Unemibuzo mayelana neCortisol? Ake siqonde kahle le 'hormone yokucindezeleka' ngeNirogi Lanka!

Kungenzeka ukuthi uke wezwa nge-" Cortisol " ( i-Cortisol ), ikakhulukazi uma kukhulunywa " ngokucindezeleka ." Kodwa-ke, i-cortisol ingaphezu nje kokuba 'i-hormone yokucindezeleka.' Eqinisweni, iyi-hormone ebalulekile edlala indima ebalulekile emisebenzini ebalulekile yomzimba wakho. Kwa-Nirogi Lanka, ake sichaze kahle ukuthi iyini i-cortisol nokuthi isebenza kanjani kuwe.

Iyini i-Cortisol? Ingabe ngempela 'iyi-hormone yokucindezeleka'?

Kalula nje, i-cortisol iyi-hormone ekhiqizwa yizindlala zakho ze-adrenal ( izindlala ze-adrenal )—izindlala ezincane ezitholakala phezu kwezinso zakho ngayinye. Luhlobo lwe- glucocorticoid , oluwela ngaphansi kwesigaba sama -hormone e-steroid .

Yebo, njengoba ungase usole, i-cortisol ihlobene kakhulu nokucindezeleka. Kungakhathaliseki ukuthi ubhekene nokucindezeleka okukhulu okungazelelwe, ukucindezeleka okuqhubekayo okuqhubekayo, noma ukucindezeleka ngemva kwesigameko esibuhlungu , umzimba wakho ukhipha i-cortisol. Yingakho nje yaziwa kabanzi ngokuthi “i-hormone yokucindezeleka.”

I-cortisol ithinta kanjani umzimba wakho?

I-Cortisol ithonya cishe zonke izitho zomzimba wakho, ilawula imisebenzi eminingana ebalulekile. Ake sibheke ukuthi iyini leyo.

Ukulawula impendulo yakho yokucindezeleka

Uma uzizwa usongelwa noma wesaba, umzimba wakho ungena ngokushesha esimweni "sokulwa noma sokubaleka". Ama-hormone afana ne-adrenaline akhishwa kuqala, kulandelwe yi-cortisol ukuze uhlale uqaphile. Ngaphezu kwalokho, i-cortisol isiza isibindi sakho ukukhulula ushukela, ikunikeze amandla asheshayo owadingayo.

I-Metabolism kanye namazinga kashukela egazini

I-Metabolism inqubo umzimba wakho oyisebenzisayo ukukhiqiza amandla okuphila kwansuku zonke. I-Cortisol ilawula lokhu ngokulawula indlela umzimba wakho osebenzisa ngayo i-glucose.

Ngokwesibonelo:

• Isebenzisana ne-pancreas yakho ukuze yehlise ukukhiqizwa kwe-insulin futhi ikhulise ukukhiqizwa kwe-glucagon. Ngenkathi i-insulin yehlisa ushukela egazini, i-glucagon iyasebenza ukuze iwukhulise.
• Iphinde ilawule indlela i-glucose esetshenziswa ngayo yizicubu zakho zamafutha, isibindi, kanye nezicubu zemisipha.

Ukuvimbela ukuvuvukala

Esikhathini esifushane, i-cortisol ingakhulisa izinga lakho loshukela egazini.ukuvikela amasosha omzimba ngokunciphisa ukuvuvukala (ukuvuvukala noma ukubomvu). Kodwa-ke, uma amazinga akho e-cortisol ehlala ephakeme isikhathi eside kakhulu, umzimba wakho ungajwayela, okungaholela emphumeleni ophambene: ukuvuvukala okwandisiwe kanye nesistimu yomzimba yokuzivikela ebuthaka.

Ukulawula umfutho wegazi

Nakuba indlela esebenza ngayo iyinkimbinkimbi, ucwaningo lubonisa ukuthi amazinga aphezulu e-cortisol angabangela umfutho wegazi ophakeme, kanti amazinga aphansi ngendlela engavamile angabangela umfutho wegazi ophansi.

Ukusiza ukulawula umjikelezo wokulala nokuvuka

Ngokuvamile, amazinga akho e-cortisol aphansi kakhulu ebusuku futhi afinyelela izinga lawo eliphakeme njengoba nje uvuka. Lokhu kubonisa ukuthi i-cortisol idlala indima ebalulekile esigqini sakho se-circadian , noma umjikelezo wakho wemvelo wokulala nokuvuka.

Umzimba wakho ulawula kanjani amazinga e-cortisol?

Umzimba wakho unesimiso esiyinkimbinkimbi sokulawula amazinga e-cortisol, esilawulwa kakhulu yi- hypothalamus kanye ne- pituitary gland ebuchosheni bakho. Lezi zingxenye ezimbili zilawula ukukhiqizwa kwe-cortisol yizindlala zakho ze-adrenal.

Nansi indlela inqubo esebenza ngayo:

1. Uma amazinga e-cortisol egazini lakho ehla, i-hypothalamus yakho ikhipha i-CRH (i-corticotropin-releasing hormone) .
2. Le CRH ikhombisa indlala yakho ye-pituitary ukuthi ikhiqize i-ACTH (i-adrenocorticotropic hormone) .
3. I-ACTH ibe isivuselela izindlala zakho ze-adrenal ukuze zikhiqize i-cortisol bese ziyikhipha egazini lakho.

Ukuze ugcine amazinga e-cortisol aphilile, i-hypothalamus yakho, i-pituitary gland, kanye nezindlala ze-adrenal kumele zisebenze ngokuvumelana. Uma uhlangabezana nezimpawu ezinzima, sicela uxhumane nezinsizakalo eziphuthumayo noma isibhedlela esiseduze nawe ngokushesha.

Kwenzekani uma amazinga akho e-cortisol ephezulu kakhulu?

Uma umzimba wakho ugcina amazinga aphezulu e-cortisol isikhathi eside, kuholela esimweni esibizwa ngokuthi i-hypercortisolism . Lokhu kuvame ukuhlotshaniswa nesimo sezokwelapha esaziwa ngokuthi i-Cushing's syndrome .

Yini ebangela amazinga aphezulu e-cortisol?

• Imithi ye-corticosteroid: Ukusetshenziswa kwesikhathi eside kwemithamo ephezulu (isb., i-prednisone, i-prednisolone, i-dexamethasone).
• Izimila ezikhipha i-ACTH: Lezi zivame ukuvela endlaleni ye-pituitary.
• Izimila ze-adrenal: Ukukhula kwezindlala zakho ze-adrenal okukhiqiza inani elikhulu le-cortisol.

Izimpawu ze-cortisol ephezulu

Uma une-cortisol ephezulu noma i-Cushing's syndrome, ungase uqaphele lezi zimpawu ezilandelayo:

• Ukwanda kwesisindo: Ngokuyinhloko ubuso bakho kanye nokuhlinzwa kwangaphakathi.
• Amanoni ahlala phakathi kwamahlombe akho, avame ukubizwa ngokuthi "i-buffalo hump."
• Izinguquko zesikhumba:Amamaki okunwebeka abanzi, ansomi esiswini sakho.
• Ubuthakathaka bemisipha: Ikakhulukazi ezingalweni zakho nasemathangeni akho angaphezulu (okuhlobene nokuwohloka kwemisipha ).
• Ushukela ophezulu egazini: Ngokuvamile uthuthukela ku-Type 2 diabetes.
• Umfutho wegazi ophakeme: Umfutho wegazi ophakeme.
• I-Hirsutism: Ukukhula kwezinwele emzimbeni ngokweqile kwabesifazane.
• Ukulahlekelwa ubuningi bamathambo: I-Osteoporosis, okwandisa kakhulu ingozi yakho yokuqhekeka kwamathambo.

Kwenzekani uma amazinga akho e-cortisol ephansi kakhulu?

Uma amazinga e-cortisol ehla ngaphansi kwesilinganiso esijwayelekile, odokotela babiza lokhu ngokuthi i-hypocortisolism noma i-adrenal insufficiency . Kunezinhlobo ezimbili eziyinhloko.

Yini ebangela i-cortisol ephansi?

• Ukuntuleka kwe-adrenal okuyinhloko: Ngokuvamile kwenzeka lapho amasosha omzimba wakho ehlasela izindlala zakho ze-adrenal; lokhu kwaziwa ngokuthi isifo sika-Addison .
• Ukungasebenzi kahle kwe-adrenal yesibili: Kubangelwa ukusebenza kabi kwe-pituitary (hypopituitarism) noma isimila se-pituitary.

Izimpawu ze-cortisol ephansi

Uma amazinga akho e-cortisol ephansi, ungase ubhekane nalokhu okulandelayo:

• Ukukhathala okungapheli: Ukuzizwa ukhathele njalo.
• Ukwehlisa isisindo okungachazeki.
• Ukulahlekelwa yisifiso sokudla.
• Umfutho wegazi ophansi (hypotension).

Ungawalawula kanjani amazinga akho e-cortisol?

Uma unesifo esifana ne-Cushing's syndrome, uzodinga ukwelashwa kochwepheshe, okungafaka phakathi imithi noma ukuhlinzwa. Kodwa-ke, ungasekela umzimba wakho ekulawuleni i-cortisol ngale mikhuba enempilo:

• Beka phambili ubuthongo obusezingeni eliphezulu: Ukungalali kahle noma izinhlelo ezingaguquki, njengokushintshana ebusuku, kungandisa i-cortisol.
• Ukuvivinya umzimba njalo: Ukuzilolonga njalo kuthuthukisa ikhwalithi yokulala futhi kunciphisa ngempumelelo ukucindezeleka.
• Ukuzivocavoca kokuphefumula okujulile: Ukuphefumula okulawulwayo kuvuselela uhlelo lwakho lwezinzwa oluhambisana ne-parasympathetic — uhlelo "lokuphumula nokugaya" olusiza ukuzola umzimba wakho.
• Gxila enjabulweni nasekuhlekeni: Ukuhleka kukhipha ama-endorphin, okusiza ukwehlisa amazinga e-cortisol ngokwemvelo.
• Hlakulela ubudlelwano obuhle: Ukungezwani okuqhubekayo ebudlelwaneni bomuntu siqu kungaholela ekucindezelekeni okungapheli.