Ingabe umama wakho, ubaba wakho, noma othile omaziyo uya ngokuya ekhohlwa? Ukukhohlwa izinto ezincane njengokuthi izikhiye zakho zikuphi noma igama lomuntu kungaba uphawu lokuqala lwesifo i-Alzheimer's. Nakuba kungekho ikhambi lalesi sifo esibi, umuthi omusha onganciphisa ukuqhubeka kwalesi sifo uvunyelwe ngokugcwele yi-US FDA (Food and Drug Administration). Leli yithemba elikhulu ngempela ezigulini emhlabeni jikelele. Ngakho ake sixoxe kabanzi ngalo muthi omusha, iLeqembi.
Uyini lo muthi omusha obizwa ngokuthi iLeqembi?
Into yokuqala okufanele uyiqonde ukuthi lokhu akulona ikhambi lesifo i-Alzheimer's. Kodwa kuyasiza. Kunganciphisa ijubane lokuqhubeka kwalesi sifo. Ucwaningo lukhombisile ukuthi kunganciphisa ukuqhubekela phambili kwalesi sifo cishe ngo-27% esikhathini esiyizinyanga ezingu-18.
Manje ungase ucabange, 'Ingabe kuzowenza umehluko ngempela?' Yebo, kuzowenza nakanjani. Cabanga nje, umuntu othatha lo muthi uzokwazi ukuphila izinyanga ezi-5 isikhathi eside ngaphandle kokuba izimpawu zibe zimbi kunomuntu ongawuthathi umuthi, futhi uzokwazi ukwenza umsebenzi wakhe, ajabule nomndeni wakhe, ayobona umzukulu ophothule iziqu... Sibaluleke kangakanani leso sikhathi esengeziwe sokwenza izinto ezinjengalesi? Leso sikhathi siyinzuzo enkulu yalo muthi.
Kodwa kubalulekile ukukhumbula lokhu: I-Leqembi inconywa kuphela kubantu abasesigabeni sokuqala sesifo i-Alzheimer's , okusho labo ababonisa ukukhubazeka okuncane kwengqondo. Ngeke isebenze kumuntu onesifo esithuthuke kakhulu.
Lomuthi usebenza kanjani?
Ukuze siqonde lokhu, ake sithathe isibonelo esincane. Ebuchosheni beziguli ze-Alzheimer's, kufakwa iphrotheni engafuneki ebizwa ngokuthi ama-amyloid plaques . Kufana nokungcola okubhajwa epayipini lamanzi bese kubhajwa kancane kancane epayipini. Ngenxa yokufakwa kwala maprotheni, ukuxhumana phakathi kwamangqamuzana obuchopho kuyaphazamiseka, futhi amangqamuzana aqala ukufa kancane kancane. Yingakho inkumbulo ilahleka futhi ukuziphatha kuyashintsha.
Lo muthi, obizwa ngokuthi iLeqembi, uhlasela futhi ususe ama-amyloid plaque akheke ebuchosheni. Ungowesigaba semithi ebizwa ngokuthi ama-monoclonal antibodies. Lo muthi uvame ukunikezwa isiguli kabili ngenyanga ngokufakwa kwe-IV.
Ake sibheke amanye amaqiniso abalulekile ngalo muthi etafuleni.
| Isifinyezo esifushane se-Leqembi (lecanemab) | |
|---|---|
| Uhlobo lomuthi | Umuthi wohlobo lwe-antibody ye-monoclonal. |
| Ifanelekela bani? | Kuphela kubantu abasesigabeni sokuqala sesifo i-Alzheimer's, abanokukhubazeka okuncane kokuqonda. |
| Inzuzo eyinhloko | Ukusabalala kwalesi sifo kwehliswa cishe ngo-27% zingakapheli izinyanga ezingu-18. |
| Indlela yokunikeza | Inikezwa nge-vein (i-IV infusion) kabili ngenyanga. |
| Umkhawulo obaluleke kakhulu | Lokhu akusiqedi lesi sifo. Akusizi ngalutho kulabo asebevele besesigabeni esibi kakhulu salesi sifo. |
Ingabe kukhona ingozi ekusebenziseni lokhu?
Yebo. Njengayo yonke imithi, lena inezingozi nemiphumela emibi. Eqinisweni, i-FDA ikhiphe "isixwayiso sebhokisi elimnyama" salo muthi, okuyilona lwazi oluphezulu kakhulu lokuphepha . Isizathu salokho yisimo esibizwa ngokuthi i-ARIA.
Iyini i-ARIA?
I-ARIA isifinyezo se-Amyloid-Related Imaging Abnormalities. Kalula nje, lo muthi ungabangela abanye abantu ukuba bavuvuke ebuchosheni noma baphume igazi elincane (microbleeds) . Nakuba lokhu ngokuvamile kungekubi kangako, ngezinye izikhathi kungaba yingozi empilweni.
- Izakhi zofuzo ze-APOE4: Abantu abanamakhophi amabili okuguqulwa kwezakhi zofuzo ze-APOE4 basengozini enkulu yokuthola lesi simo se-ARIA kunezinye.
- Izinto Zokunciphisa Igazi: Enye into ebaluleke kakhulu ukuthi odokotela baxwayisa ngokuqinile ngokusebenzisa lo muthi kumuntu othatha imithi yokunciphisa igazi. Ngoba uma wenza kanjalo, kunethuba elikhulu lokuthi ukopha okuncane kuzophenduka ukopha okukhulu, okusongela impilo (i-macro-bleed). Ngezinye izikhathi lokhu kungaholela ekuqulekeni, ukulaliswa esibhedlela, noma ngisho nokufa.
Ngakho-ke, ngaphambi kokuqala lo muthi, kubalulekile ukuxoxa ngokucacile ngazo zonke lezi zingozi nodokotela wakho, wenze izivivinyo ezidingekayo, bese uqinisekisa ukuthi lokhu kulungile yini kuwe.
Ngakho-ke kufanele ngenzeni?
Uma wena, mfundi walesi sihloko, unezinsolo ezincane kakhulu zokuthi wena noma umuntu oseduze nawe unezimpawu zokuqala zesifo i-Alzheimer's, into engcono kakhulu ongayenza ukubonana nodokotela ngokushesha bese uthola ukuxilongwa okunembile.
Ngoba njengoba sixoxile ngaphambili, imithi efana neLeqembi iwusizo kuphela ezigabeni zokuqala zesifo. Uma uphuza, ungase uphuthelwe yithuba lokwelashwa. Futhi, imithi emisha efana nalena ivame ukubiza kakhulu. Ngakho-ke kuwumqondo omuhle ukukhuluma nodokotela wakho ngalokho ngaphambi kokuqala ukwelashwa.
Ochwepheshe bakholelwa ukuthi maduze nje, kuzotholakala ukwelashwa okungabona nokuvimbela izifo ngaphambi kokuba abantu babonise noma yiziphi izimpawu. Njengoba nje singabona futhi selaphe umdlavuza webele kanye nomdlavuza wendlala kusenesikhathi, ngolunye usuku sizokwazi ukubona nokuvimbela isifo i-Alzheimer kusenesikhathi. Kuze kube yileso sikhathi, izidakamizwa ezifana neLeqembi zinikeza ithemba elikhulu kithi sonke.
Umlayezo Wokuya Nawe Ekhaya
- I-Leqembi ayilona ikhambi lesifo i-Alzheimer's. Inciphisa kuphela ukuqhubekela phambili kwalesi sifo ezigabeni zaso zokuqala.
- Lo muthi usebenza ngokususa ama-amyloid plaque ayingozi aqoqana ebuchosheni.
- Kukhona ingozi yemiphumela emibi kakhulu njengokuvuvukala kobuchopho noma ukopha okuncane (ARIA), ngakho-ke kubalulekile ukuxoxa ngazo zonke izingozi nodokotela.
- Lo muthi awufanele labo abathatha imithi yokunciphisa igazi noma labo abanesifo esibi kakhulu.
- Uma wena noma othile oseduze nawe enenkinga yokukhumbula, funa iseluleko sezokwelapha ngokushesha. Ukuxilongwa kusenesikhathi kubalulekile ekwelapheni.
💬 Comments (0)
Awekho amazwana athunyelwe okwamanje. Faka amazwana akho lapha okokuqala ngqa.
Engeza amazwana akho