Ingabe wena noma othile emndenini wakho unesifo esingavamile sofuzo esibizwa ngokuthi i-hATTR? Ingabe udokotela wakho ukunike umuthi wokugomela obizwa ngokuthi i-Inotersen njengokwelashwa kwezinkinga zezinzwa ezibangelwa yiwo? Ngakho-ke namuhla sizokhuluma ngokucacile ngalo muthi, ukuthi uwusebenzisa kanjani, kanye nezinto okudingeka siziqaphele. Njengoba lo umuthi uyinkimbinkimbi kancane, kubaluleke kakhulu ukuwuqonda kahle.
Uyini lo muthi obizwa ngokuthi i-Inotersen?
Kalula nje, i-Inotersen umuthi osetshenziselwa ukwelapha ukulimala kwemizwa ezigulini ezinesimo esithile sofuzo esibizwa ngokuthi i-hereditary transthyretin-mediated amyloidosis (hATTR) . Ngokuvamile uthengiswa ngaphansi kwegama lomkhiqizo i-Tegsedi.
Manje ake sibone ukuthi lesi simo esibizwa ngokuthi i-hATTR siyini. Lesi yisifo esingavamile esidluliselwa kusuka esizukulwaneni kuya kwesinye ngokusebenzisa izakhi zofuzo. Ngenxa yokuguquka okungajwayelekile kuphrotheni ebizwa ngokuthi i-transthyretin, ekhiqizwa esibindini somzimba wethu, le phrotheni iyaqoqana futhi ihlale ezingxenyeni ezahlukene zomzimba, ikakhulukazi ohlelweni lwezinzwa. Lawa ma-deposit (ama-amyloid deposits) alimaza imizwa futhi angabangela ukungakhululeki emilenzeni, ubuhlungu, ubuthakathaka, ubunzima bokuhamba, futhi angathinta nenhliziyo nezinso.
Ngakho-ke lokho okwenziwa umuthi wokugomela i-Inotersen ukulawula ukukhiqizwa kwaleyo phrotheni engavamile nokunciphisa umonakalo owengeziwe ezinzwa. Lokhu akulona ikhambi lesifo, kodwa kusiza kakhulu ekulawuleni ukuqhubeka kwesifo, okungukuthi, ukuba kubi kakhulu kwesifo.
Khumbula, lo muthi ungasetshenziswa nakwezinye izimo zezokwelapha njengoba kuyalelwe udokotela wakho. Ngakho-ke landela njalo imiyalelo kadokotela wakho.
Izinto okudingeka uzitshele udokotela wakho ngaphambi kokuthatha lo muthi
Ngaphambi kokuthi uqale ukwelashwa nge-Inotersen, kubalulekile ukutshela udokotela wakho ngomlando wakho wezempilo ophelele. Qiniseka ukuthi ubatshela ngalokhu:
- Isifo sezinso: Uma uke waba naso noma wake waba naso isifo sezinso.
- Izinkinga zegazi: Uma unesifo esinciphisa inani lamaseli abomvu, amaseli amhlophe, noma ama-platelet egazini lakho. Lokhu kubaluleke kakhulu ngoba lo muthi ungathinta inani lama-platelet akho.
- Ukungezwani komzimba: Uma uke waba nokusabela kokungezwani komzimba ne-Inotersen, noma yimuphi omunye umuthi, ukudla, noma udayi.
- Ukukhulelwa: Uma ukhulelwe, noma unethemba lokukhulelwa maduze.
- Ukuncelisa: Uma ungumama oncelisa ingane yakho.
Ngokusekelwe kulolu lwazi, udokotela wakho uzonquma ukuthi lo muthi ukulungele yini nokuthi yiziphi izinyathelo zokuphepha ezengeziwe okufanele uzithathe ngesikhathi sokwelashwa.
Ngingawusebenzisa kanjani umuthi?
Lona umjovo ngaphansi kwesikhumba. Ngokuvamile unikezwa kanye ngesonto.
- Ukuqeqeshwa: Udokotela wakho noma umhlengikazi oqeqeshiwe uzokukhombisa ngokucacile ukuthi ungawulungisa kanjani lo muthi wokugoma nokuthi ungawujova kanjani ekhaya. Ungakhathazeki, kulula kakhulu uma usujwayele.
- Landela imiyalelo: Thatha umuthi njengoba nje uyalelwe, ngezikhathi ezifanele, futhi ungalokothi uthathe okungaphezu kwesilinganiso esinqunyiwe.
- Ukulahla izinaliti: Ungalokothi ulahle izinaliti ezisetshenzisiwe kanye nezinaliti emgqonyeni kadoti. Kufanele zifakwe esitsheni esikhethekile sezinto zokuhlaba. Uma ungenayo, ungayithola kudokotela wakho noma esibhedlela.
- Ukweqisa umthamo: Uma ucabanga ukuthi uthathe umuthi omningi kakhulu, ungesabi futhi ngokushesha shayela i-National Poisons Information Centre e-Colombo National Hospital, noma uye e-Emergency Treatment Unit (ETU) yesibhedlela esiseduze.
- Uma uphuthelwe umthamo: Uma uphuthelwe umthamo, thatha ngokushesha nje lapho ukhumbula. Kodwa uma kungaphansi kwezinsuku ezimbili ngaphambi komthamo wakho olandelayo, yeqa umthamo ophuthelwe. Vele uthathe umthamo olandelayo ngesikhathi esihleliwe. Ungalokothi uthathe umthamo ophindwe kabili.
Imiphumela emibi engaba khona lapho uthatha umuthi
Njenganoma yimuphi umuthi, i-Inotersen ingabangela imiphumela emibi. Eminye yale miphumela ingaba mibi kakhulu, ngakho-ke kubalulekile ukuyiqaphela.
| Umphumela ongemuhle | Izici okufanele uziqaphele |
|---|---|
| Uma unalezi zimpawu, iya kudokotela wakho noma ku-ETU ngokushesha. | |
| Ukusabela Kokungezwani Nomzimba | Ukuqubuka kwesikhumba, ukulunywa, ukuvuvukala kobuso, izindebe noma ulimi, ubunzima bokuphefumula. |
| Ukopha okungavamile | Indle emnyama noma enegazi, umchamo obomvu noma onsundu omnyama, ukuhlanza into efana nekhofi eligayiwe, amabala abomvu esikhumbeni, ukuphuma kwegazi okungavamile ezinsinini, ekhaleni, noma emehlweni. |
| Izimpawu zesifo sohlangothi | Ukushintsha kombono, ukudideka, ubunzima bokukhuluma noma ukuqonda, ikhanda elibuhlungu kakhulu, ukungazweli noma ubuthakathaka obungazelelwe ebusweni, engalweni noma emlenzeni, ubunzima bokuhamba, isiyezi. |
| Izimpawu zokulimala kwezinso | Ubunzima bokuchama noma ushintsho enanini lomchamo ophumayo. |
| Izimpawu zokulimala kwesibindi | Umchamo ophuzi noma onsundu omnyama, ukuphuzi kwamehlo noma isikhumba, ukuzizwa ukhathele, umkhuhlane, ubuhlungu engxenyeni ephezulu kwesokudla yesisu, isicanucanu. |
| Tshela udokotela wakho uma lokhu kuqhubeka noma kukhathaza. | |
| Imiphumela emibi evamile | Ikhanda elibuhlungu, ubuhlungu bamalunga, ubuhlungu bemisipha, isicanucanu, ukuhlanza, ukukhathala, ukubomvu, ukulunywa, noma ubuhlungu endaweni yokujova. |
Ezinye izinto ezingase zihlangane nalo muthi
Eminye imithi oyithathayo ingase ihlangane ne-Inotersen, okuthinta ukusebenza kwayo noma imiphumela emibi. Ngakho-ke, tshela udokotela wakho ngayo yonke imithi oyithathayo. Qaphela kakhulu ngemithi elandelayo:
- Izinto zokunciphisa igazi: Imithi efana ne-warfarin, i-apixaban, i-clopidogrel, ne-aspirin. Ukuthatha lokhu nge-Inotersen kungandisa ingozi yokopha.
- Ama-Painkiller (ama-NSAID): Imithi efana ne-ibuprofen ne-naproxen. Lokhu kungathinta nezinso futhi kwandise ingozi yokopha.
- Eminye imithi engathinta izinso ihlanganisa: eminye imithi yokulwa namagciwane kanye nemithi yokukhipha umchamo (imithi ekhulisa ukuphuma komchamo).
- I-Vitamin A: Amazinga akho e-vitamin A angase ehle uma uthatha lo muthi. Ngakho-ke, kubaluleke kakhulu ukuthola i-vitamin A eyanele.Khuluma nodokotela wakho ngokudla namavithamini okudlayo, bese uthatha isithasiselo sevithamini A uma kudingeka.
Lolu hlu lungase lungahlanganisi konke ukuxhumana okungenzeka. Ngakho-ke tshela udokotela wakho ngayo yonke imithi, amakhambi, amavithamini, kanye nezithasiselo ozithathayo. Qiniseka ukuthi utshela udokotela wakho uma ubhema, uphuza utshwala, noma usebenzisa ezinye izidakamizwa.
Umlayezo Wokuya Nawe Ekhaya
- I-Inotersen umuthi osetshenziselwa ukwelapha umonakalo wezinzwa obangelwa yisimo esithile sofuzo esibizwa ngokuthi i-hATTR.
- Ngaphambi kokuqala ukwelashwa, tshela udokotela wakho ngazo zonke izimo zakho zezokwelapha (ikakhulukazi eziphathelene nezinso negazi) kanye nokungezwani komzimba.
- Funda ukuthi ungawufaka kanjani umuthi wokugoma ngendlela efanele. Lahla izinaliti ezisetshenzisiwe kanye nesirinji ngokuphephile.
- Funa usizo lwezokwelapha ngokushesha uma uhlangabezana nanoma yimiphi imiphumela emibi engathi sína, njengokuphuma kwegazi okungavamile, izimpawu zesifo sohlangothi, noma ukusabela okukhulu kokungezwani komzimba.
- Lo muthi ungowakho kuphela. Ungawubelani nabanye abantu nganoma yisiphi isizathu.
- Hlala uxhumana nodokotela wakho njalo futhi ube khona ezivivinyweni nasezinqumweni ezihleliwe.
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