Uma othile emndenini wakho, mhlawumbe umama othandekayo, ubaba, ugogo noma u-anti, ehlushwa yisifo i-Alzheimer's, siyazi ukuthi kungaba buhlungu kangakanani. Kunzima ukusho ngamazwi usizi oluzwayo njengoba ubuka inkumbulo yakho iphela kancane kancane futhi ulahlekelwa ikhono lakho lokuzibona. Nakuba imithi yamanje yalesi sifo ingalawula izimpawu ngezinga elithile, ayikakabi khona ikhambi. Kodwa-ke, isayensi yezokwelapha ayiyeki. Manje, ososayensi emhlabeni wonke bacwaninga ngomuthi wokugomela ongelapha, ulawule futhi uvimbele lesi sifo. Ngakho ake sixoxe ngaleli themba elisha namuhla.
Yimiphi imijovo engasiza ngesifo i-Alzheimer's?
Eqinisweni, ezinye izifundo zibonise ukuthi abantu abadala abathola imijovo ethile yezifo ezifana ne-chickenpox (isibonelo, umjovo we-shingles) kanye nemijovo yezifo ezifana ne-measles banengozi encane yokuthola isifo i-Alzheimer's. Kodwa lena akuyona imijovo ehloselwe ngqo isifo i-Alzheimer's.
Lapho bethuthukisa umuthi othize wokugomela isifo i-Alzheimer's, ososayensi bagxila kakhulu ezinguqukweni ezintathu eziyinhloko ebuchosheni ezibangelwa yilesi sifo. Kalula nje, kunezimbangela ezintathu eziyinhloko ngaphakathi ebuchosheni besiguli esine-Alzheimer's.
1. Ama-tau protein tangles: Lawa aqoqana ngaphakathi kwamangqamuzana ezinzwa ebuchosheni.
2. Ama-plaque e-Beta-amyloid: Lawa aqongelela phakathi kwamangqamuzana ezinzwa, okungukuthi, ezikhaleni eziphakathi kwamangqamuzana amabili.
3. Ukuvuvukala ebuchosheni: Lezi zimbangela ezimbili zibangela ukuvuvukala okuqhubekayo, noma ukuvuvukala, ebuchosheni.
Umgomo wayo yonke imijovo eyenziwayo njengamanje ukulawula eyodwa noma ngaphezulu yalezi zimbangela. Ake sibheke uhlobo ngalunye lomjovo ngokwehlukana.
| Uhlobo lomjovo kanye nomgomo | Inqubo kanye nomthelela |
|---|---|
| Imithi yokugoma ehlose amaprotheni e-Tau | Cabanga ukuthi ngaphakathi kwamangqamuzana ezinzwa zobuchopho bakho, kukhona isakhiwo esifana nohlelo lwesitimela sokuthutha izakhamzimba emuva naphambili. Le phrotheni ebizwa ngokuthi 'i-tau' yiyo egcina lawo 'mizila yesitimela' izinzile. Esifweni i-Alzheimer's, lawa maprotheni e-tau aba nesimo esingalungile, esikhundleni sokuba njengemizila, ahlangana ndawonye abe 'njengamabhola entambo'. Bese ukuthutha ngaphakathi kwamangqamuzana kuyama, futhi amangqamuzana aqala ukufa. Le mithi yokugoma izama ukuvimba lokhu kugoba. Imithi yokugoma esesigabeni sokuhlola okwamanje yi -AADvac1 kanye ne -ACI-35.030/JACI-35.054 . |
| Imithi yokugomela ehlose i-beta-amyloid | Lokhu kufana 'nodoti' noma 'imfucumfucu efana neglue' eqoqana phakathi kwamangqamuzana ezinzwa ebuchosheni. Lezi zingcezu zephrotheni ebizwa ngokuthi i-beta-amyloid ziyaqoqana futhi zakhe ama-deposit abizwa ngokuthi 'ama-plaque'. Lokhu kuvimbela amangqamuzana ezinzwa ukuthi axhumane kahle, okusho ukuthi avinjelwa ukuthumela 'izibonakaliso'. Lokho okwenziwa yile mijovo ukuvuselela amasosha omzimba ukuze asuse lo 'doti'. Imijovo efana ne -ALZ-101, i-ABvac40, kanye ne-UB-311 ingeyalesi sigaba. |
| Imithi yokugoma ehlose ukuvuvukala kobuchopho | Ebuchosheni obuphilile, kunezinhlayiya ezikhethekile ezibizwa ngokuthi i-microglia. Zifana 'neqembu lokuhlanza' lobuchopho. Umsebenzi wazo ukususa imfucuza engafuneki kanye nobuthi. Kodwa esifweni i-Alzheimer's, lezi zisebenzi ziyacasuka. Esikhundleni sokususa imfucuza, zikhiqiza amakhemikhali ayingozi abangela ukuvuvukala okuqhubekayo ebuchosheni. Lokhu futhi kulimaza amangqamuzana emizwa anempilo. Le mijovo izama ukubuyisela lolu 'hlelo lokuhlanza olungcolile'. I-GV1001 kanye ne-Protollin ziyimibili yale mijovo yokuhlola. |
Ngakho-ke, sizowuthola nini umuthi wokugomela i-Alzheimer's?
Lona ngumbuzo omkhulu engqondweni yawo wonke umuntu. Uma ngikhuluma iqiniso, lokhu kuzothatha isikhathi. Yonke le mithi yokugoma esikhulume ngayo isesesigabeni sokuhlolwa kwemitholampilo. Lokho kusho ukuthi isahlolwa ukuze kubonakale ukuthi iphephile yini ukuyinika abantu nokuthi isebenza kahle kangakanani.
Into ebaluleke kakhulu ukuthi uma lolu cwaningo luphumelela, isifo i-Alzheimer singase sivinjelwe noma selapheke ezigabeni zokuqala esikhathini esizayo.
Ngokusho kolwazi lwamanje, phakathi kwemithi yokugoma okukhulunywe ngayo ngenhla, i-GV1001Umuthi wokugoma usuthuthukile kancane ezivivinyweni zezokwelapha, kodwa lokhu akukabi yimiphumela yokugcina okwamanje.
Sizokwenzenjani kuze kube yileso sikhathi?
Kuhle ukuba nethemba ngalo muthi omusha wokugomela. Kodwa kuze kube yileso sikhathi, uma wena noma othile emndenini wakho ehlushwa yilesi sifo, into engcono kakhulu ongayenza ukulandela ukwelashwa okunconywa udokotela wakho njengamanje.
Imithi yamanje, njenge-Aducanumab ne-Lecanemab, iboniswe ukuthi inciphisa ukuqhubeka kwalesi sifo ngezinga elithile uma itholakala kusenesikhathi. Ngakho-ke, kubalulekile ukuhlala uxhumana nodokotela wakho njalo futhi ulandele imiyalelo yakhe.
Uma unesifiso sokuhlanganyela ocwaningweni lwezokwelapha olufana nalolu, ungakhuluma nodokotela wakho ngakho. Uzokwazi ukukunikeza isiqondiso esinembile sokuthi likhona yini ithuba elikufanele nokuthi uyalifanelekela yini.
Umlayezo Wokuya Nawe Ekhaya
- Isifo se-Alzheimer yisimo esibangelwa izinguquko eziyinkimbinkimbi ebuchosheni (ama-tau protein tangles, ama-beta-amyloid deposits, ukuvuvukala).
- Ososayensi basebenza kanzima ukuthuthukisa imithi yokugoma engagxila kulezi zinguquko futhi ivimbele, yelaphe, noma ilawule lesi sifo.
- Njengoba le mithi yokugoma isesesigabeni sokucwaninga, kuzothatha isikhathi ukuthi itholakale kabanzi.
- Into engcono kakhulu ongayenza ngalesi sikhathi ukuqhubeka nokwelashwa okunconywe udokotela wakho bese ulandela imiyalelo yakhe.
- Uma umuthi wokugoma usuthuthuke ngempumelelo esikhathini esizayo, ithimba lakho lezokwelapha lizokwazisa ngawo.
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