Sonke siyazi ukuba ukulwa nomhlaza akuyonto ilula. Ngeli xesha lohambo, ugqirha wakho unokukunika amayeza ahlukeneyo. I-Sunitinib yenye yezo ziyobisi, ejolise kwiiseli zomhlaza kwaye iyeke ukukhula kwazo. Ngoko ke, ukuba unikwe eli yeza, ukulazi ngokulula nangokucacileyo kuya kuba luncedo olukhulu kuhambo lwakho lonyango. Makhe sithethe ngale nto.
Luhlobo luni lweyeza iSunitinib?
Ngamafutshane, iSunitinib liyeza eliwela kudidi "lonyango olujoliswe kulo." Oku kuthetha ukuba eli yeza alichaphazeli nje kuphela zonke iiseli emzimbeni, kodwa kunoko lichonga kwaye limise iiproteni ezithile ezinceda iiseli zomhlaza zikhule kwaye zisasazeke. Oku kufana nokujolisa ngqo kutshaba.
Eli yeza lisetyenziswa kakhulu ukunyanga ezi ntlobo zilandelayo zomhlaza:
- I-GIST (Ii-Gastrointestinal Stromal Tumors): Olu luhlobo oluthile lwethumba oluvela kwinkqubo yethu yokugaya ukutya.
- Umhlaza Wezintso Oqhubele Phambili: Xa umhlaza wezintso usasazeke kwezinye iindawo zomzimba.
- IiPancreatic Neuroendocrine Tumors: Olu luhlobo olukhethekileyo lomhlaza oluvela kwipancreas.
Izinto ekufuneka uzixelele ugqirha wakho ngaphambi kokuba uqale amayeza
Ngaphambi kokuba uqale iSunitinib, kubaluleke kakhulu ukuxelela ugqirha wakho ngembali yakho epheleleyo yempilo. Oku kungenxa yokuba eli yeza lisenokudibana neemeko ezithile zempilo. Jonga itheyibhile engasezantsi. Ukuba unayo nayiphi na kwezi meko, qiniseka ukuba uxelele ugqirha wakho.
| Imeko ekufuneka uyixele | Kutheni kunjalo? (Isizathu sokuba ugqirha asazi) |
|---|---|
| Iingxaki zokopha okanye ukukrwela okulula | Eli yeza linokunyusa umngcipheko wokopha. |
| Iingxaki zamazinyo, ukuba usebenzisa amazinyo okufakelwa | Unyango lwamazinyo lufanele lucwangciswe kwangaphambili, njengoko amayeza enokuchaphazela umhlathi. |
| Isifo seswekile | Amanqanaba eswekile egazini anokuchaphazeleka. |
| Ukuba uza kutyandwa kungekudala | Ngenxa yokuba ichaphazela ukuphiliswa kwamanxeba, amayeza kufuneka amiswe ngaphambi nasemva kotyando. |
| Isifo sentliziyo, uxinzelelo lwegazi oluphezulu, iingxaki zesingqisho sentliziyo | Eli yeza linokuchaphazela ukusebenza kwentliziyo kunye noxinzelelo lwegazi. |
| Izintso (ngaphandle komhlaza) okanye isifo sesibindi | Umsebenzi wezi zitho uchaphazela isiphumo seyeza. |
| Isifo se-thyroid | Eli yeza linokuchaphazela amanqanaba ehomoni ye-thyroid. |
| Ukuba ukhulelwe, uzama ukukhulelwa, okanye uncancisa | Oku kubaluleke kakhulu! Eli yeza linokubangela ingozi enkulu kumntwana osesiswini. |
| Ukunganyamezelani neSunitinib okanye amanye amayeza okanye ukutya | Kubalulekile ukwazisa oku ukuze uphephe iimpembelelo ze-allergy. |
Ulisebenzisa njani eli yeza?
Indlela yokusebenzisa oku ilula kakhulu, kodwa ibaluleke kakhulu.
- Ginya iyeza lonke ngeglasi yamanzi.
- Ungayithatha le nto ngaphambi okanye emva kokutya. Ayizukuba yingxaki.
- Eyona nto ibalulekileyo kukuthatha amayeza kanye njengoko ugqirha ewayalele, ngexesha elimiselweyo.
- Ungaze, nangasiphi na isizathu, uyeke ukuthatha amayeza okanye utshintshe umthamo ngaphandle kwengcebiso kagqirha wakho.
Yintoni omawuyenze ukuba uphoswe yidosi yeyeza?
Ukuba uphoswe yidosi, yithathe ngokukhawuleza xa ukhumbula. Nangona kunjalo, ukuba kungaphantsi kweeyure ezili-12 ngaphambi kokuba idosi yakho elandelayo ifike, yitsibe idosi oyiphosileyo uze uthathe idosi yakho elandelayo ngexesha elicwangcisiweyo. Ungaze uthathe iidosi ezimbini ngaxeshanye.
Kuthekani ukuba ndithatha amayeza amaninzi kakhulu?
Ukuba ucinga ukuba uthathe amayeza amaninzi kunokuba ucinga, ungoyiki kwaye yiya kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane. Okanye utsalele umnxeba iZiko loLwazi lweeTyhefu leSizwe kwiSibhedlele sikaZwelonke saseColombo .
Ezinye izinto ezinokunxibelelana neSunitinib
Oku kubaluleke kakhulu. Xa usela iSunitinib, kubalulekile ukuxelela ugqirha wakho ngawo onke amayeza owasebenzisayo (kuquka amayeza ezinye izifo, iivithamini, amayeza esintu, iimveliso zezityalo). Amanye amayeza anokusebenzisana neSunitinib aze anciphise iziphumo zayo, anyuse iziphumo zayo, okanye abangele iziphumo ebezingalindelekanga eziyingozi.
Lumka ngakumbi ngezi zinto zilandelayo:
- Amanye amayeza e-HIV okanye i-hepatitis
- Amayeza osulelo lwefungus (umz. i-ketoconazole, i-itraconazole)
- Amanye amayeza okubulala iintsholongwane (umz. i-clarithromycin)
- Amanye amayeza okuxhuzula (umz. i-carbamazepine, i-phenytoin)
- Imveliso yemifuno iSt. John's Wort
- Amanye amayeza andisa ixesha le-QT
- Ijusi yegrapefruit: Le yinto abantu abaninzi abangayaziyo. Ukusela ijusi yegrapefruit kunokuchaphazela indlela esebenza ngayo iSunitinib. Ke ngoko, yiphephe ngokupheleleyo ijusi yegrapefruit kunye negrapefruit ngelixa usela eli yeza.
Amanqaku akhethekileyo ekufuneka uwaqaphele xa usebenzisa amayeza
Amazinyo kunye nempilo yomlomo
Eli yeza ngamanye amaxesha linokuchaphazela umhlathi (i-Osteonecrosis yomhlathi). Ngoko ke, kungcono ukubona ugqirha wamazinyo ngaphambi kokuba uqale iyeza kwaye ulungise naziphi na iingxaki zamazinyo. Kwakhona, xelela ugqirha wamazinyo ukuba usela eli yeza. Kububulumko ukuphepha utyando olukhulu lwamazinyo ngelixa usela eli yeza.
Utyando kunye nokuphiliswa kwamanxeba
I-Sunitinib ingayicothisa inkqubo yokuphiliswa kwamanxeba. Ukuba uza kutyandwa, xelela ugqirha wakho we-oncologist. Kucetyiswa ukuba uyeke ukuthatha amayeza kwiiveki ezi-3 ngaphambi kotyando kwaye uqalise kwakhona emva kokuba inxeba lipholile kakuhle (ubuncinane iiveki ezi-2 emva kotyando).
Ukukhulelwa, ukuzala kunye nokuncancisa
Oku kubaluleke kakhulu!Ukuba ungumfazi, kuphephe ukukhulelwa ngokupheleleyo ngelixa usebenzisa eli yeza kwaye ubuncinane iiveki ezi-4 emva kokuyeka iyeza. Ukuba uyindoda, kuphephe ukukhulelwa ngelixa usebenzisa eli yeza kwaye ubuncinane iiveki ezi-7 emva kokuyeka iyeza.
Eli yeza linokubangela ingozi enkulu kusana olungekazalwa. Kungoko ke, kubalulekile ukusebenzisa uhlobo oluthembekileyo lokulawula ukuzalwa ngeli xesha. Kwakhona, kuphephe ukuncancisa xa usebenzisa eli yeza kwaye kwiiveki ezi-4 emva kokuba uyekile.
Zithini iziphumo ebezingalindelekanga ezinokubakho?
Njengalo naliphi na iyeza, iSunitinib inokuba nemiphumo emibi. Nangona kunjalo, ayinguye wonke umntu oyifumanayo. Eyona nto ibalulekileyo kukwazi oku kwaye wazise ugqirha wakho ngokukhawuleza ukuba ufumana naziphi na iingxaki.
| Iziphumo ebezingalindelekanga ekufuneka zixelwe kugqirha wakho okanye esibhedlele ngoko nangoko | |
|---|---|
| Iimpendulo ze-allergy | Ukurhawuzelela kwesikhumba, ukurhawuzelela, ukudumba kobuso, imilebe, ulwimi |
| Ubunzima bokuphefumla, iintlungu zesifuba | Intliziyo okanye imiphunga inokuchaphazeleka. |
| Intlungu ebuhlungu esiswini, ukopha okungaqhelekanga okanye ukukrweleka | Kungaba luphawu lokopha ngaphakathi emzimbeni. |
| Ukudumba kwemilenze, amaqatha, ukunyuka kobunzima ngequbuliso | Kusenokuba kukho ingxaki yentliziyo okanye yezintso. |
| Intlungu yomhlathi (ingakumbi emva kokukhupha izinyo) | Isenokuba negalelo kwithambo lomhlathi. |
| Ubomvu, amadyungudyungu, kunye nokuxobuka kolusu | Uphawu lokusabela okukhulu kwesikhumba. |
| Uxinzelelo lwegazi oluphezulu, iintloko ezibuhlungu, ukuxhuzula | Impembelelo kwinkqubo yemithambo-luvo okanye kuxinzelelo lwegazi. |
| Xelela ugqirha wakho ukuba iyaqhubeka okanye iyakukhathaza. | |
| Urhudo | Ukuqunjelwa. |
| Isicaphucaphu nokuhlanza | Isicaphucaphu nokuhlanza. |
| Izilonda zomlomo | Izilonda emlonyeni. |
| Utshintsho lolusu | Ukutyheli kwesikhumba, ukoma, ukuqhekeka, kunye nobuhlungu besikhumba ezintendeni nasezinyaweni. |
| Ukutshintsha kombala weenwele | Ukukhanyisa umbala weenwele. |
| Ukudinwa | Ukuziva udiniwe ngendlela engaqhelekanga. |
| Ukulahlekelwa ngumdla wokutya kunye notshintsho kwincasa | Ukuncipha komnqweno wokutya kunye nokutshintsha kwencasa yokutya. |
Umyalezo Wokuya Ekhaya
- I-Sunitinib liyeza elikhethekileyo elijolise kwiiseli zomhlaza.
- Landela imiyalelo kagqirha wakho ngokuchanekileyo. Ungaze uyeke ukuthatha iyeza okanye utshintshe umthamo ngokwakho.
- Xelela ugqirha wakho ngazo zonke ezinye iziyobisi, iimveliso zezityalo, kunye nejusi yegrapefruit oyithathayo.
- Kuphephe ukukhulelwa nokuncancisa ngokupheleleyo xa usebenzisa amayeza kwaye kangangoko ugqirha wakho ekuxelela kona. Ukusebenzisa iindlela zokulawula ukukhulelwa ezithembekileyo kubalulekile.
- Ukuba ufumana naziphi na iziphumo ebezingalindelekanga ezinje ngobunzima bokuphefumla, ukopha okungaqhelekanga, okanye ukudumba komzimba, yiya kugqirha wakho ngoko nangoko okanye kwiSebe lezeMpilo eziNgxamisekileyo (ETU) lesibhedlele esikufutshane.
- Thetha nogqirha wakho ngayo nayiphi na imibuzo okanye izinto ezikuxhalabisayo. Bahlala bekulungele ukukunceda.
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