Ingabe umzimba wakho uzizwa ungasalawuleki? Ake sifunde ngalokhu (Autoimmune Autonomic Ganglionopathy - AAG)!

Ingabe ngezinye izikhathi uzizwa unesizungu ngokuzumayo? Noma uzizwa sengathi kukhona into engavamile esiswini sakho, umlomo wakho womile, noma awukwazi ukulawula ukuphefumula kwakho? Ngisho noma lezi zingase zibonakale njengezinto ezivamile, ngezinye izikhathi kungaba nendaba eyinkimbinkimbi ngemuva kwazo. Leso esinye sezimo ezingavamile, kodwa ezifanele ukuzazi, esizokhuluma ngazo namuhla.

Iyini le "Autoimmune Autonomic Ganglionopathy - AAG"? Ake sikuqonde kalula, akunjalo?

Kalula nje, i-"Autoimmune Autonomic Ganglionopathy" noma i-"(AAG)" iyisimo lapho uhlelo lokuzivikela lomzimba wethu, okungukuthi, uhlelo lokuzivikela komzimba, luhlasela ngephutha uhlelo lwethu lwezinzwa oluzimele. Cabanga nje, lokhu kufana nalokho obekungenzeka uma ibutho okufanele livikele izwe lethu lihlasela ngephutha izindawo zethu ezibalulekile.

Uhlelo lwezinzwa oluzimele lomzimba wethu lufana "nohlelo lwethu oluzenzakalelayo". Okusho ukuthi, lulawula izinto eziningi ezenzeka ngokuzenzakalelayo, ngaphandle kokuthi siqaphele. Isibonelo:

• Ukuphefumula kwakho
• Isilinganiso senhliziyo (isilinganiso senhliziyo)
• Ukushaya kwegazi
• Ukujuluka
• Ukugaya ukudla

Eziningi zalezi zinto aziyona into esiyicabangayo. Ziyenzeka ngokuzenzakalelayo. Uhlelo lwezinzwa oluzimele yilona olusiza ukugcina leyo misebenzi ezenzakalelayo isebenza kahle. Ku-AAG, lolu hlelo olubalulekile lonakele. Lesi yisimo esibizwa ngokuthi i-autonomic neuropathy, noma i-dysautonomia.

Kungani imizimba yethu yenza lokhu? Yiziphi izizathu?

Eqinisweni, ngisho nodokotela abakakwazi ukusho ngqo ukuthi iyini imbangela yangempela yalokhu `(AAG)`. Kodwa amanye amaqiniso atholakele.

• Esikhathini esiningi, okungukuthi , cishe kubantu abathathu kwabahlanu abathola i-"AAG", lesi simo senzeka ngemva kokululama kwesinye isifo, noma ngemva kokutheleleka. Kufana nomphumela ongemuhle walokho kugula.
• Abanye abantu bangaba nesifo esibizwa ngokuthi i-paraneoplastic AAG. Yilapho amanye ama-antibodies akhiqizwa yisimiso sethu somzimba sokuzivikela ezifweni ngenxa yesimo esifana nomdlavuza ehlasela isimiso sezinzwa esizimele.

Lokhu kwenzani emizimbeni yethu? Ake sibheke kabanzi.

Uhlelo lwethu lwezinzwa oluzimele luneziqoqo zamaseli ezinzwa abizwa ngokuthi ama-autonomic ganglia . Lawa afana nezinkundla zezitimela. Imiyalezo ehlukahlukene ithunyelwa futhi yamukelwe ngalezi. Lokhu kushintshana kwemiyalezo kubalulekile ukuze izenzo zomzimba wethu ezizenzakalelayo, okungukuthi, izenzo esingazilawuli (reflexes), zilawulwe.

Ku-AAG, amasosha omzimba wethu ahlasela ama-receptor athile kula ma-ganglia. Ama-receptor yizindawo lapho kwamukelwa khona imiyalezo. Ngakho-ke lapho la ma-receptor onakele, leyo miyalezo yemizwa ayihambi noma idlule kahle. Ngenxa yalokho, izinto ezenzeka ngokuzenzakalelayo, njengokulawula umfutho wegazi nokujuluka, ziqala ukuba yinkinga.

Cabanga nje, uma 'uxhumano' 'ebhodini elikhulu lokushintsha' lendlu yakho lukhululeka, izibani ngeke zivuleke, ifeni ngeke ijikeleze, njll. Kunjalo nalokhu.

Sivame kangakanani lesi simo esibizwa ngokuthi `(AAG)`?

Empeleni lesi yisimo esingavamile kakhulu. Isibonelo, e-United States, cishe abantu abayi-100 kuphela abatholakala benalesi sifo minyaka yonke. Ngakho-ke asivamile kakhulu eSri Lanka. Ngakho-ke ungesabi uma uzwa ngalokhu, lokhu akuyona into eyenzeka kubantu abaningi.

Ziyini izimpawu ze-`(AAG)`? Sizibona kanjani?

Izimpawu zalesi simo zingahluka kumuntu nomuntu. Akuwona wonke umuntu ozoba nezimpawu ezifanayo. Izimpawu ezivame kakhulu yilezi:

• Ukuqunjelwa: Lokhu kusho ukuqunjelwa kanye nobunzima bokuya endlini yangasese.
• Amehlo avuleke kakhulu (amehlo ka-Adie): Ngezinye izikhathi amehlo eliso elilodwa kuphela angavuleka futhi angase azwele ukukhanya.
• Umlomo owomile noma amehlo omile: Umuzwa sengathi akukho mathe noma izinyembezi emehlweni.
• Ukuquleka / Ukungakwazi ukulala: Ungase uquleke ngokuzumayo ngaphandle kwesizathu esibonakalayo.
• Ukwehla kwengcindezi yegazi okubangelwa yi-neurogenic orthostatic: Umuzwa wesiyezi kanye nokuphelelwa yikhanda lapho usukuma uhleli noma uvuka embhedeni. Lokhu kubangelwa ukwehla kwengcindezi yegazi ngokuzumayo .
• Ubunzima bokuchama / Ukugcinwa komchamo: Umuzwa wokungakwazi ukuchama yize ufuna ukuchama.

Cishe abantu ababili kwabathathu abane-AAG batholwe benamazinga aphezulu ama-antibodies abizwa ngokuthi ama-ganglionic acetylcholine receptor antibodies (ama-g-AChR antibodies) egazini labo. Abacwaningi bakholelwa ukuthi kukhona ukuxhumana phakathi kwamazinga ala ma-antibodies e-g-AChR kanye nobunzima bezimpawu.

Udokotela usithola kanjani lesi sifo `(AAG)`?

Uma unezimpawu ezinjengalezi, into yokuqala udokotela angayenza ukukubuza ngezimpawu zakho bese ekuxilonga. Ngemuva kwalokho, bangenza izivivinyo ezikhethekile ukuhlola ukusebenza kwesistimu yakho yezinzwa ezizimele.

Nazi ezinye zazo:

• Ukuhlolwa kwesistimu yokugaya ukudla: Isibonelo, ukuhlolwa "kokukhipha ukudla esiswini". Lokhu kuhlola ukuthi ukudla kuphuma ngokushesha kangakanani esiswini sakho.
• `Ukuhlolwa kwe-Quantitative sudomotor axon reflex (QSART)`: Lokhu kulinganisa ukuthi izindlala zakho zokujuluka zisebenza kahle kangakanani.
• `Ukuhlolwa kokujuluka kwe-Thermoregulatory`: Lokhu kuhlolwa kwenziwa ukuthola ukuthi ukujuluka komzimba kwehlile noma kukhuphukile, nokuthi imbangela iyini.
• `Ukuhlolwa kwetafula lokutsheka`: Kulolu vivinyo, wenziwa ulale embhedeni okhethekile bese umbhede uphenduka kancane kancane uqonde phezulu, kubhekwe ukuthi ukushaya kwenhliziyo yakho kanye nomfutho wegazi kushintsha kanjani.
• Ukuhlolwa komchamo: Lokhu kungakunikeza umbono wokuthi isinyi sakho sisebenza kahle kangakanani.

Ngaphezu kwalokho, ukuhlolwa kwegazi kungenziwa ukuhlola izinga lama-`(g-AChR antibodies)` ashiwo ngenhla . Uma izinga lale antibody liphezulu, kuwubufakazi obengeziwe bokuthi kungenzeka ukuthi `(AAG)`. Kodwa-ke, lokhu kuhlolwa kwegazi kuhlukile ku-`AChR antibody test`, esetshenziselwa ukuhlola esinye isifo sezinzwa esibizwa ngokuthi `(Myasthenia Gravis).`

Ingabe ikhona indlela yokwelapha lokhu? Yini engenziwa?

Ngenxa yokuthi i-AAG iyisimo esingavamile, ayikho indlela ejwayelekile, "lokhu ukwelashwa" okwamanje. Esikhathini esiningi , kugxilwe ekulawulweni kwezimpawu.

Odokotela bakha uhlelo lokwelapha ngokuhlanganisa izindlela ezahlukene zokwelapha. Ezinye zazo zifaka:

• Ukushintshaniswa kwe-plasma / i-plasmapheresis: Lokhu kuhilela ukuthatha elinye legazi lakho, ukususa izinto eziyingozi njenge-antibodies ku-plasma, bese ubuyisela igazi elihlanziwe emzimbeni wakho.
• Ukwelashwa nge-Intravenous immunoglobulin (IVIG): Lokhu kuhilela ukunikeza umzimba wakho i-immunoglobulin (ingxenye ye-plasma elwa nezifo) ethathwe kubantu abaphilile. Lokhu kusiza ukuzola amasosha omzimba.
• Ama-corticosteroids afakwa ngemithambo: Imithamo ephezulu yama-steroid alwa nokuvuvukala, njenge-methylprednisolone (Solu-Medrol®) noma i-hydrocortisone (Solu-Cortef®), inikezwa ngomjovo.
• Imithi yokucindezela amasosha omzimba: Le mithi isebenza ngokunciphisa ukusebenza ngokweqile kwesimiso somzimba sokuzivikela. Isibonelo, imithi efana ne-rituximab (Rituxan®).

Ingabe ikhona indlela yokuvimbela lesi simo `(AAG)`?

Ayikho indlela eqinisekisiwe yokuvimbela lokhu, njengoba kungavamile kakhulu. Kodwa-ke, ezinye izimo, njengomdlavuza, zingandisa kancane ingozi yakho yokuba nakho. Uma uke waba nomdlavuza, nazi ezinye izinto ongazenza ukuze unakekele impilo yakho iyonke:

• Ukuzivocavoca okuvamile: ikakhulukazi ukuzivocavoca nge-aerobic.
• Uma une-`(Dysautonomia)`, ukudla ukudla okunosawoti omningi kanye noketshezi kungasiza ekulawuleni umfutho wegazi lakho. (Lena yinto okufanele uyixoxe nodokotela wakho.)
• Ukulawula ukucindezeleka: Sebenzisa izindlela ezinempilo ezifana nokuzivocavoca umzimba, ukukhuluma nomngane, nokubhala encwadini.
• Lala kahle: Lala okungenani amahora angu-7-8 ngosuku.
• Ukugqoka izingubo zokucindezela: Lokhu kusiza ekuthuthukiseni ukujikeleza kwegazi nokunciphisa ukuvuvukala (ikakhulukazi emilenzeni).

Ingabe lesi simo `(AAG)` singalapheka ngokuphelele? Kuzokwenzekani esikhathini esizayo?

Kumelwe ngisho, nakuba ngidabukile,I-AAG ayilapheki. Kodwa-ke, abantu abaningi bangakwazi ukulawula izimpawu zabo kahle isikhathi eside. Ngokumangalisayo, cishe umuntu oyedwa kwabathathu abane-AAG uzolulama kancane kancane ngaphandle kokwelashwa. Kodwa-ke, abantu abaningi kuzodingeka babhekane nezimpawu ezithile kukho konke ukuphila kwabo.

Yini enye ofuna ukuyibuza udokotela?

Uma usola ukuthi unesifo esifana nalesi, kubaluleke kakhulu ukubona udokotela omuhle bese ubuza ngalokhu okulandelayo:

• Yini okungenzeka kakhulu ukuthi iyimbangela yezimpawu zami?
• Yiziphi izivivinyo okufanele ngizenze ukuze ngithole ukuthi ngine-`(AAG)` ngempela?
• Yiziphi izindlela zokwelapha ze-`(AAG)`?
• Angakanani amathuba okuthi izimpawu ze-`(AAG)` zizophela ngisho nangaphandle kokwelashwa?
• Yiziphi izinguquko zendlela yokuphila okufanele ngizenze ukuze ngithuthukise impilo yami iyonke?

Yiziphi ezinye izimo zokuzivikela komzimba ezihlotshaniswa ne-autonomic neuropathy?

"(AAG)" ikhethekile ngoba, ngakolunye uhlangothi, iyisifo esihlobene nesimiso somzimba sokuzivikela komzimba, kanti ngakolunye uhlangothi, iyisifo sokuzivikela komzimba esithinta isimiso sezinzwa.

Ngaphezu kwalokho, kunezinye izifo ezihlobene nesimiso sokuzivikela komzimba ezandisa ingozi yokuthola i-"dysautonomia" (izinkinga zesimiso sezinzwa esizimele). Ezinye izibonelo yilezi:

• Isifo se-Celiac
• I-Guillain-Barré syndrome (i-Guillain-Barré syndrome)
• `(Lupus / systemic lupus erythematosus)` (Isifo se-Lupus)
• `(Isifo samathambo esibizwa ngokuthi i-rheumatoid arthritis)` (Isifo samathambo esibizwa ngokuthi i-rheumatoid arthritis)
• I-Sjögren's syndrome (i-Sjögren's syndrome)

Ngakho-ke ungabona, lezi yizimo ezingaxhunyaniswa.

Okokugcina, izinto okufanele uzikhumbule (Umyalezo Wokuya Ekhaya)

Kulungile, manje usuyazi ukuthi `(Autoimmune Autonomic Ganglionopathy - AAG)` yisifo esingavamile lapho uhlelo lwethu lokuzivikela luhlasela uhlelo lwethu lwezinzwa oluzimele. Izimpawu zingafaka ukulahlekelwa yingqondo ngokuzumayo, ukwehla 'kwengcindezi' lapho umi, kanye nezinkinga zesisu.

Ungakhathazeki uma uzwa lokhu. Lokhu akuvamile kakhulu. Futhi, imithi yokucindezela amasosha omzimba kanye ne-'plasmapheresis' kusetshenziswa njengemithi yokwelapha lokhu. Nakuba kungelapheki ngokuphelele, abantu abaningi bangakwazi ukulawula izimpawu kahle futhi baphile impilo evamile.

Into ebaluleke kakhulu ukubona udokotela ofanelekayo ngokushesha okukhulu uma unalezi zimpawu. Uma uziqaphela kusenesikhathi, ungaqala ukwelashwa futhi unciphise umthelela empilweni yakho. Awuwedwa, futhi bakhona odokotela abangakusiza.

` I-Autoimmune Aneurysmal Ganglionopathy, i-AAG, Uhlelo Lwezinzwa Oluzimele, Uhlelo Lokuzivikela Emzimbeni, Isifo Sezinzwa, Izimpawu, Ukwelashwa