Ubusazi na ukuba isibindi sesinye sezitho ezinkulu emzimbeni wethu? Sifana nomzi-mveliso emzimbeni wethu. Senza umsebenzi omninzi. Kodwa ngamanye amaxesha, inkqubo yokuzikhusela yomzimba wethu iyaphambuka ize iqale ukuhlasela isibindi ngokwaso. Namhlanje siza kuthetha ngemeko engaqhelekanga, kodwa ebaluleke kakhulu ekufuneka siyiqaphele. Ibizwa ngokuba yiPrimary Biliary Cholangitis, okanye `(Primary Biliary Cholangitis - PBC)` ngamafutshane.
Kalula nje, yintoni i-PBC?
Esi sisifo "esikhusela umzimba ngokwawo". Usenokucinga ukuba elo gama liyinkimbinkimbi kancinci, kodwa lilula kakhulu. Lithetha ukuba inkqubo yethu yomzimba yokuzikhusela, esikhusela kwizifo, ihlasela iiseli zethu ezilungileyo ngempazamo. Kwi-PBC, olu hlaselo lujoliswe kwimibhobho yenyongo encinci esibindini.
Cinga ngale ndlela: inyongo, ulwelo olwenziwa sisibindi, lufana namanzi anesepha anceda imizimba yethu ukuba itye ukutya. Le nyongo ihamba ukusuka esibindini idlula kwimibhobho emincinci iye kwinkqubo yokugaya ukutya. Okwenzekayo kumntu one-PBC kukuba inkqubo yomzimba yokuzikhusela ihlasela le mibhobho yenyongo ize iyitshabalalise kancinci kancinci.
Kuza kwenzeka ntoni ke ngoko?
1. Inyongo iyaqokelelana: Xa imibhobho yonakele, inyongo ayikwazi ukuhamba kakuhle ize iqale ukuqokelelana ngaphakathi kwesibindi.
2. Ukudumba kwenzeka: Oku kuqokelelana kwenyongo konakalisa iiseli zesibindi kwaye kubangele ukudumba, okanye ukudumba.
3. Ukuvaleka kwamanxeba (i-Fibrosis) kwenzeka: Xa lo monakalo usenzeka ngokuhamba kwexesha, isibindi sizama ukulungisa umonakalo ngokwenza izicubu zamanxeba. Njengokuba inxeba eluswini lwethu liphola, kuvela amanxeba. Oku kubizwa ngokuba yi-`(fibrosis)`.
4. I-Cirrhosis: Xa inani lezicubu zesilonda lisanda kakhulu, iindawo eziphilileyo zesibindi ziyalahleka, kwaye isibindi siba njengelitye. Oku sikubiza ngokuba yi-`(cirrhosis)`. Ukuba le meko iba mandundu, isibindi sinokungasebenzi.
Eyona nto ibalulekileyo kukuba ukuba esi sifo sifunyenwe kwangethuba kwaye kuqaliswe unyango olufanelekileyo, sinokuthintelwa kakhulu ekubeni siqhubekele kwezi meko zinzima.
Ziziphi iindlela zonyango ze-PBC?
Eyona nto ibalulekileyo ekufuneka ndiyitsho kuqala kukuba akukho nyango lwe-PBC okwangoku . Kodwa ungakhathazeki. Oku akuthethi ukuba akukho nto sinokuyenza. Kukho unyango olusebenzayo kakhulu olufumanekayo namhlanje olunokucothisa ukuqhubela phambili kwesi sifo, lunciphise kakhulu umonakalo kwisibindi, kwaye lulawule iimpawu.
Kukho iinjongo ezimbini eziphambili zonyango:
- Ukucothisa izinga lokonakala kwesibindi okubangelwa sisifo.
- Ukwenza ubomi bakho bube lula ngokulawula iimpawu ezifana nokurhawuzelelwa nokudinwa.
Kukho iintlobo ezininzi eziphambili zamayeza avunyiweyo ngenxa yesi sizathu. Ugqirha wakho uya kugqiba ukuba yeyiphi efanelekileyo kuwe ngokwemeko yakho.
| Igama leziyobisi | Yintoni omawuyenze ngokulula |
|---|---|
| I-Ursodeoxycholic acid ( UDCA ) | Eli lelona yeza liqhelekileyo lokuqala. Linceda ekwenzeni lula ukuhamba kwenyongo esibindini kwaye likhusela iiseli zesibindi kwinyongo eyingozi. |
| I-obeticholic acid ( OCA ) | Eli yeza linikwa kunye okanye lodwa kunye ne-UDCA kwabo bangenazo iziphumo ezaneleyo nge-UDCA yodwa. Oku kulawula nokuveliswa kunye nokuhamba kwenyongo. |
| I-Seladelpar kunye ne-Elafibranor | La ngamayeza amatsha avunyiweyo kwi-PBC. Anciphisa ukudumba kwesibindi kunye nomonakalo obangelwa yinyongo. |
Ngokwesiqhelo, ugqirha uza kuqala ngokuqala nge-``(UDCA)``. Emva koko baza kwenza uvavanyo lwegazi ukuze babone ukuba umzimba wakho usabela njani kulo. Ukuba iziphumo azinelisekanga, banokongeza elinye iyeza okanye batshintshele kwelinye iyeza.
Masifunde okungakumbi nge-UDCA.
Le `(UDCA)` yi`(bile acid)` eveliswa ngokwemvelo emzimbeni wethu ngamanani amancinci. `UDCA`, enikwa njengonyango, ithatha indawo yee-bile acids eziyingozi eziqokelelene esibindini ngale bile acid ingenabungozi kangako. Oku kunciphisa umonakalo kwiiseli zesibindi. Ngamafutshane, isebenza njengekhaka elikhuselayo lesibindi.
Uphando olutsha kunye namathemba exesha elizayo
Uphando malunga ne-PBC luyaqhubeka luqhutywa kwihlabathi liphela. Amayeza asetyenziswa kwezinye iimeko, njengeBezafibrate kunye neFenofibrate, ayaphandwa ukuze kubonwe ukuba angaba luncedo na nakubantu abane-PBC. Oku kuthetha ukuba unyango olusebenzayo lunokufumaneka kwixesha elizayo. Oku kuyathembisa kakhulu.
Kubalulekile ukuthetha nogqirha wakho!
Xa uphila nesi sifo esifana nesi ixesha elide, ugqirha wakho ngumhlobo wakho osenyongweni. Musa ukuthandabuza ukuthetha nogqirha wakho ngayo nayiphi na imibuzo okanye iinkxalabo onokuba nazo.
- Buza ngononophelo ngamayeza owanikwayo.
- Buza ukuba zeziphi iziphumo ebezingalindelekanga ezinokuba nazo.
- Thetha ngokukhululekileyo ngeempawu onazo kunye nendlela ezikhula okanye ezincipha ngayo.
- Musa ukuyeka ukuthatha amayeza okanye ukutshintsha umthamo nangasiphi na isizathu ngaphandle kokubonisana nogqirha wakho.
Okukhona wena nogqirha wakho nisebenza kunye, kokukhona amathuba akho okulawula le meko nokuphila ubomi obusempilweni nobuqhelekileyo aba maninzi.
Umyalezo Wokuya Ekhaya
- I-Primary Biliary Cholangitis (PBC) yimeko yexesha elide apho inkqubo yomzimba yokuzikhusela yonakalisa imibhobho yenyongo yesibindi.
- Nangona ingenakunyangwa ngokupheleleyo, kukho unyango olusebenzayo kakhulu olunokulawula umonakalo obangelwe sisifo kwisibindi nokulawula iimpawu.
- Unyango lokuqala olunikwa abantu abaninzi liyeza elibizwa ngokuba yi-(UDCA).
- Kubalulekile ukuthatha amayeza owanikwe ngugqirha wakho njengoko eyalelwe nangexesha elifanelekileyo.
- Ungaphila ngempumelelo nale meko ngokunxibelelana rhoqo nogqirha wakho nokuxoxa ngeengxaki zakho ngokukhululekileyo.
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