Ngaba ngamanye amaxesha uziva udiniwe ngendlela engaqhelekanga okanye udiniwe ngaphandle kwesizathu? Ngaba ulusu lwakho lubonakala lutyheli? Okanye ingaba i-jaundice yosana lwakho olusandul’ ukuzalwa ayipheli emva kweeveki ezimbini? Unobangela wezi zinto usenokuba kukunqongophala kwe-enzyme ebizwa ngokuba yi-G6PD emzimbeni wakho. Ungakhathazeki, le yimeko eqhelekileyo kakhulu. Namhlanje, siza kuthetha ngokulula nangokucacileyo malunga nokuba yintoni i-G6PD, kwenzeka ntoni xa iphantsi, kunye novavanyo lwe-G6PD.
Yintoni i-G6PD ngokulula?
Cinga ngeeseli ezibomvu zegazi emizimbeni yethu njengamajoni asebenza. Kukho 'umlindi' okhusela la majoni kwizinto ezahlukeneyo eziyingozi. Loo mlindi yi-enzyme ebizwa ngokuba yi-G6PD.
Ngamafutshane, i-G6PD (iGlucose-6-Phosphate Dehydrogenase) yi-enzyme ebaluleke kakhulu ekhusela iiseli zethu, ingakumbi iiseli ezibomvu zegazi egazini lethu, kwiikhemikhali eziyingozi. Umzimba wethu uvelisa izinto eziyingozi (ezikwabizwa ngokuba yi -'Free Radicals' okanye 'Reactive Oxygen Species' ) eziveliswa ngexesha lokusebenza okuqhelekileyo. I-enzyme ye-G6PD yenza oku ngokuthintela ezi zinto ziyingozi ukuba zingaqokeleli kwaye zonakalise iiseli.
Kwenzeka ntoni xa i-G6PD iphantsi?
Khawucinge nje ukuba kwenzeka ntoni ukuba loo 'mkhuseli' (G6PD) uphantsi emzimbeni? Emva koko ezo zinto ziyingozi ziyafika zize ziqale ukutshabalalisa iiseli zethu ezibomvu zegazi. Le nkqubo yeeseli ezibomvu zegazi eziqhekekayo ngokukhawuleza kunokuba zinokwenziwa ibizwa ngokuba yi-hemolysis .
Xa ulahlekelwa linani elikhulu leeseli ezibomvu zegazi ngale ndlela, umzimba wakho awufumani ioksijini oyidingayo. Yiloo nto siyibiza ngokuba yi-anemia, okanye ngokuthe ngqo, i-hemolytic anemia . Yiyo loo nto uziva udiniwe, ubuthathaka, kwaye uphaphathekile ngalo lonke ixesha.
Kwenzeka njani ukuba ukungabikho kwe-G6PD kungenzeki?
Ukungabikho kwe-G6PD yimeko yemfuza ebangelwa lufuzo . Oku kuthetha ukuba yinto oyizuz’ ilifa kubazali bakho. Xa kukho utshintsho kwi-gene olukuxelela ukuba wenze i-enzyme ye-G6PD, ubungakanani bale enzyme eveliswa emzimbeni buyancipha.
Kodwa into ebalulekileyo apha kukuba ayinguye wonke umntu onesifo se-G6PD oza kuba neempawu. Abantu abaninzi baphila ubomi obuqhelekileyo ngaphandle kweengxaki. Nangona kunjalo, ezinye izinto zangaphandle (esizibiza ngokuba 'zizinto ezibangela') zinokubangela ukuba iimpawu zivele ngequbuliso.
Izinto ezibangela iimpawu ze-G6PD
Ezi zinto zibangela ukuba umzimba wonyuse ngequbuliso inani lezo 'free radicals' ziyingozi esithethe ngazo. Umntu onesifo se-G6PD akanakulawula ezi zinto ziyingozi zisandayo. Kulapho ke iiseli ezibomvu zegazi ziqala ukuwohloka, kwaye iimpawu ziyavela.
| Uhlobo lweSiqalisi | Inkcazo |
|---|---|
| Ukutya okuthile | Ingakumbi iimbotyi zeFava . Iimpawu zinokubakho xa uzitya okanye uphefumlela ipollen yazo. Le meko ikwabizwa ngokuba yi-'Favism'. |
| Amanye amayeza | Ezinye izithomalalisi zentlungu ezifana ne-Aspirin, i-Acetaminophen (i-Paracetamol), ezinye amayeza e-Sulfa, ezinye izibulali-ntsholongwane kunye namayeza e-malaria zezona ziphambili. Musa ukuthatha naluphi na unyango ngaphandle kwengcebiso kagqirha. |
| Usulelo lwentsholongwane kunye neebhaktheriya | Naluphi na usulelo, ukususela kumkhuhlane oqhelekileyo ukuya kusulelo oluqatha, lunokubangela iimpawu ze-G6PD. |
Ukunqongophala kwe-G6PD kuxhaphake kakhulu kumadoda kunabasetyhini, kwaye kuxhaphake kakhulu kubantu baseAfrika, baseAsia, nabaseMeditera.
Ngubani ekufuneka enze uvavanyo lwe-G6PD?
Ugqirha wakho unokucebisa uvavanyo lwe-G6PD (uvavanyo lwegazi olulula), ingakumbi ukuba unezinye zezi mpawu zilandelayo:
- Ukudinwa nobuthathaka obungachazekiyo
- Ulusu olukhanyayo
- Ubunzima bokuphefumla okanye ukuphefumla
- Ukubetha kwentliziyo
- Ukutyheli kolusu namehlo (i-jaundice)
- Umchamo omnyama (onombala we-cola)
- Intlungu yomqolo okanye yesisu
- Imeko yangoku yokudideka
Zikhathalele ngokukodwa iintsana ezisandul’ ukuzalwa.
Kuqhelekile ukuba umntwana osandul’ ukuzalwa abe ne-jaundice. Kodwa ukuba ihlala ixesha elingaphezu kweeveki ezimbini , umchamo womntwana uba mnyama, kwaye indle iba mhlophe, ugqirha unokurhanela ukuba akanayo i-G6PD aze enze olu vavanyo.
Ungayiqonda njani ingxelo yovavanyo?
Iziphumo zovavanyo lwe-G6PD zingahluka kancinci kwilabhoratri nganye, ngoko ke ngugqirha wakho kuphela onokukunika ulwazi oluchanekileyo . Nangona kunjalo, ngokubanzi kukho iintlobo ezintathu zeziphumo.
- Okuqhelekileyo: Une-enzyme ye-G6PD eyaneleyo emzimbeni wakho. Awunaso isiphene se-G6PD.
- Ukunqongophala Okuphakathi: Amanqanaba e-enzyme aphakathi kwe-10% kunye ne-60% yesiqhelo. Aba bantu badla ngokufumana iimpawu kuphela xa benosulelo okanye bethatha i-action engalunganga yeziyobisi.
- Ukunqongophala Okukhulu: Le enzyme ikhona ngaphantsi kwe-10% yamanqanaba aqhelekileyo. Aba bantu banokuba ne-anemia engapheliyo okanye iimpawu ezixhaphakileyo.
Unyango kunye nolawulo lokungabikho kwe-G6PD
Ukunqongophala kwe-G6PD akusisifo esinokunyangeka ngokupheleleyo, kuba sisifo semfuza. Nangona kunjalo, ukuba silawulwa kakuhle, ungaphila ubomi obusempilweni ngaphandle kweengxaki .
Eyona nto ingcono onokuyenza kukuphepha izinto ezibangela iimpawu. Olu lolona nyango luphambili.
Kufuneke u:
- Kuphephe ukutya iimbotyi zefava ngokupheleleyo.
- Kuphephe ukusebenzisa amayeza okudambisa iintlungu afana ne -Aspirin kunye ne-Acetaminophen (Paracetamol) ngaphandle kwemvume kagqirha wakho.
- Yazisa ugqirha wakho ukuba unesifo sokungabikho kwe-G6PD ngaphambi kokuba unike amayeza .
- Funa uncedo lwezonyango ngokukhawuleza ukuba unesifo esithile.
Ukuba iimpawu zakho azincinci, ugqirha wakho unokukunika iipilisi ze-folic acid kunye ne-iron. Ukuba i-anemia yakho imbi kakhulu, kunokufuneka ulaliswe esibhedlele kwaye unikwe utofelo-gazi okanye unyango lwe-oksijini.
Khumbula ukuba ii-antioxidants ezifana neVithamin E aziyi kuyinceda le meko.
Umyalezo Wokuya Ekhaya
- Ukunqongophala kwe-G6PD yimeko eqhelekileyo yemfuza edluliselwa kwizizukulwana ngezizukulwana kwaye akukho nto yoyikekayo.
- Abantu abaninzi abanazo kwaphela iimpawu. Iimpawu ziyabonakala xa bevezwa 'zizinto ezibangela' ezifana neembotyi ze-fava, amayeza athile, okanye usulelo.
- Eyona ndlela iphambili yokulawula kukuphepha ezi zinto zibangela ezi ngxaki.
- Ukuba unesiphene se-G6PD, kubalulekile ukwazisa ugqirha ngaphambi kokuba ufumane unyango.
- Ukuba ufumana iimpawu ezinje ngokudinwa okugqithisileyo ngequbuliso, ukutyheli kolusu, okanye umchamo omnyama, bonana nogqirha wakho ngoko nangoko.
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