Ingabe uneqhubu emzimbeni wakho? Ingabe lokhu kungaba yi-Epithelioid Sarcoma? Ake sithole ngokuqinisekile!

Kuvamile ukuzizwa ukhathazekile kancane uma ubona iqhubu elincane noma isimila endaweni ethile emzimbeni wakho, akunjalo? Ngezikhathi ezinjalo, ucabanga ngezinto eziningi. "Kuyini lokhu? Ingabe kuyingozi?" Imibuzo efana nale ifika engqondweni. Namuhla sizokhuluma ngohlobo lomdlavuza olungavamile kakhulu olungabonakala njengeziqhubu ezinjalo. Lokho kubizwa ngokuthi i-Epithelioid Sarcoma . Nakuba igama lingase lizwakale lingavamile, kufanelekile ukulazi.

Kuyini i-Epithelioid Sarcoma? Ukucacisa…

Kalula nje, i-Epithelioid Sarcoma (ES) uhlobo lomdlavuza olungavamile kakhulu olungolweqembu lomdlavuza olubizwa ngokuthi ama- soft tissue sarcomas . Igama elithi “soft tissue” libhekisela ezintweni ezisemizimbeni yethu njengemisipha, izicubu ezinamafutha, imithambo yegazi, kanye nemizwa. Ngakho-ke lo mdlavuza ukhula ezindaweni ezinjalo.

Ngokuvamile kuqala njengeqhubu ezingalweni zakho, ezandleni, eminweni, emilenzeni engezansi, noma ezinyaweni zakho . Kodwa-ke, lingakhula noma kuphi emzimbeni wakho. Ngezinye izikhathi, kungakhula iqhubu elingaphezu kwelilodwa. Abanye abantu bakhula nezilonda esikhumbeni lapho kukhona khona iqhubu.

Ingxenye engcono kakhulu ukuthi, i-epithelioid sarcoma umdlavuza okhula kancane kakhulu . Cabanga nje, abanye abantu bangaba nalolu hlobo lomdlavuza izinyanga, ngisho neminyaka, ngaphandle kokubonisa izimpawu. Lokho kusho ukuthi ungakhula emzimbeni wakho ngaphandle kokuthi wena wazi.

Lokhu kubizwa nangokuthi i-epithelial sarcoma. Kunezinhlobo ezimbili eziyinhloko zalokhu: i-distal kanye ne-proximal. Ake sibheke nalokho futhi.

Zikhona yini izinhlobo zalokhu? Ziyini?

Yebo, njengoba sishilo ngaphambili, kunezinhlobo ezimbili eziyinhloko ze-epithelioid sarcoma.

• Uhlobo olukude: Lolu uhlobo oluvame kakhulu . Igama elithi “Distal” lisho ukuthi kude nesikhungo somzimba. Lokhu kusho ukuthi lolu hlobo luvame kakhulu ezindaweni ezifana nezandla zakho, izinyawo, ingaphambili lezingalo zakho, kanye nengxenye engezansi yemilenze yakho .

• Uhlobo lwe-Proximal: Lolu uhlobo olungavamile kakhulu . Igama elithi “Proximal” lisho ukusondela enkabeni yomzimba. Ngakho-ke, le Proximal Epithelioid Sarcoma (PES) ingakhula ezindaweni ezifana nesifuba sakho, isisu, amakhwapha, izitho zangasese (isb. ipipi noma i-vulva), noma ikhanda nentamo .

Ngokuvamile, lolu hlobo lwe-proximal lukhulu kancane kunalolo hlobo lwe-distal.Ulaka. Lokho kusho ukuthi kungasakazeka ngokushesha futhi kube kubi kakhulu. Ngenxa yalokho, kungaba nzima kakhulu ukwelapha.

Ivame kangakanani i-epithelioid sarcoma? Ngubani okungenzeka kakhulu ukuthi ayithole?

Empeleni lo mdlavuza awuvamile. Cabanga nje, kunezinhlobo ezingaphezu kuka-50 ze-soft tissue sarcoma. Zonke zihlangene, zibanga cishe u-1% wazo zonke izinhlobo zomdlavuza kubantu abadala. Bese kuthi, le-epithelioid sarcoma, futhi, iyinani elincane kakhulu, cishe u-1% walezo zinhlobo ze-soft tissue sarcoma. Lokho kusho ukuthi, empeleni, akuvamile.

Ngokusho kochwepheshe, ngisho nasezweni elifana neMelika, okwamanje kunabantu abangaphansi kwe-1,000 abanale sarcoma ye-epithelioid. Ngakho-ke ungacabanga ukuthi lokhu kuyinto engavamile kangakanani.

Ngokuvamile,

• Uhlobo olude lwe-ES – uhlobo oluvame kakhulu – luthinta kakhulu intsha kanye nabantu abadala abasebasha .
• Uhlobo oluseduze ES – uhlobo olungavamile, olunzima kancane – luvame ukubonakala kubantu abadala .

Ziyini izimpawu? Uzibona kanjani?

Ezigabeni zokuqala, i-epithelioid sarcoma ingase ingabi nazimpawu. Lokhu kusho ukuthi ungase ungaboni lutho olungalungile ngayo. Kodwa-ke, njengoba isimila sikhula, ungase ubone izimpawu ezifana nalezi:

• Kuvela iqhubu elisha noma ukuvuvukala . Lokhu kungaba kuncane noma kube kukhulu.
• Izilonda zakheka ebusweni besikhumba lapho kukhona khona iqhubu, okufana nokusikeka okuncane noma inxeba.
• Ubuhlungu buyazwakala. Kodwa lokhu kwenzeka kuphela uma isimila sikhulu kancane futhi sicindezela imisipha noma imizwa ezungezile. Akuwona wonke umuntu ozwa ubuhlungu.
• Kuzwakala sengathi iqhubu ebelikhona isikhathi eside liyakhula .

Okubalulekile: Uma ubona iqhubu elisha noma ukuvuvukala okunje emzimbeni wakho, noma uma uzizwa sengathi elikhona liyakhula, qiniseka ukuthi ubona udokotela . Kungaba yinto elula, kodwa kungcono ukuyihlola.

Kungani lokhu kwenzeka? Yiziphi izizathu?

Uma ngikhuluma iqiniso, odokotela abakakwazi ukusho ngokuqinisekile ukuthi yini ngempela ebangela i-epithelioid sarcoma. Kodwa-ke, ucwaningo luthole ukuthi ihlotshaniswa nokungajwayelekile kwesakhi sofuzo esibizwa ngokuthi i-SMARCB1 . Lesi sakhi sofuzo yisona esitshela umzimba wethu ukuthi wenze amaprotheni. Lokhu kuguquka kwesakhi sofuzo kuvame ukwenzeka ngesikhathi sokuphila. Lokho kusho ukuthi akuyona into ozalwa nayo, ezimweni eziningi.

Njengama-sarcoma amaningi ezicubu ezithambile, ama-sarcoma e-epithelioid avame ukukhula ngaphandle kwesizathu esicacile . Kodwa-ke, avame ukutholakala ngemva komdlavuza wangaphambilini.Ingozi yokuthola lokhu iphakeme kancane kubantu abaye bathola ukwelashwa ngemisebe.

Ngaphezu kwalokho, ochwepheshe bathole ukuthi abantu abanezifo ezithile zomdlavuza womndeni bangase babe sengozini encane yokuthuthukisa i-epithelioid sarcoma. Ezinye zalezi zimo zifaka:

• Isifo sikaGardner
• Uhlobo 1 nohlobo 2 lwe-Neurofibromatosis
• I-Retinoblastoma
• I-Li-Fraumeni syndrome
• I-Tuberous sclerosis complex
• I-Werner syndrome
• I-Gorlin syndrome

Lokhu kuyinkimbinkimbi kancane, kodwa kuhle ukwazi. Uma unalesi simo, khuluma nodokotela wakho ukuze uthole iseluleko esengeziwe.

Ingabe lesi sifo sisakazeka emzimbeni wonke?

Ezimweni eziningi, i-epithelioid sarcoma ayisabalali (i-metastasize) kwezinye izindawo. Okusho ukuthi, ihlala lapho yaqala khona. Kodwa-ke, ngezinye izikhathi, ikakhulukazi izinhlobo ezinolaka kakhulu njengohlobo lwe-proximal, ingasabalala. Uma kwenzeka, kungenzeka kakhulu ukuthi iye kuma -lymph node akho, emaphashini, nasemathanjeni .

Ukubona kanjani lokhu? (Ukuxilongwa)

Udokotela uzokwenza izivivinyo eziningana ukuze anqume ukuthi une-epithelioid sarcoma. Eziyinhloko yilezi:

• Ukuhlolwa ngokomzimba : Udokotela uzokuxilonga, ahlole izinto ezifana nendawo lapho kukhona khona iqhubu kanye nobukhulu balo.
• I-Biopsy: Lolu vivinyo olubaluleke kakhulu . Kuthathwa ingxenye encane kakhulu yesigaxa bese ihlolwa ngaphansi kwe-microscope. Yilapho-ke kuphela lapho singabona khona ngokuqinisekile ukuthi umdlavuza, futhi uma kunjalo, uhlobo luni.
• Ukuhlolwa kwegazi komdlavuza: Ezinye izimpawu zomdlavuza zingatholakala egazini.
• Ukuskena kwe-MRI (I-Magnetic Resonance Imaging – i-MRI): Lokhu kungabona ngokucacile indawo yesimila, ubukhulu baso, nokuthi ngabe sisakazekele yini ezicutshini ezizungezile.
• I-CT scan (i-Computed Tomography – i-CT scan): Lokhu kungabheka nesimila futhi kubone ukuthi umdlavuza ususakazekele kwezinye izindawo, njengamaphaphu.
• Ukuskena kwe-PET (i-Positron Emission Tomography – ukuskena kwe-PET): Lokhu kusiza ukuthola izindawo emzimbeni lapho amangqamuzana omdlavuza esebenza khona.

Ungase ungadingi ukwenza zonke lezi zivivinyo. Udokotela wakho uzonquma ukuthi yiziphi izivivinyo ezidingekayo ngokusekelwe esimweni sakho.

Iyini indlela yokwelapha?

Udokotela wakho uzokhetha uhlelo lokwelashwa olusekelwe ezicini eziningana, okuhlanganisa ubukhulu besimila, indawo yaso, ukuthi umdlavuza ususakazekele kwezinye izindawo, ikhono lomzimba wakho lokuphulukisa, kanye nezintandokazi zakho.

Ukuhlinzwa

Ukwelashwa okuyinhloko nokuvame kakhulu kwe-epithelioid sarcoma ukususa isimila ngokuhlinzwa . Uma umdlavuza ususakazekele kuma-lymph node aseduze, udokotela ohlinzayo angase awasuse nawo.

Ukwelashwa Ngemisebe

Lokhu kungenye indlela yokwelapha umdlavuza evamile. Kusebenzisa ama-X-ray anamandla amakhulu ukubhubhisa amangqamuzana omdlavuza. Odokotela bangase banikeze lokhu kwelashwa ukuze banciphise isimila ngaphambi kokuhlinzwa. Noma, kungasetshenziswa ukubulala noma yimaphi amangqamuzana omdlavuza asele ngemva kokuhlinzwa.

Ukwelashwa ngamakhemikhali

Uma umdlavuza ususakazekele kwezinye izingxenye zomzimba wakho, udokotela wakho angase akuncome ukuthi unikezwe i-chemotherapy . Lokhu kuhilela ukukunikeza imithi ekhethekile yokubulala amangqamuzana omdlavuza. Le mithi ivame ukunikezwa ngemithambo yegazi. Kodwa inganikezwa futhi njengamaphilisi, uketshezi, ukhilimu osetshenziswa esikhumbeni, noma umjovo.

Ukwelashwa Kwemithi Okuqondiwe

Lokhu kuyindlela yokwelapha entsha sha. Kuhilela ukunikeza imithi ehlose kuphela izakhi zofuzo namaprotheni alawula indlela amangqamuzana omdlavuza akhula futhi ahlukane ngayo. Lokhu kusho ukuthi amangqamuzana anempilo awanamathuba amaningi okulimala. Kunezinhlobo eziningana zemithi esetshenziselwa lokhu. Udokotela wakho uzokwakhela uhlelo oluthile lokwelashwa olusekelwe esimweni sakho. I-Tazemetostat uhlobo lomuthi osetshenziselwa i-epithelioid sarcoma. Isiza ekwelapheni amangqamuzana omdlavuza angenakususwa ngokuphelele ngokuhlinzwa.

Ingabe lokhu kungavinjelwa ukuthi kwenzeke?

Into edabukisayo ukuthi, ngoba i-epithelioid sarcoma ivame ukwenzeka ngaphandle kwesizathu esicacile, asinayo indlela yokuyivimbela ukuthi ingakhuli . Lokho kusho ukuthi kunzima ukuthi, "Uma wenza lokhu, ngeke kwenzeke."

Kwenzekani uma uba ne-epithelioid sarcoma? Ingabe ingelapheka?

Kuvamile ukuzizwa wesaba uma uzwa lokhu. Kodwa-ke, i-epithelioid sarcoma iyisifo esingelapheka , ikakhulukazi uma sitholakale kusenesikhathi . Udokotela wakho uzokwenza izivivinyo ezithile ukuze abone ukuthi isimila sikhulu kangakanani nokuthi sisakazekele kwezinye izindawo yini. Ngemuva kwalokho, bazokwakha uhlelo lokwelashwa olufanele wena.

Kungase kube nethimba lodokotela abakwelaphayo. Phakathi kwabo kukhona:

• Udokotela wakho oyinhloko ( udokotela ovame ukukubona).
• Odokotela Bezifo Zomdlavuza: Laba bahlanganisa odokotela bezifo zomdlavuza zamathambo, odokotela abahlinzayo bezifo zomdlavuza, kanye nodokotela abanikeza ukwelashwa ngamakhemikhali kanye nemisebe.
• Odokotela Besikhumba: Ngezinkinga zesikhumba.
• Odokotela bezifo: Labo ababheka imibiko yegazi lakho kanye neyokuhlolwa kwegazi bese bekunikeza imininingwane.
• Odokotela Bezokwelapha: Abantu abakusizayo ukubhekana nokucindezeleka nokwesaba okuhambisana nesifo esifana nalesi.

Ukuphela kwendlela yokwelapha ngokuphelele i-epithelioid sarcoma ukususa ngokuphelele isimila ngokuhlinzwa . Kodwa-ke, kungase kungabi njalo ukuthi sisuswe ngokuphelele.

Uma udokotela ohlinzayo engakwazi ukususa ngokuphelele isimila, udokotela wakho uvame ukuncoma inhlanganisela yezindlela zokwelapha ukulawula isimo sakho. Ngenxa yokuthi i-epithelioid sarcoma ingumdlavuza okhula kancane, abantu abaningi abanalesi sifo basaphila impilo ende nejabulisayo .

Kunemibiko eminingi yocwaningo mayelana nezinga lokusinda kwalesi sifo. Kodwa-ke, ngenxa yokuthi yisifo esingavamile kakhulu, izibalo ziyahlukahluka kakhulu. Ngokusho kweminye imibiko, izinga lokusinda kweminyaka emihlanu lisukela ku-25% kuya ku-92%. Kuncike ezintweni eziningi, njengohlobo lwesifo kanye nempendulo yokwelashwa.

Kufanele ngimbone nini udokotela?

Uma ubona iqhubu elingavamile noma ukuvuvukala noma kuphi emzimbeni wakho, ungakushayi indiva. Qiniseka ukuthi ubona udokotela. Abantu abane-epithelioid sarcoma bavame ukuba namaqhubu ezingalweni, ezandleni, eminweni, emilenzeni engezansi, noma ezinyaweni. Kodwa khumbula, la maqhubu angakhula noma kuphi emzimbeni.

Yimiphi imibuzo okufanele uyibuze udokotela?

Uma wena noma othandekayo wakho nitholakala ninesifo se-epithelioid sarcoma, nansi eminye imibuzo ongayibuza udokotela wakho:

• Ikuphi ithumba?
• Ingabe nginesimila esisodwa kuphela? Noma zikhona ezinye?
• Ingabe umdlavuza ususakazekele kwezinye izingxenye zomzimba?
• Yikuphi ukwelashwa okuncomayo?
• Ukwelashwa kwami ​​kuzothatha isikhathi esingakanani?
• Ngizozizwa kanjani ngesikhathi sokwelashwa? (Izinto ezifana nemiphumela emibi)
• Zikhona yini izindawo lapho ngingafunda khona okwengeziwe ngalokhu? (njengamawebhusayithi athembekile, izincwadi)

Kuvamile ukuzizwa wesaba, uthukuthele, futhi ukhungathekile uma uthola ukuxilongwa okufana nalokhu. Khuluma nodokotela wakho ngalokho ongakulindela ngaphambi, ngesikhathi, nangemva kokwelashwa. Kungasiza futhi ukukhuluma nomeluleki noma uchwepheshe wezokwelapha. Bangakusiza ukubhekana nemizwa eyinkimbinkimbi obhekene nayo ngesikhathi esifana nalesi. Uma kungenzeka, joyina iqembu lokusekelana nabantu ababhekene nento efanayo nawe. Lokhu kungakusiza uzizwe ungedwa.

Umlayezo Wokuya Nawe Ekhaya

• I-Epithelioid sarcoma umdlavuza wezicubu ezithambile ongavamile kakhulu futhi odlangile .
• Ngokuvamile kuba nezigaxa ezithweniKungabonakala njengokuqhuma, ngezinye izikhathi kube nezilonda zesikhumba.
• Izimpawu zingase zingabonakali ezigabeni zokuqala.
• Kuhlotshaniswa nephutha ku-gene ebizwa ngokuthi i-SMARCB1 , kodwa imbangela eqondile ayaziwa okwamanje.
• Ukuhlinzwa kuyindlela yokwelapha eyinhloko . Ukwelashwa ngemisebe, i-chemotherapy, kanye nemithi eqondiwe nakho kuyasetshenziswa.
• Kunzima ukuvimbela , kodwa uma kutholakale kusenesikhathi, kungelashwa .
• Uma ubona iqhubu elisha emzimbeni wakho, bonana nodokotela ngokushesha.
• Ungesabi, ungesabi, futhi ulandele iseluleko esifanele sezokwelapha . Awuwedwa, bakhona odokotela nabathandekayo abazokusiza.

Khumbula, lesi sihloko singesolwazi olujwayelekile kuphela. Uma unemibuzo, kungcono ukubonana nodokotela.