Ngaba kukho umntu kusapho lwakho, mhlawumbi umama wakho omthandayo, utata, okanye iqabane lakho lobomi, onesifo se-Alzheimer? Ngoko ke mhlawumbi uyazi kakuhle ukuba kunzima kwaye kubuhlungu kangakanani kuwo wonke umntu kusapho. Akulula ukubukela esi sifo apho ulahlekelwa yinkumbulo yakho imihla ngemihla uze ulibale ukuba ungubani. Ngoko ke xa kufika iindaba malunga neyeza elitsha lesi sifo, kuzisa ithemba elikhulu nemibuzo emininzi engqondweni. "Ngaba oku kuyasebenza ngokwenene? Ngaba kukho iziphumo ebezingalindelekanga? Ngubani onokusebenzisa oku?" Kufuneka ukuba kukho imibuzo emininzi engqondweni yakho. Ngoko masithethe ngayo yonke into ngokucacileyo nangokulula namhlanje.
Yintoni le ndlela intsha yokunyanga ukuthetha?
Igama lale yeza litsha yiLecanemab, kwaye liza kuthengiswa phantsi kwegama elithi Leqembi. Okokuqala, eyona nto ibalulekileyo ekufuneka siyiqonde kukuba eli asilonyango lwesifo i-Alzheimer's. Nangona kunjalo, lenza into enkulu. Oko kukuthi, linciphisa isantya sokuqhubeka kwesi sifo kwizigaba zokuqala . Ngamafutshane, linciphisa ukuwohloka kwenkumbulo kunye nobuchule bokucinga besigulana.
Oku kunikwa njenge-intravenous infusion rhoqo kwiiveki ezimbini. Eli yeza lifakwa kancinci kancinci emzimbeni, njenge-saline.
Lisebenza njani eli yeza?
Khawucinge nje, xa sifumana isifo se-Alzheimer, into enamathelayo nefana nenkunkuma iqokelelana phakathi kweeseli zethu zobuchopho. Siyibiza ngokuba yi-amyloid. Le protein ebizwa ngokuba yi-amyloid yeyona nto iphambili ebangela umonakalo kwiiseli zobuchopho kunye nokulahlekelwa yinkumbulo. Ngoko ke into eyenziwa leli yeza litsha kukuba lijolise kule protein ye-amyloid engafunekiyo engqondweni kwaye liyisuse. Ngamanye amazwi, eli yeza lihlasela unobangela wesifo.
Eli linyathelo elikhulu eliya phambili kwicandelo lethu lezonyango. Kuba uninzi lwamayeza abekho ixesha elide akwazile ukulawula ezinye zeempawu. Kodwa eli yeza lizama ukutshintsha indlela esi sifo esihamba ngayo.
Zithini iziphumo kunye neengozi zoku?
Njengalo naliphi na iyeza, eli lineengenelo kunye neengozi zalo. Kubalulekile ukuba sizazi zombini ezi zinto.
Uphando lubonise ukuba izigulane ezithathe eli yeza kangangeenyanga ezili-18 zazinokwehla kwe-27% kwinkumbulo kunye nobuchule bokucinga xa kuthelekiswa neqela le-placebo. Ubungakanani be-amyloid ebuchotsheni nabo buncitshisiwe kakhulu. Nangona oku kunokubonakala ngathi yipesenti encinci, yinto enkulu ukuba isigulane sisenokubona abantu esibathandayo size senze umsebenzi waso kangangeenyanga ezimbalwa.
Kodwa, siyayazi nemingcipheko.
Umngcipheko ophambili wale chiza yimeko ebizwa ngokuba yi-ARIA (amyloid-related imaging abnormalities). Ngamafutshane, oku kunokubangela ukudumba okuncinci okanye ukopha okuncinci engqondweni.Inokwenzeka. Kuphando, le meko ibikwe malunga ne-14% yabantu abathathe iyeza. Nangona kunjalo, kubantu abaninzi, oku akubangeli zimpawu zinkulu. Nangona kunjalo, akunakuba nzima kangako.
Lo mngcipheko uphezulu kakhulu kwizigulane ezithatha amayeza okunciphisa igazi . Kungoko ke, kubalulekile ukuba isigulane sixelele ugqirha ngazo zonke ezinye iindlela esizisebenzisayo ngaphambi kokuba siqale la mayeza.
Ukongeza, iziphumo ebezingalindelekanga ezifana nomkhuhlane, iintlungu zomzimba, isicaphucaphu, ukuhlanza, kunye notshintsho kuxinzelelo lwegazi zinokwenzeka ngexesha lokufakwa kwenaliti.
| Iingcali | Iingozi kunye neengozi |
|---|---|
| Inciphisa ukulahleka kwenkumbulo kwizigaba zokuqala zesifo. | Umngcipheko wokudumba nokopha kwengqondo (ARIA). |
| Isusa iiproteni ze-amyloid eziyingozi engqondweni. | Kufuneka ifakelwe emthanjeni rhoqo kwiiveki ezimbini. |
| Kuzisa ithemba elitsha lokunyanga esi sifo. | Ibiza kakhulu kumazwe ngamazwe. |
| Inika isigulana kunye nosapho ixesha elingakumbi. | Iziphumo ebezingalindelekanga ezifana nomkhuhlane kunye nokucaphuka zinokubakho. |
Ngubani kanye kanye ofanelekileyo kweli yeza?
Le yeyona ngongoma ibalulekileyo. Eli yeza alifanelekanga kubo bonke abaguli abane-Alzheimer's.
- Kuphela kwizigulane ezikwinqanaba lokuqala lesifo: Eli yeza lisebenza kakhulu kwizigulane ezikwinqanaba lokuqala lesifo, oko kuthetha ukuba zisandula ukuqala ukubonisa iimpawu. Akulula ukuba lisebenze kwizigulane ezikwinqanaba lokugqibela lesifo, xa isifo sinzima kakhulu.
- Kufuneka kuqinisekiswe ukuba i-Amyloid ifakiwe: Kubalulekile ukuqinisekisa ukuba isigulana sine-amyloid deposits engqondweni ngokusebenzisa iimvavanyo ezikhethekileyo (i-PET scan okanye i-lumbar puncture).
- Ayifanelekanga kwezinye iintlobo ze-dementia: Eli yeza alifanelekanga kwezinye iintlobo zokulahlekelwa yinkumbulo, ngaphandle kwe-Alzheimer's (umz. i-vascular dementia).
Ngoko ke, yingcali yezifo zengqondo kuphela enokugqiba ukuba eli yeza lifanelekile na kumguli.
Ixabiso kunye nemeko eSri Lanka
Ixabiso lale mayeza liphezulu kakhulu. Ixabiso lonyaka eMelika limalunga ne-$26,500 (imali engaphezulu kwezigidi ezisi-8 zaseSri Lanka). Kungathatha ixesha ukuba amayeza amatsha, akhethekileyo nabiza kakhulu abhaliswe kwilizwe lethu aze afumaneke kwizigulana eziqhelekileyo. Kwakhona, ngenxa yexabiso eliphezulu, kunokuba nzima ukuba wonke umntu awafumane.
Nangona kunjalo, eli lithemba elikhulu ngekamva. Ngokuhambela phambili kwesayensi, sinethemba lokuba ngenye imini, amayeza anjalo aya kuphuhliswa ngakumbi kwaye aya kufikeleleka kwaye afumaneke lula kuye wonke umntu.
Umyalezo Wokuya Ekhaya
- I-Lecanemab ayilonyango lwesifo se-Alzheimer, kodwa liyeza elicothisa ukuqhubela phambili kwesi sifo kwizigaba zokuqala .
- Oku kususa iiproteni ze-amyloid eziyingozi engqondweni, kodwa kukwaneziphumo ebezingalindelekanga eziyingozi ezifana nokudumba kobuchopho kunye nokopha.
- Eli yeza alifanelekanga kuye wonke umntu, ingakumbi kwizigulana ezikwinqanaba lokuqala lesi sifo kwaye kuye kwaqinisekiswa ukuba zine-amyloid engqondweni.
- Oku kubiza kakhulu, kwaye ukufumaneka kwayo eSri Lanka okwangoku akuqinisekanga.
- Ukuba kukho umntu kusapho lwakho onesifo se-Alzheimer, bonana nogqirha wakho ukuze nixoxe ngazo naziphi na iindlela zonyango ezintsha okanye iimeko zonyango. Musa ukwenza izigqibo ngokusekelwe koko ukubonayo kwi-intanethi.
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