabile kakhulu) kunokukhokelela ekuphuhlisweni kwe-fibrosarcomas.
• I-Osteomyelitis: Olu luhlobo losulelo oluchaphazela izicubu ezithambileyo ngaphakathi kwamathambo athile, olubizwa ngokuba yi-bone marrow. Oku kunokwenzeka ukuba iintsholongwane okanye ezinye iintsholongwane zihamba zisuka egazini lakho ziye ethanjeni zize zosulele iiseli apho.
• Isifo sePaget sethambo: Esi sisifo esihlala ixesha elide (esingapheliyo). Sibangela ukuba amathambo abe buthathaka kwaye aphuke lula. Oku kunokunyusa umngcipheko wokuba nomhlaza wethambo, kuquka ne-spindle cell sarcoma.
• Ekubeni sele ndifumene unyango lwe-radiation lomhlaza ngaphambili:Unyango lwemitha lusebenzisa imitha enamandla aphezulu (ngokuqhelekileyo i-X-reyi enamandla aphezulu) ukutshabalalisa iiseli zomhlaza. Azifane zenzeke ii-sarcomas ze-spindle cell kwiindawo ezinyangwa ngemitha. Xa oku kusenzeka, i-sarcoma idla ngokukhula emva kweminyaka eliqela emva konyango (iminyaka esixhenxe ukuya kwengamashumi amabini). Kodwa khumbula, ngaphantsi kwe-1% yabantu abafumana unyango lwemitha bahlakulela olu hlobo lomhlaza olunxulumene nemitha.

Ziziphi iingxaki ze-spindle cell sarcoma?

Lo mhlaza wenza amathambo akho aphuke lula (aqhekeke) kwindawo yethumba. Xa ithambo liphuke, iiseli zomhlaza ezivela kwithumba zinokuhamba ziye kwiindawo ezikufutshane.

Nangona kunjalo, kusekho impikiswano malunga nokuba olu hlobo lokuqhekeka kwamathambo lwenza umahluko na kwi-prognosis iyonke (oko kukuthi, isiphumo esinokwenzeka) somhlaza, okanye ingaba isiphumo sinxulumene kuphela nokusasazeka okukude komhlaza (ukusasazeka kwe-metastatic).

Ifunyanwa njani i-spindle cell sarcoma?

Ngaphambi kokuba ugqirha wakho akwazi ukuxilonga nokubeka umhlaza wakho kwinqanaba elithile, kusenokwenzeka ukuba uya kuba neemvavanyo ezininzi kunye neenkqubo. Ukubeka umhlaza kwinqanaba elithile kuvumela oogqirha ukuba bahlele ubunzima bomhlaza ngokusekwe kubukhulu bethumba, indawo elikuyo, kunye nokuba lisasazeke na. Xa bebeka umhlaza wamathambo kwinqanaba elithile, bajonga nokuba ithumba 'lisezingeni eliphezulu' okanye 'lisezingeni eliphantsi'. Iithumba eziphezulu zineeseli ezibonakala zingaqhelekanga . Zinokukhula kwaye zisasazeke ngokukhawuleza.

Uninzi lwee-sarcomas ze-spindle cell zikumgangatho ophezulu.

Uvavanyo lokufota

Nangona uvavanyo lwemifanekiso lungenakukwazi ukubona uhlobo lomhlaza, lunokubonisa ubungakanani kunye nendawo yethumba. Lunokubonisa nokuba umhlaza usasazeke ngaphaya kwethumba eliphambili.

• Ii-X-reyi: Ii-X-reyi zinokubonisa iithumba okanye ezinye izinto ezingaqhelekanga emathanjeni akho. I-X-reyi yesifuba inokubona ukuba umhlaza usasazeke emiphungeni. I-Metastatic spindle cell sarcoma idla ngokusasazeka emiphungeni kuqala.
• I-MRI Scan: I-MRI isebenzisa imagnethi enkulu, amaza erediyo, kunye nekhompyutha ukuthatha imifanekiso yezinto ezingaphakathi emzimbeni. Ngokungafaniyo ne-X-reyi, i-MRI inokubonisa izicubu ezithambileyo ngokweenkcukacha. Oku kuluncedo ngakumbi koogqirha ekuchongeni amaqhuma ezicubu ezithambileyo abacinga ukuba angaba zii-sarcomas.
• Ii-CT Scans: Ii-CT scans zisebenzisa ii-X-reyi kunye nekhompyutha ukwenza imifanekiso ye-three-dimensional (3D) yamathambo kunye nezicubu ezithambileyo. Kwimeko ye-spindle cell sarcoma, ii-CT scans zinokubonisa ukuba umhlaza usasazeke kwizicubu ezithambileyo. Zikwalungele ukufumana iindawo ezaphukileyo okanye apho amathambo abuthathaka khona.
• Ii-PET Scans: Ii-PET scans zisebenzisa into ebizwa ngokuba yi-tracer ukufumana iiseli zomhlaza emzimbeni wonke. Zinokunceda ekufumaneni i-metastasized spindle cell sarcoma. Ungaphinda wenze i-PET scan ukuze ubone ukuba unyango lwakho lusebenza njani. Nangona kunjalo, ii-PET scans azisetyenziswa kuzo zonke iintlobo ze-sarcoma. Ugqirha wakho uya kugqiba ukuba i-PET scan ikulungele na.

Uvavanyo lwegazi

Akukho vavanyo lwegazi luthile olunokufumanisa i-spindle cell sarcoma. Nangona kunjalo, uvavanyo lwegazi lubonelela ngolwazi olubalulekileyo malunga nempilo yakho, kwaye kubalulekile ukuba ugqirha wakho alwazi olo lwazi. Ngokubanzi, uvavanyo lwegazi lunokubonelela ngolwazi malunga nezinto ezifana nezi:

• Iiseli zakho zegazi
• Umsebenzi womzimba
• Amanqanaba e-enzyme (ii-enzyme ziikhemikhali ezinceda amalungu omzimba ukuba enze iinkqubo ezibalulekileyo)

I-Biopsy

Eyona ndlela ilungileyo yokwazi ngokuqinisekileyo ukuba iqhuma linomhlaza kukwenza i-biopsy. Kwakhona yindlela ekuphela kwayo yokwazi uhlobo lomhlaza kunye nomgangatho walo. Ngexesha le-biopsy, ugqirha uthatha isampuli yezicubu kwiqhuma aze azithumele kwilebhu ukuze zihlolwe iiseli.

Uninzi lwabantu abane-spindle cell sarcoma bane-needle biopsy. Oogqirha bayayibopha izicubu ezijikeleze ithumba baze basebenzise inaliti encinci, engenanto ukuthatha isampuli. Ukuze ugqirha azi kakuhle apho kufuneka ufake khona inaliti emzimbeni wakho, unokufuna i-X-ray okanye i-CT scan.

Iphathwa njani i-spindle cell sarcoma?

Unyango olufumanayo luya kuxhomekeka kwimpilo yakho, indawo, ubungakanani, ibanga, kunye nezinye izinto. Kwakhona kuxhomekeke ekubeni ufumana unyango okokuqala okanye ukuba umhlaza ubuyile emva konyango (oluphindaphindayo).

Utyando

Injongo yotyando kukususa ithumba ngelixa kugcinwa ithambo lakho elininzi kangangoko kunokwenzeka. Ukuba zonke iimpawu zomhlaza kwithumba eliphambili kunye nethumba lesibini zinokususwa, umhlaza unokunyangeka. Nangona kunjalo, xa umhlaza usasazeke ngaphaya kwethumba lokuqala, kunzima kakhulu ukuwususa ngokupheleleyo.

Unyango ngamakhemikhali

I-Chemotherapy lunyango olusebenzisa amayeza ukubulala iiseli zomhlaza emzimbeni wonke. Usenokunikwa i-chemotherapy ngaphambi kotyando ukuze unciphise ithumba kwaye kube lula ukulisusa. Okanye, unganikwa i-chemotherapy ukubulala naziphi na iiseli zomhlaza eziseleyo emva kotyando. I-Chemotherapy ikwasetyenziswa 'njengonyango lwe-palliative'. Nangona ingenakunyanga umhlaza, i-chemotherapy inokubulala iiseli zomhlaza ukunciphisa iimpawu ezifana neentlungu zamathambo.

Abantu abaninzi banikwa indibaniselwano yamayeza e-chemotherapy ukuze unyango lusebenze ngakumbi. Ngokuxhomekeke ekubeni ufumana unyango okokuqala, awusabeli kakuhle kwamanye amayeza e-chemotherapy, okanye ukuba umhlaza ubuyile emva kokuba ungene "kwi-remission", unganikwa amayeza e-chemotherapy ahlukeneyo. "Remission" ithetha ukuba umhlaza uphucukile okanye uphele ngokupheleleyo emva konyango.

Unyango lweMisebe

Unyango lweMisebe yangaphandle (i-EBRT) lusebenzisa umatshini ukuqondisa ii-X-rays kwithumba ukuze kubulawe iiseli zomhlaza. Ukuba awukwazi ukwenza utyando, unyango lwemitha lunokunikwa ukutshabalalisa ithumba. Ngamanye amaxesha, ugqirha wotyando usenokungakwazi ukufikelela kwithumba ngotyando. Lisenokuba nzulu kakhulu kwizicubu okanye lisondele kakhulu kwizitho ezibalulekileyo ukuba lisuswe ngokukhuselekileyo. Kwiimeko ezinjalo, unokunikwa unyango lwemitha endaweni yoko.

Njenge-chemotherapy, unyango lwe-radiation lunokunciphisa iimpawu ukuba umhlaza awunakunyangwa.

Zithini iingxaki okanye iziphumo ebezingalindelekanga zonyango?

Kuqhelekile ukuba neziphumo ebezingalindelekanga ezivela kwi-chemotherapy kunye ne-radiation therapy ngexesha lonyango lomhlaza. Ezi zinokuhlala ixesha elide emva kokuba unyango luphelile. Kubalulekile ukubuza ugqirha wakho ngeziphumo ebezingalindelekanga ezinokubakho, kuxhomekeke kunyango olufumanayo.

Ndifanele ndimbone nini ugqirha wam?

Ugqirha wakho uza kukuxelela ukuba kufuneka uye kangaphi ukuze ufumane unyango, okanye wenze uvavanyo ukuze kubonwe ukuba umhlaza "usekwimeko yokuxolelwa." Abantu abaninzi abanomhlaza abasele bekwimeko yokuxolelwa kuya kufuneka baye kugqirha rhoqo kwizigaba zokuqala. Njengoko uhlala ungenawo umhlaza ixesha elide, inani lee-aphoyintimenti zokulandelela ukuze kuhlolwe ukuba umhlaza awuphinde ubuye liya kuncipha.

Luhlobo luni lonyango lokulandelela endiludingayo?

Kuxhomekeke ekubeni ingakanani ithambo ekwakufuneka lisuswe ngugqirha, ungadinga ezinye iindlela zotyando. Ezi ndlela zinceda ekugcineni ukusebenza kwethambo. Umzekelo, ungadinga i-bone graft. I-bone graft ibandakanya ukutshintsha izicubu ezisusiweyo ngezicubu ezivela kwelinye ilungu lomzimba wakho okanye ezivela kumnikeli. Ungadinga nelungu lomzimba elenziweyo. Ungadinga unyango olongezelelweyo ukukunceda ulungele olu tshintsho.

Yeyiphi imibuzo endifanele ndiyibuze ugqirha wam malunga ne-spindle cell sarcoma?

Nazi ezinye zemibuzo ebalulekileyo ekufuneka uyibuze ugqirha wakho:

• Uphi umhlaza?
• Ithini inqanaba/inqanaba lomhlaza?
• Elo nqanaba/ibakala lichaphazela njani isicwangciso sam sonyango?
• Zeziphi iziphumo ebezingalindelekanga zonyango endimele ndizilindele?
• Ngaba umhlaza wam unganyangeka?
• Zithini iinjongo zonyango?
• Ungandiqhagamshela kwiinkonzo zokhathalelo lwentlungu ukuze undincede ndikwazi ukumelana nokuxilongwa kwam ngumhlaza?

Ngaba i-spindle cell sarcoma inganyangeka? Ingakanani ingxaki?

Ukuba zonke iimpawu zomhlaza zingasuswa, oogqirha banokunyanga i-spindle cell sarcoma. I-Spindle cell sarcoma engazange isasazeke ngaphaya kwendawo yayo yokuqala kulula kakhulu ukuyinyanga. Nangona kunjalo, ukunyanga ii-sarcomas ezisasazekileyo kunzima kakhulu . I-Metastatic Spindle Cell Sarcomas ayinyangeki rhoqo.

Olu hlobo lomhlaza ludla ngokuba 'luphezulu'. Oku kuthetha ukuba lukhula ngokukhawuleza kwaye lusasazeka ngokukhawuleza. Emva kokuphela kwesifo, kunokwenzeka ukuba lubuye, ngamanye amaxesha kwindawo enye apho ithumba lokuqala lalikhona, ngamanye amaxesha kwindawo eyahlukileyo.

Kodwa khumbula, ukuxilongwa komhlaza ngakunye kwahlukile. Ugqirha wakho angakuxelela iziphumo zonyango (ukuxela kwangaphambili) ngokusekelwe kuhlobo oluthile lomhlaza onalo, inqanaba lawo, impilo yakho iyonke, indlela osabela ngayo kunyango, kunye nezinye izinto ezahlukeneyo. Ugqirha wakho ngumntu ongcono ukukunika ingcebiso malunga nendlela olu nyango oluya kukuchaphazela ngayo.

Izinto esifanele sizikhumbule kweli bali (Umyalezo Wokubuyela Ekhaya)

Ukufunyaniswa une-Spindle Cell Sarcoma kunokuba ngamava abangela uxinzelelo. Le meko inokukwenza uzive udiniwe kwaye ungakhululekanga. Unyango ludla ngokuba nzima, kwaye unokujongana nemingeni efana nokuqhelana nokufakelwa kwamathambo okanye ilungu lomzimba elenziweyo.

Kungoko ke, kubaluleke kakhulu ukuba nencoko enyanisekileyo nevulekileyo nogqirha wakho kwasekuqaleni. Ngale ndlela, unokuyiqonda imeko yakho, umlinganiselo wonyango lwakho lomhlaza, iinjongo zonyango lwakho, kunye notshintsho lwendlela yokuphila oza kufuneka ulwenze ngexesha lonyango kunye nokuchacha.

I-Spindle cell sarcoma ngumhlaza onzima nokhula ngokukhawuleza. Nangona kunjalo, kukho unyango olunokulawula ukukhula kwawo kwaye, kwezinye iimeko, luwunyange ngokupheleleyo. Thetha nogqirha wakho malunga noko unokukulindela. Ungaze ulahle ithemba. Ukulandela iingcebiso zonyango ezifanelekileyo nokuhlala unethemba kubaluleke kakhulu kulo mlo.

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