Ingaba umzimba wakho uqinile ngaphandle kwesizathu? Masithethe ngeStiff Person Syndrome!

Ngaba ngamanye amaxesha uziva izihlunu zakho ziqina ngendlela engaqondakaliyo, okanye izihlunu zakho ziqhaqhazela kabuhlungu? Ngamanye amaxesha oku kungenzeka xa usiva ingxolo enkulu okanye umntu ekungquba. Ukuba ezi zinto zenzeka rhoqo, licebo elihle ukuzijonga. Namhlanje siza kuthetha ngemeko engaqhelekanga kakhulu enokubangela iimpawu ezifanayo. Oko kubizwa ngokuba yi -Stiff Person Syndrome (SPS) .

Yintoni iStiff Person Syndrome?

Ngamafutshane, i-Stiff Person Syndrome (SPS) sisifo semithambo-luvo esingaqhelekanga . Sivela xa inkqubo yomzimba wethu yokuzikhusela, esikhusela kwizifo, ihlasela ngempazamo iiseli zethu zemithambo-luvo ezisempilweni. Yimeko yokuzikhusela komzimba. Oku kubangela ukuba izihlunu ezisembindini wakho, ingakumbi isisu sakho, isifuba, nomqolo , zibe lukhuni okanye ziqine . Ekuhambeni kwexesha, olu kuqina kunye nokuxinana kunokusasazeka kwezinye izihlunu ezisemilenzeni nasezingalweni zakho. Oku kunokwenza kube nzima ukuhamba, kukwenze uwe rhoqo, kwaye kukwenze ube sengozini yokwenzakala.

Oku kwakubizwa ngokuba yi-"stiff man syndrome," kodwa elo gama ngoku litshintshiwe kuba esi sifo sinokuchaphazela nabani na, kungakhathaliseki ubudala okanye isini.

Ukufunyanwa ukuba unale meko kunokuba nzima kancinci. Kodwa iqela lakho lezonyango liza kudala isicwangciso sonyango esilungele wena kunye neempawu zakho. Oku kunokwahluka kumntu nomntu. Eyona nto ibalulekileyo kukubona oogqirha bakho rhoqo, ufumane inkxaso oyifunayo, kwaye uzame ukuhlala usempilweni.

Zithini iimpawu zeStiff Person Syndrome (SPS)?

Kukho iimpawu ezimbini eziphambili zesi sifo:

• Ukuqina okanye ukuqina kwemisipha.
• Ukuqaqamba kwemisipha okubuhlungu.

Nangona ezi mpawu ziqala nakweyiphi na iminyaka, zixhaphake kakhulu phakathi kweminyaka engama-30 nama-40 ubudala .

Iimpawu zeStiff Person Syndrome zinokusasazeka ziye kwezinye iindawo zomzimba kwaye zibe mandundu ngokuhamba kwexesha. Kwabanye abantu, kungathatha iinyanga ukuya kwiminyaka ukuba iimpawu zibonakale. Kwabanye, iimpawu zinokuhlala zifana iminyaka. Kwabanye abantu, iimpawu zinokuba mandundu kancinci kancinci kwaye zenze kube nzima ukwenza imisebenzi yemihla ngemihla.

Ukuqina kwemisipha

Rhoqo, uphawu lokuqala olubonayo ngeStiff Person Syndrome kukuqina kwemisipha esiqwini . Oku kuthetha ukuba kwiindawo ezifana nesisu, isifuba, nomqolo. Oku kuqina kunokubangela iintlungu nokungonwabi. Ezi mpawu zinokuvela ziphele ngaphandle kwesizathu esicacileyo. Le meko inokuchaphazela neengalo nemilenze. Njengoko ukuqina kusanda, abanye abantu banokuba neendlela ezingaqhelekanga zokuma ezenza kube nzima ukuhamba okanye ukushukuma.

Ukuqaqamba kwemisipha

Ukuqaqamba kwemisipha okubuhlungu lolunye uphawu oluphambili lwale meko. Oku kunokuchaphazela umzimba wonke, okanye kunokuthi kubekwe kwindawo ethile. Oku kuqaqamba kunokuhlala imizuzwana, imizuzu, okanye iiyure. Khawuthelekelele, xa umi nje, ngequbuliso umlenze okanye umqolo wakho uzive uqinile kwaye udiniwe. Liliva elibuhlungu kakhulu.

Zithini izizathu zeStiff Person Syndrome (SPS)?

Kukho izizathu ezahlukeneyo zokuba kutheni iimpawu ezifana nokuxhuzula kwemisipha zinokuvela ngequbuliso:

• Ingxolo ekhawulezileyo okanye enkulu. Khawuthelekelele ukuba ubuhamba esitalatweni uze imoto ivuthele ixilongo layo ngequbuliso, okanye ukuba into ethile ekhaya iwele phantsi ngesandi esikhulu.
• Ukuchukumisa okanye ukukukhuthaza. Ukuba umntu ngequbuliso uyakuchukumisa.
• Utshintsho kumaqondo obushushu, ingakumbi iindawo ezibandayo. Ukuba ngequbuliso uye kwindawo ebandayo, okanye ukuba amanzi abandayo awela emzimbeni wakho.
• Iziganeko ezibangela uxinezeleko. Amaxesha aphazamisayo nawoyikisayo.

Ngenxa yokuba ezi ntlungu zemisipha zinokwenzeka ngamaxesha angalindelekanga, abanye abantu abaneStiff Person Syndrome baba nexhala kunye ne -agoraphobia . I-Agoraphobia luloyiko olukhulu lokuya kwiindawo ezixineneyo, ukuphuma ngaphandle, okanye ukuphuma ekhaya. Kuba xa sele uphumile, kunzima ukubaleka kwezi zinto.

Yintoni ebangela iStiff Person Syndrome (SPS)?

Abaphandi abakaqiniseki ukuba yintoni ebangela esi sifo, kodwa bakholelwa ukuba yimeko yokuzikhusela komzimba, oko kuthetha ukuba inkqubo yomzimba wethu yokuzikhusela ihlasela iiseli ezisempilweni.

Uphando lubonise ukuba ii-antibodies ziyabandakanyeka. Abantu abaninzi abane-Stiff Person Syndrome bane-antibodies ezichasene ne-enzyme ebizwa ngokuba yi -Glutamic Acid Decarboxylase (GAD) . Le enzyme (GAD) inceda ekwenzeni i-neurotransmitter gamma-aminobutyric acid (GABA) . Le neurotransmitter (GABA) inceda ukulawula ukusebenza kwemisipha.

Kodwa abaphandi abakayiqondi ngokupheleleyo indlela i-enzyme `(GAD)` echaphazela ngayo uphuhliso kunye nokuqhubela phambili kweStiff Person Syndrome. Into enye ekufuneka uyikhumbule kukuba ukuba nee-antibodies `(GAD)` emzimbeni wakho akuthethi ukuba uneStiff Person Syndrome. Ipesenti encinci yoluntu ngokubanzi inokuba nezi antibodies `(GAD)` emizimbeni yabo ngaphandle kwemiphumo emibi.

Ukongeza kwi-GAD, ezinye ii-antibodies ezifana ne-glycine receptor, i-amphiphysin, kunye ne-DPPX (iproteni efana ne-dipeptidyl peptidase 6) zifunyenwe zidibene nesi sifo. Kwakhona, ezinye izigulana zisenokungabi nazo ezi antibodies. Uphando olongezelelweyo luyaqhubeka ukuze kuchongwe ukuba zeziphi ezinye ii-antibodies ezinokuba negalelo.

Ziziphi izinto ezibangela umngcipheko weStiff Person Syndrome (SPS)?

I-Stiff person syndrome ixhaphake kabini kubasetyhini . Inokwenzeka nakwezinye iimeko zokuzikhusela komzimba. Umzekelo:

• Uhlobo loku-1 lweswekile
• Isifo se-thyroid esizikhuselayo
• I-Vitiligo
• I-anemia eyingozi
• Isifo seCeliac

Ixhaphake kangakanani iStiff Person Syndrome (SPS)?

Esi sisifo esingaqhelekanga kakhulu . Kuthiwa ngumntu omnye kuphela kwisigidi sabantu onesifo. Oko kuthetha ukuba sisifo esingaqhelekanga kakhulu.

Ifunyanwa njani iStiff Person Syndrome (SPS)?

Ugqirha uxilonga esi sifo ngeempawu ezithile, uvavanyo, kunye novavanyo. Baza kukubuza ngeempawu zakho, benze uvavanyo lomzimba, kwaye benze uvavanyo lwemithambo-luvo.

Ukuba ugqirha urhanela ukuba uneStiff Person Syndrome, angenza uvavanyo olufana nolu:

• Uvavanyo lwegazi lwe-antibody: Oku kunceda ukujonga ubukho bee-antibodies kwi-(GAD) (okanye ezinye ii-antibodies ezinxulumene noko) kunye nokuthintela ezinye iimeko zonyango.
• I-Electromyography (EMG): Le ndlela ilinganisa umbane wemisipha yakho. Oku kunokunceda ekususeni ezinye izizathu zeempawu zakho.
• Ukubhobozwa kweLumbar (i-spinal tap): Kolu vavanyo, ugqirha usebenzisa inaliti ukuthatha isampuli yolwelo oluvela kwi-spinal cord yakho aze aluvavanye ukuze abone ukuba kukho ii-antibodies kwi-GAD. Oku kubalulekile ukuze kuthintelwe ezinye iimeko.

I-Stiff Person Syndrome inokuba nzima ukuyifumanisa kuba ayiqhelekanga kwaye iimpawu zayo zinokufana nezinye izifo ezizikhuselayo emzimbeni, ezifana ne-ankylosing spondylitis kunye ne-multiple sclerosis.

Ngaba kukho iintlobo zeStiff Person Syndrome (SPS)?

Kukho iintlobo ezahlukeneyo zesi sifo:

• I-Classic stiff person syndrome: Olu lolona hlobo luqhelekileyo. Ludla ngokunxulunyaniswa nee-GAD antibodies, kodwa uphando lufumanise ukuba nezinye ii-antibodies ziyabandakanyeka.
• Iindidi ze-Stiff person syndrome:Phantsi koku, kukho iintlobo ezahlukeneyo ezichaphazela kuphela iindawo ezithile zomzimba, okanye ezibonisa iimpawu ezininzi ezifana nokulahlekelwa kukulawula xa uhamba (`ataxia`).
• I-progressive encephalomyelitis ene-rigidity kunye ne-myoclonus (PERM): I-PERM luhlobo olubi kakhulu lwe-stiff person syndrome. Inokubangela ukulahlekelwa yingqondo, iingxaki zokunyakaza kwamehlo, i-ataxia, kunye nokungasebenzi kakuhle kwe-autonomic. Ukungasebenzi kakuhle kwe-autonomic kufuna ukuba abantu abane-PERM balaliswe esibhedlele.

Inyangwa njani iStiff Person Syndrome (SPS)?

Kukho iindlela ezimbini eziphambili zokunyanga oku:

• Amayeza kunye nonyango lokulawula iimpawu.
• Unyango lwe-immunotherapy, okanye unyango oluguqula izifo.

Iindlela zonyango ziyahluka ngokuxhomekeke kwiimpawu zakho. Injongo ephambili yonyango kukulawula indlela iimpawu zakho ezikuchaphazela ngayo kunye nokuphucula ukuhamba kwakho kunye nentuthuzelo.

Iqela lakho lezonyango lingabandakanya iingcali ezininzi, ezinje:

• Iingcali ze-neurologists, ingakumbi iingcali ze-neuroimmunoimmunology.
• Iingcali zonyango zomsebenzi kunye neengcali zonyango lomzimba.
• Iingcali zonyango lomzimba kunye nonyango lokubuyisela kwimeko yesiqhelo.
• Iingcali zonyango lwentetho.
• Iingcali zempilo yengqondo, umzekelo iingcali zengqondo.

Amayeza kunye nonyango

Amayeza anjengala anokunceda ekunciphiseni ukuqina kwemisipha, ukuqina kwayo, kunye nokuqaqamba kwemisipha okubuhlungu:

• IiBenzodiazepines: Ezi ziindidi zamayeza asetyenziselwa ukunyanga iimeko ezahlukeneyo, kuquka ixhala, isifo sokuwa, kunye nokungalali. Zichaphazela i-neurotransmitter (GABA) signaling. Oogqirha badla ngokunika i-diazepam njengonyango lokuqala lwe-Stiff Person Syndrome.
• Iziphumzi zemisipha: Amayeza afana neBaclofen anokunceda ekuxinezelekeni kwemisipha. Akhulula izihlunu aze anciphise ukuqina.
• Amayeza eentlungu ze-neuropathic: Amayeza afana ne -gabapentin kunye ne-pregabalin nawo achaphazela ukubonakaliswa kwe-GABA kwaye anceda kwiimpawu.

Ezinye iindlela zonyango ezinokunceda ukulawula iimpawu ziquka:

• Unyango lomzimba okanye unyango lomsebenzi.
• Ukuphulula umzimba.
• Unyango ngamanzi (unyango ngamanzi).
• Unyango lobushushu.
• Unyango lokuxubha nge-acupuncture.

Unyango lwe-immunotherapy

Kukho ubungqina bokuba unyango lwe -intravenous immunoglobulin (IVIg) (kwakhona uhlobo lwe-immunotherapy) lunokunceda ekunciphiseni iimpawu ze-Stiff Person Syndrome. I-IVIg iqulethe ii-immunoglobulin (ii-antibodies zendalo) ezinikelwa ngamawaka abantu abaneenkqubo zomzimba eziphilileyo.

Ngaba iStiff Person Syndrome (SPS) inganyangeka?

Okwangoku, akukho nyango lweStiff Person Syndrome. Unyango lunokunceda kuphela ekulawuleni iimpawu.

Iyintoni ingqikelelo yeStiff Person Syndrome (SPS)?

Le yimeko ehlala ixesha elide (engapheliyo) . Imbono iyahluka ukusuka kumntu ukuya komnye kuxhomekeke kwizinto ezininzi:

• Ubunzima beempawu.
• Isantya sesifo sasasazeka.
• Luphumelele kangakanani unyango?

Kubalulekile ukuqala unyango kwangoko nje ukuba iimpawu ziqale. Oku kunokunceda ekuthinteleni okanye ekunciphiseni ukusasazeka kwesi sifo kwaye kuncede ekuthinteleni iingxaki ezihlala ixesha elide. Nangona abantu abaninzi befumana isiqabu ngamayeza, ngamanye amaxesha kunokuba nzima ukulawula izinto ezibangela ukuqaqamba kwemisipha.

Ukuhamba kunokuba nzima ngakumbi ngokuhamba kwexesha. Amandla okwenza imisebenzi yemihla ngemihla nawo anokuncipha kancinci kancinci. Njengoko isifo siqhubeka, umngcipheko wokuwa uyanda. Kusenokufuneka usebenzise intonga, i-walker, okanye nesihlalo esinamavili.

Ngaba iStiff Person Syndrome (SPS) ingathintelwa?

Ngenxa yokuba esi sisifo esibangelwa kukuzikhusela komzimba, akukho nto unokuyenza ukusithintela .

Ndingazinyamekela njani ukuba ndineStiff Person Syndrome (SPS)?

Ukuba kunokwenzeka, zama ukufumana ugqirha ogxile ekuphandeni nasekunyangeni iStiff Person Syndrome. Le meko ayiqhelekanga, ngoko ke inokuba nzima kancinci. Ukuba ufuna unyango olungcono kwaye ube nobomi obusemgangathweni, kuya kufuneka uthethe kwaye ube nomdla kuyo.

Kuqhelekile ukuba abantu abanale sifo babe neengxaki zempilo yengqondo, ezinje ngexhala okanye ukudakumba . Ukuba uhlangabezana nezi mpawu, kubalulekile ukuthetha nogqirha wakho okanye ingcali yezempilo yengqondo, efana nengcali yezengqondo.

Ukuba wena nosapho lwakho niyakwazi, ningajoyina iqela lenkxaso apho ningadibana khona nabanye abaqonda amava enu.

Ndifanele ndimbone nini ugqirha?

Ukuba uneStiff Person Syndrome, kufuneka udibane neqela lakho lezonyango rhoqo ukuze ubone ukuba unyango lwakho luphumelele na kwaye ujonge uphuhliso lweempawu zakho.

Ukuba ubona iimpawu ezintsha okanye unemiphumo emibi evela kumayeza, xelela ugqirha wakho.

Ndingayibuza yiphi imibuzo ugqirha wam?

Ukuba une-Stiff Person Syndrome, kunokuba luncedo ukubuza ugqirha wakho le mibuzo:

• Loluphi unyango olucebisayo kwiimpawu zam?
• Ndingenza ntoni ekhaya ukunceda ngeempawu zam?
• Zeziphi iimpawu zeengxaki ekufuneka ndiziqaphele?
• Ndingalindela ukuba impilo yam ibe njani kwixesha elizayo?
• Ngaba kukho iimvavanyo zonyango zeStiff Person Syndrome?

Okokugqibela, izinto ekufuneka uzikhumbule (Umyalezo Wokuya Ekhaya)

Ukufumanisa ukuba unesifo esingaqhelekanga esifana neStiff Person Syndrome akulula. Usenokuziva uxinezelekile, uxhalabile, kwaye ungaqinisekanga ngekamva. Kodwa akufuneki ujongane noku wedwa. Iqela lakho lezonyango lilapha ukuphendula nayiphi na imibuzo onokuba nayo kwaye likuncede ukulawula iimpawu zakho.

Nangona unyango lwakho lugxile kwimpilo yakho yomzimba, lumkele nempilo yakho yengqondo . Iimpawu ziyahluka kumntu nomntu. Kodwa ukuphila neentlungu, ukungonwabi, kunye nokuxinana kwemisipha okungalindelekanga kunokubangela umonakalo kwimpilo-ntle yakho yengqondo. Le meko inokwenza kube nzima ukuphuma uye kwenza imisebenzi yemihla ngemihla. Ngoko ke, ukuba ufuna inkxaso, ungathandabuzi ukunxibelelana nogqirha ukongeza kubantu obathandayo. Khumbula, awuwedwa.

I- Stiff Person Syndrome, ukuqina kwemisipha, izifo zemithambo-luvo, i-autoimmune, ii-antibodies ze-GAD, i-GABA, ukuxhuzula kwemisipha, iimpawu ze-SPS