Uke wezwa ngesifo sikaParkinson? Noma ukungaphumuli okungabekezeleleki ngezinye izikhathi emilenzeni, okungukuthi, i-Restless Legs Syndrome? Namuhla sizokhuluma ngohlobo olukhethekile lomuthi olusetshenziswa ukwelapha izimo eziningana ezinjalo. Laba babizwa ngokuthi ama-Dopamine Agonists. Nakuba igama liyinkimbinkimbi kancane, indlela abasebenza ngayo ilula kakhulu.
Ayini ngempela ama-dopamine agonists?
Ukuze siqonde lokhu, ake sicabange ngobuchopho bethu isikhashana. Amangqamuzana ezinzwa ebuchosheni bethu ayaxhumana, noma ashintshana ngemiyalezo, ngamakhemikhali akhethekile. Siwabiza lawa ma-neurotransmitter . Cabanga ngamangqamuzana ethu obuchopho njengezingidi ezihlangana ndawonye. Lawa ma-neurotransmitter afana nezihluthulelo ezikhethekile ezingavula lawo mangidi.
I-Dopamine "iyisihluthulelo" esibaluleke kakhulu. Leli khemikhali libalulekile lapho sifunda okuthile, lapho sizizwa sijabule futhi sanelisekile, nalapho silawula ukunyakaza kwemizimba yethu.
Kalula nje, ama-dopamine agonist ayizidakamizwa ezisebenza njenge-dopamine, kodwa empeleni aziyona i-dopamine. Zifana ne-'key' ebizwa ngokuthi i-dopamine. Ngenxa yokuthi amangqamuzana ethu obuchopho awakwazi ukubona umehluko phakathi kwalezi ezimbili, lapho ethola i-dopamine agonist, acabanga ukuthi empeleni athola i-dopamine. Ngakho-ke, le mithi isiza ukunqoba izinkinga ezivelayo lapho amazinga e-dopamine ephansi.
Yiziphi izifo ezisetshenziswa yilo muthi?
Ukwehla kwamazinga e-dopamine emzimbeni kungaholela ezimweni ezahlukene zezokwelapha. Ngezansi kunezinye zezimo zezokwelapha ezisetshenziswa kakhulu ama-dopamine agonists.
| Isimo sezokwelapha | Incazelo elula |
|---|---|
| Isifo sikaParkinson kanye nezinkinga zokunyakaza ezihlobene | Isimo esibangelwa ukuntuleka kwe-dopamine ezingxenyeni zobuchopho ezilawula ukunyakaza komzimba. |
| Isifo Semilenze Engaphumli | Isifiso esinamandla sokunyakaza imilenze, ikakhulukazi ebusuku, kanye nomuzwa wokungakhululeki. |
| I-Hyperprolactinemia | Ukwanda kwamazinga e-hormone prolactin emzimbeni. Lokhu kungabangela izinkinga ezifana nokujikeleza kokuya esikhathini okungajwayelekile. |
| I-Neuroleptic Malignant Syndrome | Inkinga engavamile kodwa eyingozi engabangelwa imithi ethile esetshenziselwa ukwelapha izifo zengqondo. |
| Isifo Sikashukela Sohlobo 2 | Amanye ama-agonist e-dopamine nawo asiza ukulawula amazinga kashukela egazini. |
Ziyini izinzuzo zale mithi?
Kunezizathu eziningana zokuthi kungani uhlobo lwemithi olubizwa ngokuthi ama-dopamine agonists lubaluleke kangaka ezigulini.
- Izinga lempumelelo eliphezulu: Ucwaningo luye lwafakazela ukuthi lolu hlobo lomuthi lusebenza kahle kakhulu ekwelapheni izimo eziningi zezokwelapha.
- Ingasetshenziswa ezifweni ezahlukahlukene: Njengoba sixoxile ngenhla, lezi zisetshenziselwa izifo eziningi ezahlukene, kusukela ezinkingeni zokunyakaza kobuchopho kuya ezinkingeni zamahomoni.
- Ukuhlanganiswa neminye imithi: Isibonelo esihle yisifo sikaParkinson. Ukuhlanganisa i-dopamine agonist nomuthi 'iLevodopa' osetshenziswa kulesi sifo kunganikeza umphumela ophezulu ngisho noma kunomthamo ophansi we-levodopa. Kuphinde kusize ekubambezeleni ukuqala kwe-levodopa.
- Ukusindisa impilo: Ngezinye izikhathi le mithi ingasiza ngisho nasekusindiseni impilo. Isibonelo, ingalawula isimo esiyingozi esibizwa ngokuthi 'i-Neuroleptic Malignant Syndrome'.
Azikho yini izingozi nemiphumela emibi?
Njenganoma yimuphi umuthi, kunemiphumela emibi engaba khona. Kodwa ungesabi. Into ebaluleke kakhulu ukuqaphela lokhu. Ngokuvamile, uma umthamo uphakeme, amathuba okuba nemiphumela emibi ayanda.
| Imiphumela emibi evamile | |
|---|---|
| - Ukuqunjelwa | - Isicanucanu nokuhlanza |
| - Isiyezi | - Ikhanda elibuhlungu |
| - Izinkinga zokugaya ukudla | - Ukuquleka uma umile (i-Orthostatic hypotension) |
Izinkinga Zokulawula Umfutho
Lokhu kuyinto okudingeka ixoxwe ngayo ngokuningiliziwe. I-Dopamine iyikhemikhali esisiza sizizwe izinto ezifana nenjabulo nokwaneliseka. Ngakho-ke nakuba le mithi ivuselela leyo nqubo, ingathinta nekhono labanye abantu lokulawula izifiso zabo . Okusho ukuthi, abakwazi ukulawula izifiso zabo zokwenza okuthile. Isibonelo:
- Ukulutheka ngokweqile kokugembula.
- Ukuthenga izinto ngaphandle kokulawula, noma ngabe awuzidingi.
- Ukucwasa ngokobulili.
- Ukudla ngokweqile okungalawulwa.
Lokhu kubaluleke kakhulu. Uma wena noma umndeni wakho nibona noma yiziphi izinguquko ezingavamile ekuziphatheni kwenu, ningabi namahloni futhi nikhulume nodokotela wakho ngokushesha okukhulu. Kubalulekile ukwazisa udokotela wakho ngalokhu, njengoba kungaba umphumela omubi womuthi.
Kwenzekani uma uyeka ukuthatha imithi ngokuzumayo?
Lokhu futhi kuyiphuzu elibaluleke kakhulu. Uma uyeka ukusebenzisa umuthi we-dopamine agonist ngokuzumayo noma wehlisa umthamo ngaphandle kweseluleko sikadokotela , abanye abantu bangase babe nochungechunge lokungakhululeki. Lokhu sikubiza ngokuthi i-Dopamine Agonist Withdrawal Syndrome (DAWS) . Izimpawu ezingase zivele yilezi:
- Ukukhathazeka nokungaphumuli
- Ukujuluka ngokweqile
- Ukukhathala
- Ubuhlungu bomzimba
- Isicanucanu
Ngakho-ke, into ebaluleke kakhulu okufanele uyikhumbule ukuthi ungalokothi uyeke ukuthatha lo muthi noma ushintshe umthamo ngaphandle kweseluleko sikadokotela wakho.
Zikhona yini izimo lapho kungafanele khona ukuthatha lo muthi?
Yebo, abanye abantu abafaneleki lolu hlobo lwemithi. Lokhu sikubiza ngokuthi "izithiyo."
- Omama abakhulelwe nabancelisayo:Lo muthi awunconywa phakathi nalezi zikhathi ngoba ungathinta ukuncelisa.
- Abantu abanomfutho wegazi ophakeme: Amanye ama-dopamine agonists angakhuphula umfutho wegazi kakhulu.
- Abantu abanesifo sezinso noma sesibindi: Ngoba lezi zifo zithinta inqubo yokususa imithi emzimbeni.
- Abantu abasebenzisa eminye imithi: Ikakhulukazi uma uthatha imithi ye-MAOI, kufanele uyeke ukuyithatha okungenani amasonto amabili ngaphambi kokuqala lo muthi.
- Abantu abanomlando we-psychosis: Le mithi ingandisa ingozi yezimpawu ze-psychosis.
Uma unezinye zalezi zimo, tshela udokotela wakho ngakho ngaphambi kokuqala ukwelashwa.
Uyini umehluko phakathi kwe-dopamine kanye ne-dopamine agonists?
Lona umbuzo abantu abaningi abanawo. Uma i-dopamine iphansi, kungani unikeza ama-agonist e-dopamine esikhundleni sokunikeza i-dopamine ngqo? Kunezizathu eziningana.
Isizathu esiyinhloko isithiyo segazi nobuchopho . Cabanga ngobuchopho bethu njengesihlungi esivikelayo. I-dopamine enikezwa ngaphandle ayikwazi ukudlula kulesi sihlungi ingene ebuchosheni. Kodwa-ke, imithi ye-dopamine agonist ingadlula kulesi sithintelo ingene ebuchosheni ngqo. Yingakho isebenza kangcono.
Umlayezo Wokuya Nawe Ekhaya
- I-dopamine agonist uhlobo lomuthi oluvuselela amangqamuzana obuchopho ngendlela efana ne-dopamine yamakhemikhali, kodwa akuyona i-dopamine uqobo.
- Lezi zisetshenziselwa ukwelapha izimo eziningi, njengesifo sikaParkinson kanye ne-Restless Legs Syndrome.
- Njengayo yonke imithi, lokhu kungaba nemiphumela emibi, ikakhulukazi izinkinga zokulawula ukushukuma komzimba.
- Uma wena noma umndeni wakho nibona noma yiziphi izinguquko ezingavamile, khuluma nodokotela wakho ngokushesha.
- Ungalokothi uyeke ukuthatha lo muthi ngokuzumayo noma ushintshe umthamo ngaphandle kweseluleko sikadokotela.
- Ukukhuluma ngokukhululekile nangokwethembeka nodokotela wakho kuyindlela engcono kakhulu yokuthola imiphumela ephumelela kakhulu.
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