Unemibuzo mayelana ne-cortisol? Ake sifunde kabanzi ngale 'hormone yokucindezeleka'!

Cishe uke wezwa igama elithi " cortisol , " ikakhulukazi uma kukhulunywa " ngokucindezeleka ." Kodwa i-cortisol akuyona nje "i-hormone yokucindezeleka." Eqinisweni, iyi-hormone ebalulekile edlala indima ebaluleke kakhulu emizimbeni yethu. Ngakho-ke, namuhla, ake sixoxe nge-cortisol ngendlela elula ongayiqonda.

Iyini i-cortisol? Ingabe ngempela 'iyi-hormone yokucindezeleka'?

Kalula nje, i-cortisol iyi-hormone ekhiqizwa futhi ikhishwa yizindlala zethu ze-adrenal - izindlala ezimbili ezincane ezitholakala ngaphezu kwezinso. Luhlobo lwe-hormone ye-steroid ebizwa ngokuthi i-glucocorticoid .

Yebo, njengoba ungalindela, i-cortisol ihlobene kakhulu nokucindezeleka. Kungakhathaliseki ukuthi sibhekene nokucindezeleka okukhulu , ukucindezeleka okungapheli , noma ukucindezeleka okubuhlungu, imizimba yethu ikhipha i-cortisol. Yingakho ibizwa nangokuthi "i-hormone yokucindezeleka."

Iyini imiphumela ye-cortisol emizimbeni yethu?

I-Cortisol iyi-hormone ethinta cishe zonke izitho zomzimba wethu futhi ilawula imisebenzi eminingi ebalulekile. Ake sibheke ukuthi iyini.

Ukulawula indlela osabela ngayo ekucindezelekeni

Uma uzwa ingozi noma ukwesaba, umzimba wakho ungena ngokushesha esimweni "sokulwa noma sokubaleka," akunjalo? Ngaleso sikhathi, ama-hormone afana ne-adrenaline ayakhishwa. Bese kuthi, ukuze uhlale uqaphile, i-cortisol iqala ukukhishwa. Futhi, i-cortisol isiza ekukhipheni i-glucose , noma ushukela, esibindini sethu ukuze inikeze amandla adingekayo ngalesi sikhathi.

I-Metabolism kanye namazinga kashukela egazini

I-Metabolism imane nje inqubo imizimba yethu esebenzisa ngayo amandla ukuze iphile, isebenze, futhi isebenze. I-Cortisol iyasiza kulokhu ngokulawula indlela imizimba yethu esebenzisa ngayo i-glucose ukuze ibe namandla.

Ngokwesibonelo:

• Kuthinta ama-pancreas ethu, kunciphisa ukukhiqizwa kwe-insulini futhi kwandise ukukhiqizwa kwe-glucagon. Ngenkathi i-insulini yehlisa ushukela egazini, i-glucagon yandisa amazinga kashukela.
• Kuthinta nezicubu zamafutha, isibindi, kanye nemisipha emzimbeni wethu, kulawula indlela esisebenzisa ngayo i-glucose.

Ukuvimbela ukuvuvukala

Esikhathini esifushane, i-cortisol ingakhulisa amasosha omzimba wethu ngokunciphisa ukuvuvukala , okuwukuvuvukala nokubomvu emzimbeni. Kodwa-ke, uma amazinga e-cortisol ephakeme njalo, umzimba wethu ungajwayela. Bese kwenzeka okuphambene nalokho. Ukuvuvukala kunganda futhi amasosha omzimba angaba buthaka.

Ukulawula umfutho wegazi

Akukaqondakali kahle ukuthi i-cortisol ilawula kanjani umfutho wegazi. Kodwa-ke, kutholakale ukuthi amazinga aphezulu e-cortisol angaholela ekucindezelekeni kwegazi okuphezulu, kanti amazinga aphansi ngendlela engavamile angaholela ekucindezelekeni kwegazi okuphansi.

Kusiza ukulawula umjikelezo wokulala nokuvuka

Ngokuvamile, amazinga e-cortisol aphansi uma silala ebusuku. Afinyelela phezulu ngaphambi nje kokuba sivuke ekuseni. Lokhu kubonisa ukuthi i-cortisol inomthelela omkhulu ku- circadian rhythm yethu, noma umjikelezo wokulala nokuvuka.

Imizimba yethu ilawula kanjani amazinga e-cortisol?

Umzimba wethu unesimiso esiyinkimbinkimbi kakhulu sokulawula amazinga e-cortisol. Izindima eziyinhloko kulokhu zidlalwa yi -hypothalamus kanye ne-pituitary gland ebuchosheni bethu. Lezi ezimbili zilawula ukukhiqizwa kwe-cortisol yizindlala ze-adrenal.

Nansi indlela okwenzeka ngayo:

1. Uma amazinga e-cortisol egazini lakho ehla, i-hypothalamus ikhipha i-hormone ebizwa ngokuthi i-CRH (i-corticotropin-releasing hormone) .
2. Le hormone ye-CRH itshela i-pituitary gland ukuthi ikhiqize i-hormone ebizwa ngokuthi i-ACTH (i-adrenocorticotropic hormone) .
3. Le hormone ye-ACTH ibe isivuselela izindlala ze-adrenal ukuthi zikhiqize i-cortisol bese ziyikhipha egazini.

Ngakho-ke, ukuze kugcinwe amazinga e-cortisol anempilo, zonke lezi zitho ezintathu—i-hypothalamus, i-pituitary gland, kanye nezindlala ze-adrenal—kumele zisebenze kahle.

Kwenzekani uma amazinga e-cortisol enyuka?

Uma amazinga e-cortisol ephezulu isikhathi eside, leso simo sisibiza ngokuthi i-hypercortisolism . Lokhu kuvame ukwenzeka ngesimo esibizwa ngokuthi i-Cushing's syndrome .

Yiziphi izimbangela zokwanda kwe-cortisol?

• Ukusetshenziswa isikhathi eside kwemithi ye-corticosteroid (isb., i-prednisone, i-prednisolone, i-dexamethasone) ngemithamo ephezulu.
• Izimila ezikhiqiza i-ACTH – Lezi zivame ukuvela endlaleni ye-pituitary.
• Ama-cyst akha ezindlala ze-adrenal futhi akhiqize i-cortisol eningi.

Izimpawu ze-cortisol ephezulu

Uma amazinga e-cortisol ephakeme, noma uma une-Cushing's syndrome, ungase ube nezimpawu ezifana nalezi:

• Ukwanda kwesisindo , ikakhulukazi ebusweni nasesiswini.
• Amafutha ahlala emhlane phakathi kwamahlombe (iqhubu elifana neqhubu le-buffalo).
• Ukubonakala kwamabala abanzi, ansomi okwelula esiswini.
• Ubuthakathaka bemisipha ezingalweni nasemathangeni angenhla.
• Ukwanda kwamazinga kashukela egazini , okuvame ukuholela kusifo sikashukela sohlobo 2.
• Umfutho wegazi ophakeme .
• Ukukhula kwezinwele okungafunwa kwabesifazane – isimo esibizwa ngokuthi i-hirsutism .
• Ubuthakathaka bamathambo - I-Osteoporosis kanye nokuqhekeka kwamathambo kungenzeka.

Kwenzekani uma amazinga e-cortisol ehla?

Uma amazinga e-cortisol ephansi kunokuvamile, odokotela bakubiza ngokuthi i-hypocortisolism , noma i-adrenal insufficiency . Kunezinhlobo ezimbili eziyinhloko zalokhu.

Yiziphi izimbangela ze-cortisol ephansi?

• Ukungasebenzi kahle kwe-adrenal okuyinhloko: Lokhu kuvame ukubangelwa amasosha omzimba ethu ahlasela izindlala ze-adrenal. Lokhu kubizwa nangokuthi isifo sika-Addison .
• Ukungasebenzi kahle kwe-adrenal yesibili: Lokhu kwenzeka uma i-pituitary gland ingasebenzi kahle ( i-hypopituitarism ) noma uma kukhona isimila se-pituitary.

Izimpawu ze-cortisol ephansi

Uma amazinga e-cortisol ephansi, ungase ube nezimpawu ezifana nalezi:

• Ukuzizwa ukhathele kakhulu (ukukhathala).
• Ukwehlisa isisindo ngokungahlosile.
• Ukulahlekelwa yisifiso sokudla .
• Umfutho wegazi ophansi .

Yini engingayenza ukuze nginciphise amazinga e-cortisol?

Uma unesifo esifana ne-Cushing's syndrome, ungadinga ukwelashwa ukuze wehlise amazinga akho e-cortisol. Lokhu kuvame ukuhilela imithi kanye/noma ukuhlinzwa. Kodwa-ke, kunezinto ezimbalwa esingazenza ukusiza ukulawula amazinga ethu e-cortisol:

• Lala kahle: Izinkinga ezifana nokungalali kahle nokusebenza ebusuku kungakhuphula amazinga e-cortisol.
• Ukuzivocavoca: Ukuzivocavoca njalo kuthuthukisa ikhwalithi yokulala futhi kunciphisa ukucindezeleka.
• Prakthiza ukuphefumula okujulile: Ukuphefumula ngendlela elawulwayo kuvuselela uhlelo lwethu lwezinzwa oluthinta inhliziyo - uhlelo oluzolisa umzimba wethu futhi olulawula "ukuphumula nokugaya".
• Jabula futhi umomotheke: Uma umomotheka, ama-hormone abizwa ngokuthi ama-endorphin ayakhishwa futhi amazinga e-cortisol ayancipha.
• Gcina ubudlelwano obuhle phakathi kwabantu: Ubudlelwano obuhlala bunezinkinga futhi bushubile bungabangela ukucindezeleka okuqhubekayo.