Kuyini i-calcitonin? Ake sifunde ngayo kalula!

Wake wezwa igama elithi calcitonin? Mhlawumbe walizwa kudokotela, noma mhlawumbe walifunda ndawana thize. Empeleni leli yi-hormone ekhethekile emizimbeni yethu. Kodwa kungashiwo nokuthi liyi-hormone eyimfihlakalo kancane. Ake sibone ukuthi iyini le calcitonin nokuthi yenzani emizimbeni yethu ngendlela elula.

Iyini i-calcitonin? Ivelaphi?

Kalula nje, i-calcitonin iyi-hormone ekhiqizwa yi-thyroid gland yethu. Uyazi ukuthi i-thyroid gland iyi-gland encane efana novemvane etholakala ngaphambili kwentamo yethu, ngaphansi kwesikhumba. Uhlobo olukhethekile lweseli ku-thyroid gland, olubizwa ngokuthi ama-C-cell noma amaseli e-parafollicular, lwenza le hormone ye-calcitonin futhi luyikhiphe egazini lethu.

Kodwa into exakile ukuthi, ososayensi abakaqondi ngokugcwele umsebenzi oqondile wale hormone, i-calcitonin. Okusho ukuthi, siyazi ukuthi yenzani, kodwa asazi ngempela ukuthi kungani sinayo. Ngisho noma kukhona ukungalingani emazingeni e-calcitonin, akuvamile ukubangela noma yiziphi izimpawu ezinkulu, noma ngezinye izikhathi azibangeli nhlobo nhlobo.

Esikhathini esidlule, odokotela babesebenzisa izinhlobo zokwenziwa ze-calcitonin njengokwelapha izimo ezithile. Isibonelo, ukwelapha izimo ezifana nesifo sikaPaget sethambo, noma i-hypercalcemia, isimo lapho i-calcium egazini iphezulu kakhulu. Kodwa manje, ngokufika kwemithi emisha, ikakhulukazi ama-bisphosphonates, i-calcitonin ayisetshenziswa kakhulu njengokwelapha.

Yini eyenziwa yi-calcitonin emizimbeni yethu?

Umsebenzi oyinhloko we-hormone i-calcitonin ukwehlisa izinga le-calcium egazini lethu. Khumbula, lokhu kumayelana ne-calcium egazini, hhayi i-calcium emathanjeni. Lokhu kwenza ngezindlela ezimbili eziyinhloko:

1. Kumisa umsebenzi wamaseli avuselela amathambo: Kukhona uhlobo lweseli olubizwa ngokuthi ama-osteoclasts emathanjeni ethu. Lawa maseli aphula amathambo ethu bese enezela i-calcium egazini. I-hormone i-calcitonin imisa okwesikhashana umsebenzi wala ma-osteoclasts. Lokhu kunciphisa inani le-calcium elifakwa egazini.

2. Kunciphisa ukumuncwa kabusha kwe-calcium ezinso iye egazini: I-calcium ikhishwa umchamo uhlungwa yizinso zethu. Kodwa-ke, i-calcium ethile imuncwa kabusha yizinso iye egazini. I-hormone i-calcitonin inciphisa ukumuncwa kabusha kwe-calcium ezinso iye egazini ngale ndlela. Ngenxa yalokhu, izinga le-calcium egazini liyehla.

Cabanga ngale ndlela: izinga le-calcium egazini lethu lifana nezinga lamanzi ethangini lamanzi. I-Calcitonin ifana nomuntu osiza ukwehlisa lelo zinga lamanzi uma likhuphuka.

Kungani i-thyroid yethu ikhiqiza i-calcitonin?

Indlala yethu yegilo ikhiqiza i-calcitonin ngokusekelwe ezingeni le-calcium egazini lethu. Lapho izinga le-calcium egazini landa, indlala yegilo ikhiqiza i-calcitonin eningi. Ngokufanayo, lapho izinga le-calcium egazini lehla, inani le-calcitonin elikhiqizwa yindlala yegilo nalo liyancipha. Lokhu kufana nokulawula okuzenzakalelayo.

Ungawahlola kanjani amazinga e-calcitonin? Kungani kwenziwa lokhu kuhlolwa?

Udokotela wakho angenza ukuhlolwa kwegazi ukuze ahlole amazinga akho e-calcitonin.

Kodwa-ke, ngenxa yokuthi amazinga e-calcitonin angajwayelekile avame ukubangela izimpawu ezinkulu, odokotela bavame uku-oda lokhu kuhlolwa ngezizathu ezimbalwa ezithile. Lezi zifaka:

• Ukusiza ekuxilongeni izimo ezifana ne -Medullary Thyroid Cancer (MTC) noma i-C-cell hyperplasia .
• Qapha impumelelo yokwelashwa komdlavuza we-thyroid we-medullary (MTC).
• Uma othile emndenini wakho enesifo esibizwa ngokuthi i-Multiple Endocrine Neoplasia (MEN type 2) .

Iyini izinga elijwayelekile le-calcitonin?

Ngokuvamile, amanani ajwayelekile e-calcitonin alandelayo:

• Kwabesilisa: Ngaphansi kwama-picogram angu-25 nge-milliliter (Ngaphansi kwama-pg/mL angu-25)
• Kwabesifazane: Ngaphansi kwama-picogram angu-20 nge-milliliter (Ngaphansi kwama-pg/mL angu-20)

Kodwa into eyodwa okufanele uyikhumbule ukuthi la manani ajwayelekile angahluka kancane kuye ngelabhorethri. Ngakho-ke, kufanele uhlale ubheka amanani ajwayelekile elabhorethri embikweni wakho wegazi.

Uma une-calcitonin test, udokotela wakho uzokuchazela imiphumela futhi akutshele ukuthi kudingeka yini ukuhlolwa okwengeziwe.

Kwenzekani uma amazinga e-calcitonin enyuka?

Ukuba namazinga aphezulu e-calcitonin akubonakali kunemiphumela emibi kakhulu emizimbeni yethu. Futhi akubanga izimpawu ezinkulu. Kodwa-ke, amazinga aphezulu e-calcitonin angaba uphawu lwezimo ezimbili ezingavamile kakhulu. Ziyini lezi:

1. Umdlavuza We-Medullary Thyroid (MTC): Lolu uhlobo lomdlavuza olungavamile oluvela endlaleni ye-thyroid. Luqala kumaseli e-C akhiqiza i-calcitonin. Lo mdlavuza ubangela ukuthi lawa maseli akhiqize i-calcitonin eningi kakhulu.

2. I-hyperplasia yamaseli e-C:Lokhu akusiwo umdlavuza (ongenawo umdlavuza). Kodwa okwenzekayo kulokhu ukuthi ama-C-cell akhula ngendlela engavamile. Lesi zicubu ezikhulisiwe zingakhiqiza i-calcitonin eningi kakhulu. Ngezinye izikhathi lesi simo, esibizwa ngokuthi i-C-cell hyperplasia, kamuva singaphenduka umdlavuza we-thyroid we-medullary (MTC).

Uma unezimpawu zanoma iyiphi yalezi zimo, udokotela wakho angase ancome ukuhlolwa kwe-calcitonin.

Kwenzekani uma amazinga e-calcitonin ehla?

Amazinga aphansi e-calcitonin awabonakali enethonya elikhulu emizimbeni yethu. Ngisho nabantu abasuswe ngokuphelele i-thyroid yabo, futhi ngenxa yalokho abanamazinga angabonakali e-calcitonin, ababi nazo izimpawu ezihlobene namazinga abo e-calcium egazini. Lokhu kuyinto exakile ngale hormone.

Uyini umehluko phakathi kwe-Parathyroid Hormone ne-Calcitonin?

I-Parathyroid Hormone (PTH) kanye neCalcitonin zombili zisiza ekulawuleni izinga le-calcium egazini lethu. Kodwa-ke, umehluko ukhona endleleni ezisebenza ngayo nokuthi zithinta kangakanani amazinga ethu e-calcium.

• I-Parathyroid hormone (PTH) inyusa izinga le-calcium egazini lethu. I-PTH isiza futhi ekulawuleni izinga le-phosphorus egazini nasemathanjeni ethu. Iphinde isebenze i-vitamin D.
• I-Calcitonin yehlisa izinga le-calcium egazini lethu.

Kodwa-ke, ososayensi bakholelwa ukuthi i-parathyroid hormone (PTH) idlala indima enkulu kune-calcitonin ekulawuleni izinga le-calcium egazini lethu. Lokhu kungenxa yokuthi amazinga e-PTH angajwayelekile angaholela ezimweni ezibucayi njenge-hypercalcemia (i-calcium ephezulu egazini) noma i-hypocalcemia (i-calcium ephansi egazini). Kodwa-ke, amazinga e-calcitonin angajwayelekile awanayo ithonya elibalulekile emzimbeni.

Ingabe i-calcitonin ne-calcitriol ziyinto efanayo?

Cha, i-calcitonin ne-calcitriol ziyizinto ezimbili ezihlukene. Nakuba womabili ama-hormone ethinta amazinga e-calcium, anemisebenzi ehlukene.

• I-Calcitriol elinye igama le-vitamin D esebenzayo. Yandisa izinga le-calcium egazini. Ikwenza kanjani lokho? Yandisa inani le-calcium elingamuncwa emathunjini ethu kusukela ekudleni esikudlayo. Leyo calcium bese ingena egazini. I-Calcitriol ivimbela nezinso ekulahlekelweni yi-calcium. I-Parathyroid hormone (PTH) ivuselela i-enzyme eguqula i-vitamin D ibe yi-calcitriol.
• I-Calcitonin isebenza ngokunciphisa amazinga e-calcium egazini.

Ngakho-ke, ekugcineni, izinto okudingeka sizikhumbule (Umyalezo Wokuya Ekhaya)

I-Calcitonin iyi-hormone engavamile futhi eyimfihlakalo.

• Kungakhathaliseki ukuthi izinga liphansi noma liphezulu, cishe ngeke libangele noma yimiphi imiphumela emibi noma izimpawu ezinkulu.
• Kodwa-ke, amazinga aphezulu e-calcitonin angaba uphawu lwesimo esifana nomdlavuza we-thyroid we-medullary (MTC) noma i-C-cell hyperplasia.
• Uma unezimpawu zalezi zimo, noma uma unemibuzo mayelana nengozi yakho yokuba nazo, qiniseka ukuthi ukhuluma nodokotela wakho. Bakhona ukukusiza. Ungesabi, into ebaluleke kakhulu ukucaca ngakho konke.

Uyaqonda? Ngithemba ukuthi lolu lwazi luwusizo kuwe.

I- Calcitonin, i-Calcitonin, i-thyroid, i-hormone, i-calcium, i-calcium yegazi, umdlavuza we-thyroid we-medullary